LOCUS       XM_047444284            9878 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ALF transcription elongation factor 3
            (AFF3), transcript variant X14, mRNA.
ACCESSION   XM_047444284
VERSION     XM_047444284.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9878
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..9878
                     /gene="AFF3"
                     /gene_synonym="KINS; LAF4; MLLT2-like"
                     /note="ALF transcription elongation factor 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 4 mRNAs, 58 ESTs, 449 long SRA reads, 2 Proteins, and
                     97% coverage of the annotated genomic feature by RNAseq
                     alignments, including 3 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:3899"
                     /db_xref="HGNC:HGNC:6473"
                     /db_xref="MIM:601464"
     CDS             146..3823
                     /gene="AFF3"
                     /gene_synonym="KINS; LAF4; MLLT2-like"
                     /codon_start=1
                     /product="AF4/FMR2 family member 3 isoform X11"
                     /protein_id="XP_047300240.1"
                     /db_xref="GeneID:3899"
                     /db_xref="HGNC:HGNC:6473"
                     /db_xref="MIM:601464"
                     /translation="MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDG
                     TFNSSYSLFSEPYKTNKGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQ
                     TPVNKIDEHFVADSRAQNQPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQ
                     RATQQGSLRTLLGDGVGRQQPRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPP
                     SLASKPSLVQQKPTAYVRPMDGQDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPAR
                     AKAKLSKFSIPKQGEESRSGETNSCVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNK
                     DSQLVSSGHNNPKKGDAEPESPDNGTSNTSMLEDDLKLSSDEEENEQAAQRTALRALS
                     DSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPP
                     HFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGK
                     VPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAV
                     PCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPT
                     KTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLES
                     EQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQ
                     FYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSES
                     APPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANH
                     CNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSK
                     KPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDM
                     PRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTM
                     YSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKA
                     LIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTI
                     VSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSSM
                     EHLVQYSQQGLHWLRNSAHLS"
ORIGIN      
