LOCUS       NM_001351071            4019 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens actin filament associated protein 1 like 2 (AFAP1L2),
            transcript variant 11, mRNA.
ACCESSION   NM_001351071 XM_017016820
VERSION     NM_001351071.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4019)
  AUTHORS   Ungarreevittaya,P., Nintra,O., Sirithanaphol,W., Chindaprasirt,J.
            and Sangkhamanon,S.
  TITLE     High XB130 expression in renal cell carcinoma is strongly
            associated with poor prognosis
  JOURNAL   Ann Diagn Pathol 67, 152190 (2023)
   PUBMED   37729738
  REMARK    GeneRIF: High XB130 expression in renal cell carcinoma is strongly
            associated with poor prognosis.
REFERENCE   2  (bases 1 to 4019)
  AUTHORS   Yang,S., Wang,B., Liao,J., Hong,Z., Zhong,X., Chen,S., Wu,Z.,
            Zhang,X. and Zuo,Q.
  TITLE     Molecular mechanism of XB130 adaptor protein mediates trastuzumab
            resistance in gastric cancer
  JOURNAL   Clin Transl Oncol 25 (3), 685-695 (2023)
   PUBMED   36284062
  REMARK    GeneRIF: Molecular mechanism of XB130 adaptor protein mediates
            trastuzumab resistance in gastric cancer.
REFERENCE   3  (bases 1 to 4019)
  AUTHORS   Poosekeaw,P., Pairojkul,C., Sripa,B., Sa Ngiamwibool,P.,
            Iamsaard,S., Sakonsinsiri,C., Thanan,R. and Ungarreevittaya,P.
  TITLE     Adaptor protein XB130 regulates the aggressiveness of
            cholangiocarcinoma
  JOURNAL   PLoS One 16 (11), e0259075 (2021)
   PUBMED   34780466
  REMARK    GeneRIF: Adaptor protein XB130 regulates the aggressiveness of
            cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4019)
  AUTHORS   Wang,Q., Yang,G., Jiang,Y., Luo,M., Li,C., Zhao,Y., Xie,Y., Song,K.
            and Zhou,J.
  TITLE     XB130, regulated by miR-203, miR-219, and miR-4782-3p, mediates the
            proliferation and metastasis of non-small-cell lung cancer cells
  JOURNAL   Mol Carcinog 59 (5), 557-568 (2020)
   PUBMED   32159887
  REMARK    GeneRIF: High XB130 expression is associated with proliferation and
            metastasis of non-small-cell lung cancer.
REFERENCE   5  (bases 1 to 4019)
  AUTHORS   Xie,T., Jiang,C., Dai,T., Xu,R., Zhou,X., Su,X. and Zhao,X.
  TITLE     Knockdown of XB130 restrains cancer stem cell-like phenotype
            through inhibition of Wnt/beta-Catenin signaling in breast cancer
  JOURNAL   Mol Carcinog 58 (10), 1832-1845 (2019)
   PUBMED   31219645
  REMARK    GeneRIF: This study indicates that XB130 plays an important role in
            maintaining the epithelial-mesenchymal transition (EMT) and stem
            cell-like characteristics of breast cancer cells, supporting the
            significance of XB130 as a new potential therapeutic target for
            early diagnosis and prognosis of breast cancer.
REFERENCE   6  (bases 1 to 4019)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE   7  (bases 1 to 4019)
  AUTHORS   Xu,J., Bai,X.H., Lodyga,M., Han,B., Xiao,H., Keshavjee,S., Hu,J.,
            Zhang,H., Yang,B.B. and Liu,M.
  TITLE     XB130, a novel adaptor protein for signal transduction
  JOURNAL   J Biol Chem 282 (22), 16401-16412 (2007)
   PUBMED   17412687
REFERENCE   8  (bases 1 to 4019)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4019)
  AUTHORS   Zhang,Y., Wolf-Yadlin,A., Ross,P.L., Pappin,D.J., Rush,J.,
            Lauffenburger,D.A. and White,F.M.
