LOCUS       XM_006715491            7964 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens afadin, adherens junction formation factor
            (AFDN), transcript variant X45, mRNA.
ACCESSION   XM_006715491
VERSION     XM_006715491.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_006715491.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..7964
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /note="afadin, adherens junction formation factor; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 mRNAs, 54 ESTs, 1590 long SRA reads, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 22 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
     CDS             570..5876
                     /gene="AFDN"
                     /gene_synonym="AF6; l-afadin; MLL-AF6; MLLT4"
                     /codon_start=1
                     /product="afadin isoform X45"
                     /protein_id="XP_006715554.1"
                     /db_xref="GeneID:4301"
                     /db_xref="HGNC:HGNC:7137"
                     /db_xref="MIM:159559"
                     /translation="MSAGGRDEERRKLADIIHHWNANRLDLFEISQPTEDLEFHGVMR
                     FYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGEE
                     RRLDIDEKPLVVQLNWNKDDREGRFVLKNENDAIPPKKAQSNGPEKQEKEGVIQNFKR
                     TLSKKEKKEKKKREKEALRQASDKDDRPFQGEDVENSRLAAEVYKDMPETSFTRTISN
                     PEVVMKRRRQQKLEKRMQEFRSSDGRPDSGGTLRIYADSLKPNIPYKTILLSTTDPAD
                     FAVAEALEKYGLEKENPKDYCIARVMLPPGAQHSDEKGAKEIILDDDECPLQIFREWP
                     SDKGILVFQLKRRPPDHIPKKTKKHLEGKTPKGKERADGSGYGSTLPPEKLPYLVELS
                     PGRRNHFAYYNYHTYEDGSDSRDKPKLYRLQLSVTEVGTEKLDDNSIQLFGPGIQPHH
                     CDLTNMDGVVTVTPRSMDAETYVEGQRISETTMLQSGMKVQFGASHVFKFVDPSQDHA
                     LAKRSVDGGLMVKGPRHKPGIVQETTFDLGGDIHSGTALPTSKSTTRLDSDRVSSASS
                     TAERGMVKPMIRVEQQPDYRRQESRTQDASGPELILPASIEFRESSEDSFLSAIINYT
                     NSSTVHFKLSPTYVLYMACRYVLSNQYRPDISPTERTHKVIAVVNKMVSMMEGVIQEV
                     DQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVH
                     CLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQL
                     FHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQ
                     ATTLLTMDKYAPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVTVA
                     ENTADELARSDGREVQLEEDPDLQLPFLLPEDGYSCDVVRNIPNGLQEFLDPLCQRGF
                     CRLIPHTRSPGTWTIYFEGADYESHLLRENTELAQPLRKEPEIITVTLKKQNGMGLSI
                     VAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTR
                     TSSVVTLEVAKQGAIYHGLATLLNQPSPMMQRISDRRGSGKPRPKSEGFELYNNSTQN
                     GSPESPQLPWAEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSAYASGTTAK
