LOCUS       XM_047418821            8090 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens afadin, adherens junction formation factor
            (AFDN), transcript variant X37, mRNA.
ACCESSION   XM_047418821
VERSION     XM_047418821.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..8090
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /note="afadin, adherens junction formation factor; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 57 ESTs, 2512 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 123 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
     CDS             570..6002
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /codon_start=1
                     /product="afadin isoform X37"
                     /protein_id="XP_047274777.1"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
                     /translation="MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMR
                     FYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEE
                     RRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKR
                     TLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISN
                     PEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPAD
                     FAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWP
                     SDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELS
                     PDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPR
                     SMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGP
                     RHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQ
                     QPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVL
                     YMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANAS
                     ELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSL
                     QRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCS
                     HYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTC
                     FKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPD
                     LQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADY
                     ESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGG
                     AADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATL
                     LNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGD
                     DRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEA
                     YPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQ
                     EELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPAST
                     LTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPP
                     SANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLN
                     PAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSG
                     DSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQF
                     QKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEEMRKREA
                     EDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPG
                     LCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEE
                     DCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLF
                     SQGQDVSNKVKASRKLTELENELNTK"
ORIGIN      
        1 actctgcacc gcgcgtccgg acccaacaca gcaccaccca tcggacccag cactgcccat
       61 ttagatccag cagcgcgcgt ccgaaccgaa cctagcaccg ctggtcggga aggaacccgg
      121 taccgccggt tgggacccac caccgccagt ccagacggaa ccctagcacc gcgcggggcc
      181 cgccctccga cacctccctc cctggcggcc gcggcagcag cacctagtgg agcggcccgg
      241 aggtgcggcg gcgccgcgcg gggcggcggc gcgcacggcg ggcggcggcg cgcacggcgg
      301 cgggcggggc gcgggcgggt gcgggcggcg ggcggcgggc gccgggcgca caccggccgg
      361 cggggctgag gcggcgcggc gcggcgcgga ctgagcccca ggcggaggcc aagtcggagg
      421 acgcggcgcg gccgcggagg cggaggcagc cgcggaggcg gaggcggccg gcggggggtg
      481 gcgaggggcg ccgggccccc gcggacctgt cgtcctcggc ccgtcctccg gccccggccc
      541 cgcgcggctg aggaggcgcg gccaggacca tgtcggcggg cggccgtgac gaggagcggc
      601 ggaagctggc cgacatcatc caccactgga acgccaaccg gctggacctg ttcgagatca
      661 gccagccgac cgaggatttg gagttccatg gagtgatgag attttatttt caagataaag
      721 ctgctggaaa ctttgcaaca aaatgtattc gggtctctag tactgccacc actcaagatg
      781 taatcgaaac gctcgcggag aaatttcgac ctgatatgcg aatgctgtcc tctcccaagt
      841 attcactcta tgaagtgcat gtcagcggag aagaaagaag attggatata gatgagaaac
      901 ctctagttgt acaactgaat tggaacaaag atgatcggga aggcagattt gttcttaaga
      961 atgagaatga cgccattcct cctaagaagg ctcaaagtaa tggacctgaa aagcaggaaa
     1021 aagaaggggt tatccagaac ttcaagagaa ctctctcaaa gaaagaaaag aaggaaaaaa
     1081 agaagagaga aaaagaggca ttgcgacagg catctgataa agatgataga cctttccaag
     1141 gggaggatgt tgaaaattct cgactggctg ctgaggttta caaagacatg ccggaaacca
     1201 gctttactcg aaccatttct aatcctgagg tggttatgaa acgacggagg cagcaaaaat
     1261 tggaaaagag aatgcaggaa tttcggagct cagatgggcg gcctgattca ggtggaacat
     1321 tgagaattta tgcagatagt ttaaaaccaa atattcccta caagacaatc ctgctgtcta
     1381 ctacagatcc tgcagacttt gctgtggctg aagctttaga gaagtatggt ctggaaaaag
     1441 aaaaccctaa ggattactgc atcgcccggg ttatgcttcc tcctggagcc cagcattctg
     1501 atgaaaaggg tgctaaagaa attattcttg atgatgatga gtgtccttta caaatcttca
     1561 gggaatggcc aagtgacaaa gggattttag tctttcagtt gaagaggagg ccaccagacc
     1621 acatcccaaa gaaaaccaag aaacacttgg aaggcaagac acccaaggga aaggagagag
     1681 ctgacgggtc tggctatggc tccacccttc ctccggagaa gctgccctat ttagtagagt
     1741 taagcccaga tggttctgac tctagagata agccaaagct ttaccgcctt cagttaagtg
     1801 ttactgaagt tgggacagaa aagttggatg acaactctat ccagttgttt ggcccaggaa
     1861 ttcagcccca tcactgtgac cttaccaaca tggatggagt ggtcactgtg acgcccagaa
     1921 gtatggacgc agaaacctac gtggaaggcc agcgcatctc agaaaccacc atgctgcaga
     1981 gtggcatgaa agtgcagttt ggggcgtccc atgtatttaa gtttgtggac cccagtcagg
     2041 atcatgctct tgcaaaaaga tctgtggatg gaggcctgat ggttaagggc ccaagacata
     2101 aacctggaat tgttcaggag acaacttttg atttgggagg agatattcat agtgggacag
     2161 cattaccgac aagcaagagc accactaggc tggacagcga cagagtgtcg tctgcctcta
     2221 gcacagccga gcggggaatg gtgaagccga tgatcagagt agaacagcag ccagattatc
     2281 gcaggcaaga aagcagaaca caggatgctt ctgggcctga gctgatacta cctgcaagca
     2341 ttgaattcag ggaaagttct gaagattcat ttttgtctgc cattataaat tatactaata
     2401 gctctacagt ccactttaag ttgtccccta catatgtatt atatatggca tgccggtatg
     2461 tattgtccaa ccagtacaga cctgacatca gccctacaga gcgcacacat aaagtcattg
     2521 cagtcgtcaa caagatggtg agcatgatgg agggtgtcat ccagaaacag aagaatattg
     2581 caggggcact tgccttctgg atggcaaatg catctgaact tctcaacttc attaagcaag
     2641 accgagacct tagtcggatc acactggatg ctcaagatgt tttagcacat ttggttcaaa
