LOCUS       XM_047418797            8339 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens afadin, adherens junction formation factor
            (AFDN), transcript variant X10, mRNA.
ACCESSION   XM_047418797
VERSION     XM_047418797.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8339
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..8339
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /note="afadin, adherens junction formation factor; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 50 ESTs, 1622 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 77 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
     CDS             570..6251
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /codon_start=1
                     /product="afadin isoform X10"
                     /protein_id="XP_047274753.1"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
                     /translation="MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMR
                     FYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEE
                     RRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKAQSNGPEKQEKEGVIQNFKRT
                     LSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISNP
                     EVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPADF
                     AVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWPS
                     DKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELSP
                     DGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHHCDLTNMDGVVTVTPRS
                     MDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHALAKRSVDGGLMVKGPR
                     HKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASSTAERGMVKPMIRVEQQ
                     PDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYTNSSTVHFKLSPTYVLY
                     MACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQEVDQVDQKQKNIAGALAF
                     WMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDD
                     PEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDP
                     DSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYAPDDIP
                     NINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADELARSDGREVQ
                     LEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHTRSPGTWTIY
                     FEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAGQDKLGIYVK
                     SVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQGAIY
                     HGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQLPWAEYSEP
                     KKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTGNLCTEEQTP
                     PPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTDSNHSSIAIQ
                     RVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQEHLNHSSKS
                     VTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAGDFDGMSMDL
                     PLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRREQERKLGQM
                     RTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITVSK
                     EELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSAEESDRLRKL
                     MLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARLQDEERRRQQQLEE
                     MRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHDEAARRLL
                     EPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFTAKFVAYN
                     EEEEEEDCSLAGQDKYSSTRKSHGDLLPAPLKPRPPPCQPRPASDGVFLSNSFQPPSA