                     ITSVSTGNLCTEEQTPPPRPEAYPIPTQTYTREYFTFPASKSQDRMAPPQNQWPNYEE
                     KPHMHTDSNHSSIAIQRVTRSQEELREDKAYQLERHRIEAAMDRKSDSDMWINQSSSL
                     DSSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAIPATPVAVSQPIRTDLPPPPPP
                     PPVHYAGDFDGMSMDLPLPPPPSANQIGLPSAQVAAAERRKREEHQRWYEKEKARLEE
                     ERERKRREQERKLGQMRTQSLNPAPFSPLTAQQMKPEKPSTLQRPQETVIRELQPQQQ
                     PRTIERRDLQYITVSKEELSSGDSLSPDPWKRDAKEKLEKQQQMHIVDMLSKEIQELQ
                     SKPDRSAEESDRLRKLMLEWQFQKRLQESKQKDEDDEEEEDDDVDTMLIMQRLEAERR
                     ARLQDEERRRQQQLEEMRKREAEDRARQEEERRRQEEERTKRDAEEKRRQEEGYYSRL
                     EAERRRQHDEAARRLLEPEAPGPNSYPGSTGAAVGAHDACRDAKEKRSKSQDADSPGS
                     SGAPENLTFKERQRLFSQGQDVSNKVKASRKLTELENELNTK"
ORIGIN      
        1 actctgcacc gcgcgtccgg acccaacaca gcaccaccca tcggacccag cactgcccat
       61 ttagatccag cagcgcgcgt ccgaaccgaa cctagcaccg ctggtcggga aggaacccgg
      121 taccgccggt tgggacccac caccgccagt ccagacggaa ccctagcacc gcgcggggcc
      181 cgccctccga cacctccctc cctggcggcc gcggcagcag cacctagtgg agcggcccgg
      241 aggtgcggcg gcgccgcgcg gggcggcggc gcgcacggcg ggcggcggcg cgcacggcgg
      301 cgggcggggc gcgggcgggt gcgggcggcg ggcggcgggc gccgggcgca caccggccgg
      361 cggggctgag gcggcgcggc gcggcgcgga ctgagcccca ggcggaggcc aagtcggagg
      421 acgcggcgcg gccgcggagg cggaggcagc cgcggaggcg gaggcggccg gcggggggtg
      481 gcgaggggcg ccgggccccc gcggacctgt cgtcctcggc ccgtcctccg gccccggccc
      541 cgcgcggctg aggaggcgcg gccaggacca tgtcggcggg cggccgtgac gaggagcggc
      601 ggaagctggc cgacatcatc caccactgga acgccaaccg gctggacctg ttcgagatca
      661 gccagccgac cgaggatttg gagttccatg gagtgatgag attttatttt caagataaag
      721 ctgctggaaa ctttgcaaca aaatgtattc gggtctctag tactgccacc actcaagatg
      781 taatcgaaac gctcgcggag aaatttcgac ctgatatgcg aatgctgtcc tctcccaagt
      841 attcactcta tgaagtgcat gtcagcggag aagaaagaag attggatata gatgagaaac
      901 ctctagttgt acaactgaat tggaacaaag atgatcggga aggcagattt gttcttaaga
      961 atgagaatga cgccattcct cctaagaagg ctcaaagtaa tggacctgaa aagcaggaaa
     1021 aagaaggggt tatccagaac ttcaagagaa ctctctcaaa gaaagaaaag aaggaaaaaa
     1081 agaagagaga aaaagaggca ttgcgacagg catctgataa agatgataga cctttccaag
     1141 gggaggatgt tgaaaattct cgactggctg ctgaggttta caaagacatg ccggaaacca
     1201 gctttactcg aaccatttct aatcctgagg tggttatgaa acgacggagg cagcaaaaat
     1261 tggaaaagag aatgcaggaa tttcggagct cagatgggcg gcctgattca ggtggaacat
     1321 tgagaattta tgcagatagt ttaaaaccaa atattcccta caagacaatc ctgctgtcta
     1381 ctacagatcc tgcagacttt gctgtggctg aagctttaga gaagtatggt ctggaaaaag
     1441 aaaaccctaa ggattactgc atcgcccggg ttatgcttcc tcctggagcc cagcattctg