        1 gggccggggg cggggggcgg cggcggcgcg gcgagctcgc tgctctctct tgagtgtgcc
       61 tgcgcgcaag ccggggagcg gcgcgcgggc ggcccgagcc tcggcggcgg cggtagcggc
      121 ggcggcgacg ctgacacctc ccaccatgga cagcttcgac ttagccctgc tccaggaatg
      181 ggacctcgag tcactgtgtg tctatgaacc agatagaaat gcattacgga ggaaagaacg
      241 agaaagaaga aatcaagaaa ctcaacagga tgatggcacg tttaattcta gttactctct
      301 cttcagtgag ccctacaaga ctaacaaggg ggatgaactc tccaaccgga tccagaacac
      361 tttaggcaat tatgatgaaa tgaaagactt tttaactgat agatccaatc agagtcatct
      421 cgttggagtt cccaaacctg gggttcctca gactcctgtg aacaagatcg atgaacattt
      481 tgttgcagat tcaagagccc agaaccagcc ctcgtctatc tgtagcacta caacttccac
      541 accagcagct gtccccgtgc agcagagtaa gagaggcact atgggctggc agaaggctgg
      601 gcacccaccc tctgacggcc aacagagagc aacacaacag ggctctctca ggaccttgct
      661 tggagatggt gttggcagac agcagcctcg ggccaaacaa gtgtgcaatg tggaggtggg
      721 ccttcagacc caggagaggc cacctgccat ggcggccaag cacagcagca gcggacactg
      781 tgttcagaac tttcctccat ccctagcttc aaaacccagc ctggtccagc agaaaccgac
      841 cgcgtatgtg aggccaatgg acggccaaga tcaggcccct gatgagtctc ctaagctgaa
      901 gtcgtcttcg gaaaccagcg tgcactgcac atcatacagg ggagtccctg ccagcaagcc
      961 ggagcctgcc agagccaagg ccaagctctc caagttcagc atccccaagc agggggagga
     1021 gagtagatct ggagaaacca acagctgtgt tgaagaaata atccgggaga tgacctggct
     1081 tccaccactt tctgctattc aagcacctgg caaagtggaa ccaaccaaat ttccatttcc
     1141 aaataaggac tctcagcttg tatcctctgg acacaataat ccaaagaaag gtgatgcaga
     1201 gccagagagt ccagacaatg gcacatcgaa tacatcaatg ctggaagatg accttaagct
     1261 aagcagtgat gaagaggaga atgaacaggc agctcagaga acggctctcc gcgctctctc
     1321 tgacagcgcc gtggtccagc agcccaactg cagaacctcg gtgccttcca gcaagggcag
     1381 cagcagcagc agcagcagcg gcagcagcag ctcctccagc gactcagaga gcagctccgg
     1441 atctgactcg gagaccgaga gcagctccag cgagagtgag ggcagcaagc ccccccactt
     1501 ctccagcccc gaggctgaac cggcatcctc taacaagtgg cagctggata aatggctaaa
     1561 caaagttaat ccccacaagc ctcctattct gatccaaaat gaaagccacg ggtcagagag
     1621 caatcagtac tacaacccgg tgaaagagga cgtccaggac tgtgggaaag tccccgacgt
     1681 ttgccagccc agcctgagag agaaggagat caagagcact tgcaaggagg agcaaaggcc
     1741 aaggacagcc aacaaggccc ctgggagtaa aggcgtgaag cagaagtccc cgcccgcggc
     1801 cgtggccgtg gcggtgagcg cagccgcccc gccacccgca gtgccctgtg cgcccgcgga
     1861 gaacgcgccc gcgcctgccc ggaggtccgc gggcaagaag cccaccaggc gcaccgagag
     1921 gacctcagcc ggggacggcg ccaactgcca ccggcccgag gagcccgcgg ccgcggacgc
     1981 gctggggacg agcgtggtgg tccccccgga gcccaccaaa accaggccct gtggcaacaa
     2041 cagagcgagc caccgcaagg agctgcgctc ctccgtgacc tgcgagaagc gccgcacgcg
     2101 ggggctaagc aggatcgtcc ccaaatccaa ggagttcatt gagacagagt cgtcatcttc
     2161 atcctcctcc tcggactccg acctggagtc cgagcaggag gagtaccctc tgtccaaagc
     2221 acagaccgtg gctgcctctg cctcctccgg gaatgatcag aggctgaagg aggccgctgc
     2281 caacgggggc agtggtccta gggcccctgt aggctccatc aacgccagga ccaccagtga
     2341 catcgccaag gagctggagg agcagttcta cacactggtc ccctttggcc ggaacgaact
     2401 tctctcccct ctaaaggaca gtgatgagat caggtctctc tgggtcaaaa tcgacctgac
