LOCUS       XM_047418810            8312 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens afadin, adherens junction formation factor
            (AFDN), transcript variant X23, mRNA.
ACCESSION   XM_047418810
VERSION     XM_047418810.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8312
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..8312
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /note="afadin, adherens junction formation factor; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 51 ESTs, 1628 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 74 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
     CDS             570..6224
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /codon_start=1
                     /product="afadin isoform X23"
                     /protein_id="XP_047274766.1"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
                     /translation="MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMR
                     FYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEE
                     RRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRT
                     LSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNP
                     EVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADF
                     AVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPS
                     DKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSP
                     DGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRS
                     MDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPR
                     HKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQ
                     PDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLY
                     MACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQKQKNIAGALAFWMANASE
                     LLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQ
                     RPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSH
                     YWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIPNINSTCF
                     KLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQLEEDPDL
                     QLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIYFEGADYE
                     SHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGA
                     ADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIYHGLATLL
                     NQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEPKKLPGDD
                     RLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTPPPRPEAY
                     PIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQRVTRSQE
                     ELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKSVTPASTL
                     TKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDLPLPPPPS
                     ANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNP
                     APFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSKEELSSGD
                     SLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKLMLEWQFQ
                     KRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARDEERRRQQQLEEMRKREAEDR
                     ARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLLEPEAPGLCR
                     PPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYNEEEEEEDCS
                     LAGQDKYSSTRKSHGDLLPAPLKPRPPPCQPRPASDGVFLSNSFQPPSAKANSTAHKK
                     GQPLPPPKKSSSYHPSHCKGRGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGS
