LOCUS       XM_011511178            8660 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ALF transcription elongation factor 3
            (AFF3), transcript variant X22, mRNA.
ACCESSION   XM_011511178
VERSION     XM_011511178.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011511178.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..8660
                     /gene="AFF3"
                     /gene_synonym="KINS; LAF4; MLLT2-like"
                     /note="ALF transcription elongation factor 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 4 mRNAs, 43 ESTs, 421 long SRA reads, 1 Protein, and
                     96% coverage of the annotated genomic feature by RNAseq
                     alignments, including 3 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:3899"
                     /db_xref="HGNC:HGNC:6473"
                     /db_xref="MIM:601464"
     CDS             8..2605
                     /gene="AFF3"
                     /gene_synonym="KINS; LAF4; MLLT2-like"
                     /codon_start=1
                     /product="AF4/FMR2 family member 3 isoform X18"
                     /protein_id="XP_011509480.1"
                     /db_xref="GeneID:3899"
                     /db_xref="HGNC:HGNC:6473"
                     /db_xref="MIM:601464"
                     /translation="MVALQAAGLLSAKCELLCSWQAAQRTALRALSDSAVVQQPNCRT
                     SVPSSKGSSSSSSSGSSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASS
                     NKWQLDKWLNKVNPHKPPILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREK
                     EIKSTCKEEQRPRTANKAPGSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPA
                     RRSAGKKPTRRTERTSAGDGANCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASH
                     RKELRSSVTCEKRRTRGLSRIVPKSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQT
                     VAASASSGNDQRLKEAAANGGSGPRAPVGSINARTTSDIAKELEEQFYTLVPFGRNEL
                     LSPLKDSDEIRSLWVKIDLTLLSRIPEHLPQEPGVLSAPATKDSESAPPSHTSDTPAE
                     KALPKSKRKRKCDNEDDYREIKKSQGEKDSSSRLATSTSNTLSANHCNMNINSVAIPI
                     NKNEKMLRSPISPLSDASKHKYTSEDLTSSSRPNGNSLFTSASSSKKPKADSQLQPHG
                     GDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGHRDCKRQKLVFDDMPRSADYFMQEAK
                     RMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQGPMESKSPYTMYSETVELIRYAM
                     RLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKRDHAVKYSKALIDYFKNSSKAA
                     QAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNASALSPSTIVSIPQRIHQMAA
                     NHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVTLHSSMEHLVQYSQQGLH
                     WLRNSAHLS"
ORIGIN      
        1 aagctgaatg gtggcactcc aggctgctgg tcttttgtct gctaagtgtg agcttctatg
       61 cagttggcag gcagctcaga gaacggctct ccgcgctctc tctgacagcg ccgtggtcca
      121 gcagcccaac tgcagaacct cggtgccttc cagcaagggc agcagcagca gcagcagcag
      181 cggcagcagc agctcctcca gcgactcaga gagcagctcc ggatctgact cggagaccga
      241 gagcagctcc agcgagagtg agggcagcaa gcccccccac ttctccagcc ccgaggctga
      301 accggcatcc tctaacaagt ggcagctgga taaatggcta aacaaagtta atccccacaa
      361 gcctcctatt ctgatccaaa atgaaagcca cgggtcagag agcaatcagt actacaaccc
      421 ggtgaaagag gacgtccagg actgtgggaa agtccccgac gtttgccagc ccagcctgag
      481 agagaaggag atcaagagca cttgcaagga ggagcaaagg ccaaggacag ccaacaaggc
