LOCUS       XM_047418794            8360 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens afadin, adherens junction formation factor
            (AFDN), transcript variant X7, mRNA.
ACCESSION   XM_047418794
VERSION     XM_047418794.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..8360
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /note="afadin, adherens junction formation factor; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 55 ESTs, 1563 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 33 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
     CDS             570..6272
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /codon_start=1
                     /product="afadin isoform X7"
                     /protein_id="XP_047274750.1"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
                     /translation="MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMR
                     FYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEE
                     RRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKR
                     TLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISN
                     PEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPAD
                     FAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWP
                     SDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELS
                     PGRRNHFAYYNYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHH
                     CDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHA
                     LAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASS
                     TAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYT
                     NSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQKQ
                     KNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELN
                     NYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMW
                     LFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTM
                     DKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVAENTADEL
                     ARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGFCRLIPHT
                     RSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSIVAAKGAG
                     QDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTL
                     EVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQNGSPESPQ
                     LPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAKITSVSTG
                     NLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEEKPHMHTD
                     SNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSLDSSTSSQ
                     EHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPPPPVHYAG
                     DFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEEERERKRR
                     EQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQPRTIERR
                     DLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQSKPDRSA
                     EESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERRARDEERR
                     RQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRLEAERRRQHD
                     EAARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQVLSPDSLFT
                     AKFVAYNEEEEEEDCSLAGQDKYSSTRKSHGDLLPAPLKPRPPPCQPRPASDGVFLSN
                     SFQPPSAKANSTAHKKGQPLPPPKKSSSYHPSHCKGRGPNSYPGSTGAAVGAHDACRD
                     AKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK
