LOCUS       XM_047418827            8078 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens afadin, adherens junction formation factor
            (AFDN), transcript variant X44, mRNA.
ACCESSION   XM_047418827
VERSION     XM_047418827.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..8078
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /note="afadin, adherens junction formation factor; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 3 mRNAs, 51 ESTs, 2040 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 121 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
     CDS             570..5990
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /codon_start=1
                     /product="afadin isoform X44"
                     /protein_id="XP_047274783.1"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
                     /translation="MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMR
                     FYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGER
                     RLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRTL
                     SKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNPE
                     VVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADFA
                     VAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPSD
                     KGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSPD
                     GSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRSM
                     DAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPRH
                     KPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQP
                     DYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLYM
                     ACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASEL
                     LNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQR
                     PKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHY
                     WGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCFK
                     LNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDLQ
                     LPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYES
                     HLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAA
                     DVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLLN
                     QPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDDR
                     LMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEAYP
                     IPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQEE
                     LREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTLT
                     KSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPSA
                     NQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPA
                     PFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGDS
                     LSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQK
                     RLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARDEERRRQQQLEEMRKREAEDRA
                     RQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGLCRP
                     PLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCSL
                     AGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQ
                     DVSNKVKASRKLTELENELNTK"
ORIGIN      