                     KANSTAHKKGQPLPPPKKSSSYHPSHCKGRGPNSYPGSTGAAVGAHDACRDAKEKRSK
                     SQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK"
ORIGIN      
        1 actctgcacc gcgcgtccgg acccaacaca gcaccaccca tcggacccag cactgcccat
       61 ttagatccag cagcgcgcgt ccgaaccgaa cctagcaccg ctggtcggga aggaacccgg
      121 taccgccggt tgggacccac caccgccagt ccagacggaa ccctagcacc gcgcggggcc
      181 cgccctccga cacctccctc cctggcggcc gcggcagcag cacctagtgg agcggcccgg
      241 aggtgcggcg gcgccgcgcg gggcggcggc gcgcacggcg ggcggcggcg cgcacggcgg
      301 cgggcggggc gcgggcgggt gcgggcggcg ggcggcgggc gccgggcgca caccggccgg
      361 cggggctgag gcggcgcggc gcggcgcgga ctgagcccca ggcggaggcc aagtcggagg
      421 acgcggcgcg gccgcggagg cggaggcagc cgcggaggcg gaggcggccg gcggggggtg
      481 gcgaggggcg ccgggccccc gcggacctgt cgtcctcggc ccgtcctccg gccccggccc
      541 cgcgcggctg aggaggcgcg gccaggacca tgtcggcggg cggccgtgac gaggagcggc
      601 ggaagctggc cgacatcatc caccactgga acgccaaccg gctggacctg ttcgagatca
      661 gccagccgac cgaggatttg gagttccatg gagtgatgag attttatttt caagataaag
      721 ctgctggaaa ctttgcaaca aaatgtattc gggtctctag tactgccacc actcaagatg
      781 taatcgaaac gctcgcggag aaatttcgac ctgatatgcg aatgctgtcc tctcccaagt
      841 attcactcta tgaagtgcat gtcagcggag aagaaagaag attggatata gatgagaaac
      901 ctctagttgt acaactgaat tggaacaaag atgatcggga aggcagattt gttcttaaga
      961 atgagaatga cgccattcct cctaaggctc aaagtaatgg acctgaaaag caggaaaaag
     1021 aaggggttat ccagaacttc aagagaactc tctcaaagaa agaaaagaag gaaaaaaaga
     1081 agagagaaaa agaggcattg cgacaggcat ctgataaaga tgatagacct ttccaagggg
     1141 aggatgttga aaattctcga ctggctgctg aggtttacaa agacatgccg gaaaccagct
     1201 ttactcgaac catttctaat cctgaggtgg ttatgaaacg acggaggcag caaaaattgg
     1261 aaaagagaat gcaggaattt cggagctcag atgggcggcc tgattcaggt ggaacattga
     1321 gaatttatgc agatagttta aaaccaaata ttccctacaa gacaatcctg ctgtctacta
     1381 cagatcctgc agactttgct gtggctgaag ctttagagaa gtatggtctg gaaaaagaaa
     1441 accctaagga ttactgcatc gcccgggtta tgcttcctcc tggagcccag cattctgatg
     1501 aaaagggtgc taaagaaatt attcttgatg atgatgagtg tcctttacaa atcttcaggg
     1561 aatggccaag tgacaaaggg attttagtct ttcagttgaa gaggaggcca ccagaccaca
     1621 tcccaaagaa aaccaagaaa cacttggaag gcaagacacc caagggaaag gagagagctg
     1681 acgggtctgg ctatggctcc acccttcctc cggagaagct gccctattta gtagagttaa
     1741 gcccagatgg ttctgactct agagataagc caaagcttta ccgccttcag ttaagtgtta
     1801 ctgaagttgg gacagaaaag ttggatgaca actctatcca gttgtttggc ccaggaattc
     1861 agccccatca ctgtgacctt accaacatgg atggagtggt cactgtgacg cccagaagta
     1921 tggacgcaga aacctacgtg gaaggccagc gcatctcaga aaccaccatg ctgcagagtg
     1981 gcatgaaagt gcagtttggg gcgtcccatg tatttaagtt tgtggacccc agtcaggatc
     2041 atgctcttgc aaaaagatct gtggatggag gcctgatggt taagggccca agacataaac
     2101 ctggaattgt tcaggagaca acttttgatt tgggaggaga tattcatagt gggacagcat
     2161 taccgacaag caagagcacc actaggctgg acagcgacag agtgtcgtct gcctctagca
     2221 cagccgagcg gggaatggtg aagccgatga tcagagtaga acagcagcca gattatcgca
     2281 ggcaagaaag cagaacacag gatgcttctg ggcctgagct gatactacct gcaagcattg
     2341 aattcaggga aagttctgaa gattcatttt tgtctgccat tataaattat actaatagct
     2401 ctacagtcca ctttaagttg tcccctacat atgtattata tatggcatgc cggtatgtat
     2461 tgtccaacca gtacagacct gacatcagcc ctacagagcg cacacataaa gtcattgcag
     2521 tcgtcaacaa gatggtgagc atgatggagg gtgtcatcca ggaagtagac caggttgacc
     2581 agaaacagaa gaatattgca ggggcacttg ccttctggat ggcaaatgca tctgaacttc
     2641 tcaacttcat taagcaagac cgagacctta gtcggatcac actggatgct caagatgttt