  TITLE     Time-resolved mass spectrometry of tyrosine phosphorylation sites
            in the epidermal growth factor receptor signaling network reveals
            dynamic modules
  JOURNAL   Mol Cell Proteomics 4 (9), 1240-1250 (2005)
   PUBMED   15951569
REFERENCE   10 (bases 1 to 4019)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024314.1, DA122692.1, DA213501.1, BC033212.1, AC005383.2,
            AK123108.1, BC035713.1 and AB067501.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001351071.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.231013.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BC024314.1         255-285
            32-563              DA122692.1         1-532
            564-819             DA213501.1         301-556
            820-1081            BC033212.1         494-755
            1082-1082           AC005383.2         100873-100873       c
            1083-1960           BC033212.1         757-1634
            1961-3684           AK123108.1         1698-3421
            3685-3826           BC035713.1         1569-1710
            3827-3982           BC035713.1         1714-1869
            3983-3987           AB067501.1         3666-3670
            3988-4019           BC024314.1         3931-3962
FEATURES             Location/Qualifiers
     source          1..4019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..4019
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="actin filament associated protein 1 like 2"
                     /db_xref="GeneID:84632"
                     /db_xref="HGNC:HGNC:25901"
                     /db_xref="MIM:612420"
     exon            1..63
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            64..288
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            289..417
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            418..492
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     CDS             441..2801
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="isoform 11 is encoded by transcript variant 11;
                     AFAP1-like protein 2; CTB-1144G6.6"
                     /codon_start=1
                     /product="actin filament-associated protein 1-like 2
                     isoform 11"
                     /protein_id="NP_001338000.1"
                     /db_xref="GeneID:84632"
                     /db_xref="HGNC:HGNC:25901"
                     /db_xref="MIM:612420"
                     /translation="MNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDL
                     PPPKMIPERKQLAIPKTESPEGYYEEAEPYDTSLNGHSGGFLPTGVPRWVQVPEGVIY
                     ATITLEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICAFLWRKKWL
                     GQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLKITPMNA
                     DVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRFNCQKPDIAEKYLSA
                     SEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYLNV
                     LVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHK
                     GEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIVSAAKNSLLL
                     MQRKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVADDPNERESDRV
                     YLDLTPVKSFLHGPSSAQAQASSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLG
                     EQQLESLEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRLRVTSA
                     EIKLGKNRTEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLA
                     SLEQKLKEIDEECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVDTTHLENPKA
                     VTPASAPDCTPVNSATTLKNRPLSVVVTGKGTVLQKAKEWEKKGAS"
     exon            493..587
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            588..678
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            679..762
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            763..968
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1148
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1238
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1323
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1428
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1640
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1786
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1898
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2144
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2313
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2469
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2651
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2774
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..4019
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3572..3577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="hexamer: ATTAAA"
     polyA_site      3602
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="major polyA site"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="hexamer: TATAAA"
     polyA_site      3686
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
     regulatory      3996..4001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="hexamer: AATAAA"