        1 actctgcacc gcgcgtccgg acccaacaca gcaccaccca tcggacccag cactgcccat
       61 ttagatccag cagcgcgcgt ccgaaccgaa cctagcaccg ctggtcggga aggaacccgg
      121 taccgccggt tgggacccac caccgccagt ccagacggaa ccctagcacc gcgcggggcc
      181 cgccctccga cacctccctc cctggcggcc gcggcagcag cacctagtgg agcggcccgg
      241 aggtgcggcg gcgccgcgcg gggcggcggc gcgcacggcg ggcggcggcg cgcacggcgg
      301 cgggcggggc gcgggcgggt gcgggcggcg ggcggcgggc gccgggcgca caccggccgg
      361 cggggctgag gcggcgcggc gcggcgcgga ctgagcccca ggcggaggcc aagtcggagg
      421 acgcggcgcg gccgcggagg cggaggcagc cgcggaggcg gaggcggccg gcggggggtg
      481 gcgaggggcg ccgggccccc gcggacctgt cgtcctcggc ccgtcctccg gccccggccc
      541 cgcgcggctg aggaggcgcg gccaggacca tgtcggcggg cggccgtgac gaggagcggc
      601 ggaagctggc cgacatcatc caccactgga acgccaaccg gctggacctg ttcgagatca
      661 gccagccgac cgaggatttg gagttccatg gagtgatgag attttatttt caagataaag
      721 ctgctggaaa ctttgcaaca aaatgtattc gggtctctag tactgccacc actcaagatg
      781 taatcgaaac gctcgcggag aaatttcgac ctgatatgcg aatgctgtcc tctcccaagt
      841 attcactcta tgaagtgcat gtcagcggag aaagaagatt ggatatagat gagaaacctc
      901 tagttgtaca actgaattgg aacaaagatg atcgggaagg cagatttgtt cttaagaatg
      961 agaatgacgc cattcctcct aaggctcaaa gtaatggacc tgaaaagcag gaaaaagaag
     1021 gggttatcca gaacttcaag agaactctct caaagaaaga aaagaaggaa aaaaagaaga
     1081 gagaaaaaga ggcattgcga caggcatctg ataaagatga tagacctttc caaggggagg
     1141 atgttgaaaa ttctcgactg gctgctgagg tttacaaaga catgccggaa accagcttta
     1201 ctcgaaccat ttctaatcct gaggtggtta tgaaacgacg gaggcagcaa aaattggaaa
     1261 agagaatgca ggaatttcgg agctcagatg ggcggcctga ttcaggtgga acattgagaa
     1321 tttatgcaga tagtttaaaa ccaaatattc cctacaagac aatcctgctg tctactacag
     1381 atcctgcaga ctttgctgtg gctgaagctt tagagaagta tggtctggaa aaagaaaacc
     1441 ctaaggatta ctgcatcgcc cgggttatgc ttcctcctgg agcccagcat tctgatgaaa
     1501 agggtgctaa agaaattatt cttgatgatg atgagtgtcc tttacaaatc ttcagggaat
     1561 ggccaagtga caaagggatt ttagtctttc agttgaagag gaggccacca gaccacatcc
     1621 caaagaaaac caagaaacac ttggaaggca agacacccaa gggaaaggag agagctgacg
     1681 ggtctggcta tggctccacc cttcctccgg agaagctgcc ctatttagta gagttaagcc
     1741 cagatggttc tgactctaga gataagccaa agctttaccg ccttcagtta agtgttactg
     1801 aagttgggac agaaaagttg gatgacaact ctatccagtt gtttggccca ggaattcagc
     1861 cccatcactg tgaccttacc aacatggatg gagtggtcac tgtgacgccc agaagtatgg
     1921 acgcagaaac ctacgtggaa ggccagcgca tctcagaaac caccatgctg cagagtggca
     1981 tgaaagtgca gtttggggcg tcccatgtat ttaagtttgt ggaccccagt caggatcatg
     2041 ctcttgcaaa aagatctgtg gatggaggcc tgatggttaa gggcccaaga cataaacctg
     2101 gaattgttca ggagacaact tttgatttgg gaggagatat tcatagtggg acagcattac
     2161 cgacaagcaa gagcaccact aggctggaca gcgacagagt gtcgtctgcc tctagcacag
     2221 ccgagcgggg aatggtgaag ccgatgatca gagtagaaca gcagccagat tatcgcaggc
     2281 aagaaagcag aacacaggat gcttctgggc ctgagctgat actacctgca agcattgaat
     2341 tcagggaaag ttctgaagat tcatttttgt ctgccattat aaattatact aatagctcta
     2401 cagtccactt taagttgtcc cctacatatg tattatatat ggcatgccgg tatgtattgt
     2461 ccaaccagta cagacctgac atcagcccta cagagcgcac acataaagtc attgcagtcg
     2521 tcaacaagat ggtgagcatg atggagggtg tcatccagaa acagaagaat attgcagggg
     2581 cacttgcctt ctggatggca aatgcatctg aacttctcaa cttcattaag caagaccgag
     2641 accttagtcg gatcacactg gatgctcaag atgttttagc acatttggtt caaatggcat
