LOCUS       XM_005263945            9084 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens ALF transcription elongation factor 3
            (AFF3), transcript variant X18, mRNA.
ACCESSION   XM_005263945
VERSION     XM_005263945.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005263945.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..9084
                     /gene="AFF3"
                     /gene_synonym="KINS; LAF4; MLLT2-like"
                     /note="ALF transcription elongation factor 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 4 mRNAs, 44 ESTs, 432 long SRA reads, 1 Protein, and
                     97% coverage of the annotated genomic feature by RNAseq
                     alignments, including 18 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:3899"
                     /db_xref="HGNC:HGNC:6473"
                     /db_xref="MIM:601464"
     CDS             342..3029
                     /gene="AFF3"
                     /gene_synonym="KINS; LAF4; MLLT2-like"
                     /codon_start=1
                     /product="AF4/FMR2 family member 3 isoform X14"
                     /protein_id="XP_005264002.1"
                     /db_xref="GeneID:3899"
                     /db_xref="HGNC:HGNC:6473"
                     /db_xref="MIM:601464"
                     /translation="MGKNNLWNFRMLLQASLLVFDLLSHNWSQPSSGMLEDDLKLSSD
                     EEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSGSSSSSSDSESSSG
                     SDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKPPILIQNESHGS
                     ESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAPGSKGVKQKS
                     PPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGANCHRPEE
                     PAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVPKSKEF
                     IETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPRAPV
                     GSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPEH
                     LPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEK
                     DSSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLT
                     SSSRPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSP
                     GSNGHRDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIE
                     CGNAMEQGPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALL
                     YWRMFRLKRDHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASS
                     VGSQGSLSNASALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENRE
                     FFNDLDLLMGPVTLHSSMEHLVQYSQQGLHWLRNSAHLS"
ORIGIN      
        1 aatatcaaag aaggctacct aacttcagtt tatgttacta agacgcgttt gaaacttcgt
       61 ggataacctt ttgtttgttt gcctcgtgct gaaatgcaaa aaaattatct gatacttgat
      121 acgaagagga atttacctct gtttaaaaat cacacatttc tcccatgaag catgaagatg
      181 gcttttttaa tttaaaaata ttaactgaca gcttcaagat tgattttttt ttctttaatc
      241 tctaaccaga caaattacta aaagcaagaa ggctcttcct ttaatcttgg acatgtcaca
      301 gatatgacac tgttctgtag gagatggctt tttaactgtg gatggggaag aataaccttt
      361 ggaattttag gatgttgtta caggcaagtt tactagtttt tgacttgcta agccacaact
      421 ggagccagcc ttcatcggga atgctggaag atgaccttaa gctaagcagt gatgaagagg
      481 agaatgaaca gcaggcagct cagagaacgg ctctccgcgc tctctctgac agcgccgtgg
      541 tccagcagcc caactgcaga acctcggtgc cttccagcaa gggcagcagc agcagcagca
      601 gcagcggcag cagcagctcc tccagcgact cagagagcag ctccggatct gactcggaga
      661 ccgagagcag ctccagcgag agtgagggca gcaagccccc ccacttctcc agccccgagg