     2701 tagcacattt ggttcaaatg gcatttaaat acttggttca ctgtcttcaa tcagaactta
     2761 ataattacat gccagccttt ctagatgacc ctgaagagaa cagtctgcaa cgaccaaaaa
     2821 tagatgatgt gctgcacacg ctcacaggag ccatgtcctt gctacgacgc tgcagagtca
     2881 atgccgccct gaccatccag ctcttctctc agctcttcca cttcatcaat atgtggctgt
     2941 tcaatagatt ggtgaccgac ccagattcgg ggctgtgctc ccattactgg ggtgcgatta
     3001 tccgtcagca gttgggccat attgaagcct gggctgagaa gcaggggctg gaactggctg
     3061 cggactgtca tctgagcagg atcgtgcagg caacgacttt gcttaccatg gataagtatg
     3121 cacctgatga cattccaaat ataaacagca cctgctttaa gttaaattca ttacaacttc
     3181 aagccttatt acagaactat cactgtgcac ctgatgagcc ttttatccca acggatctta
     3241 tagaaaatgt agtgactgtg gctgaaaaca ctgccgatga gctggcccgc agtgatggaa
     3301 gggaagtgca gttggaggag gatcctgatc tgcagctgcc gtttcttttg ccagaagatg
     3361 gttattcttg tgatgttgtc agaaacattc caaatggttt acaagaattt ttagaccctc
     3421 tgtgccagag aggattttgc aggttaattc ctcacacacg ttcaccaggt acttggacaa
     3481 tatattttga aggtgcagat tatgaaagtc accttctgcg tgagaacaca gagctggctc
     3541 agcctctgag gaaagaacct gaaataatca ctgtgaccct aaaaaagcag aatggaatgg
     3601 gccttagcat tgttgcagca aagggtgctg gtcaagataa actaggaatc tatgtgaagt
     3661 cggttgtgaa aggaggtgct gcagatgtgg atggacgtct agctgcaggt gatcagctcc
     3721 tcagtgtgga tggacgaagt ctggttggac tctctcagga aagggcggca gaactcatga
     3781 caagaacaag ctctgtggtg acactggaag tagcaaagca gggtgccatc taccacggtc
     3841 tggccaccct tctcaatcag ccatccccca tgatgcagag aatttcagat cgtcgtggct
     3901 caggtaaacc ccgaccaaag agtgaaggct ttgagctcta taataattca actcaaaatg
     3961 ggtctcctga gagtcctcag ctgccttggg cagaatatag tgaaccaaag aaattgcctg
     4021 gtgatgacag actgatgaaa aatagagctg atcaccgttc cagccccaac gtagcaaatc
     4081 agcctcctag tcctggaggg aaaagtgcat atgcctctgg aacaacagcg aagataacat
     4141 ctgtctctac tggaaacctc tgcactgagg agcagacgcc tccgcctaga cctgaagcct
     4201 accccatccc cactcagacg tacaccagag agtattttac cttcccagct tccaaatccc
     4261 aggatcggat ggctcctcct cagaaccagt ggccaaatta tgaggaaaag ccacatatgc
     4321 acacagatag taatcattcc agtattgcaa ttcagcgtgt tacacgttcc caagaagaac
     4381 ttcgagaaga taaagcttac caacttgagc ggcatcgaat agaggcagct atggaccgaa
     4441 agtctgatag tgatatgtgg ataaatcaga gctcctcact ggactccagt acctctagcc
     4501 aggagcatct gaaccattcc tctaagtcgg tcacccctgc ttccacactg accaaaagtg
     4561 gccctggccg ttggaaaaca ccagcagcca taccggccac ccctgtggcc gtctcccagc
     4621 caatccgaac agacctgcct ccgccacccc cgccacctcc agtccactat gccggtgatt
     4681 tcgatggaat gtccatggat ttgcctctcc caccaccccc ttccgccaac cagatagggc
     4741 tgccgtctgc gcaggtggct gctgctgaac ggagaaagag agaagaacat cagcgttggt
     4801 atgagaagga gaaggcccgc ctggaggagg agcgggagag gaagcggaga gagcaggaga
     4861 ggaagttggg ccagatgcgc actcagtcct taaaccctgc tccgttttct cccctgactg
     4921 cacagcagat gaagcccgaa aagccttcca cactccagcg gccacaggaa acagtcattc
     4981 gggagctgca gcctcagcag cagccccgca cgatcgagcg cagagacttg cagtacatta
     5041 cagtcagcaa agaggagctt tcctcggggg acagtctgtc ccccgacccg tggaagcggg
     5101 acgccaagga gaagctggag aagcagcagc agatgcacat cgtggacatg ctgagcaagg
     5161 agatccagga gctccagagc aaaccggacc gcagcgccga ggagagcgac cggctgcgca
     5221 agctcatgct ggagtggcag ttccagaaga gactccagga gtcgaagcag aaggacgaag
     5281 atgacgagga ggaggaggac gatgatgtgg acaccatgct gatcatgcag cgcctggagg
     5341 ctgaacgaag agcgaggttg caggacgagg agcggaggcg gcagcagcag ttagaagaga
     5401 tgcgcaagcg ggaagcggaa gaccgagcga ggcaagagga agagcgccgg cggcaggagg
     5461 aggagcgaac aaaacgagac gctgaagaaa agaggcgaca ggaagaaggg tattacagcc