     2701 ttaaatactt ggttcactgt cttcaatcag aacttaataa ttacatgcca gcctttctag
     2761 atgaccctga agagaacagt ctgcaacgac caaaaataga tgatgtgctg cacacgctca
     2821 caggagccat gtccttgcta cgacgctgca gagtcaatgc cgccctgacc atccagctct
     2881 tctctcagct cttccacttc atcaatatgt ggctgttcaa tagattggtg accgacccag
     2941 attcggggct gtgctcccat tactggggtg cgattatccg tcagcagttg ggccatattg
     3001 aagcctgggc tgagaagcag gggctggaac tggctgcgga ctgtcatctg agcaggatcg
     3061 tgcaggcaac gactttgctt accatggata agtatgcacc tgatgacatt ccaaatataa
     3121 acagcacctg ctttaagtta aattcattac aacttcaagc cttattacag aactatcact
     3181 gtgcacctga tgagcctttt atcccaacgg atcttataga aaatgtagtg actgtggctg
     3241 aaaacactgc cgatgagctg gcccgcagtg atggaaggga agtgcagttg gaggaggatc
     3301 ctgatctgca gctgccgttt cttttgccag aagatggtta ttcttgtgat gttgtcagaa
     3361 acattccaaa tggtttacaa gaatttttag accctctgtg ccagagagga ttttgcaggt
     3421 taattcctca cacacgttca ccaggtactt ggacaatata ttttgaaggt gcagattatg
     3481 aaagtcacct tctgcgtgag aacacagagc tggctcagcc tctgaggaaa gaacctgaaa
     3541 taatcactgt gaccctaaaa aagcagaatg gaatgggcct tagcattgtt gcagcaaagg
     3601 gtgctggtca agataaacta ggaatctatg tgaagtcggt tgtgaaagga ggtgctgcag
     3661 atgtggatgg acgtctagct gcaggtgatc agctcctcag tgtggatgga cgaagtctgg
     3721 ttggactctc tcaggaaagg gcggcagaac tcatgacaag aacaagctct gtggtgacac
     3781 tggaagtagc aaagcagggt gccatctacc acggtctggc cacccttctc aatcagccat
     3841 cccccatgat gcagagaatt tcagatcgtc gtggctcagg taaaccccga ccaaagagtg
     3901 aaggctttga gctctataat aattcaactc aaaatgggtc tcctgagagt cctcagctgc
     3961 cttgggcaga atatagtgaa ccaaagaaat tgcctggtga tgacagactg atgaaaaata
     4021 gagctgatca ccgttccagc cccaacgtag caaatcagcc tcctagtcct ggagggaaaa
     4081 gtgcatatgc ctctggaaca acagcgaaga taacatctgt ctctactgga aacctctgca
     4141 ctgaggagca gacgcctccg cctagacctg aagcctaccc catccccact cagacgtaca
     4201 ccagagagta ttttaccttc ccagcttcca aatcccagga tcggatggct cctcctcaga
     4261 accagtggcc aaattatgag gaaaagccac atatgcacac agatagtaat cattccagta
     4321 ttgcaattca gcgtgttaca cgttcccaag aagaacttcg agaagataaa gcttaccaac
     4381 ttgagcggca tcgaatagag gcagctatgg accgaaagtc tgatagtgat atgtggataa
     4441 atcagagctc ctcactggac tccagtacct ctagccagga gcatctgaac cattcctcta
     4501 agtcggtcac ccctgcttcc acactgacca aaagtggccc tggccgttgg aaaacaccag
     4561 cagccatacc ggccacccct gtggccgtct cccagccaat ccgaacagac ctgcctccgc
     4621 cacccccgcc acctccagtc cactatgccg gtgatttcga tggaatgtcc atggatttgc
     4681 ctctcccacc acccccttcc gccaaccaga tagggctgcc gtctgcgcag gtggctgctg
     4741 ctgaacggag aaagagagaa gaacatcagc gttggtatga gaaggagaag gcccgcctgg
     4801 aggaggagcg ggagaggaag cggagagagc aggagaggaa gttgggccag atgcgcactc
     4861 agtccttaaa ccctgctccg ttttctcccc tgactgcaca gcagatgaag cccgaaaagc
     4921 cttccacact ccagcggcca caggaaacag tcattcggga gctgcagcct cagcagcagc
     4981 cccgcacgat cgagcgcaga gacttgcagt acattacagt cagcaaagag gagctttcct
     5041 cgggggacag tctgtccccc gacccgtgga agcgggacgc caaggagaag ctggagaagc
     5101 agcagcagat gcacatcgtg gacatgctga gcaaggagat ccaggagctc cagagcaaac
     5161 cggaccgcag cgccgaggag agcgaccggc tgcgcaagct catgctggag tggcagttcc
     5221 agaagagact ccaggagtcg aagcagaagg acgaagatga cgaggaggag gaggacgatg
     5281 atgtggacac catgctgatc atgcagcgcc tggaggctga acgaagagcg agggacgagg
     5341 agcggaggcg gcagcagcag ttagaagaga tgcgcaagcg ggaagcggaa gaccgagcga