      721 ctgaaccggc atcctctaac aagtggcagc tggataaatg gctaaacaaa gttaatcccc
      781 acaagcctcc tattctgatc caaaatgaaa gccacgggtc agagagcaat cagtactaca
      841 acccggtgaa agaggacgtc caggactgtg ggaaagtccc cgacgtttgc cagcccagcc
      901 tgagagagaa ggagatcaag agcacttgca aggaggagca aaggccaagg acagccaaca
      961 aggcccctgg gagtaaaggc gtgaagcaga agtccccgcc cgcggccgtg gccgtggcgg
     1021 tgagcgcagc cgccccgcca cccgcagtgc cctgtgcgcc cgcggagaac gcgcccgcgc
     1081 ctgcccggag gtccgcgggc aagaagccca ccaggcgcac cgagaggacc tcagccgggg
     1141 acggcgccaa ctgccaccgg cccgaggagc ccgcggccgc ggacgcgctg gggacgagcg
     1201 tggtggtccc cccggagccc accaaaacca ggccctgtgg caacaacaga gcgagccacc
     1261 gcaaggagct gcgctcctcc gtgacctgcg agaagcgccg cacgcggggg ctaagcagga
     1321 tcgtccccaa atccaaggag ttcattgaga cagagtcgtc atcttcatcc tcctcctcgg
     1381 actccgacct ggagtccgag caggaggagt accctctgtc caaagcacag accgtggctg
     1441 cctctgcctc ctccgggaat gatcagaggc tgaaggaggc cgctgccaac gggggcagtg
     1501 gtcctagggc ccctgtaggc tccatcaacg ccaggaccac cagtgacatc gccaaggagc
     1561 tggaggagca gttctacaca ctggtcccct ttggccggaa cgaacttctc tcccctctaa
     1621 aggacagtga tgagatcagg tctctctggg tcaaaatcga cctgaccctc ctgtccagga
     1681 tcccagaaca cctgccccag gagccagggg tattgagcgc ccctgccacc aaggactctg
     1741 agagcgcacc gcccagccac acctcggaca cacctgcaga aaaggctttg ccaaaatcca
     1801 agaggaaacg caagtgtgac aacgaagacg actacaggga gatcaagaag tcccagggag
     1861 agaaagacag ctcttcaaga ctggccacct ccaccagtaa tactttgtct gcaaaccact
     1921 gcaacatgaa catcaacagt gtggcaatac caataaataa aaatgaaaaa atgcttcggt
     1981 cgcccatctc acccctctct gatgcatcta aacacaaata caccagcgag gacttaactt
     2041 cttccagccg acctaatggc aacagtttgt ttacttcagc ctcttccagc aaaaagccta
     2101 aggccgacag ccagctgcag cctcacggcg gagacctcac gaaagcagct cacaacaatt
     2161 ctgaaaacat tcccctccac aagtcacggc cgcagacgaa gccgtggtct ccaggctcca
     2221 acggccacag ggactgcaag aggcagaaac ttgtcttcga tgatatgcct cgcagtgccg
     2281 attattttat gcaagaagct aaacgaatga agcataaagc agatgcaatg gtggaaaagt
     2341 ttggaaaggc tttgaactat gctgaagcag cattgtcgtt tatcgagtgt ggaaatgcaa
     2401 tggaacaagg ccccatggaa tccaaatctc cttatacgat gtattcagaa acagtagagc
     2461 tcatcaggta tgctatgaga ctaaaaaccc actcaggccc caatgccaca ccagaagaca
     2521 aacaactggc tgcattatgt taccgatgcc tggccctcct gtactggcgg atgtttcgac
     2581 tcaaaaggga ccacgctgta aagtattcaa aagcactaat cgactatttc aagaactcat
     2641 ctaaagccgc ccaagcccca tctccgtggg gggccagtgg aaagagcact ggaaccccat
     2701 cccccatgtc tcccaacccc tctcccgcca gctccgtggg gtctcagggc agcctctcca
     2761 acgccagcgc cctgtccccg tcgaccatcg tcagcatccc acagcgcatc caccagatgg
     2821 cggccaacca cgtcagcatc accaacagca tcctgcacag ctacgactac tgggagatgg
     2881 ccgacaacct ggccaaggaa aaccgagaat tcttcaacga cctggatctg ctcatggggc
     2941 cggtcaccct gcacagcagc atggagcacc tggtccagta ctcccaacag ggcctgcact
     3001 ggctgcggaa cagcgcccac ctgtcatagg gacctcaccc tggggccaga gtgggctctg
     3061 gtctccacag atggctcaac gtttttggac actgtgctac tgaaactccc agccacagca
     3121 tttatcagac tgcggtgaac atttcctcag cattgaacaa tgatcttttg cagggcatgt
     3181 gtgtttgtat gtgtgggtat ataagaagcc gcctgtgtat gtgtgtaaga tacacagctc
     3241 ttcagaacac accttctttg tctagtttcc ataatcccag gctagacaaa gtgatcagag
     3301 gtttctgact agaggaagta cacacacaca cacacacaca cacacacacc gtacactcac
     3361 acacaatcac agacacacac tttctattcc attccagtgc taaaccgtga cttcttagaa
     3421 aattcaacca aaatctcatg ggttagttaa ccaggtgcaa tacagcacac caaaagcttg