      541 ccctgggagt aaaggcgtga agcagaagtc cccgcccgcg gccgtggccg tggcggtgag
      601 cgcagccgcc ccgccacccg cagtgccctg tgcgcccgcg gagaacgcgc ccgcgcctgc
      661 ccggaggtcc gcgggcaaga agcccaccag gcgcaccgag aggacctcag ccggggacgg
      721 cgccaactgc caccggcccg aggagcccgc ggccgcggac gcgctgggga cgagcgtggt
      781 ggtccccccg gagcccacca aaaccaggcc ctgtggcaac aacagagcga gccaccgcaa
      841 ggagctgcgc tcctccgtga cctgcgagaa gcgccgcacg cgggggctaa gcaggatcgt
      901 ccccaaatcc aaggagttca ttgagacaga gtcgtcatct tcatcctcct cctcggactc
      961 cgacctggag tccgagcagg aggagtaccc tctgtccaaa gcacagaccg tggctgcctc
     1021 tgcctcctcc gggaatgatc agaggctgaa ggaggccgct gccaacgggg gcagtggtcc
     1081 tagggcccct gtaggctcca tcaacgccag gaccaccagt gacatcgcca aggagctgga
     1141 ggagcagttc tacacactgg tcccctttgg ccggaacgaa cttctctccc ctctaaagga
     1201 cagtgatgag atcaggtctc tctgggtcaa aatcgacctg accctcctgt ccaggatccc
     1261 agaacacctg ccccaggagc caggggtatt gagcgcccct gccaccaagg actctgagag
     1321 cgcaccgccc agccacacct cggacacacc tgcagaaaag gctttgccaa aatccaagag
     1381 gaaacgcaag tgtgacaacg aagacgacta cagggagatc aagaagtccc agggagagaa
     1441 agacagctct tcaagactgg ccacctccac cagtaatact ttgtctgcaa accactgcaa
     1501 catgaacatc aacagtgtgg caataccaat aaataaaaat gaaaaaatgc ttcggtcgcc
     1561 catctcaccc ctctctgatg catctaaaca caaatacacc agcgaggact taacttcttc
     1621 cagccgacct aatggcaaca gtttgtttac ttcagcctct tccagcaaaa agcctaaggc
     1681 cgacagccag ctgcagcctc acggcggaga cctcacgaaa gcagctcaca acaattctga
     1741 aaacattccc ctccacaagt cacggccgca gacgaagccg tggtctccag gctccaacgg
     1801 ccacagggac tgcaagaggc agaaacttgt cttcgatgat atgcctcgca gtgccgatta
     1861 ttttatgcaa gaagctaaac gaatgaagca taaagcagat gcaatggtgg aaaagtttgg
     1921 aaaggctttg aactatgctg aagcagcatt gtcgtttatc gagtgtggaa atgcaatgga
     1981 acaaggcccc atggaatcca aatctcctta tacgatgtat tcagaaacag tagagctcat
     2041 caggtatgct atgagactaa aaacccactc aggccccaat gccacaccag aagacaaaca
     2101 actggctgca ttatgttacc gatgcctggc cctcctgtac tggcggatgt ttcgactcaa
     2161 aagggaccac gctgtaaagt attcaaaagc actaatcgac tatttcaaga actcatctaa
     2221 agccgcccaa gccccatctc cgtggggggc cagtggaaag agcactggaa ccccatcccc
     2281 catgtctccc aacccctctc ccgccagctc cgtggggtct cagggcagcc tctccaacgc
     2341 cagcgccctg tccccgtcga ccatcgtcag catcccacag cgcatccacc agatggcggc
     2401 caaccacgtc agcatcacca acagcatcct gcacagctac gactactggg agatggccga
     2461 caacctggcc aaggaaaacc gagaattctt caacgacctg gatctgctca tggggccggt
     2521 caccctgcac agcagcatgg agcacctggt ccagtactcc caacagggcc tgcactggct
     2581 gcggaacagc gcccacctgt catagggacc tcaccctggg gccagagtgg gctctggtct
     2641 ccacagatgg ctcaacgttt ttggacactg tgctactgaa actcccagcc acagcattta
     2701 tcagactgcg gtgaacattt cctcagcatt gaacaatgat cttttgcagg gcatgtgtgt
     2761 ttgtatgtgt gggtatataa gaagccgcct gtgtatgtgt gtaagataca cagctcttca
     2821 gaacacacct tctttgtcta gtttccataa tcccaggcta gacaaagtga tcagaggttt
     2881 ctgactagag gaagtacaca cacacacaca cacacacaca cacaccgtac actcacacac
     2941 aatcacagac acacactttc tattccattc cagtgctaaa ccgtgacttc ttagaaaatt
     3001 caaccaaaat ctcatgggtt agttaaccag gtgcaataca gcacaccaaa agcttgactg
     3061 ccagtgaaga tggacctgct cttatactgt tgattacttt cagtattaat atactattcc
     3121 ccaattattt tttgattggt atgtattaat gggtaattga ataatgaaaa taagccaggt
     3181 atttttgtgc cggaagttta ctagattgca tgttaccaaa taccctgctc ttcctctaat
