LOCUS       XM_047418788            8387 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens afadin, adherens junction formation factor
            (AFDN), transcript variant X1, mRNA.
ACCESSION   XM_047418788
VERSION     XM_047418788.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..8387
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /note="afadin, adherens junction formation factor; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 54 ESTs, 1589 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 31 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
     CDS             570..6299
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /codon_start=1
                     /product="afadin isoform X1"
                     /protein_id="XP_047274744.1"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
                     /translation="MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMR
                     FYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEE
                     RRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKR
                     TLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISN
                     PEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPAD
                     FAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWP
                     SDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELS
                     PGRRNHFAYYNYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHH
                     CDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHA
                     LAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASS
                     TAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYT
                     NSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQEV
                     DQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVH
                     CLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQL
                     FHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQ
                     ATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVA
                     ENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGF
                     CRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSI
                     VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTR
                     TSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQN
                     GSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAK
                     ITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEE
                     KPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSL
                     DSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPP
                     PPVHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEE
                     ERERKRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQ
                     PRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQ
                     SKPDRSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERR
                     ARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRL
                     EAERRRQHDEAARRLLEPEAPGLCRPPLPRDYEPPSPSPAPGAPPPPPQRNASYLKTQ
                     VLSPDSLFTAKFVAYNEEEEEEDCSLAGQDKYSSTRKSHGDLLPAPLKPRPPPCQPRP
                     ASDGVFLSNSFQPPSAKANSTAHKKGQPLPPPKKSSSYHPSHCKGRGPNSYPGSTGAA
                     VGAHDACRDAKEKRSKSQDADSPGSSGAPENLTFKERQRLFSQGQDVSNKVKASRKLT
                     ELENELNTK"
ORIGIN      