     3481 actgccagtg aagatggacc tgctcttata ctgttgatta ctttcagtat taatatacta
     3541 ttccccaatt attttttgat tggtatgtat taatgggtaa ttgaataatg aaaataagcc
     3601 aggtattttt gtgccggaag tttactagat tgcatgttac caaataccct gctcttcctc
     3661 taattccctt cccccatctg actctattat caactaaatg cattccaggc aaacagatgg
     3721 acactcacag cccttcccag ccccacctcc aagtagtatg caaatggcac tgagatttag
     3781 caaaaacgcg gcgtctttga aagttaacag acactaaggt agcagtgcct gtgtgttgga
     3841 gctcagttag gagttgaagt tttctgcacc tgtgataaca agcccaccag ccacatgcat
     3901 ttcttcttcc tgccactgtg actcggtggc tgtagagcca catggcattt gtcagccaat
     3961 ctgtttcaag tcttttcttt ccaccaatag ctttcttaca gattttcttg gctaaatgag
     4021 gccattacct agattgtccc ttcagtagga gcctgaatcc ttcgcttacc aggctgagag
     4081 ctatttgcca tgataatgct gattctctca ctcctcatgc agaatgtgca cctgcagccc
     4141 tttgatgcgt tttgatttgg gggcgatttt tcaggctttg attagcaggc tgcttgcaat
     4201 gcagaagatc acagttcctt tctggggcag cagcaaccag agcctcttcc tgtgtcctgt
     4261 gtgtctggta tgtttacacc ttgctctgag tttttctctt gttttctttt tttaattaag
     4321 tttacatttt agtttctttg acatcttgtt tacagttttt gtctgatgtt ttttcttttg
     4381 tagtgtctta tgccctagat ttagtcatct tgttaaatat atttggatat gaaatcttga
     4441 cgaaaagaaa ataactcctg aaaaagaggg tctatcttgc cacacgttaa aaacaaaaat
     4501 aatgtccttg tggcctctta cttgataaag ttgcaccagg acggtctgag aaaggcaggc
     4561 ggtgtaatat gtggtgcaat ccattttttc aaggtgatga cggcacaaaa tacttagact
     4621 agatgctgat ccataaacat tcactgatat tcttacaggt tggtttgcag tgttaacatt
     4681 tttgttagcc tgatctgtag gtgggaagta agatcatcat aattccttag ctctgagcac
     4741 tgattcaaaa ttgtataaat gactgaacaa cttagatgat ttgaaattaa ttgaaaataa
     4801 gaagggcttg tggaatttgc atttggcttt ggccttcaag catttggaaa tattaagaga
     4861 atttccattt tacatgtctc caactggggt gcttcttaca accctttcac tttttttttg
     4921 agacgagttt cgctctgttg cccaggctgg agtgcagtgg cacgatctcg gctcactgca
     4981 tcctctgcct cctgggttca agtgattgtc ccgcctcagc ctcccaagta gctgggatta
     5041 caggtgtgca ctaccatgcc cagctaattt ttgtgttttt agtagagact gggtttcacc
     5101 atgttggcca ggctcgtctc aaactcctga cctcaggtga tctacccgcc tccacctccc
     5161 aaagtgttgt gattacaggc gtgagccacc acacccagcc ctttcactaa tttttggcag
     5221 agttcacaat cccatcctat gtcagaaact tgaacctaac ttaagaaatt ttgagtcatt
     5281 tttttggagg actgaggctt tgttctacct actcttgaag aatcctgatg aaatattcaa
     5341 acacataaag ggatggccct ggaggtctat cctgcatacc tggagagctt ctctggtcct
     5401 gcccaccttg aaagttgcag actttgttgt aacatctatg tgatgagctt ccctgtgaag
     5461 ccccatttga caggtgggcc agcagtgttt tatcagcact ctgatggccc acatttccca
     5521 ggaaaacttc ttgaaactta ccgttgtggg cagtggtcag agcgtgtagt tcttatgact
     5581 gtcttgtttc atctgtggag cacgtgtgga gcacgttggt acagcagttt ctgtggggtt
     5641 tggcatgggt gattttggtt agtaaccatc ctccaattgt tgcttgtgaa agtcattcat
     5701 aacttgttcc ttttacttag ttttgttgtt actgctgttg ttgttggttt ggttggtttt
     5761 gagaccgggt ctggctctgt agcccaagct ggaatgcggt ggcgcgatca tggctccctg
     5821 cagcctcaaa ctcctgggct caagcaatcc tcctgcctca gcctcccaag cagctgggaa
     5881 gataggcacg tgccaccaca cccggctaat tttttcttta ttttttttgt agagatgggg
     5941 gtctcactat gttgcccagg ctggtctcaa actcctgggc tcaagcgatc ctttggcctc
     6001 ggcctcccaa agtgcatgag ccaccatgcc tggcctgttt agttttgttt caagttgaaa
     6061 tacctttctt gtgttttcta attagaaaag taatatctac tcattgtaaa aactcaaaca
     6121 gtgcagaaat gtagaaagta gaaagtgtaa gtccctggtt gtcccttctg cctgagacaa
     6181 ccactgctca cagtttgatg tatatccttc cagagactct caaatttaag caaataattt
     6241 ttattaccat gtctttttat ttgaagacgt acatttgcct ccaaagttca acacaagttc