                     SGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK"
ORIGIN      
        1 actctgcacc gcgcgtccgg acccaacaca gcaccaccca tcggacccag cactgcccat
       61 ttagatccag cagcgcgcgt ccgaaccgaa cctagcaccg ctggtcggga aggaacccgg
      121 taccgccggt tgggacccac caccgccagt ccagacggaa ccctagcacc gcgcggggcc
      181 cgccctccga cacctccctc cctggcggcc gcggcagcag cacctagtgg agcggcccgg
      241 aggtgcggcg gcgccgcgcg gggcggcggc gcgcacggcg ggcggcggcg cgcacggcgg
      301 cgggcggggc gcgggcgggt gcgggcggcg ggcggcgggc gccgggcgca caccggccgg
      361 cggggctgag gcggcgcggc gcggcgcgga ctgagcccca ggcggaggcc aagtcggagg
      421 acgcggcgcg gccgcggagg cggaggcagc cgcggaggcg gaggcggccg gcggggggtg
      481 gcgaggggcg ccgggccccc gcggacctgt cgtcctcggc ccgtcctccg gccccggccc
      541 cgcgcggctg aggaggcgcg gccaggacca tgtcggcggg cggccgtgac gaggagcggc
      601 ggaagctggc cgacatcatc caccactgga acgccaaccg gctggacctg ttcgagatca
      661 gccagccgac cgaggatttg gagttccatg gagtgatgag attttatttt caagataaag
      721 ctgctggaaa ctttgcaaca aaatgtattc gggtctctag tactgccacc actcaagatg
      781 taatcgaaac gctcgcggag aaatttcgac ctgatatgcg aatgctgtcc tctcccaagt
      841 attcactcta tgaagtgcat gtcagcggag aagaaagaag attggatata gatgagaaac
      901 ctctagttgt acaactgaat tggaacaaag atgatcggga aggcagattt gttcttaaga
      961 atgagaatga cgccattcct cctaaggctc aaagtaatgg acctgaaaag caggaaaaag
     1021 aaggggttat ccagaacttc aagagaactc tctcaaagaa agaaaagaag gaaaaaaaga
     1081 agagagaaaa agaggcattg cgacaggcat ctgataaaga tgatagacct ttccaagggg
     1141 aggatgttga aaattctcga ctggctgctg aggtttacaa agacatgccg gaaaccagct
     1201 ttactcgaac catttctaat cctgaggtgg ttatgaaacg acggaggcag caaaaattgg
     1261 aaaagagaat gcaggaattt cggagctcag atgggcggcc tgattcaggt ggaacattga
     1321 gaatttatgc agatagttta aaaccaaata ttccctacaa gacaatcctg ctgtctacta
     1381 cagatcctgc agactttgct gtggctgaag ctttagagaa gtatggtctg gaaaaagaaa
     1441 accctaagga ttactgcatc gcccgggtta tgcttcctcc tggagcccag cattctgatg
     1501 aaaagggtgc taaagaaatt attcttgatg atgatgagtg tcctttacaa atcttcaggg
     1561 aatggccaag tgacaaaggg attttagtct ttcagttgaa gaggaggcca ccagaccaca
     1621 tcccaaagaa aaccaagaaa cacttggaag gcaagacacc caagggaaag gagagagctg
     1681 acgggtctgg ctatggctcc acccttcctc cggagaagct gccctattta gtagagttaa
     1741 gcccagatgg ttctgactct agagataagc caaagcttta ccgccttcag ttaagtgtta
     1801 ctgaagttgg gacagaaaag ttggatgaca actctatcca gttgtttggc ccaggaattc
     1861 agccccatca ctgtgacctt accaacatgg atggagtggt cactgtgacg cccagaagta
     1921 tggacgcaga aacctacgtg gaaggccagc gcatctcaga aaccaccatg ctgcagagtg
     1981 gcatgaaagt gcagtttggg gcgtcccatg tatttaagtt tgtggacccc agtcaggatc
     2041 atgctcttgc aaaaagatct gtggatggag gcctgatggt taagggccca agacataaac
     2101 ctggaattgt tcaggagaca acttttgatt tgggaggaga tattcatagt gggacagcat
     2161 taccgacaag caagagcacc actaggctgg acagcgacag agtgtcgtct gcctctagca
     2221 cagccgagcg gggaatggtg aagccgatga tcagagtaga acagcagcca gattatcgca
     2281 ggcaagaaag cagaacacag gatgcttctg ggcctgagct gatactacct gcaagcattg
     2341 aattcaggga aagttctgaa gattcatttt tgtctgccat tataaattat actaatagct
     2401 ctacagtcca ctttaagttg tcccctacat atgtattata tatggcatgc cggtatgtat
     2461 tgtccaacca gtacagacct gacatcagcc ctacagagcg cacacataaa gtcattgcag
     2521 tcgtcaacaa gatggtgagc atgatggagg gtgtcatcca gaaacagaag aatattgcag
     2581 gggcacttgc cttctggatg gcaaatgcat ctgaacttct caacttcatt aagcaagacc
     2641 gagaccttag tcggatcaca ctggatgctc aagatgtttt agcacatttg gttcaaatgg
