LOCUS       NM_001001936            3722 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens actin filament associated protein 1 like 2 (AFAP1L2),
            transcript variant 1, mRNA.
ACCESSION   NM_001001936
VERSION     NM_001001936.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3722)
  AUTHORS   Ungarreevittaya,P., Nintra,O., Sirithanaphol,W., Chindaprasirt,J.
            and Sangkhamanon,S.
  TITLE     High XB130 expression in renal cell carcinoma is strongly
            associated with poor prognosis
  JOURNAL   Ann Diagn Pathol 67, 152190 (2023)
   PUBMED   37729738
  REMARK    GeneRIF: High XB130 expression in renal cell carcinoma is strongly
            associated with poor prognosis.
REFERENCE   2  (bases 1 to 3722)
  AUTHORS   Yang,S., Wang,B., Liao,J., Hong,Z., Zhong,X., Chen,S., Wu,Z.,
            Zhang,X. and Zuo,Q.
  TITLE     Molecular mechanism of XB130 adaptor protein mediates trastuzumab
            resistance in gastric cancer
  JOURNAL   Clin Transl Oncol 25 (3), 685-695 (2023)
   PUBMED   36284062
  REMARK    GeneRIF: Molecular mechanism of XB130 adaptor protein mediates
            trastuzumab resistance in gastric cancer.
REFERENCE   3  (bases 1 to 3722)
  AUTHORS   Poosekeaw,P., Pairojkul,C., Sripa,B., Sa Ngiamwibool,P.,
            Iamsaard,S., Sakonsinsiri,C., Thanan,R. and Ungarreevittaya,P.
  TITLE     Adaptor protein XB130 regulates the aggressiveness of
            cholangiocarcinoma
  JOURNAL   PLoS One 16 (11), e0259075 (2021)
   PUBMED   34780466
  REMARK    GeneRIF: Adaptor protein XB130 regulates the aggressiveness of
            cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3722)
  AUTHORS   Wang,Q., Yang,G., Jiang,Y., Luo,M., Li,C., Zhao,Y., Xie,Y., Song,K.
            and Zhou,J.
  TITLE     XB130, regulated by miR-203, miR-219, and miR-4782-3p, mediates the
            proliferation and metastasis of non-small-cell lung cancer cells
  JOURNAL   Mol Carcinog 59 (5), 557-568 (2020)
   PUBMED   32159887
  REMARK    GeneRIF: High XB130 expression is associated with proliferation and
            metastasis of non-small-cell lung cancer.
REFERENCE   5  (bases 1 to 3722)
  AUTHORS   Xie,T., Jiang,C., Dai,T., Xu,R., Zhou,X., Su,X. and Zhao,X.
  TITLE     Knockdown of XB130 restrains cancer stem cell-like phenotype
            through inhibition of Wnt/beta-Catenin signaling in breast cancer
  JOURNAL   Mol Carcinog 58 (10), 1832-1845 (2019)
   PUBMED   31219645
  REMARK    GeneRIF: This study indicates that XB130 plays an important role in
            maintaining the epithelial-mesenchymal transition (EMT) and stem
            cell-like characteristics of breast cancer cells, supporting the
            significance of XB130 as a new potential therapeutic target for
            early diagnosis and prognosis of breast cancer.
REFERENCE   6  (bases 1 to 3722)
  AUTHORS   Cirulli,E.T., Kasperaviciute,D., Attix,D.K., Need,A.C., Ge,D.,
            Gibson,G. and Goldstein,D.B.
  TITLE     Common genetic variation and performance on standardized cognitive
            tests
  JOURNAL   Eur J Hum Genet 18 (7), 815-820 (2010)
   PUBMED   20125193
  REMARK    Erratum:[Eur J Hum Genet. 2010 Jul;18(7):820]
REFERENCE   7  (bases 1 to 3722)
  AUTHORS   Xu,J., Bai,X.H., Lodyga,M., Han,B., Xiao,H., Keshavjee,S., Hu,J.,
            Zhang,H., Yang,B.B. and Liu,M.
  TITLE     XB130, a novel adaptor protein for signal transduction
  JOURNAL   J Biol Chem 282 (22), 16401-16412 (2007)
   PUBMED   17412687
REFERENCE   8  (bases 1 to 3722)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 3722)
  AUTHORS   Zhang,Y., Wolf-Yadlin,A., Ross,P.L., Pappin,D.J., Rush,J.,
            Lauffenburger,D.A. and White,F.M.