        1 actctgcacc gcgcgtccgg acccaacaca gcaccaccca tcggacccag cactgcccat
       61 ttagatccag cagcgcgcgt ccgaaccgaa cctagcaccg ctggtcggga aggaacccgg
      121 taccgccggt tgggacccac caccgccagt ccagacggaa ccctagcacc gcgcggggcc
      181 cgccctccga cacctccctc cctggcggcc gcggcagcag cacctagtgg agcggcccgg
      241 aggtgcggcg gcgccgcgcg gggcggcggc gcgcacggcg ggcggcggcg cgcacggcgg
      301 cgggcggggc gcgggcgggt gcgggcggcg ggcggcgggc gccgggcgca caccggccgg
      361 cggggctgag gcggcgcggc gcggcgcgga ctgagcccca ggcggaggcc aagtcggagg
      421 acgcggcgcg gccgcggagg cggaggcagc cgcggaggcg gaggcggccg gcggggggtg
      481 gcgaggggcg ccgggccccc gcggacctgt cgtcctcggc ccgtcctccg gccccggccc
      541 cgcgcggctg aggaggcgcg gccaggacca tgtcggcggg cggccgtgac gaggagcggc
      601 ggaagctggc cgacatcatc caccactgga acgccaaccg gctggacctg ttcgagatca
      661 gccagccgac cgaggatttg gagttccatg gagtgatgag attttatttt caagataaag
      721 ctgctggaaa ctttgcaaca aaatgtattc gggtctctag tactgccacc actcaagatg
      781 taatcgaaac gctcgcggag aaatttcgac ctgatatgcg aatgctgtcc tctcccaagt
      841 attcactcta tgaagtgcat gtcagcggag aagaaagaag attggatata gatgagaaac
      901 ctctagttgt acaactgaat tggaacaaag atgatcggga aggcagattt gttcttaaga
      961 atgagaatga cgccattcct cctaagaagg ctcaaagtaa tggacctgaa aagcaggaaa
     1021 aagaaggggt tatccagaac ttcaagagaa ctctctcaaa gaaagaaaag aaggaaaaaa
     1081 agaagagaga aaaagaggca ttgcgacagg catctgataa agatgataga cctttccaag
     1141 gggaggatgt tgaaaattct cgactggctg ctgaggttta caaagacatg ccggaaacca
     1201 gctttactcg aaccatttct aatcctgagg tggttatgaa acgacggagg cagcaaaaat
     1261 tggaaaagag aatgcaggaa tttcggagct cagatgggcg gcctgattca ggtggaacat
     1321 tgagaattta tgcagatagt ttaaaaccaa atattcccta caagacaatc ctgctgtcta
     1381 ctacagatcc tgcagacttt gctgtggctg aagctttaga gaagtatggt ctggaaaaag
     1441 aaaaccctaa ggattactgc atcgcccggg ttatgcttcc tcctggagcc cagcattctg
     1501 atgaaaaggg tgctaaagaa attattcttg atgatgatga gtgtccttta caaatcttca
     1561 gggaatggcc aagtgacaaa gggattttag tctttcagtt gaagaggagg ccaccagacc
     1621 acatcccaaa gaaaaccaag aaacacttgg aaggcaagac acccaaggga aaggagagag
     1681 ctgacgggtc tggctatggc tccacccttc ctccggagaa gctgccctat ttagtagagt
     1741 taagcccagg gagaaggaat cactttgcct actacaacta tcacacttac gaagatggtt
     1801 ctgactctag agataagcca aagctttacc gccttcagtt aagtgttact gaagttggga
     1861 cagaaaagtt ggatgacaac tctatccagt tgtttggccc aggaattcag ccccatcact
     1921 gtgaccttac caacatggat ggagtggtca ctgtgacgcc cagaagtatg gacgcagaaa
     1981 cctacgtgga aggccagcgc atctcagaaa ccaccatgct gcagagtggc atgaaagtgc
     2041 agtttggggc gtcccatgta tttaagtttg tggaccccag tcaggatcat gctcttgcaa
     2101 aaagatctgt ggatggaggc ctgatggtta agggcccaag acataaacct ggaattgttc
     2161 aggagacaac ttttgatttg ggaggagata ttcatagtgg gacagcatta ccgacaagca
     2221 agagcaccac taggctggac agcgacagag tgtcgtctgc ctctagcaca gccgagcggg
     2281 gaatggtgaa gccgatgatc agagtagaac agcagccaga ttatcgcagg caagaaagca
     2341 gaacacagga tgcttctggg cctgagctga tactacctgc aagcattgaa ttcagggaaa
     2401 gttctgaaga ttcatttttg tctgccatta taaattatac taatagctct acagtccact
     2461 ttaagttgtc ccctacatat gtattatata tggcatgccg gtatgtattg tccaaccagt
     2521 acagacctga catcagccct acagagcgca cacataaagt cattgcagtc gtcaacaaga
     2581 tggtgagcat gatggagggt gtcatccagg aagtagacca ggttgaccag aaacagaaga
     2641 atattgcagg ggcacttgcc ttctggatgg caaatgcatc tgaacttctc aacttcatta
     2701 agcaagaccg agaccttagt cggatcacac tggatgctca agatgtttta gcacatttgg
     2761 ttcaaatggc atttaaatac ttggttcact gtcttcaatc agaacttaat aattacatgc