     2461 cctcctgtcc aggatcccag aacacctgcc ccaggagcca ggggtattga gcgcccctgc
     2521 caccaaggac tctgagagcg caccgcccag ccacacctcg gacacacctg cagaaaaggc
     2581 tttgccaaaa tccaagagga aacgcaagtg tgacaacgaa gacgactaca gggagatcaa
     2641 gaagtcccag ggagagaaag acagctcttc aagactggcc acctccacca gtaatacttt
     2701 gtctgcaaac cactgcaaca tgaacatcaa cagtgtggca ataccaataa ataaaaatga
     2761 aaaaatgctt cggtcgccca tctcacccct ctctgatgca tctaaacaca aatacaccag
     2821 cgaggactta acttcttcca gccgacctaa tggcaacagt ttgtttactt cagcctcttc
     2881 cagcaaaaag cctaaggccg acagccagct gcagcctcac ggcggagacc tcacgaaagc
     2941 agctcacaac aattctgaaa acattcccct ccacaagtca cggccgcaga cgaagccgtg
     3001 gtctccaggc tccaacggcc acagggactg caagaggcag aaacttgtct tcgatgatat
     3061 gcctcgcagt gccgattatt ttatgcaaga agctaaacga atgaagcata aagcagatgc
     3121 aatggtggaa aagtttggaa aggctttgaa ctatgctgaa gcagcattgt cgtttatcga
     3181 gtgtggaaat gcaatggaac aaggccccat ggaatccaaa tctccttata cgatgtattc
     3241 agaaacagta gagctcatca ggtatgctat gagactaaaa acccactcag gccccaatgc
     3301 cacaccagaa gacaaacaac tggctgcatt atgttaccga tgcctggccc tcctgtactg
     3361 gcggatgttt cgactcaaaa gggaccacgc tgtaaagtat tcaaaagcac taatcgacta
     3421 tttcaagaac tcatctaaag ccgcccaagc cccatctccg tggggggcca gtggaaagag
     3481 cactggaacc ccatccccca tgtctcccaa cccctctccc gccagctccg tggggtctca
     3541 gggcagcctc tccaacgcca gcgccctgtc cccgtcgacc atcgtcagca tcccacagcg
     3601 catccaccag atggcggcca accacgtcag catcaccaac agcatcctgc acagctacga
     3661 ctactgggag atggccgaca acctggccaa ggaaaaccga gaattcttca acgacctgga
     3721 tctgctcatg gggccggtca ccctgcacag cagcatggag cacctggtcc agtactccca
     3781 acagggcctg cactggctgc ggaacagcgc ccacctgtca tagggacctc accctggggc
     3841 cagagtgggc tctggtctcc acagatggct caacgttttt ggacactgtg ctactgaaac
     3901 tcccagccac agcatttatc agactgcggt gaacatttcc tcagcattga acaatgatct
     3961 tttgcagggc atgtgtgttt gtatgtgtgg gtatataaga agccgcctgt gtatgtgtgt
     4021 aagatacaca gctcttcaga acacaccttc tttgtctagt ttccataatc ccaggctaga
     4081 caaagtgatc agaggtttct gactagagga agtacacaca cacacacaca cacacacaca
     4141 caccgtacac tcacacacaa tcacagacac acactttcta ttccattcca gtgctaaacc
     4201 gtgacttctt agaaaattca accaaaatct catgggttag ttaaccaggt gcaatacagc
     4261 acaccaaaag cttgactgcc agtgaagatg gacctgctct tatactgttg attactttca
     4321 gtattaatat actattcccc aattattttt tgattggtat gtattaatgg gtaattgaat
     4381 aatgaaaata agccaggtat ttttgtgccg gaagtttact agattgcatg ttaccaaata
     4441 ccctgctctt cctctaattc ccttccccca tctgactcta ttatcaacta aatgcattcc
     4501 aggcaaacag atggacactc acagcccttc ccagccccac ctccaagtag tatgcaaatg
     4561 gcactgagat ttagcaaaaa cgcggcgtct ttgaaagtta acagacacta aggtagcagt
     4621 gcctgtgtgt tggagctcag ttaggagttg aagttttctg cacctgtgat aacaagccca
     4681 ccagccacat gcatttcttc ttcctgccac tgtgactcgg tggctgtaga gccacatggc
     4741 atttgtcagc caatctgttt caagtctttt ctttccacca atagctttct tacagatttt
     4801 cttggctaaa tgaggccatt acctagattg tcccttcagt aggagcctga atccttcgct
     4861 taccaggctg agagctattt gccatgataa tgctgattct ctcactcctc atgcagaatg