     polyA_site      4019
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
ORIGIN      
        1 agagcagcgc agaagccgag ccgcgaggag cgcactccgt ggccccgatg gagcggtaca
       61 aaggaacccg tttccccagt ttgctgctta tgtgttcaga acctgctcct gcaagatgac
      121 gacgcccagt gctgagaggc tcggatccca ctgtcaccaa gtgaggggcc gaccccagcg
      181 gagagcagcc tgggcacagt cctctctggt gggctccatg cagctgtccc tccccacctg
      241 tcgggctgcc accagggaat tccccggccc actgtgcgtc agcttttccc ctggaacagc
      301 tgctgacaga gttggatgac ttcctcaaga ttcttgacca ggagaacctg agcagcacag
      361 cactggtgaa gaagagctgc ctggcggagc tcctccggct ttacaccaaa agcagcagct
      421 ctgatgagga gtacatttat atgaacaaag tgaccatcaa caagcaacag aatgcagagt
      481 ctcaaggcaa agcgcctgag gagcagggcc tgctacccaa tggggagccc agccagcact
      541 cctcggcccc tcagaagagc cttccagacc tcccgccacc caagatgatt ccagaacgga
      601 aacagcttgc catcccaaag acggagtctc cagagggcta ctatgaagag gctgagccat
      661 atgacacatc cctcaatggt cactctggcg gatttctccc cactggagtc cccagatggg
      721 tgcaggtgcc cgaaggagtc atttatgcca cgatcacctt ggaggacgga gaggctgtga
      781 gcagctccta cgagtcctac gatgaagagg acggcagcaa gggcaagtcg gccccttacc
      841 agtggccctc gccggaggcc ggcatcgagc tgatgcgtga cgcccgcatc tgcgccttcc
      901 tgtggcgcaa gaagtggctg ggacagtggg ccaagcagct ctgtgtcatc aaggacaaca
      961 ggcttctgtg ctacaaatcc tccaaggacc acagccctca gctggacgtg aacctactgg
     1021 gcagcagcgt cattcacaag gagaagcaag tgcggaagaa ggagcacaag ctgaagatca
     1081 cgccgatgaa tgccgatgtg attgtgctgg gcctgcagag caaggaccag gctgagcagt
     1141 ggctcagggt catccaggaa gtgagcggcc tgccttccga aggagcatct gaaggaaacc
     1201 agtacacccc ggatgcccag cgctttaact gccagaaacc agatatagct gagaagtacc
     1261 tgtcggcttc agagtatggg agctccgtgg atggccaccc tgaggtccca gaaaccaaag
     1321 acgtcaagaa gaaatgttct gctggcctca aactgagcaa cctaatgaat ctgggcagga
     1381 agaaatccac ctcactggag cctgtggaga ggtccctcga gacatccagt tacctgaacg
     1441 tgctggtgaa cagccagtgg aagtctcgct ggtgctctgt cagggacaat cacctgcact
     1501 tctaccagga ccggaaccgg agcaaggtgg cccagcaacc cctcagcctg gtgggctgcg
     1561 aggtggtccc agaccccagc cccgaccacc tctactcctt ccgcatcctc cacaagggcg
     1621 aggagctggc caagcttgag gccaagtctt ccgaggaaat gggccactgg ctgggtctcc
     1681 tgctctctga gtcaggctcc aagacagacc cagaagagtt cacctacgac tatgtggatg
     1741 ccgatagggt ctcctgtatt gtgagtgcgg ccaaaaactc tctcttactg atgcagagaa
     1801 agttctcaga gcccaacact tacatcgatg gcctgcctag ccaggaccgc caggaggagc
     1861 tgtatgacga cgtggacctg tcagagctca cagctgcggt ggagcctacc gaggaagcca
     1921 cccctgttgc agatgaccca aatgagagag aatctgaccg agtgtacctg gacctcacac
     1981 ctgtcaagtc ctttctgcat ggccccagca gtgcacaggc ccaggcctcc tccccgacgt
     2041 tgtcctgcct ggacaatgca actgaggccc tcccggcaga ctcaggccca ggtcccaccc
     2101 cagatgagcc ctgcataaag tgtccagaga acctgggaga acagcagctg gagagtttgg
     2161 agccagagga tccttccctg agaatcacca ccgtcaaaat ccagacggaa cagcagagaa
     2221 tctccttccc accgagctgc ccggatgccg tggtggccac cccacctggt gccagcccac
     2281 ctgtgaagga caggttgcgc gtgaccagtg cagagatcaa gcttggcaag aatcggacag
     2341 aagctgaggt gaagcggtac acagaggaga aggagaggct tgaaaagaag aaggaagaaa
     2401 tccgggggca cctggctcag ctccggaaag agaaacggga gctaaaggaa accctactga
     2461 aatgcacaga caaggaagtc ctggcgagcc tggagcagaa gctgaaggaa attgacgagg
     2521 agtgccgggg cgaggagagc aggcgcgtgg acctggagct cagcatcatg gaggtgaagg
     2581 acaacctgaa gaaggctgag gcagggcctg tgacgttagg caccaccgtg gacaccaccc
     2641 acctggagaa tcccaaagct gtcacacctg cctctgcccc agactgtacc ccagtcaact
     2701 ctgcaaccac actcaagaac aggcctctct cggtcgtggt cacaggcaaa ggcactgtac
     2761 tccagaaagc caaggaatgg gagaagaaag gagcaagtta gaaaacaagc ttcatctaaa
     2821 gactctcatg tcaatgtgga ccttggtgac aatcctgctt tgttaaagca aaaactatgc
     2881 gaaagggtga gtctgtttag aagaaaaagc aaagactgag gtactgtgaa tggagagctt
     2941 cagctaagag gaggctctgt cccttttcag agccaaagga aataatacaa caaaaaggag
     3001 gcttctttgg agacctaagt ctattggatg taaacaagac gttgtattta gggatgttct
     3061 gtgtttcttt cttttttgaa gttgtcatca attgctttac taagattttt aaatagtgaa
     3121 aacctcctgt ttagactttg gtggaagatg aatcaaggaa gcagggccct gtcttatggg
     3181 tcacgtgtct ttggtgagtg agaagaccta aactcctggc catcatctct tatccaatac
     3241 ttagcagttg gggattaaac catccttgcc ttcagttctc tccaatatta ccaggcccaa
     3301 ctcagtcttc agtgatttta aacagcattg acatcatctg taaaaccatc atctgtaaaa
     3361 ccatctatga catgagtttt gagaaacaat aatggggaaa atatttggga ccaagctgaa
     3421 gcactaatcc cactaagtta aagacttctt tccagtccaa ggcaggcctg aatcaactgt
     3481 ctttaaataa aattttaagt gatgctgtat tatatatagg aaaaaatgct taaaatcctg
     3541 tcatttagaa cagtgaaaag tatcttttga gattaaagtg actctttact gtaggaaaaa
     3601 tattactctg tgtttacaga ttcattgctg tggtcaggcc atttttaagg gaagagttat
     3661 ttaatataaa tagtctctga ttttaagttc tgtttaatgt tcattctcct tccaagaaca
     3721 aagtggtgat ttttggttag ggtgatcgcc ctcttaaaat tggcagtgct gttccttgtg
     3781 ctgcccctgt cttttcctct gatggcattt tttttttttt ttttttaaca caggttgaaa
     3841 catttcatct attatctctg cctcatttct ggagggttgt gtatcagttc tctaacactt
     3901 gttcctgaga actaaatgtc ttttttattc ttatttcctc tctcataaac atttggtgac
     3961 cttttaccaa gtggtgagtt agttaggttt tttaaaataa aatgttcatt gtatttgaa
//