     2821 cagcctttct agatgaccct gaagagaaca gtctgcaacg accaaaaata gatgatgtgc
     2881 tgcacacgct cacaggagcc atgtccttgc tacgacgctg cagagtcaat gccgccctga
     2941 ccatccagct cttctctcag ctcttccact tcatcaatat gtggctgttc aatagattgg
     3001 tgaccgaccc agattcgggg ctgtgctccc attactgggg tgcgattatc cgtcagcagt
     3061 tgggccatat tgaagcctgg gctgagaagc aggggctgga actggctgcg gactgtcatc
     3121 tgagcaggat cgtgcaggca acgactttgc ttaccatgga taagtatgca cctgatgaca
     3181 ttccaaatat aaacagcacc tgctttaagt taaattcatt acaacttcaa gccttattac
     3241 agaactatca ctgtgcacct gatgagcctt ttatcccaac ggatcttata gaaaatgtag
     3301 tgactgtggc tgaaaacact gccgatgagc tggcccgcag tgatggaagg gaagtgcagt
     3361 tggaggagga tcctgatctg cagctgccgt ttcttttgcc agaagatggt tattcttgtg
     3421 atgttgtcag aaacattcca aatggtttac aagaattttt agaccctctg tgccagagag
     3481 gattttgcag gttaattcct cacacacgtt caccaggtac ttggacaata tattttgaag
     3541 gtgcagatta tgaaagtcac cttctgcgtg agaacacaga gctggctcag cctctgagga
     3601 aagaacctga aataatcact gtgaccctaa aaaagcagaa tggaatgggc cttagcattg
     3661 ttgcagcaaa gggtgctggt caagataaac taggaatcta tgtgaagtcg gttgtgaaag
     3721 gaggtgctgc agatgtggat ggacgtctag ctgcaggtga tcagctcctc agtgtggatg
     3781 gacgaagtct ggttggactc tctcaggaaa gggcggcaga actcatgaca agaacaagct
     3841 ctgtggtgac actggaagta gcaaagcagg gtgccatcta ccacggtctg gccacccttc
     3901 tcaatcagcc atcccccatg atgcagagaa tttcagatcg tcgtggctca ggtaaacccc
     3961 gaccaaagag tgaaggcttt gagctctata ataattcaac tcaaaatggg tctcctgaga
     4021 gtcctcagct gccttgggca gaatatagtg aaccaaagaa attgcctggt gatgacagac
     4081 tgatgaaaaa tagagctgat caccgttcca gccccaacgt agcaaatcag cctcctagtc
     4141 ctggagggaa aagtgcatat gcctctggaa caacagcgaa gataacatct gtctctactg
     4201 gaaacctctg cactgaggag cagacgcctc cgcctagacc tgaagcctac cccatcccca
     4261 ctcagacgta caccagagag tattttacct tcccagcttc caaatcccag gatcggatgg
     4321 ctcctcctca gaaccagtgg ccaaattatg aggaaaagcc acatatgcac acagatagta
     4381 atcattccag tattgcaatt cagcgtgtta cacgttccca agaagaactt cgagaagata
     4441 aagcttacca acttgagcgg catcgaatag aggcagctat ggaccgaaag tctgatagtg
     4501 atatgtggat aaatcagagc tcctcactgg actccagtac ctctagccag gagcatctga
     4561 accattcctc taagtcggtc acccctgctt ccacactgac caaaagtggc cctggccgtt
     4621 ggaaaacacc agcagccata ccggccaccc ctgtggccgt ctcccagcca atccgaacag
     4681 acctgcctcc gccacccccg ccacctccag tccactatgc cggtgatttc gatggaatgt
     4741 ccatggattt gcctctccca ccaccccctt ccgccaacca gatagggctg ccgtctgcgc
     4801 aggtggctgc tgctgaacgg agaaagagag aagaacatca gcgttggtat gagaaggaga
     4861 aggcccgcct ggaggaggag cgggagagga agcggagaga gcaggagagg aagttgggcc
     4921 agatgcgcac tcagtcctta aaccctgctc cgttttctcc cctgactgca cagcagatga
     4981 agcccgaaaa gccttccaca ctccagcggc cacaggaaac agtcattcgg gagctgcagc
     5041 ctcagcagca gccccgcacg atcgagcgca gagacttgca gtacattaca gtcagcaaag
     5101 aggagctttc ctcgggggac agtctgtccc ccgacccgtg gaagcgggac gccaaggaga
     5161 agctggagaa gcagcagcag atgcacatcg tggacatgct gagcaaggag atccaggagc
     5221 tccagagcaa accggaccgc agcgccgagg agagcgaccg gctgcgcaag ctcatgctgg
     5281 agtggcagtt ccagaagaga ctccaggagt cgaagcagaa ggacgaagat gacgaggagg
     5341 aggaggacga tgatgtggac accatgctga tcatgcagcg cctggaggct gaacgaagag
     5401 cgaggttgca ggacgaggag cggaggcggc agcagcagtt agaagagatg cgcaagcggg
     5461 aagcggaaga ccgagcgagg caagaggaag agcgccggcg gcaggaggag gagcgaacaa
     5521 aacgagacgc tgaagaaaag aggcgacagg aagaagggta ttacagccgc ctggaagccg