     1501 atgaaaaggg tgctaaagaa attattcttg atgatgatga gtgtccttta caaatcttca
     1561 gggaatggcc aagtgacaaa gggattttag tctttcagtt gaagaggagg ccaccagacc
     1621 acatcccaaa gaaaaccaag aaacacttgg aaggcaagac acccaaggga aaggagagag
     1681 ctgacgggtc tggctatggc tccacccttc ctccggagaa gctgccctat ttagtagagt
     1741 taagcccagg gagaaggaat cactttgcct actacaacta tcacacttac gaagatggtt
     1801 ctgactctag agataagcca aagctttacc gccttcagtt aagtgttact gaagttggga
     1861 cagaaaagtt ggatgacaac tctatccagt tgtttggccc aggaattcag ccccatcact
     1921 gtgaccttac caacatggat ggagtggtca ctgtgacgcc cagaagtatg gacgcagaaa
     1981 cctacgtgga aggccagcgc atctcagaaa ccaccatgct gcagagtggc atgaaagtgc
     2041 agtttggggc gtcccatgta tttaagtttg tggaccccag tcaggatcat gctcttgcaa
     2101 aaagatctgt ggatggaggc ctgatggtta agggcccaag acataaacct ggaattgttc
     2161 aggagacaac ttttgatttg ggaggagata ttcatagtgg gacagcatta ccgacaagca
     2221 agagcaccac taggctggac agcgacagag tgtcgtctgc ctctagcaca gccgagcggg
     2281 gaatggtgaa gccgatgatc agagtagaac agcagccaga ttatcgcagg caagaaagca
     2341 gaacacagga tgcttctggg cctgagctga tactacctgc aagcattgaa ttcagggaaa
     2401 gttctgaaga ttcatttttg tctgccatta taaattatac taatagctct acagtccact
     2461 ttaagttgtc ccctacatat gtattatata tggcatgccg gtatgtattg tccaaccagt
     2521 acagacctga catcagccct acagagcgca cacataaagt cattgcagtc gtcaacaaga
     2581 tggtgagcat gatggagggt gtcatccagg aagtagacca ggttgaccag aaacagaaga
     2641 atattgcagg ggcacttgcc ttctggatgg caaatgcatc tgaacttctc aacttcatta
     2701 agcaagaccg agaccttagt cggatcacac tggatgctca agatgtttta gcacatttgg
     2761 ttcaaatggc atttaaatac ttggttcact gtcttcaatc agaacttaat aattacatgc
     2821 cagcctttct agatgaccct gaagagaaca gtctgcaacg accaaaaata gatgatgtgc
     2881 tgcacacgct cacaggagcc atgtccttgc tacgacgctg cagagtcaat gccgccctga
     2941 ccatccagct cttctctcag ctcttccact tcatcaatat gtggctgttc aatagattgg
     3001 tgaccgaccc agattcgggg ctgtgctccc attactgggg tgcgattatc cgtcagcagt
     3061 tgggccatat tgaagcctgg gctgagaagc aggggctgga actggctgcg gactgtcatc
     3121 tgagcaggat cgtgcaggca acgactttgc ttaccatgga taagtatgca cctgatgaca
     3181 ttccaaatat aaacagcacc tgctttaagt taaattcatt acaacttcaa gccttattac
     3241 agaactatca ctgtgcacct gatgagcctt ttatcccaac ggatcttata gaaaatgtag
     3301 tgactgtggc tgaaaacact gccgatgagc tggcccgcag tgatggaagg gaagtgcagt
     3361 tggaggagga tcctgatctg cagctgccgt ttcttttgcc agaagatggt tattcttgtg
     3421 atgttgtcag aaacattcca aatggtttac aagaattttt agaccctctg tgccagagag
     3481 gattttgcag gttaattcct cacacacgtt caccaggtac ttggacaata tattttgaag
     3541 gtgcagatta tgaaagtcac cttctgcgtg agaacacaga gctggctcag cctctgagga
     3601 aagaacctga aataatcact gtgaccctaa aaaagcagaa tggaatgggc cttagcattg