     2701 catttaaata cttggttcac tgtcttcaat cagaacttaa taattacatg ccagcctttc
     2761 tagatgaccc tgaagagaac agtctgcaac gaccaaaaat agatgatgtg ctgcacacgc
     2821 tcacaggagc catgtccttg ctacgacgct gcagagtcaa tgccgccctg accatccagc
     2881 tcttctctca gctcttccac ttcatcaata tgtggctgtt caatagattg gtgaccgacc
     2941 cagattcggg gctgtgctcc cattactggg gtgcgattat ccgtcagcag ttgggccata
     3001 ttgaagcctg ggctgagaag caggggctgg aactggctgc ggactgtcat ctgagcagga
     3061 tcgtgcaggc aacgactttg cttaccatgg ataagtatgc acctgatgac attccaaata
     3121 taaacagcac ctgctttaag ttaaattcat tacaacttca agccttatta cagaactatc
     3181 actgtgcacc tgatgagcct tttatcccaa cggatcttat agaaaatgta gtgactgtgg
     3241 ctgaaaacac tgccgatgag ctggcccgca gtgatggaag ggaagtgcag ttggaggagg
     3301 atcctgatct gcagctgccg tttcttttgc cagaagatgg ttattcttgt gatgttgtca
     3361 gaaacattcc aaatggttta caagaatttt tagaccctct gtgccagaga ggattttgca
     3421 ggttaattcc tcacacacgt tcaccaggta cttggacaat atattttgaa ggtgcagatt
     3481 atgaaagtca ccttctgcgt gagaacacag agctggctca gcctctgagg aaagaacctg
     3541 aaataatcac tgtgacccta aaaaagcaga atggaatggg ccttagcatt gttgcagcaa
     3601 agggtgctgg tcaagataaa ctaggaatct atgtgaagtc ggttgtgaaa ggaggtgctg
     3661 cagatgtgga tggacgtcta gctgcaggtg atcagctcct cagtgtggat ggacgaagtc
     3721 tggttggact ctctcaggaa agggcggcag aactcatgac aagaacaagc tctgtggtga
     3781 cactggaagt agcaaagcag ggtgccatct accacggtct ggccaccctt ctcaatcagc
     3841 catcccccat gatgcagaga atttcagatc gtcgtggctc aggtaaaccc cgaccaaaga
     3901 gtgaaggctt tgagctctat aataattcaa ctcaaaatgg gtctcctgag agtcctcagc
     3961 tgccttgggc agaatatagt gaaccaaaga aattgcctgg tgatgacaga ctgatgaaaa
     4021 atagagctga tcaccgttcc agccccaacg tagcaaatca gcctcctagt cctggaggga
     4081 aaagtgcata tgcctctgga acaacagcga agataacatc tgtctctact ggaaacctct
     4141 gcactgagga gcagacgcct ccgcctagac ctgaagccta ccccatcccc actcagacgt
     4201 acaccagaga gtattttacc ttcccagctt ccaaatccca ggatcggatg gctcctcctc
     4261 agaaccagtg gccaaattat gaggaaaagc cacatatgca cacagatagt aatcattcca
     4321 gtattgcaat tcagcgtgtt acacgttccc aagaagaact tcgagaagat aaagcttacc
     4381 aacttgagcg gcatcgaata gaggcagcta tggaccgaaa gtctgatagt gatatgtgga
     4441 taaatcagag ctcctcactg gactccagta cctctagcca ggagcatctg aaccattcct
     4501 ctaagtcggt cacccctgct tccacactga ccaaaagtgg ccctggccgt tggaaaacac
     4561 cagcagccat accggccacc cctgtggccg tctcccagcc aatccgaaca gacctgcctc
     4621 cgccaccccc gccacctcca gtccactatg ccggtgattt cgatggaatg tccatggatt
     4681 tgcctctccc accaccccct tccgccaacc agatagggct gccgtctgcg caggtggctg
     4741 ctgctgaacg gagaaagaga gaagaacatc agcgttggta tgagaaggag aaggcccgcc
     4801 tggaggagga gcgggagagg aagcggagag agcaggagag gaagttgggc cagatgcgca
     4861 ctcagtcctt aaaccctgct ccgttttctc ccctgactgc acagcagatg aagcccgaaa
     4921 agccttccac actccagcgg ccacaggaaa cagtcattcg ggagctgcag cctcagcagc
     4981 agccccgcac gatcgagcgc agagacttgc agtacattac agtcagcaaa gaggagcttt
     5041 cctcggggga cagtctgtcc cccgacccgt ggaagcggga cgccaaggag aagctggaga
     5101 agcagcagca gatgcacatc gtggacatgc tgagcaagga gatccaggag ctccagagca
     5161 aaccggaccg cagcgccgag gagagcgacc ggctgcgcaa gctcatgctg gagtggcagt
     5221 tccagaagag actccaggag tcgaagcaga aggacgaaga tgacgaggag gaggaggacg
     5281 atgatgtgga caccatgctg atcatgcagc gcctggaggc tgaacgaaga gcgagggacg
     5341 aggagcggag gcggcagcag cagttagaag agatgcgcaa gcgggaagcg gaagaccgag
     5401 cgaggcaaga ggaagagcgc cggcggcagg aggaggagcg aacaaaacga gacgctgaag
     5461 aaaagaggcg acaggaagaa gggtattaca gccgcctgga agccgagagg cgcagacagc