                     "
ORIGIN      
        1 actctgcacc gcgcgtccgg acccaacaca gcaccaccca tcggacccag cactgcccat
       61 ttagatccag cagcgcgcgt ccgaaccgaa cctagcaccg ctggtcggga aggaacccgg
      121 taccgccggt tgggacccac caccgccagt ccagacggaa ccctagcacc gcgcggggcc
      181 cgccctccga cacctccctc cctggcggcc gcggcagcag cacctagtgg agcggcccgg
      241 aggtgcggcg gcgccgcgcg gggcggcggc gcgcacggcg ggcggcggcg cgcacggcgg
      301 cgggcggggc gcgggcgggt gcgggcggcg ggcggcgggc gccgggcgca caccggccgg
      361 cggggctgag gcggcgcggc gcggcgcgga ctgagcccca ggcggaggcc aagtcggagg
      421 acgcggcgcg gccgcggagg cggaggcagc cgcggaggcg gaggcggccg gcggggggtg
      481 gcgaggggcg ccgggccccc gcggacctgt cgtcctcggc ccgtcctccg gccccggccc
      541 cgcgcggctg aggaggcgcg gccaggacca tgtcggcggg cggccgtgac gaggagcggc
      601 ggaagctggc cgacatcatc caccactgga acgccaaccg gctggacctg ttcgagatca
      661 gccagccgac cgaggatttg gagttccatg gagtgatgag attttatttt caagataaag
      721 ctgctggaaa ctttgcaaca aaatgtattc gggtctctag tactgccacc actcaagatg
      781 taatcgaaac gctcgcggag aaatttcgac ctgatatgcg aatgctgtcc tctcccaagt
      841 attcactcta tgaagtgcat gtcagcggag aagaaagaag attggatata gatgagaaac
      901 ctctagttgt acaactgaat tggaacaaag atgatcggga aggcagattt gttcttaaga
      961 atgagaatga cgccattcct cctaagaagg ctcaaagtaa tggacctgaa aagcaggaaa
     1021 aagaaggggt tatccagaac ttcaagagaa ctctctcaaa gaaagaaaag aaggaaaaaa
     1081 agaagagaga aaaagaggca ttgcgacagg catctgataa agatgataga cctttccaag
     1141 gggaggatgt tgaaaattct cgactggctg ctgaggttta caaagacatg ccggaaacca
     1201 gctttactcg aaccatttct aatcctgagg tggttatgaa acgacggagg cagcaaaaat
     1261 tggaaaagag aatgcaggaa tttcggagct cagatgggcg gcctgattca ggtggaacat
     1321 tgagaattta tgcagatagt ttaaaaccaa atattcccta caagacaatc ctgctgtcta
     1381 ctacagatcc tgcagacttt gctgtggctg aagctttaga gaagtatggt ctggaaaaag
     1441 aaaaccctaa ggattactgc atcgcccggg ttatgcttcc tcctggagcc cagcattctg
     1501 atgaaaaggg tgctaaagaa attattcttg atgatgatga gtgtccttta caaatcttca
     1561 gggaatggcc aagtgacaaa gggattttag tctttcagtt gaagaggagg ccaccagacc
     1621 acatcccaaa gaaaaccaag aaacacttgg aaggcaagac acccaaggga aaggagagag
     1681 ctgacgggtc tggctatggc tccacccttc ctccggagaa gctgccctat ttagtagagt
     1741 taagcccagg gagaaggaat cactttgcct actacaacta tcacacttac gaagatggtt
     1801 ctgactctag agataagcca aagctttacc gccttcagtt aagtgttact gaagttggga
     1861 cagaaaagtt ggatgacaac tctatccagt tgtttggccc aggaattcag ccccatcact
     1921 gtgaccttac caacatggat ggagtggtca ctgtgacgcc cagaagtatg gacgcagaaa
     1981 cctacgtgga aggccagcgc atctcagaaa ccaccatgct gcagagtggc atgaaagtgc
     2041 agtttggggc gtcccatgta tttaagtttg tggaccccag tcaggatcat gctcttgcaa
     2101 aaagatctgt ggatggaggc ctgatggtta agggcccaag acataaacct ggaattgttc
     2161 aggagacaac ttttgatttg ggaggagata ttcatagtgg gacagcatta ccgacaagca
     2221 agagcaccac taggctggac agcgacagag tgtcgtctgc ctctagcaca gccgagcggg
     2281 gaatggtgaa gccgatgatc agagtagaac agcagccaga ttatcgcagg caagaaagca
     2341 gaacacagga tgcttctggg cctgagctga tactacctgc aagcattgaa ttcagggaaa
     2401 gttctgaaga ttcatttttg tctgccatta taaattatac taatagctct acagtccact
     2461 ttaagttgtc ccctacatat gtattatata tggcatgccg gtatgtattg tccaaccagt
     2521 acagacctga catcagccct acagagcgca cacataaagt cattgcagtc gtcaacaaga
     2581 tggtgagcat gatggagggt gtcatccaga aacagaagaa tattgcaggg gcacttgcct
     2641 tctggatggc aaatgcatct gaacttctca acttcattaa gcaagaccga gaccttagtc
     2701 ggatcacact ggatgctcaa gatgttttag cacatttggt tcaaatggca tttaaatact