     3241 tcccttcccc catctgactc tattatcaac taaatgcatt ccaggcaaac agatggacac
     3301 tcacagccct tcccagcccc acctccaagt agtatgcaaa tggcactgag atttagcaaa
     3361 aacgcggcgt ctttgaaagt taacagacac taaggtagca gtgcctgtgt gttggagctc
     3421 agttaggagt tgaagttttc tgcacctgtg ataacaagcc caccagccac atgcatttct
     3481 tcttcctgcc actgtgactc ggtggctgta gagccacatg gcatttgtca gccaatctgt
     3541 ttcaagtctt ttctttccac caatagcttt cttacagatt ttcttggcta aatgaggcca
     3601 ttacctagat tgtcccttca gtaggagcct gaatccttcg cttaccaggc tgagagctat
     3661 ttgccatgat aatgctgatt ctctcactcc tcatgcagaa tgtgcacctg cagccctttg
     3721 atgcgttttg atttgggggc gatttttcag gctttgatta gcaggctgct tgcaatgcag
     3781 aagatcacag ttcctttctg gggcagcagc aaccagagcc tcttcctgtg tcctgtgtgt
     3841 ctggtatgtt tacaccttgc tctgagtttt tctcttgttt tcttttttta attaagttta
     3901 cattttagtt tctttgacat cttgtttaca gtttttgtct gatgtttttt cttttgtagt
     3961 gtcttatgcc ctagatttag tcatcttgtt aaatatattt ggatatgaaa tcttgacgaa
     4021 aagaaaataa ctcctgaaaa agagggtcta tcttgccaca cgttaaaaac aaaaataatg
     4081 tccttgtggc ctcttacttg ataaagttgc accaggacgg tctgagaaag gcaggcggtg
     4141 taatatgtgg tgcaatccat tttttcaagg tgatgacggc acaaaatact tagactagat
     4201 gctgatccat aaacattcac tgatattctt acaggttggt ttgcagtgtt aacatttttg
     4261 ttagcctgat ctgtaggtgg gaagtaagat catcataatt ccttagctct gagcactgat
     4321 tcaaaattgt ataaatgact gaacaactta gatgatttga aattaattga aaataagaag
     4381 ggcttgtgga atttgcattt ggctttggcc ttcaagcatt tggaaatatt aagagaattt
     4441 ccattttaca tgtctccaac tggggtgctt cttacaaccc tttcactttt tttttgagac
     4501 gagtttcgct ctgttgccca ggctggagtg cagtggcacg atctcggctc actgcatcct
     4561 ctgcctcctg ggttcaagtg attgtcccgc ctcagcctcc caagtagctg ggattacagg
     4621 tgtgcactac catgcccagc taatttttgt gtttttagta gagactgggt ttcaccatgt
     4681 tggccaggct cgtctcaaac tcctgacctc aggtgatcta cccgcctcca cctcccaaag
     4741 tgttgtgatt acaggcgtga gccaccacac ccagcccttt cactaatttt tggcagagtt
     4801 cacaatccca tcctatgtca gaaacttgaa cctaacttaa gaaattttga gtcatttttt
     4861 tggaggactg aggctttgtt ctacctactc ttgaagaatc ctgatgaaat attcaaacac
     4921 ataaagggat ggccctggag gtctatcctg catacctgga gagcttctct ggtcctgccc
     4981 accttgaaag ttgcagactt tgttgtaaca tctatgtgat gagcttccct gtgaagcccc
     5041 atttgacagg tgggccagca gtgttttatc agcactctga tggcccacat ttcccaggaa
     5101 aacttcttga aacttaccgt tgtgggcagt ggtcagagcg tgtagttctt atgactgtct
     5161 tgtttcatct gtggagcacg tgtggagcac gttggtacag cagtttctgt ggggtttggc
     5221 atgggtgatt ttggttagta accatcctcc aattgttgct tgtgaaagtc attcataact
     5281 tgttcctttt acttagtttt gttgttactg ctgttgttgt tggtttggtt ggttttgaga
     5341 ccgggtctgg ctctgtagcc caagctggaa tgcggtggcg cgatcatggc tccctgcagc
     5401 ctcaaactcc tgggctcaag caatcctcct gcctcagcct cccaagcagc tgggaagata
     5461 ggcacgtgcc accacacccg gctaattttt tctttatttt ttttgtagag atgggggtct
     5521 cactatgttg cccaggctgg tctcaaactc ctgggctcaa gcgatccttt ggcctcggcc
     5581 tcccaaagtg catgagccac catgcctggc ctgtttagtt ttgtttcaag ttgaaatacc
     5641 tttcttgtgt tttctaatta gaaaagtaat atctactcat tgtaaaaact caaacagtgc
     5701 agaaatgtag aaagtagaaa gtgtaagtcc ctggttgtcc cttctgcctg agacaaccac
     5761 tgctcacagt ttgatgtata tccttccaga gactctcaaa tttaagcaaa taatttttat
     5821 taccatgtct ttttatttga agacgtacat ttgcctccaa agttcaacac aagttcaact
     5881 gaccatatcc ttccatgacc tgaatagatg ctatccttta tcacgatgtt caattgcctt