     4921 tgcacctgca gccctttgat gcgttttgat ttgggggcga tttttcaggc tttgattagc
     4981 aggctgcttg caatgcagaa gatcacagtt cctttctggg gcagcagcaa ccagagcctc
     5041 ttcctgtgtc ctgtgtgtct ggtatgttta caccttgctc tgagtttttc tcttgttttc
     5101 tttttttaat taagtttaca ttttagtttc tttgacatct tgtttacagt ttttgtctga
     5161 tgttttttct tttgtagtgt cttatgccct agatttagtc atcttgttaa atatatttgg
     5221 atatgaaatc ttgacgaaaa gaaaataact cctgaaaaag agggtctatc ttgccacacg
     5281 ttaaaaacaa aaataatgtc cttgtggcct cttacttgat aaagttgcac caggacggtc
     5341 tgagaaaggc aggcggtgta atatgtggtg caatccattt tttcaaggtg atgacggcac
     5401 aaaatactta gactagatgc tgatccataa acattcactg atattcttac aggttggttt
     5461 gcagtgttaa catttttgtt agcctgatct gtaggtggga agtaagatca tcataattcc
     5521 ttagctctga gcactgattc aaaattgtat aaatgactga acaacttaga tgatttgaaa
     5581 ttaattgaaa ataagaaggg cttgtggaat ttgcatttgg ctttggcctt caagcatttg
     5641 gaaatattaa gagaatttcc attttacatg tctccaactg gggtgcttct tacaaccctt
     5701 tcactttttt tttgagacga gtttcgctct gttgcccagg ctggagtgca gtggcacgat
     5761 ctcggctcac tgcatcctct gcctcctggg ttcaagtgat tgtcccgcct cagcctccca
     5821 agtagctggg attacaggtg tgcactacca tgcccagcta atttttgtgt ttttagtaga
     5881 gactgggttt caccatgttg gccaggctcg tctcaaactc ctgacctcag gtgatctacc
     5941 cgcctccacc tcccaaagtg ttgtgattac aggcgtgagc caccacaccc agccctttca
     6001 ctaatttttg gcagagttca caatcccatc ctatgtcaga aacttgaacc taacttaaga
     6061 aattttgagt catttttttg gaggactgag gctttgttct acctactctt gaagaatcct
     6121 gatgaaatat tcaaacacat aaagggatgg ccctggaggt ctatcctgca tacctggaga
     6181 gcttctctgg tcctgcccac cttgaaagtt gcagactttg ttgtaacatc tatgtgatga
     6241 gcttccctgt gaagccccat ttgacaggtg ggccagcagt gttttatcag cactctgatg
     6301 gcccacattt cccaggaaaa cttcttgaaa cttaccgttg tgggcagtgg tcagagcgtg
     6361 tagttcttat gactgtcttg tttcatctgt ggagcacgtg tggagcacgt tggtacagca
     6421 gtttctgtgg ggtttggcat gggtgatttt ggttagtaac catcctccaa ttgttgcttg
     6481 tgaaagtcat tcataacttg ttccttttac ttagttttgt tgttactgct gttgttgttg
     6541 gtttggttgg ttttgagacc gggtctggct ctgtagccca agctggaatg cggtggcgcg
     6601 atcatggctc cctgcagcct caaactcctg ggctcaagca atcctcctgc ctcagcctcc
     6661 caagcagctg ggaagatagg cacgtgccac cacacccggc taattttttc tttatttttt
     6721 ttgtagagat gggggtctca ctatgttgcc caggctggtc tcaaactcct gggctcaagc
     6781 gatcctttgg cctcggcctc ccaaagtgca tgagccacca tgcctggcct gtttagtttt
     6841 gtttcaagtt gaaatacctt tcttgtgttt tctaattaga aaagtaatat ctactcattg
     6901 taaaaactca aacagtgcag aaatgtagaa agtagaaagt gtaagtccct ggttgtccct
     6961 tctgcctgag acaaccactg ctcacagttt gatgtatatc cttccagaga ctctcaaatt
     7021 taagcaaata atttttatta ccatgtcttt ttatttgaag acgtacattt gcctccaaag
     7081 ttcaacacaa gttcaactga ccatatcctt ccatgacctg aatagatgct atcctttatc
     7141 acgatgttca attgcctttg aaagagagta gtccaggtat attcctgatc aaaatttggc
     7201 atttttgatg atactactct acacagatca gactcatgtg cagaatcgtg cctggagaga
     7261 gaggtttggt taagacagag atttctggaa acattcaaat tgcaaatgga aacttgaaac
     7321 ccacaatcta atgaggaatg tactggaaaa ataatctgaa gagttgacaa attgtgtact
     7381 agattgaaca catggaatgc aatgcaatga gactttctgc actaaaactt atcctcatat