     2761 tggttcactg tcttcaatca gaacttaata attacatgcc agcctttcta gatgaccctg
     2821 aagagaacag tctgcaacga ccaaaaatag atgatgtgct gcacacgctc acaggagcca
     2881 tgtccttgct acgacgctgc agagtcaatg ccgccctgac catccagctc ttctctcagc
     2941 tcttccactt catcaatatg tggctgttca atagattggt gaccgaccca gattcggggc
     3001 tgtgctccca ttactggggt gcgattatcc gtcagcagtt gggccatatt gaagcctggg
     3061 ctgagaagca ggggctggaa ctggctgcgg actgtcatct gagcaggatc gtgcaggcaa
     3121 cgactttgct taccatggat aagtatgcac ctgatgacat tccaaatata aacagcacct
     3181 gctttaagtt aaattcatta caacttcaag ccttattaca gaactatcac tgtgcacctg
     3241 atgagccttt tatcccaacg gatcttatag aaaatgtagt gactgtggct gaaaacactg
     3301 ccgatgagct ggcccgcagt gatggaaggg aagtgcagtt ggaggaggat cctgatctgc
     3361 agctgccgtt tcttttgcca gaagatggtt attcttgtga tgttgtcaga aacattccaa
     3421 atggtttaca agaattttta gaccctctgt gccagagagg attttgcagg ttaattcctc
     3481 acacacgttc accaggtact tggacaatat attttgaagg tgcagattat gaaagtcacc
     3541 ttctgcgtga gaacacagag ctggctcagc ctctgaggaa agaacctgaa ataatcactg
     3601 tgaccctaaa aaagcagaat ggaatgggcc ttagcattgt tgcagcaaag ggtgctggtc
     3661 aagataaact aggaatctat gtgaagtcgg ttgtgaaagg aggtgctgca gatgtggatg
     3721 gacgtctagc tgcaggtgat cagctcctca gtgtggatgg acgaagtctg gttggactct
     3781 ctcaggaaag ggcggcagaa ctcatgacaa gaacaagctc tgtggtgaca ctggaagtag
     3841 caaagcaggg tgccatctac cacggtctgg ccacccttct caatcagcca tcccccatga
     3901 tgcagagaat ttcagatcgt cgtggctcag gtaaaccccg accaaagagt gaaggctttg
     3961 agctctataa taattcaact caaaatgggt ctcctgagag tcctcagctg ccttgggcag
     4021 aatatagtga accaaagaaa ttgcctggtg atgacagact gatgaaaaat agagctgatc
     4081 accgttccag ccccaacgta gcaaatcagc ctcctagtcc tggagggaaa agtgcatatg
     4141 cctctggaac aacagcgaag ataacatctg tctctactgg aaacctctgc actgaggagc
     4201 agacgcctcc gcctagacct gaagcctacc ccatccccac tcagacgtac accagagagt
     4261 attttacctt cccagcttcc aaatcccagg atcggatggc tcctcctcag aaccagtggc
     4321 caaattatga ggaaaagcca catatgcaca cagatagtaa tcattccagt attgcaattc
     4381 agcgtgttac acgttcccaa gaagaacttc gagaagataa agcttaccaa cttgagcggc
     4441 atcgaataga ggcagctatg gaccgaaagt ctgatagtga tatgtggata aatcagagct
     4501 cctcactgga ctccagtacc tctagccagg agcatctgaa ccattcctct aagtcggtca
     4561 cccctgcttc cacactgacc aaaagtggcc ctggccgttg gaaaacacca gcagccatac
     4621 cggccacccc tgtggccgtc tcccagccaa tccgaacaga cctgcctccg ccacccccgc
     4681 cacctccagt ccactatgcc ggtgatttcg atggaatgtc catggatttg cctctcccac
     4741 cacccccttc cgccaaccag atagggctgc cgtctgcgca ggtggctgct gctgaacgga
     4801 gaaagagaga agaacatcag cgttggtatg agaaggagaa ggcccgcctg gaggaggagc
     4861 gggagaggaa gcggagagag caggagagga agttgggcca gatgcgcact cagtccttaa
     4921 accctgctcc gttttctccc ctgactgcac agcagatgaa gcccgaaaag ccttccacac
     4981 tccagcggcc acaggaaaca gtcattcggg agctgcagcc tcagcagcag ccccgcacga
     5041 tcgagcgcag agacttgcag tacattacag tcagcaaaga ggagctttcc tcgggggaca
     5101 gtctgtcccc cgacccgtgg aagcgggacg ccaaggagaa gctggagaag cagcagcaga
     5161 tgcacatcgt ggacatgctg agcaaggaga tccaggagct ccagagcaaa ccggaccgca
     5221 gcgccgagga gagcgaccgg ctgcgcaagc tcatgctgga gtggcagttc cagaagagac
     5281 tccaggagtc gaagcagaag gacgaagatg acgaggagga ggaggacgat gatgtggaca
     5341 ccatgctgat catgcagcgc ctggaggctg aacgaagagc gagggacgag gagcggaggc
     5401 ggcagcagca gttagaagag atgcgcaagc gggaagcgga agaccgagcg aggcaagagg
     5461 aagagcgccg gcggcaggag gaggagcgaa caaaacgaga cgctgaagaa aagaggcgac
     5521 aggaagaagg gtattacagc cgcctggaag ccgagaggcg cagacagcac gacgaggcgg