     3661 ttgcagcaaa gggtgctggt caagataaac taggaatcta tgtgaagtcg gttgtgaaag
     3721 gaggtgctgc agatgtggat ggacgtctag ctgcaggtga tcagctcctc agtgtggatg
     3781 gacgaagtct ggttggactc tctcaggaaa gggcggcaga actcatgaca agaacaagct
     3841 ctgtggtgac actggaagta gcaaagcagg gtgccatcta ccacggtctg gccacccttc
     3901 tcaatcagcc atcccccatg atgcagagaa tttcagatcg tcgtggctca ggtaaacccc
     3961 gaccaaagag tgaaggcttt gagctctata ataattcaac tcaaaatggg tctcctgaga
     4021 gtcctcagct gccttgggca gaatatagtg aaccaaagaa attgcctggt gatgacagac
     4081 tgatgaaaaa tagagctgat caccgttcca gccccaacgt agcaaatcag cctcctagtc
     4141 ctggagggaa aagtgcatat gcctctggaa caacagcgaa gataacatct gtctctactg
     4201 gaaacctctg cactgaggag cagacgcctc cgcctagacc tgaagcctac cccatcccca
     4261 ctcagacgta caccagagag tattttacct tcccagcttc caaatcccag gatcggatgg
     4321 ctcctcctca gaaccagtgg ccaaattatg aggaaaagcc acatatgcac acagatagta
     4381 atcattccag tattgcaatt cagcgtgtta cacgttccca agaagaactt cgagaagata
     4441 aagcttacca acttgagcgg catcgaatag aggcagctat ggaccgaaag tctgatagtg
     4501 atatgtggat aaatcagagc tcctcactgg actccagtac ctctagccag gagcatctga
     4561 accattcctc taagtcggtc acccctgctt ccacactgac caaaagtggc cctggccgtt
     4621 ggaaaacacc agcagccata ccggccaccc ctgtggccgt ctcccagcca atccgaacag
     4681 acctgcctcc gccacccccg ccacctccag tccactatgc cggtgatttc gatggaatgt
     4741 ccatggattt gcctctccca ccaccccctt ccgccaacca gatagggctg ccgtctgcgc
     4801 aggtggctgc tgctgaacgg agaaagagag aagaacatca gcgttggtat gagaaggaga
     4861 aggcccgcct ggaggaggag cgggagagga agcggagaga gcaggagagg aagttgggcc
     4921 agatgcgcac tcagtcctta aaccctgctc cgttttctcc cctgactgca cagcagatga
     4981 agcccgaaaa gccttccaca ctccagcggc cacaggaaac agtcattcgg gagctgcagc
     5041 ctcagcagca gccccgcacg atcgagcgca gagacttgca gtacattaca gtcagcaaag
     5101 aggagctttc ctcgggggac agtctgtccc ccgacccgtg gaagcgggac gccaaggaga
     5161 agctggagaa gcagcagcag atgcacatcg tggacatgct gagcaaggag atccaggagc
     5221 tccagagcaa accggaccgc agcgccgagg agagcgaccg gctgcgcaag ctcatgctgg
     5281 agtggcagtt ccagaagaga ctccaggagt cgaagcagaa ggacgaagat gacgaggagg
     5341 aggaggacga tgatgtggac accatgctga tcatgcagcg cctggaggct gaacgaagag
     5401 cgaggttgca ggacgaggag cggaggcggc agcagcagtt agaagagatg cgcaagcggg
     5461 aagcggaaga ccgagcgagg caagaggaag agcgccggcg gcaggaggag gagcgaacaa
     5521 aacgagacgc tgaagaaaag aggcgacagg aagaagggta ttacagccgc ctggaagccg
     5581 agaggcgcag acagcacgac gaggcggcgc gcaggttgct ggagcccgag gcgcccggac
     5641 caaactctta cccaggatct actggagcag ctgttggagc ccatgacgcc tgtcgggatg
     5701 caaaagagaa gcgctctaaa agccaagatg cagattcacc tggaagttct ggggcccctg
     5761 aaaacttgac attcaaggaa cgccagcgtc ttttttcaca aggtcaagat gtatccaata