     5521 acgacgaggc ggcgcgcagg ttgctggagc ccgaggcgcc cggtctgtgc cgccctccgc
     5581 ttccccggga ctacgagccc ccgtccccgt cccccgcgcc cggcgcccct cctcccccgc
     5641 ctcagcgaaa cgcctcctac ctcaaaacac aggtcctctc ccccgactcg ctgttcactg
     5701 ccaagtttgt tgcatacaat gaggaggagg aggaggagga ctgcagccta gcaggtcagg
     5761 ataagtactc cagcacaaga aagtctcatg gggaccttct tcctgcccct cttaaaccac
     5821 ggccaccccc ctgccagcca cgcccggcct ccgatggcgt ctttctctcc aactcattcc
     5881 agccaccctc agccaaagcc aacagtactg ctcacaaaaa aggccagccc ctgccccctc
     5941 caaaaaaatc cagctcctac catcccagcc actgcaaagg tagaggacca aactcttacc
     6001 caggatctac tggagcagct gttggagccc atgacgcctg tcgggatgca aaagagaagc
     6061 gctctaaaag ccaagatgca gattcacctg gaagttctgg ggcccctgaa aacttgacat
     6121 tcaaggaacg ccagcgtctt ttttcacaag gtcaagatgt atccaataaa gtgaaagctt
     6181 ctcgtaaatt aacagaactg gagaatgaac tgaacacaaa gtgaaagaaa atgaggagaa
     6241 cactttgtat ttaccccaaa atcttttcag ttgtgggttt gtaggtgcga gtttgaagag
     6301 gaaaagagga agggggttat atttctaagt gatttacaat ttctgtttct aaaattgttg
     6361 ggatttagaa atgtttcaat tccaagaaat tttattttac tttaccatga gattgccatt
     6421 tatgtaattt aaacactgtc tagtttctta attatctaac tcacacgagg gtaagttttt
     6481 tgttggtttc ttttttggag tcctgagttc aaaggggaca gaactaaggg caggagaaga
     6541 gaatggatgt gtcttctctc ccatcttccc ctcatcatcg accgaggagc acaaagaagt
     6601 tctgtttctg tttttttcag aaactttatt ttagctgtca agcagagaat agcttgaact
     6661 attcagacta ttgttggcac tgtttagtag tgaccacacg ctcttctacc cgggaaggaa
     6721 catatgacga catgctcctc ccatgtcccc tgatggtgtc tgttcccaca atatccttct
     6781 agtctgcatc gtgaagtggc ttaggccaaa gcttcctgtg tgatgacgca cgtccgagac
     6841 tgttccatct cattcctcgc aaatttgagc tcttctgatc aattctaaat atttgattaa
     6901 ttttaattct gaaagaaaat tttgaggatt taagcttagg ggattttatt tttataaata
     6961 ccagattatt gttagactta ataaatcact gttaaattta aagatgacag ttaccttgga
     7021 aagttcacta atacttcgct ccaaggcgtc tgtaaaagaa gatatcttta ttggagcaat
     7081 gttcatgtga ctgggaatga cagaagaatg ggagatgagt agggacccct caagcacagc
     7141 tgtcactcag aaattttaaa tttgaaaaag aaatcgattt tcatctgtat gccgtcaagg
     7201 aaggaattca gttacagggc atctgtaact taaatattgt aagaataact catatggaag
     7261 ttcaagctat ttttatacta taatagagtt atttaatttt aatttgttga attattagtt
     7321 accactgtca tttcttcagc tatggatatg tggctgatgt tggggagacg gacctcagtg
     7381 tgttttatat tgtctggtgt taagatgata aattactttg tgattacaag caaattttct
     7441 atttgacaaa gcccttggtg gagtccaaat gatttttctg taccatattg ttctcttaca
     7501 catacgtatg ttaggaaaat aggcacactt tcaaagagaa tgttctctta cacatacgta
     7561 tgttaggaaa atagacacat tttcaaagag aatgttctct tacatatgtt aggaaaatag
     7621 gcacactttc aaagagaggt ataggggctt tttactgcct tcgaaatcac ttttaataaa
     7681 agttgtatga taaatcatta aaaatgcgag tgtaaatatt tttttttacc tctatcaggg
     7741 tttttatttg aaagtgtgct cttaccattt ccttgtttga gtaagagagt gaatggttct
     7801 gagtgtttag gaaggatttg cttgcttgca gcagaagttc taggaaaagc aggcacctcc
     7861 caaatatctt gaggacactg gcagccttat ggtgactaaa tccacacttt ctttaaagag
     7921 atgcagatga attacttttc tgttaatata tagaaaaata cacaggagaa catgcagata
     7981 catgtaaata tctacataca gggatatttg tatgtgtggt tgtgaaaccc atacacaagt
     8041 ggatttggcc atctttgggc agtgaggtca aatgtgaata tgtgtaaaag tgcttttcag
     8101 aactgcatta ctatgagaaa acatcaaaac tgctgtagtt ttccatttct actgtatttc
     8161 agttgcaacc tatttttaat aaactttgta tgtatttaag tgtatttgct attgttttga
     8221 aagtgctgac aaagtttata tttgtaacat cagccttcct cgcccatctc tttccatctg
     8281 tctcttcttc attaaacact tactgagtat ga
//
