LOCUS       XM_047418818            8105 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens afadin, adherens junction formation factor
            (AFDN), transcript variant X34, mRNA.
ACCESSION   XM_047418818
VERSION     XM_047418818.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8105
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..8105
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /note="afadin, adherens junction formation factor; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 54 ESTs, 1925 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 137 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
     CDS             570..6017
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /codon_start=1
                     /product="afadin isoform X34"
                     /protein_id="XP_047274774.1"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
                     /translation="MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMR
                     FYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEE
                     RRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKR
                     TLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISN
                     PEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPAD
                     FAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWP
                     SDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELS
                     PDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPR
                     SMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGP
                     RHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQ
                     QPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVL
                     YMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALA
                     FWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLD
                     DPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTD
                     PDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDI
                     PNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREV
                     QLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTI
                     YFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYV
                     KSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAI
                     YHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSE
                     PKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQT
                     PPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAI
                     QRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSK
                     SVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMD
                     LPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQ
                     MRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVS
                     KEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRK
                     LMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARDEERRRQQQLEEM
                     RKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLE
                     PEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNE
                     EEEEEDCSLAGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKE
                     RQRLFSQGQDVSNKVKASRKLTELENELNTK"
ORIGIN      
        1 actctgcacc gcgcgtccgg acccaacaca gcaccaccca tcggacccag cactgcccat
       61 ttagatccag cagcgcgcgt ccgaaccgaa cctagcaccg ctggtcggga aggaacccgg
      121 taccgccggt tgggacccac caccgccagt ccagacggaa ccctagcacc gcgcggggcc
      181 cgccctccga cacctccctc cctggcggcc gcggcagcag cacctagtgg agcggcccgg
      241 aggtgcggcg gcgccgcgcg gggcggcggc gcgcacggcg ggcggcggcg cgcacggcgg
      301 cgggcggggc gcgggcgggt gcgggcggcg ggcggcgggc gccgggcgca caccggccgg
      361 cggggctgag gcggcgcggc gcggcgcgga ctgagcccca ggcggaggcc aagtcggagg
      421 acgcggcgcg gccgcggagg cggaggcagc cgcggaggcg gaggcggccg gcggggggtg
      481 gcgaggggcg ccgggccccc gcggacctgt cgtcctcggc ccgtcctccg gccccggccc
      541 cgcgcggctg aggaggcgcg gccaggacca tgtcggcggg cggccgtgac gaggagcggc
      601 ggaagctggc cgacatcatc caccactgga acgccaaccg gctggacctg ttcgagatca
      661 gccagccgac cgaggatttg gagttccatg gagtgatgag attttatttt caagataaag
      721 ctgctggaaa ctttgcaaca aaatgtattc gggtctctag tactgccacc actcaagatg
      781 taatcgaaac gctcgcggag aaatttcgac ctgatatgcg aatgctgtcc tctcccaagt
      841 attcactcta tgaagtgcat gtcagcggag aagaaagaag attggatata gatgagaaac
      901 ctctagttgt acaactgaat tggaacaaag atgatcggga aggcagattt gttcttaaga
      961 atgagaatga cgccattcct cctaagaagg ctcaaagtaa tggacctgaa aagcaggaaa
     1021 aagaaggggt tatccagaac ttcaagagaa ctctctcaaa gaaagaaaag aaggaaaaaa
     1081 agaagagaga aaaagaggca ttgcgacagg catctgataa agatgataga cctttccaag
     1141 gggaggatgt tgaaaattct cgactggctg ctgaggttta caaagacatg ccggaaacca
     1201 gctttactcg aaccatttct aatcctgagg tggttatgaa acgacggagg cagcaaaaat
     1261 tggaaaagag aatgcaggaa tttcggagct cagatgggcg gcctgattca ggtggaacat
     1321 tgagaattta tgcagatagt ttaaaaccaa atattcccta caagacaatc ctgctgtcta
     1381 ctacagatcc tgcagacttt gctgtggctg aagctttaga gaagtatggt ctggaaaaag
     1441 aaaaccctaa ggattactgc atcgcccggg ttatgcttcc tcctggagcc cagcattctg
     1501 atgaaaaggg tgctaaagaa attattcttg atgatgatga gtgtccttta caaatcttca
     1561 gggaatggcc aagtgacaaa gggattttag tctttcagtt gaagaggagg ccaccagacc
     1621 acatcccaaa gaaaaccaag aaacacttgg aaggcaagac acccaaggga aaggagagag
     1681 ctgacgggtc tggctatggc tccacccttc ctccggagaa gctgccctat ttagtagagt
     1741 taagcccaga tggttctgac tctagagata agccaaagct ttaccgcctt cagttaagtg
     1801 ttactgaagt tgggacagaa aagttggatg acaactctat ccagttgttt ggcccaggaa
     1861 ttcagcccca tcactgtgac cttaccaaca tggatggagt ggtcactgtg acgcccagaa
     1921 gtatggacgc agaaacctac gtggaaggcc agcgcatctc agaaaccacc atgctgcaga
     1981 gtggcatgaa agtgcagttt ggggcgtccc atgtatttaa gtttgtggac cccagtcagg
     2041 atcatgctct tgcaaaaaga tctgtggatg gaggcctgat ggttaagggc ccaagacata
     2101 aacctggaat tgttcaggag acaacttttg atttgggagg agatattcat agtgggacag
     2161 cattaccgac aagcaagagc accactaggc tggacagcga cagagtgtcg tctgcctcta
     2221 gcacagccga gcggggaatg gtgaagccga tgatcagagt agaacagcag ccagattatc
     2281 gcaggcaaga aagcagaaca caggatgctt ctgggcctga gctgatacta cctgcaagca
     2341 ttgaattcag ggaaagttct gaagattcat ttttgtctgc cattataaat tatactaata
     2401 gctctacagt ccactttaag ttgtccccta catatgtatt atatatggca tgccggtatg
     2461 tattgtccaa ccagtacaga cctgacatca gccctacaga gcgcacacat aaagtcattg
     2521 cagtcgtcaa caagatggtg agcatgatgg agggtgtcat ccaggaagta gaccaggttg
     2581 accagaaaca gaagaatatt gcaggggcac ttgccttctg gatggcaaat gcatctgaac
     2641 ttctcaactt cattaagcaa gaccgagacc ttagtcggat cacactggat gctcaagatg