     2701 tggcatttaa atacttggtt cactgtcttc aatcagaact taataattac atgccagcct
     2761 ttctagatga ccctgaagag aacagtctgc aacgaccaaa aatagatgat gtgctgcaca
     2821 cgctcacagg agccatgtcc ttgctacgac gctgcagagt caatgccgcc ctgaccatcc
     2881 agctcttctc tcagctcttc cacttcatca atatgtggct gttcaataga ttggtgaccg
     2941 acccagattc ggggctgtgc tcccattact ggggtgcgat tatccgtcag cagttgggcc
     3001 atattgaagc ctgggctgag aagcaggggc tggaactggc tgcggactgt catctgagca
     3061 ggatcgtgca ggcaacgact ttgcttacca tggataagta tgcacctgat gacattccaa
     3121 atataaacag cacctgcttt aagttaaatt cattacaact tcaagcctta ttacagaact
     3181 atcactgtgc acctgatgag ccttttatcc caacggatct tatagaaaat gtagtgactg
     3241 tggctgaaaa cactgccgat gagctggccc gcagtgatgg aagggaagtg cagttggagg
     3301 aggatcctga tctgcagctg ccgtttcttt tgccagaaga tggttattct tgtgatgttg
     3361 tcagaaacat tccaaatggt ttacaagaat ttttagaccc tctgtgccag agaggatttt
     3421 gcaggttaat tcctcacaca cgttcaccag gtacttggac aatatatttt gaaggtgcag
     3481 attatgaaag tcaccttctg cgtgagaaca cagagctggc tcagcctctg aggaaagaac
     3541 ctgaaataat cactgtgacc ctaaaaaagc agaatggaat gggccttagc attgttgcag
     3601 caaagggtgc tggtcaagat aaactaggaa tctatgtgaa gtcggttgtg aaaggaggtg
     3661 ctgcagatgt ggatggacgt ctagctgcag gtgatcagct cctcagtgtg gatggacgaa
     3721 gtctggttgg actctctcag gaaagggcgg cagaactcat gacaagaaca agctctgtgg
     3781 tgacactgga agtagcaaag cagggtgcca tctaccacgg tctggccacc cttctcaatc
     3841 agccatcccc catgatgcag agaatttcag atcgtcgtgg ctcaggtaaa ccccgaccaa
     3901 agagtgaagg ctttgagctc tataataatt caactcaaaa tgggtctcct gagagtcctc
     3961 agctgccttg ggcagaatat agtgaaccaa agaaattgcc tggtgatgac agactgatga
     4021 aaaatagagc tgatcaccgt tccagcccca acgtagcaaa tcagcctcct agtcctggag
     4081 ggaaaagtgc atatgcctct ggaacaacag cgaagataac atctgtctct actggaaacc
     4141 tctgcactga ggagcagacg cctccgccta gacctgaagc ctaccccatc cccactcaga
     4201 cgtacaccag agagtatttt accttcccag cttccaaatc ccaggatcgg atggctcctc
     4261 ctcagaacca gtggccaaat tatgaggaaa agccacatat gcacacagat agtaatcatt
     4321 ccagtattgc aattcagcgt gttacacgtt cccaagaaga acttcgagaa gataaagctt
     4381 accaacttga gcggcatcga atagaggcag ctatggaccg aaagtctgat agtgatatgt
     4441 ggataaatca gagctcctca ctggactcca gtacctctag ccaggagcat ctgaaccatt
     4501 cctctaagtc ggtcacccct gcttccacac tgaccaaaag tggccctggc cgttggaaaa
     4561 caccagcagc cataccggcc acccctgtgg ccgtctccca gccaatccga acagacctgc
     4621 ctccgccacc cccgccacct ccagtccact atgccggtga tttcgatgga atgtccatgg
     4681 atttgcctct cccaccaccc ccttccgcca accagatagg gctgccgtct gcgcaggtgg
     4741 ctgctgctga acggagaaag agagaagaac atcagcgttg gtatgagaag gagaaggccc
     4801 gcctggagga ggagcgggag aggaagcgga gagagcagga gaggaagttg ggccagatgc
     4861 gcactcagtc cttaaaccct gctccgtttt ctcccctgac tgcacagcag atgaagcccg
     4921 aaaagccttc cacactccag cggccacagg aaacagtcat tcgggagctg cagcctcagc
     4981 agcagccccg cacgatcgag cgcagagact tgcagtacat tacagtcagc aaagaggagc
     5041 tttcctcggg ggacagtctg tcccccgacc cgtggaagcg ggacgccaag gagaagctgg
     5101 agaagcagca gcagatgcac atcgtggaca tgctgagcaa ggagatccag gagctccaga
     5161 gcaaaccgga ccgcagcgcc gaggagagcg accggctgcg caagctcatg ctggagtggc
     5221 agttccagaa gagactccag gagtcgaagc agaaggacga agatgacgag gaggaggagg
     5281 acgatgatgt ggacaccatg ctgatcatgc agcgcctgga ggctgaacga agagcgaggt
     5341 tgcaggacga ggagcggagg cggcagcagc agttagaaga gatgcgcaag cgggaagcgg