     5581 agaggcgcag acagcacgac gaggcggcgc gcaggttgct ggagcccgag gcgcccggtc
     5641 tgtgccgccc tccgcttccc cgggactacg agcccccgtc cccgtccccc gcgcccggcg
     5701 cccctcctcc cccgcctcag cgaaacgcct cctacctcaa aacacaggtc ctctcccccg
     5761 actcgctgtt cactgccaag tttgttgcat acaatgagga ggaggaggag gaggactgca
     5821 gcctagcagg tcaggataag tactccagca caagaaagtc tcatggggac cttcttcctg
     5881 cccctcttaa accacggcca cccccctgcc agccacgccc ggcctccgat ggcgtctttc
     5941 tctccaactc attccagcca ccctcagcca aagccaacag tactgctcac aaaaaaggcc
     6001 agcccctgcc ccctccaaaa aaatccagct cctaccatcc cagccactgc aaaggtagag
     6061 gaccaaactc ttacccagga tctactggag cagctgttgg agcccatgac gcctgtcggg
     6121 atgcaaaaga gaagcgctct aaaagccaag atgcagattc acctggaagt tctggggccc
     6181 ctgaaaactt gacattcaag gaacgccagc gtcttttttc acaaggtcaa gatgtatcca
     6241 ataaagtgaa agcttctcgt aaattaacag aactggagaa tgaactgaac acaaagtgaa
     6301 agaaaatgag gagaacactt tgtatttacc ccaaaatctt ttcagttgtg ggtttgtagg
     6361 tgcgagtttg aagaggaaaa gaggaagggg gttatatttc taagtgattt acaatttctg
     6421 tttctaaaat tgttgggatt tagaaatgtt tcaattccaa gaaattttat tttactttac
     6481 catgagattg ccatttatgt aatttaaaca ctgtctagtt tcttaattat ctaactcaca
     6541 cgagggtaag ttttttgttg gtttcttttt tggagtcctg agttcaaagg ggacagaact
     6601 aagggcagga gaagagaatg gatgtgtctt ctctcccatc ttcccctcat catcgaccga
     6661 ggagcacaaa gaagttctgt ttctgttttt ttcagaaact ttattttagc tgtcaagcag
     6721 agaatagctt gaactattca gactattgtt ggcactgttt agtagtgacc acacgctctt
     6781 ctacccggga aggaacatat gacgacatgc tcctcccatg tcccctgatg gtgtctgttc
     6841 ccacaatatc cttctagtct gcatcgtgaa gtggcttagg ccaaagcttc ctgtgtgatg
     6901 acgcacgtcc gagactgttc catctcattc ctcgcaaatt tgagctcttc tgatcaattc
     6961 taaatatttg attaatttta attctgaaag aaaattttga ggatttaagc ttaggggatt
     7021 ttatttttat aaataccaga ttattgttag acttaataaa tcactgttaa atttaaagat
     7081 gacagttacc ttggaaagtt cactaatact tcgctccaag gcgtctgtaa aagaagatat
     7141 ctttattgga gcaatgttca tgtgactggg aatgacagaa gaatgggaga tgagtaggga
     7201 cccctcaagc acagctgtca ctcagaaatt ttaaatttga aaaagaaatc gattttcatc
     7261 tgtatgccgt caaggaagga attcagttac agggcatctg taacttaaat attgtaagaa
     7321 taactcatat ggaagttcaa gctattttta tactataata gagttattta attttaattt
     7381 gttgaattat tagttaccac tgtcatttct tcagctatgg atatgtggct gatgttgggg
     7441 agacggacct cagtgtgttt tatattgtct ggtgttaaga tgataaatta ctttgtgatt
     7501 acaagcaaat tttctatttg acaaagccct tggtggagtc caaatgattt ttctgtacca
     7561 tattgttctc ttacacatac gtatgttagg aaaataggca cactttcaaa gagaatgttc
     7621 tcttacacat acgtatgtta ggaaaataga cacattttca aagagaatgt tctcttacat
     7681 atgttaggaa aataggcaca ctttcaaaga gaggtatagg ggctttttac tgccttcgaa
     7741 atcactttta ataaaagttg tatgataaat cattaaaaat gcgagtgtaa atattttttt
     7801 ttacctctat cagggttttt atttgaaagt gtgctcttac catttccttg tttgagtaag
     7861 agagtgaatg gttctgagtg tttaggaagg atttgcttgc ttgcagcaga agttctagga
     7921 aaagcaggca cctcccaaat atcttgagga cactggcagc cttatggtga ctaaatccac
     7981 actttcttta aagagatgca gatgaattac ttttctgtta atatatagaa aaatacacag
     8041 gagaacatgc agatacatgt aaatatctac atacagggat atttgtatgt gtggttgtga
     8101 aacccataca caagtggatt tggccatctt tgggcagtga ggtcaaatgt gaatatgtgt
     8161 aaaagtgctt ttcagaactg cattactatg agaaaacatc aaaactgctg tagttttcca
     8221 tttctactgt atttcagttg caacctattt ttaataaact ttgtatgtat ttaagtgtat
     8281 ttgctattgt tttgaaagtg ctgacaaagt ttatatttgt aacatcagcc ttcctcgccc
     8341 atctctttcc atctgtctct tcttcattaa acacttactg agtatga
//