     2701 ttttagcaca tttggttcaa atggcattta aatacttggt tcactgtctt caatcagaac
     2761 ttaataatta catgccagcc tttctagatg accctgaaga gaacagtctg caacgaccaa
     2821 aaatagatga tgtgctgcac acgctcacag gagccatgtc cttgctacga cgctgcagag
     2881 tcaatgccgc cctgaccatc cagctcttct ctcagctctt ccacttcatc aatatgtggc
     2941 tgttcaatag attggtgacc gacccagatt cggggctgtg ctcccattac tggggtgcga
     3001 ttatccgtca gcagttgggc catattgaag cctgggctga gaagcagggg ctggaactgg
     3061 ctgcggactg tcatctgagc aggatcgtgc aggcaacgac tttgcttacc atggataagt
     3121 atgcacctga tgacattcca aatataaaca gcacctgctt taagttaaat tcattacaac
     3181 ttcaagcctt attacagaac tatcactgtg cacctgatga gccttttatc ccaacggatc
     3241 ttatagaaaa tgtagtgact gtggctgaaa acactgccga tgagctggcc cgcagtgatg
     3301 gaagggaagt gcagttggag gaggatcctg atctgcagct gccgtttctt ttgccagaag
     3361 atggttattc ttgtgatgtt gtcagaaaca ttccaaatgg tttacaagaa tttttagacc
     3421 ctctgtgcca gagaggattt tgcaggttaa ttcctcacac acgttcacca ggtacttgga
     3481 caatatattt tgaaggtgca gattatgaaa gtcaccttct gcgtgagaac acagagctgg
     3541 ctcagcctct gaggaaagaa cctgaaataa tcactgtgac cctaaaaaag cagaatggaa
     3601 tgggccttag cattgttgca gcaaagggtg ctggtcaaga taaactagga atctatgtga
     3661 agtcggttgt gaaaggaggt gctgcagatg tggatggacg tctagctgca ggtgatcagc
     3721 tcctcagtgt ggatggacga agtctggttg gactctctca ggaaagggcg gcagaactca
     3781 tgacaagaac aagctctgtg gtgacactgg aagtagcaaa gcagggtgcc atctaccacg
     3841 gtctggccac ccttctcaat cagccatccc ccatgatgca gagaatttca gatcgtcgtg
     3901 gctcaggtaa accccgacca aagagtgaag gctttgagct ctataataat tcaactcaaa
     3961 atgggtctcc tgagagtcct cagctgcctt gggcagaata tagtgaacca aagaaattgc
     4021 ctggtgatga cagactgatg aaaaatagag ctgatcaccg ttccagcccc aacgtagcaa
     4081 atcagcctcc tagtcctgga gggaaaagtg catatgcctc tggaacaaca gcgaagataa
     4141 catctgtctc tactggaaac ctctgcactg aggagcagac gcctccgcct agacctgaag
     4201 cctaccccat ccccactcag acgtacacca gagagtattt taccttccca gcttccaaat
     4261 cccaggatcg gatggctcct cctcagaacc agtggccaaa ttatgaggaa aagccacata
     4321 tgcacacaga tagtaatcat tccagtattg caattcagcg tgttacacgt tcccaagaag
     4381 aacttcgaga agataaagct taccaacttg agcggcatcg aatagaggca gctatggacc
     4441 gaaagtctga tagtgatatg tggataaatc agagctcctc actggactcc agtacctcta
     4501 gccaggagca tctgaaccat tcctctaagt cggtcacccc tgcttccaca ctgaccaaaa
     4561 gtggccctgg ccgttggaaa acaccagcag ccataccggc cacccctgtg gccgtctccc
     4621 agccaatccg aacagacctg cctccgccac ccccgccacc tccagtccac tatgccggtg
     4681 atttcgatgg aatgtccatg gatttgcctc tcccaccacc cccttccgcc aaccagatag
     4741 ggctgccgtc tgcgcaggtg gctgctgctg aacggagaaa gagagaagaa catcagcgtt
     4801 ggtatgagaa ggagaaggcc cgcctggagg aggagcggga gaggaagcgg agagagcagg
     4861 agaggaagtt gggccagatg cgcactcagt ccttaaaccc tgctccgttt tctcccctga
     4921 ctgcacagca gatgaagccc gaaaagcctt ccacactcca gcggccacag gaaacagtca
     4981 ttcgggagct gcagcctcag cagcagcccc gcacgatcga gcgcagagac ttgcagtaca
     5041 ttacagtcag caaagaggag ctttcctcgg gggacagtct gtcccccgac ccgtggaagc
     5101 gggacgccaa ggagaagctg gagaagcagc agcagatgca catcgtggac atgctgagca
     5161 aggagatcca ggagctccag agcaaaccgg accgcagcgc cgaggagagc gaccggctgc
     5221 gcaagctcat gctggagtgg cagttccaga agagactcca ggagtcgaag cagaaggacg
     5281 aagatgacga ggaggaggag gacgatgatg tggacaccat gctgatcatg cagcgcctgg
     5341 aggctgaacg aagagcgagg gacgaggagc ggaggcggca gcagcagtta gaagagatgc