     5941 tgaaagagag tagtccaggt atattcctga tcaaaatttg gcatttttga tgatactact
     6001 ctacacagat cagactcatg tgcagaatcg tgcctggaga gagaggtttg gttaagacag
     6061 agatttctgg aaacattcaa attgcaaatg gaaacttgaa acccacaatc taatgaggaa
     6121 tgtactggaa aaataatctg aagagttgac aaattgtgta ctagattgaa cacatggaat
     6181 gcaatgcaat gagactttct gcactaaaac ttatcctcat atgtacaaca atgatgtgtg
     6241 tattatataa cagtgatgtg tacatttctg acaccccata cataatatac acagtttgta
     6301 taaatgcata catttaaaaa tatatatgta caatacagct aacataaaac tgtagtacgc
     6361 ctgaaggata ttactagtgc ctaatattga gtatgagtca ctgcgtgttc gcatcaactt
     6421 ggaagtgcag taattgttat aaaattaatc agtgcagcca acattattta tgaatcacat
     6481 ctttgaaact gtgcagtagc atatacatat atatttttaa ataacatttt tcacagtttt
     6541 ccagagttac tgttgaaatc tgcatcacca aaaaaaaaaa aaagcaagat ttttttaaca
     6601 atgtagacac tcttcagacc cagtaatctg cgtgtgattt cctatttgta gattcccaag
     6661 agactttagc agtcaccagc cttaatgcat gtacaggata ttattgtgac ttaatttatc
     6721 tgcagttttt aatccatgtg aaattggaat ttataaacgg acttggatta aacatgtctg
     6781 cctttctaag gttgcaaatg ttacattaaa tgatttatgt tgtaaatgag agaagttgag
     6841 ttgtacgtaa aagacatcca ccaatttctg tgaatatttt tacacggaaa cttgagaatc
     6901 aaaatacgtt caagtcagtt gttctggctc ccagtttata atctcgaaaa gcaatctttt
     6961 tgtttcataa atggcttaaa tgtagctccc acagattatc agtatgaagt ctgacatttt
     7021 tcatggaaaa gaagtatgtt tttcttcatt ataactatag tttactattt gtctttgcta
     7081 tttcctgata catacacata cgcacacacg cgcgcacatg catgcacgta tgcacatgca
     7141 cgctcccagt gtcccagtga aggctcaaca ggaagcttga gaaggtcatc tcaatggcca
     7201 cagggttcct gttcaaccag tagccctggg atgccgcttt gcttgtcatt ctttagtgtc
     7261 acaagttagt tccctgactt gtgtgcagtc agggaactgc acacaactga aaccaacatg
     7321 gtggaatcat gtttgcaata tttggttgag taaaataaga taattttgaa ctaaagaaga
     7381 cggaggcatt agaccagtgg cttgacatga agcatcccct atgtgggagg gtaagtttgt
     7441 taacttcatt tttagtctta tctccaaccc ttttccttat cctcctcccc aaactaaaga
     7501 agcagaaaca gcaacaaaag caaaaccatc ccttcacctg atccagccca tgtccttaga
     7561 ttcaaatatc ctttgtcttt ttcccattat accatctgac ataactcact cgtgtctaga
     7621 gagaaaaatg cagaaagggt ttgtttgcag atgggcagtt cagttgagtc ctcattaacc
     7681 aggcagaggg gtgcagaaga agcctgactc agggtcacca tggagaactc ctcatcccag
     7741 agatgggtgg gacaggaact tggctttgct tcaccaacca ctgagcttga tactctttca
     7801 gaggtggttt gtgctaagaa acacccagca gtctttcaag aacgttctct tctgtagctt
     7861 tgcctgctac acagctgaag tctgtcccta taagaattat atttgtaaaa agtaatacat
     7921 tttcgaagaa acccggatca agtggaatct tgaaagtttt tttaatgaaa ggggaaaaac
     7981 aacctgacca cataaactgc acttccaacc atttggaacc agagtttatg tcctcatttt
     8041 cccattctca gaagagcaca gtttttcaat attacaactt cctggcaaat agcacaagaa
     8101 atgttcagac ttgagatttg tgttcccttt gtccagatta ttctgtatat gtcaccaaag
     8161 gggttaactt gtttgcttgg catgaggaaa attataaact ccgttctcaa actaattaca
     8221 tctgcccacg gttttggttt ttattatttt aattggcact ccgaggcagc agggggtaaa
     8281 ttttgtgttg gctgcaaggg gatttaggtt cacagctctt actcacagta atgggaatca
     8341 agggattaaa tctctgtgtg ttactttgaa aatccacctc ttacagccaa ttttatagac
     8401 attgatctga gggttgaatt cagggcacta attgccagtc agtacaaggg tcagcatttg
     8461 tgttgaagca ccaggggtat tgatgtagcc tgaaaagctg aatcagggac ttgggttttg
     8521 ttttgttttg ttttttttac ccatttttaa aataggaaag ctcatccaga aatacttgga
     8581 tctagacatg atataacata gcaccaatgt ttaggatttt tagagtgctg ttgggtaatt
     8641 aaaataatat caatgttcta
//