     5401 ggcaagagga agagcgccgg cggcaggagg aggagcgaac aaaacgagac gctgaagaaa
     5461 agaggcgaca ggaagaaggg tattacagcc gcctggaagc cgagaggcgc agacagcacg
     5521 acgaggcggc gcgcaggttg ctggagcccg aggcgcccgg tctgtgccgc cctccgcttc
     5581 cccgggacta cgagcccccg tccccgtccc ccgcgcccgg cgcccctcct cccccgcctc
     5641 agcgaaacgc ctcctacctc aaaacacagg tcctctcccc cgactcgctg ttcactgcca
     5701 agtttgttgc atacaatgag gaggaggagg aggaggactg cagcctagca ggaccaaact
     5761 cttacccagg atctactgga gcagctgttg gagcccatga cgcctgtcgg gatgcaaaag
     5821 agaagcgctc taaaagccaa gatgcagatt cacctggaag ttctggggcc cctgaaaact
     5881 tgacattcaa ggaacgccag cgtctttttt cacaaggtca agatgtatcc aataaagtga
     5941 aagcttctcg taaattaaca gaactggaga atgaactgaa cacaaagtga aagaaaatga
     6001 ggagaacact ttgtatttac cccaaaatct tttcagttgt gggtttgtag gtgcgagttt
     6061 gaagaggaaa agaggaaggg ggttatattt ctaagtgatt tacaatttct gtttctaaaa
     6121 ttgttgggat ttagaaatgt ttcaattcca agaaatttta ttttacttta ccatgagatt
     6181 gccatttatg taatttaaac actgtctagt ttcttaatta tctaactcac acgagggtaa
     6241 gttttttgtt ggtttctttt ttggagtcct gagttcaaag gggacagaac taagggcagg
     6301 agaagagaat ggatgtgtct tctctcccat cttcccctca tcatcgaccg aggagcacaa
     6361 agaagttctg tttctgtttt tttcagaaac tttattttag ctgtcaagca gagaatagct
     6421 tgaactattc agactattgt tggcactgtt tagtagtgac cacacgctct tctacccggg
     6481 aaggaacata tgacgacatg ctcctcccat gtcccctgat ggtgtctgtt cccacaatat
     6541 ccttctagtc tgcatcgtga agtggcttag gccaaagctt cctgtgtgat gacgcacgtc
     6601 cgagactgtt ccatctcatt cctcgcaaat ttgagctctt ctgatcaatt ctaaatattt
     6661 gattaatttt aattctgaaa gaaaattttg aggatttaag cttaggggat tttattttta
     6721 taaataccag attattgtta gacttaataa atcactgtta aatttaaaga tgacagttac
     6781 cttggaaagt tcactaatac ttcgctccaa ggcgtctgta aaagaagata tctttattgg
     6841 agcaatgttc atgtgactgg gaatgacaga agaatgggag atgagtaggg acccctcaag
     6901 cacagctgtc actcagaaat tttaaatttg aaaaagaaat cgattttcat ctgtatgccg
     6961 tcaaggaagg aattcagtta cagggcatct gtaacttaaa tattgtaaga ataactcata
     7021 tggaagttca agctattttt atactataat agagttattt aattttaatt tgttgaatta
     7081 ttagttacca ctgtcatttc ttcagctatg gatatgtggc tgatgttggg gagacggacc
     7141 tcagtgtgtt ttatattgtc tggtgttaag atgataaatt actttgtgat tacaagcaaa
     7201 ttttctattt gacaaagccc ttggtggagt ccaaatgatt tttctgtacc atattgttct
     7261 cttacacata cgtatgttag gaaaataggc acactttcaa agagaatgtt ctcttacaca
     7321 tacgtatgtt aggaaaatag acacattttc aaagagaatg ttctcttaca tatgttagga
     7381 aaataggcac actttcaaag agaggtatag gggcttttta ctgccttcga aatcactttt
     7441 aataaaagtt gtatgataaa tcattaaaaa tgcgagtgta aatatttttt tttacctcta
     7501 tcagggtttt tatttgaaag tgtgctctta ccatttcctt gtttgagtaa gagagtgaat
     7561 ggttctgagt gtttaggaag gatttgcttg cttgcagcag aagttctagg aaaagcaggc
     7621 acctcccaaa tatcttgagg acactggcag ccttatggtg actaaatcca cactttcttt
     7681 aaagagatgc agatgaatta cttttctgtt aatatataga aaaatacaca ggagaacatg
     7741 cagatacatg taaatatcta catacaggga tatttgtatg tgtggttgtg aaacccatac
     7801 acaagtggat ttggccatct ttgggcagtg aggtcaaatg tgaatatgtg taaaagtgct
     7861 tttcagaact gcattactat gagaaaacat caaaactgct gtagttttcc atttctactg
     7921 tatttcagtt gcaacctatt tttaataaac tttgtatgta tttaagtgta tttgctattg
     7981 ttttgaaagt gctgacaaag tttatatttg taacatcagc cttcctcgcc catctctttc
     8041 catctgtctc ttcttcatta aacacttact gagtatga
//