     5821 aagtgaaagc ttctcgtaaa ttaacagaac tggagaatga actgaacaca aagtgaaaga
     5881 aaatgaggag aacactttgt atttacccca aaatcttttc agttgtgggt ttgtaggtgc
     5941 gagtttgaag aggaaaagag gaagggggtt atatttctaa gtgatttaca atttctgttt
     6001 ctaaaattgt tgggatttag aaatgtttca attccaagaa attttatttt actttaccat
     6061 gagattgcca tttatgtaat ttaaacactg tctagtttct taattatcta actcacacga
     6121 gggtaagttt tttgttggtt tcttttttgg agtcctgagt tcaaagggga cagaactaag
     6181 ggcaggagaa gagaatggat gtgtcttctc tcccatcttc ccctcatcat cgaccgagga
     6241 gcacaaagaa gttctgtttc tgtttttttc agaaacttta ttttagctgt caagcagaga
     6301 atagcttgaa ctattcagac tattgttggc actgtttagt agtgaccaca cgctcttcta
     6361 cccgggaagg aacatatgac gacatgctcc tcccatgtcc cctgatggtg tctgttccca
     6421 caatatcctt ctagtctgca tcgtgaagtg gcttaggcca aagcttcctg tgtgatgacg
     6481 cacgtccgag actgttccat ctcattcctc gcaaatttga gctcttctga tcaattctaa
     6541 atatttgatt aattttaatt ctgaaagaaa attttgagga tttaagctta ggggatttta
     6601 tttttataaa taccagatta ttgttagact taataaatca ctgttaaatt taaagatgac
     6661 agttaccttg gaaagttcac taatacttcg ctccaaggcg tctgtaaaag aagatatctt
     6721 tattggagca atgttcatgt gactgggaat gacagaagaa tgggagatga gtagggaccc
     6781 ctcaagcaca gctgtcactc agaaatttta aatttgaaaa agaaatcgat tttcatctgt
     6841 atgccgtcaa ggaaggaatt cagttacagg gcatctgtaa cttaaatatt gtaagaataa
     6901 ctcatatgga agttcaagct atttttatac tataatagag ttatttaatt ttaatttgtt
     6961 gaattattag ttaccactgt catttcttca gctatggata tgtggctgat gttggggaga
     7021 cggacctcag tgtgttttat attgtctggt gttaagatga taaattactt tgtgattaca
     7081 agcaaatttt ctatttgaca aagcccttgg tggagtccaa atgatttttc tgtaccatat
     7141 tgttctctta cacatacgta tgttaggaaa ataggcacac tttcaaagag aatgttctct
     7201 tacacatacg tatgttagga aaatagacac attttcaaag agaatgttct cttacatatg
     7261 ttaggaaaat aggcacactt tcaaagagag gtataggggc tttttactgc cttcgaaatc
     7321 acttttaata aaagttgtat gataaatcat taaaaatgcg agtgtaaata ttttttttta
     7381 cctctatcag ggtttttatt tgaaagtgtg ctcttaccat ttccttgttt gagtaagaga
     7441 gtgaatggtt ctgagtgttt aggaaggatt tgcttgcttg cagcagaagt tctaggaaaa
     7501 gcaggcacct cccaaatatc ttgaggacac tggcagcctt atggtgacta aatccacact
     7561 ttctttaaag agatgcagat gaattacttt tctgttaata tatagaaaaa tacacaggag
     7621 aacatgcaga tacatgtaaa tatctacata cagggatatt tgtatgtgtg gttgtgaaac
     7681 ccatacacaa gtggatttgg ccatctttgg gcagtgaggt caaatgtgaa tatgtgtaaa
     7741 agtgcttttc agaactgcat tactatgaga aaacatcaaa actgctgtag ttttccattt
     7801 ctactgtatt tcagttgcaa cctattttta ataaactttg tatgtattta agtgtatttg
     7861 ctattgtttt gaaagtgctg acaaagttta tatttgtaac atcagccttc ctcgcccatc
     7921 tctttccatc tgtctcttct tcattaaaca cttactgagt atga
//