     5521 gcctggaagc cgagaggcgc agacagcacg acgaggcggc gcgcaggttg ctggagcccg
     5581 aggcgcccgg tctgtgccgc cctccgcttc cccgggacta cgagcccccg tccccgtccc
     5641 ccgcgcccgg cgcccctcct cccccgcctc agcgaaacgc ctcctacctc aaaacacagg
     5701 tcctctcccc cgactcgctg ttcactgcca agtttgttgc atacaatgag gaggaggagg
     5761 aggaggactg cagcctagca ggtcaggata agtactccag cacaagaaag tctcatgggg
     5821 accttcttcc tgcccctctt aaaccacggc cacccccctg ccagccacgc ccggcctccg
     5881 atggcgtctt tctctccaac tcattccagc caccctcagc caaagccaac agtactgctc
     5941 acaaaaaagg ccagcccctg ccccctccaa aaaaatccag ctcctaccat cccagccact
     6001 gcaaaggtag aggaccaaac tcttacccag gatctactgg agcagctgtt ggagcccatg
     6061 acgcctgtcg ggatgcaaaa gagaagcgct ctaaaagcca agatgcagat tcacctggaa
     6121 gttctggggc ccctgaaaac ttgacattca aggaacgcca gcgtcttttt tcacaaggtc
     6181 aagatgtatc caataaagtg aaagcttctc gtaaattaac agaactggag aatgaactga
     6241 acacaaagtg aaagaaaatg aggagaacac tttgtattta ccccaaaatc ttttcagttg
     6301 tgggtttgta ggtgcgagtt tgaagaggaa aagaggaagg gggttatatt tctaagtgat
     6361 ttacaatttc tgtttctaaa attgttggga tttagaaatg tttcaattcc aagaaatttt
     6421 attttacttt accatgagat tgccatttat gtaatttaaa cactgtctag tttcttaatt
     6481 atctaactca cacgagggta agttttttgt tggtttcttt tttggagtcc tgagttcaaa
     6541 ggggacagaa ctaagggcag gagaagagaa tggatgtgtc ttctctccca tcttcccctc
     6601 atcatcgacc gaggagcaca aagaagttct gtttctgttt ttttcagaaa ctttatttta
     6661 gctgtcaagc agagaatagc ttgaactatt cagactattg ttggcactgt ttagtagtga
     6721 ccacacgctc ttctacccgg gaaggaacat atgacgacat gctcctccca tgtcccctga
     6781 tggtgtctgt tcccacaata tccttctagt ctgcatcgtg aagtggctta ggccaaagct
     6841 tcctgtgtga tgacgcacgt ccgagactgt tccatctcat tcctcgcaaa tttgagctct
     6901 tctgatcaat tctaaatatt tgattaattt taattctgaa agaaaatttt gaggatttaa
     6961 gcttagggga ttttattttt ataaatacca gattattgtt agacttaata aatcactgtt
     7021 aaatttaaag atgacagtta ccttggaaag ttcactaata cttcgctcca aggcgtctgt
     7081 aaaagaagat atctttattg gagcaatgtt catgtgactg ggaatgacag aagaatggga
     7141 gatgagtagg gacccctcaa gcacagctgt cactcagaaa ttttaaattt gaaaaagaaa
     7201 tcgattttca tctgtatgcc gtcaaggaag gaattcagtt acagggcatc tgtaacttaa
     7261 atattgtaag aataactcat atggaagttc aagctatttt tatactataa tagagttatt
     7321 taattttaat ttgttgaatt attagttacc actgtcattt cttcagctat ggatatgtgg
     7381 ctgatgttgg ggagacggac ctcagtgtgt tttatattgt ctggtgttaa gatgataaat
     7441 tactttgtga ttacaagcaa attttctatt tgacaaagcc cttggtggag tccaaatgat
     7501 ttttctgtac catattgttc tcttacacat acgtatgtta ggaaaatagg cacactttca
     7561 aagagaatgt tctcttacac atacgtatgt taggaaaata gacacatttt caaagagaat
     7621 gttctcttac atatgttagg aaaataggca cactttcaaa gagaggtata ggggcttttt
     7681 actgccttcg aaatcacttt taataaaagt tgtatgataa atcattaaaa atgcgagtgt
     7741 aaatattttt ttttacctct atcagggttt ttatttgaaa gtgtgctctt accatttcct
     7801 tgtttgagta agagagtgaa tggttctgag tgtttaggaa ggatttgctt gcttgcagca
     7861 gaagttctag gaaaagcagg cacctcccaa atatcttgag gacactggca gccttatggt
     7921 gactaaatcc acactttctt taaagagatg cagatgaatt acttttctgt taatatatag
     7981 aaaaatacac aggagaacat gcagatacat gtaaatatct acatacaggg atatttgtat
     8041 gtgtggttgt gaaacccata cacaagtgga tttggccatc tttgggcagt gaggtcaaat
     8101 gtgaatatgt gtaaaagtgc ttttcagaac tgcattacta tgagaaaaca tcaaaactgc
     8161 tgtagttttc catttctact gtatttcagt tgcaacctat ttttaataaa ctttgtatgt
     8221 atttaagtgt atttgctatt gttttgaaag tgctgacaaa gtttatattt gtaacatcag
     8281 ccttcctcgc ccatctcttt ccatctgtct cttcttcatt aaacacttac tgagtatga
//