     5401 aagaccgagc gaggcaagag gaagagcgcc ggcggcagga ggaggagcga acaaaacgag
     5461 acgctgaaga aaagaggcga caggaagaag ggtattacag ccgcctggaa gccgagaggc
     5521 gcagacagca cgacgaggcg gcgcgcaggt tgctggagcc cgaggcgccc ggtctgtgcc
     5581 gccctccgct tccccgggac tacgagcccc cgtccccgtc ccccgcgccc ggcgcccctc
     5641 ctcccccgcc tcagcgaaac gcctcctacc tcaaaacaca ggtcctctcc cccgactcgc
     5701 tgttcactgc caagtttgtt gcatacaatg aggaggagga ggaggaggac tgcagcctag
     5761 caggaccaaa ctcttaccca ggatctactg gagcagctgt tggagcccat gacgcctgtc
     5821 gggatgcaaa agagaagcgc tctaaaagcc aagatgcaga ttcacctgga agttctgggg
     5881 cccctgaaaa cttgacattc aaggaacgcc agcgtctttt ttcacaaggt caagatgtat
     5941 ccaataaagt gaaagcttct cgtaaattaa cagaactgga gaatgaactg aacacaaagt
     6001 gaaagaaaat gaggagaaca ctttgtattt accccaaaat cttttcagtt gtgggtttgt
     6061 aggtgcgagt ttgaagagga aaagaggaag ggggttatat ttctaagtga tttacaattt
     6121 ctgtttctaa aattgttggg atttagaaat gtttcaattc caagaaattt tattttactt
     6181 taccatgaga ttgccattta tgtaatttaa acactgtcta gtttcttaat tatctaactc
     6241 acacgagggt aagttttttg ttggtttctt ttttggagtc ctgagttcaa aggggacaga
     6301 actaagggca ggagaagaga atggatgtgt cttctctccc atcttcccct catcatcgac
     6361 cgaggagcac aaagaagttc tgtttctgtt tttttcagaa actttatttt agctgtcaag
     6421 cagagaatag cttgaactat tcagactatt gttggcactg tttagtagtg accacacgct
     6481 cttctacccg ggaaggaaca tatgacgaca tgctcctccc atgtcccctg atggtgtctg
     6541 ttcccacaat atccttctag tctgcatcgt gaagtggctt aggccaaagc ttcctgtgtg
     6601 atgacgcacg tccgagactg ttccatctca ttcctcgcaa atttgagctc ttctgatcaa
     6661 ttctaaatat ttgattaatt ttaattctga aagaaaattt tgaggattta agcttagggg
     6721 attttatttt tataaatacc agattattgt tagacttaat aaatcactgt taaatttaaa
     6781 gatgacagtt accttggaaa gttcactaat acttcgctcc aaggcgtctg taaaagaaga
     6841 tatctttatt ggagcaatgt tcatgtgact gggaatgaca gaagaatggg agatgagtag
     6901 ggacccctca agcacagctg tcactcagaa attttaaatt tgaaaaagaa atcgattttc
     6961 atctgtatgc cgtcaaggaa ggaattcagt tacagggcat ctgtaactta aatattgtaa
     7021 gaataactca tatggaagtt caagctattt ttatactata atagagttat ttaattttaa
     7081 tttgttgaat tattagttac cactgtcatt tcttcagcta tggatatgtg gctgatgttg
     7141 gggagacgga cctcagtgtg ttttatattg tctggtgtta agatgataaa ttactttgtg
     7201 attacaagca aattttctat ttgacaaagc ccttggtgga gtccaaatga tttttctgta
     7261 ccatattgtt ctcttacaca tacgtatgtt aggaaaatag gcacactttc aaagagaatg
     7321 ttctcttaca catacgtatg ttaggaaaat agacacattt tcaaagagaa tgttctctta
     7381 catatgttag gaaaataggc acactttcaa agagaggtat aggggctttt tactgccttc
     7441 gaaatcactt ttaataaaag ttgtatgata aatcattaaa aatgcgagtg taaatatttt
     7501 tttttacctc tatcagggtt tttatttgaa agtgtgctct taccatttcc ttgtttgagt
     7561 aagagagtga atggttctga gtgtttagga aggatttgct tgcttgcagc agaagttcta
     7621 ggaaaagcag gcacctccca aatatcttga ggacactggc agccttatgg tgactaaatc
     7681 cacactttct ttaaagagat gcagatgaat tacttttctg ttaatatata gaaaaataca
     7741 caggagaaca tgcagataca tgtaaatatc tacatacagg gatatttgta tgtgtggttg
     7801 tgaaacccat acacaagtgg atttggccat ctttgggcag tgaggtcaaa tgtgaatatg
     7861 tgtaaaagtg cttttcagaa ctgcattact atgagaaaac atcaaaactg ctgtagtttt
     7921 ccatttctac tgtatttcag ttgcaaccta tttttaataa actttgtatg tatttaagtg
     7981 tatttgctat tgttttgaaa gtgctgacaa agtttatatt tgtaacatca gccttcctcg
     8041 cccatctctt tccatctgtc tcttcttcat taaacactta ctgagtatga
//