     5401 gcaagcggga agcggaagac cgagcgaggc aagaggaaga gcgccggcgg caggaggagg
     5461 agcgaacaaa acgagacgct gaagaaaaga ggcgacagga agaagggtat tacagccgcc
     5521 tggaagccga gaggcgcaga cagcacgacg aggcggcgcg caggttgctg gagcccgagg
     5581 cgcccggtct gtgccgccct ccgcttcccc gggactacga gcccccgtcc ccgtcccccg
     5641 cgcccggcgc ccctcctccc ccgcctcagc gaaacgcctc ctacctcaaa acacaggtcc
     5701 tctcccccga ctcgctgttc actgccaagt ttgttgcata caatgaggag gaggaggagg
     5761 aggactgcag cctagcagga ccaaactctt acccaggatc tactggagca gctgttggag
     5821 cccatgacgc ctgtcgggat gcaaaagaga agcgctctaa aagccaagat gcagattcac
     5881 ctggaagttc tggggcccct gaaaacttga cattcaagga acgccagcgt cttttttcac
     5941 aaggtcaaga tgtatccaat aaagtgaaag cttctcgtaa attaacagaa ctggagaatg
     6001 aactgaacac aaagtgaaag aaaatgagga gaacactttg tatttacccc aaaatctttt
     6061 cagttgtggg tttgtaggtg cgagtttgaa gaggaaaaga ggaagggggt tatatttcta
     6121 agtgatttac aatttctgtt tctaaaattg ttgggattta gaaatgtttc aattccaaga
     6181 aattttattt tactttacca tgagattgcc atttatgtaa tttaaacact gtctagtttc
     6241 ttaattatct aactcacacg agggtaagtt ttttgttggt ttcttttttg gagtcctgag
     6301 ttcaaagggg acagaactaa gggcaggaga agagaatgga tgtgtcttct ctcccatctt
     6361 cccctcatca tcgaccgagg agcacaaaga agttctgttt ctgttttttt cagaaacttt
     6421 attttagctg tcaagcagag aatagcttga actattcaga ctattgttgg cactgtttag
     6481 tagtgaccac acgctcttct acccgggaag gaacatatga cgacatgctc ctcccatgtc
     6541 ccctgatggt gtctgttccc acaatatcct tctagtctgc atcgtgaagt ggcttaggcc
     6601 aaagcttcct gtgtgatgac gcacgtccga gactgttcca tctcattcct cgcaaatttg
     6661 agctcttctg atcaattcta aatatttgat taattttaat tctgaaagaa aattttgagg
     6721 atttaagctt aggggatttt atttttataa ataccagatt attgttagac ttaataaatc
     6781 actgttaaat ttaaagatga cagttacctt ggaaagttca ctaatacttc gctccaaggc
     6841 gtctgtaaaa gaagatatct ttattggagc aatgttcatg tgactgggaa tgacagaaga
     6901 atgggagatg agtagggacc cctcaagcac agctgtcact cagaaatttt aaatttgaaa
     6961 aagaaatcga ttttcatctg tatgccgtca aggaaggaat tcagttacag ggcatctgta
     7021 acttaaatat tgtaagaata actcatatgg aagttcaagc tatttttata ctataataga
     7081 gttatttaat tttaatttgt tgaattatta gttaccactg tcatttcttc agctatggat
     7141 atgtggctga tgttggggag acggacctca gtgtgtttta tattgtctgg tgttaagatg
     7201 ataaattact ttgtgattac aagcaaattt tctatttgac aaagcccttg gtggagtcca
     7261 aatgattttt ctgtaccata ttgttctctt acacatacgt atgttaggaa aataggcaca
     7321 ctttcaaaga gaatgttctc ttacacatac gtatgttagg aaaatagaca cattttcaaa
     7381 gagaatgttc tcttacatat gttaggaaaa taggcacact ttcaaagaga ggtatagggg
     7441 ctttttactg ccttcgaaat cacttttaat aaaagttgta tgataaatca ttaaaaatgc
     7501 gagtgtaaat attttttttt acctctatca gggtttttat ttgaaagtgt gctcttacca
     7561 tttccttgtt tgagtaagag agtgaatggt tctgagtgtt taggaaggat ttgcttgctt
     7621 gcagcagaag ttctaggaaa agcaggcacc tcccaaatat cttgaggaca ctggcagcct
     7681 tatggtgact aaatccacac tttctttaaa gagatgcaga tgaattactt ttctgttaat
     7741 atatagaaaa atacacagga gaacatgcag atacatgtaa atatctacat acagggatat
     7801 ttgtatgtgt ggttgtgaaa cccatacaca agtggatttg gccatctttg ggcagtgagg
     7861 tcaaatgtga atatgtgtaa aagtgctttt cagaactgca ttactatgag aaaacatcaa
     7921 aactgctgta gttttccatt tctactgtat ttcagttgca acctattttt aataaacttt
     7981 gtatgtattt aagtgtattt gctattgttt tgaaagtgct gacaaagttt atatttgtaa
     8041 catcagcctt cctcgcccat ctctttccat ctgtctcttc ttcattaaac acttactgag
     8101 tatga
//