     5581 cgcgcaggtt gctggagccc gaggcgcccg gtctgtgccg ccctccgctt ccccgggact
     5641 acgagccccc gtccccgtcc cccgcgcccg gcgcccctcc tcccccgcct cagcgaaacg
     5701 cctcctacct caaaacacag gtcctctccc ccgactcgct gttcactgcc aagtttgttg
     5761 catacaatga ggaggaggag gaggaggact gcagcctagc aggtcaggat aagtactcca
     5821 gcacaagaaa gtctcatggg gaccttcttc ctgcccctct taaaccacgg ccacccccct
     5881 gccagccacg cccggcctcc gatggcgtct ttctctccaa ctcattccag ccaccctcag
     5941 ccaaagccaa cagtactgct cacaaaaaag gccagcccct gccccctcca aaaaaatcca
     6001 gctcctacca tcccagccac tgcaaaggta gaggaccaaa ctcttaccca ggatctactg
     6061 gagcagctgt tggagcccat gacgcctgtc gggatgcaaa agagaagcgc tctaaaagcc
     6121 aagatgcaga ttcacctgga agttctgggg cccctgaaaa cttgacattc aaggaacgcc
     6181 agcgtctttt ttcacaaggt caagatgtat ccaataaagt gaaagcttct cgtaaattaa
     6241 cagaactgga gaatgaactg aacacaaagt gaaagaaaat gaggagaaca ctttgtattt
     6301 accccaaaat cttttcagtt gtgggtttgt aggtgcgagt ttgaagagga aaagaggaag
     6361 ggggttatat ttctaagtga tttacaattt ctgtttctaa aattgttggg atttagaaat
     6421 gtttcaattc caagaaattt tattttactt taccatgaga ttgccattta tgtaatttaa
     6481 acactgtcta gtttcttaat tatctaactc acacgagggt aagttttttg ttggtttctt
     6541 ttttggagtc ctgagttcaa aggggacaga actaagggca ggagaagaga atggatgtgt
     6601 cttctctccc atcttcccct catcatcgac cgaggagcac aaagaagttc tgtttctgtt
     6661 tttttcagaa actttatttt agctgtcaag cagagaatag cttgaactat tcagactatt
     6721 gttggcactg tttagtagtg accacacgct cttctacccg ggaaggaaca tatgacgaca
     6781 tgctcctccc atgtcccctg atggtgtctg ttcccacaat atccttctag tctgcatcgt
     6841 gaagtggctt aggccaaagc ttcctgtgtg atgacgcacg tccgagactg ttccatctca
     6901 ttcctcgcaa atttgagctc ttctgatcaa ttctaaatat ttgattaatt ttaattctga
     6961 aagaaaattt tgaggattta agcttagggg attttatttt tataaatacc agattattgt
     7021 tagacttaat aaatcactgt taaatttaaa gatgacagtt accttggaaa gttcactaat
     7081 acttcgctcc aaggcgtctg taaaagaaga tatctttatt ggagcaatgt tcatgtgact
     7141 gggaatgaca gaagaatggg agatgagtag ggacccctca agcacagctg tcactcagaa
     7201 attttaaatt tgaaaaagaa atcgattttc atctgtatgc cgtcaaggaa ggaattcagt
     7261 tacagggcat ctgtaactta aatattgtaa gaataactca tatggaagtt caagctattt
     7321 ttatactata atagagttat ttaattttaa tttgttgaat tattagttac cactgtcatt
     7381 tcttcagcta tggatatgtg gctgatgttg gggagacgga cctcagtgtg ttttatattg
     7441 tctggtgtta agatgataaa ttactttgtg attacaagca aattttctat ttgacaaagc
     7501 ccttggtgga gtccaaatga tttttctgta ccatattgtt ctcttacaca tacgtatgtt
     7561 aggaaaatag gcacactttc aaagagaatg ttctcttaca catacgtatg ttaggaaaat
     7621 agacacattt tcaaagagaa tgttctctta catatgttag gaaaataggc acactttcaa
     7681 agagaggtat aggggctttt tactgccttc gaaatcactt ttaataaaag ttgtatgata
     7741 aatcattaaa aatgcgagtg taaatatttt tttttacctc tatcagggtt tttatttgaa
     7801 agtgtgctct taccatttcc ttgtttgagt aagagagtga atggttctga gtgtttagga
     7861 aggatttgct tgcttgcagc agaagttcta ggaaaagcag gcacctccca aatatcttga
     7921 ggacactggc agccttatgg tgactaaatc cacactttct ttaaagagat gcagatgaat
     7981 tacttttctg ttaatatata gaaaaataca caggagaaca tgcagataca tgtaaatatc
     8041 tacatacagg gatatttgta tgtgtggttg tgaaacccat acacaagtgg atttggccat
     8101 ctttgggcag tgaggtcaaa tgtgaatatg tgtaaaagtg cttttcagaa ctgcattact
     8161 atgagaaaac atcaaaactg ctgtagtttt ccatttctac tgtatttcag ttgcaaccta
     8221 tttttaataa actttgtatg tatttaagtg tatttgctat tgttttgaaa gtgctgacaa
     8281 agtttatatt tgtaacatca gccttcctcg cccatctctt tccatctgtc tcttcttcat
     8341 taaacactta ctgagtatga
//