     7441 gtacaacaat gatgtgtgta ttatataaca gtgatgtgta catttctgac accccataca
     7501 taatatacac agtttgtata aatgcataca tttaaaaata tatatgtaca atacagctaa
     7561 cataaaactg tagtacgcct gaaggatatt actagtgcct aatattgagt atgagtcact
     7621 gcgtgttcgc atcaacttgg aagtgcagta attgttataa aattaatcag tgcagccaac
     7681 attatttatg aatcacatct ttgaaactgt gcagtagcat atacatatat atttttaaat
     7741 aacatttttc acagttttcc agagttactg ttgaaatctg catcaccaaa aaaaaaaaaa
     7801 agcaagattt ttttaacaat gtagacactc ttcagaccca gtaatctgcg tgtgatttcc
     7861 tatttgtaga ttcccaagag actttagcag tcaccagcct taatgcatgt acaggatatt
     7921 attgtgactt aatttatctg cagtttttaa tccatgtgaa attggaattt ataaacggac
     7981 ttggattaaa catgtctgcc tttctaaggt tgcaaatgtt acattaaatg atttatgttg
     8041 taaatgagag aagttgagtt gtacgtaaaa gacatccacc aatttctgtg aatattttta
     8101 cacggaaact tgagaatcaa aatacgttca agtcagttgt tctggctccc agtttataat
     8161 ctcgaaaagc aatctttttg tttcataaat ggcttaaatg tagctcccac agattatcag
     8221 tatgaagtct gacatttttc atggaaaaga agtatgtttt tcttcattat aactatagtt
     8281 tactatttgt ctttgctatt tcctgataca tacacatacg cacacacgcg cgcacatgca
     8341 tgcacgtatg cacatgcacg ctcccagtgt cccagtgaag gctcaacagg aagcttgaga
     8401 aggtcatctc aatggccaca gggttcctgt tcaaccagta gccctgggat gccgctttgc
     8461 ttgtcattct ttagtgtcac aagttagttc cctgacttgt gtgcagtcag ggaactgcac
     8521 acaactgaaa ccaacatggt ggaatcatgt ttgcaatatt tggttgagta aaataagata
     8581 attttgaact aaagaagacg gaggcattag accagtggct tgacatgaag catcccctat
     8641 gtgggagggt aagtttgtta acttcatttt tagtcttatc tccaaccctt ttccttatcc
     8701 tcctccccaa actaaagaag cagaaacagc aacaaaagca aaaccatccc ttcacctgat
     8761 ccagcccatg tccttagatt caaatatcct ttgtcttttt cccattatac catctgacat
     8821 aactcactcg tgtctagaga gaaaaatgca gaaagggttt gtttgcagat gggcagttca
     8881 gttgagtcct cattaaccag gcagaggggt gcagaagaag cctgactcag ggtcaccatg
     8941 gagaactcct catcccagag atgggtggga caggaacttg gctttgcttc accaaccact
     9001 gagcttgata ctctttcaga ggtggtttgt gctaagaaac acccagcagt ctttcaagaa
     9061 cgttctcttc tgtagctttg cctgctacac agctgaagtc tgtccctata agaattatat
     9121 ttgtaaaaag taatacattt tcgaagaaac ccggatcaag tggaatcttg aaagtttttt
     9181 taatgaaagg ggaaaaacaa cctgaccaca taaactgcac ttccaaccat ttggaaccag
     9241 agtttatgtc ctcattttcc cattctcaga agagcacagt ttttcaatat tacaacttcc
     9301 tggcaaatag cacaagaaat gttcagactt gagatttgtg ttccctttgt ccagattatt
     9361 ctgtatatgt caccaaaggg gttaacttgt ttgcttggca tgaggaaaat tataaactcc
     9421 gttctcaaac taattacatc tgcccacggt tttggttttt attattttaa ttggcactcc
     9481 gaggcagcag ggggtaaatt ttgtgttggc tgcaagggga tttaggttca cagctcttac
     9541 tcacagtaat gggaatcaag ggattaaatc tctgtgtgtt actttgaaaa tccacctctt
     9601 acagccaatt ttatagacat tgatctgagg gttgaattca gggcactaat tgccagtcag
     9661 tacaagggtc agcatttgtg ttgaagcacc aggggtattg atgtagcctg aaaagctgaa
     9721 tcagggactt gggttttgtt ttgttttgtt ttttttaccc atttttaaaa taggaaagct
     9781 catccagaaa tacttggatc tagacatgat ataacatagc accaatgttt aggattttta
     9841 gagtgctgtt gggtaattaa aataatatca atgttcta
//