     6301 aactgaccat atccttccat gacctgaata gatgctatcc tttatcacga tgttcaattg
     6361 cctttgaaag agagtagtcc aggtatattc ctgatcaaaa tttggcattt ttgatgatac
     6421 tactctacac agatcagact catgtgcaga atcgtgcctg gagagagagg tttggttaag
     6481 acagagattt ctggaaacat tcaaattgca aatggaaact tgaaacccac aatctaatga
     6541 ggaatgtact ggaaaaataa tctgaagagt tgacaaattg tgtactagat tgaacacatg
     6601 gaatgcaatg caatgagact ttctgcacta aaacttatcc tcatatgtac aacaatgatg
     6661 tgtgtattat ataacagtga tgtgtacatt tctgacaccc catacataat atacacagtt
     6721 tgtataaatg catacattta aaaatatata tgtacaatac agctaacata aaactgtagt
     6781 acgcctgaag gatattacta gtgcctaata ttgagtatga gtcactgcgt gttcgcatca
     6841 acttggaagt gcagtaattg ttataaaatt aatcagtgca gccaacatta tttatgaatc
     6901 acatctttga aactgtgcag tagcatatac atatatattt ttaaataaca tttttcacag
     6961 ttttccagag ttactgttga aatctgcatc accaaaaaaa aaaaaaagca agattttttt
     7021 aacaatgtag acactcttca gacccagtaa tctgcgtgtg atttcctatt tgtagattcc
     7081 caagagactt tagcagtcac cagccttaat gcatgtacag gatattattg tgacttaatt
     7141 tatctgcagt ttttaatcca tgtgaaattg gaatttataa acggacttgg attaaacatg
     7201 tctgcctttc taaggttgca aatgttacat taaatgattt atgttgtaaa tgagagaagt
     7261 tgagttgtac gtaaaagaca tccaccaatt tctgtgaata tttttacacg gaaacttgag
     7321 aatcaaaata cgttcaagtc agttgttctg gctcccagtt tataatctcg aaaagcaatc
     7381 tttttgtttc ataaatggct taaatgtagc tcccacagat tatcagtatg aagtctgaca
     7441 tttttcatgg aaaagaagta tgtttttctt cattataact atagtttact atttgtcttt
     7501 gctatttcct gatacataca catacgcaca cacgcgcgca catgcatgca cgtatgcaca
     7561 tgcacgctcc cagtgtccca gtgaaggctc aacaggaagc ttgagaaggt catctcaatg
     7621 gccacagggt tcctgttcaa ccagtagccc tgggatgccg ctttgcttgt cattctttag
     7681 tgtcacaagt tagttccctg acttgtgtgc agtcagggaa ctgcacacaa ctgaaaccaa
     7741 catggtggaa tcatgtttgc aatatttggt tgagtaaaat aagataattt tgaactaaag
     7801 aagacggagg cattagacca gtggcttgac atgaagcatc ccctatgtgg gagggtaagt
     7861 ttgttaactt catttttagt cttatctcca acccttttcc ttatcctcct ccccaaacta
     7921 aagaagcaga aacagcaaca aaagcaaaac catcccttca cctgatccag cccatgtcct
     7981 tagattcaaa tatcctttgt ctttttccca ttataccatc tgacataact cactcgtgtc
     8041 tagagagaaa aatgcagaaa gggtttgttt gcagatgggc agttcagttg agtcctcatt
     8101 aaccaggcag aggggtgcag aagaagcctg actcagggtc accatggaga actcctcatc
     8161 ccagagatgg gtgggacagg aacttggctt tgcttcacca accactgagc ttgatactct
     8221 ttcagaggtg gtttgtgcta agaaacaccc agcagtcttt caagaacgtt ctcttctgta
     8281 gctttgcctg ctacacagct gaagtctgtc cctataagaa ttatatttgt aaaaagtaat
     8341 acattttcga agaaacccgg atcaagtgga atcttgaaag tttttttaat gaaaggggaa
     8401 aaacaacctg accacataaa ctgcacttcc aaccatttgg aaccagagtt tatgtcctca
     8461 ttttcccatt ctcagaagag cacagttttt caatattaca acttcctggc aaatagcaca
     8521 agaaatgttc agacttgaga tttgtgttcc ctttgtccag attattctgt atatgtcacc
     8581 aaaggggtta acttgtttgc ttggcatgag gaaaattata aactccgttc tcaaactaat
     8641 tacatctgcc cacggttttg gtttttatta ttttaattgg cactccgagg cagcaggggg
     8701 taaattttgt gttggctgca aggggattta ggttcacagc tcttactcac agtaatggga
     8761 atcaagggat taaatctctg tgtgttactt tgaaaatcca cctcttacag ccaattttat
     8821 agacattgat ctgagggttg aattcagggc actaattgcc agtcagtaca agggtcagca
     8881 tttgtgttga agcaccaggg gtattgatgt agcctgaaaa gctgaatcag ggacttgggt
     8941 tttgttttgt tttgtttttt ttacccattt ttaaaatagg aaagctcatc cagaaatact
     9001 tggatctaga catgatataa catagcacca atgtttagga tttttagagt gctgttgggt
     9061 aattaaaata atatcaatgt tcta
//