  TITLE     Time-resolved mass spectrometry of tyrosine phosphorylation sites
            in the epidermal growth factor receptor signaling network reveals
            dynamic modules
  JOURNAL   Mol Cell Proteomics 4 (9), 1240-1250 (2005)
   PUBMED   15951569
REFERENCE   10 (bases 1 to 3722)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC024314.1, BC033212.1, AC005383.2, AK123108.1, BC035713.1 and
            AB067501.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001001936.2.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 3. It encodes
            isoform 1, which is shorter than isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF474151.1, SRR1803617.110518.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304129.9/ ENSP00000303042.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BC024314.1         255-271
            18-772              BC033212.1         1-755
            773-773             AC005383.2         100873-100873       c
            774-1651            BC033212.1         757-1634
            1652-2342           AK123108.1         1698-2388
            2343-2354           BC033212.1         2326-2337
            2355-3387           AK123108.1         2389-3421
            3388-3529           BC035713.1         1569-1710
            3530-3685           BC035713.1         1714-1869
            3686-3690           AB067501.1         3666-3670
            3691-3722           BC024314.1         3931-3962
FEATURES             Location/Qualifiers
     source          1..3722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..3722
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="actin filament associated protein 1 like 2"
                     /db_xref="GeneID:84632"
                     /db_xref="HGNC:HGNC:25901"
                     /db_xref="MIM:612420"
     exon            1..63
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..2504
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="isoform 1 is encoded by transcript variant 1;
                     AFAP1-like protein 2; CTB-1144G6.6"
                     /codon_start=1
                     /product="actin filament-associated protein 1-like 2
                     isoform 1"
                     /protein_id="NP_001001936.1"
                     /db_xref="CCDS:CCDS31286.1"
                     /db_xref="GeneID:84632"
                     /db_xref="HGNC:HGNC:25901"
                     /db_xref="MIM:612420"
                     /translation="MERYKALEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLY
                     TKSSSSDEEYIYMNKVTINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPP
                     PKMIPERKQLAIPKTESPEGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAP
                     YQWPSPEAGIELMRDARICAFLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDV
                     NLLGSSVIHKEKQVRKKEHKLKITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEG
                     ASEGNQYTPDAQRFNCQKPDIAEKYLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLS
                     NLMNLGRKKSTSLEPVERSLETSSYLNVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVA
                     QQPLSLVGCEVVPDPSPDHLYSFRILHKGEELAKLEAKSSEEMGHWLGLLLSESGSKT
                     DPEEFTYDYVDADRVSCIVSAAKNSLLLMQRKFSEPNTYIDGLPSQDRQEELYDDVDL
                     SELTAAVEPTEEATPVADDPNERESDRVYLDLTPVKSFLHGPSSAQAQASSPTLSCLD
                     NATEALPADSGPGPTPDEPCIKCPENLGEQQLESLEPEDPSLRITTVKIQTEQQRISF
                     PPSCPDAVVATPPGASPPVKDRLRVTSAEIKLGKNRTEAEVKRYTEEKERLEKKKEEI
                     RGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEIDEECRGEESRRVDLELSIMEV
                     KDNLKKAEAGPVTLGTTVDTTHLENVSPRPKAVTPASAPDCTPVNSATTLKNRPLSVV
                     VTGKGTVLQKAKEWEKKGAS"
     exon            64..192
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            193..267
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            268..362
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            363..453
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            454..659
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            660..839
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            840..929
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1014
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1119
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1331
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1477
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1589
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1835
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2004
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2160
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2354
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2477
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..3722
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3275..3280
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="hexamer: ATTAAA"
     polyA_site      3305
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="major polyA site"
     regulatory      3368..3373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="hexamer: TATAAA"
     polyA_site      3389
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
     regulatory      3699..3704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
                     /note="hexamer: AATAAA"
     polyA_site      3722
                     /gene="AFAP1L2"
                     /gene_synonym="CTB-1144G6.4; KIAA1914; XB130"
ORIGIN      
        1 agagcagcgc agaagccgag ccgcgaggag cgcactccgt ggccccgatg gagcggtaca
       61 aagccctgga acagctgctg acagagttgg atgacttcct caagattctt gaccaggaga
      121 acctgagcag cacagcactg gtgaagaaga gctgcctggc ggagctcctc cggctttaca
      181 ccaaaagcag cagctctgat gaggagtaca tttatatgaa caaagtgacc atcaacaagc
      241 aacagaatgc agagtctcaa ggcaaagcgc ctgaggagca gggcctgcta cccaatgggg
      301 agcccagcca gcactcctcg gcccctcaga agagccttcc agacctcccg ccacccaaga
      361 tgattccaga acggaaacag cttgccatcc caaagacgga gtctccagag ggctactatg
      421 aagaggctga gccatatgac acatccctca atgaggacgg agaggctgtg agcagctcct
      481 acgagtccta cgatgaagag gacggcagca agggcaagtc ggccccttac cagtggccct
      541 cgccggaggc cggcatcgag ctgatgcgtg acgcccgcat ctgcgccttc ctgtggcgca
      601 agaagtggct gggacagtgg gccaagcagc tctgtgtcat caaggacaac aggcttctgt
      661 gctacaaatc ctccaaggac cacagccctc agctggacgt gaacctactg ggcagcagcg
      721 tcattcacaa ggagaagcaa gtgcggaaga aggagcacaa gctgaagatc acgccgatga
      781 atgccgatgt gattgtgctg ggcctgcaga gcaaggacca ggctgagcag tggctcaggg
      841 tcatccagga agtgagcggc ctgccttccg aaggagcatc tgaaggaaac cagtacaccc
      901 cggatgccca gcgctttaac tgccagaaac cagatatagc tgagaagtac ctgtcggctt
      961 cagagtatgg gagctccgtg gatggccacc ctgaggtccc agaaaccaaa gacgtcaaga
     1021 agaaatgttc tgctggcctc aaactgagca acctaatgaa tctgggcagg aagaaatcca
     1081 cctcactgga gcctgtggag aggtccctcg agacatccag ttacctgaac gtgctggtga
     1141 acagccagtg gaagtctcgc tggtgctctg tcagggacaa tcacctgcac ttctaccagg
     1201 accggaaccg gagcaaggtg gcccagcaac ccctcagcct ggtgggctgc gaggtggtcc
     1261 cagaccccag ccccgaccac ctctactcct tccgcatcct ccacaagggc gaggagctgg
     1321 ccaagcttga ggccaagtct tccgaggaaa tgggccactg gctgggtctc ctgctctctg
     1381 agtcaggctc caagacagac ccagaagagt tcacctacga ctatgtggat gccgataggg
     1441 tctcctgtat tgtgagtgcg gccaaaaact ctctcttact gatgcagaga aagttctcag
     1501 agcccaacac ttacatcgat ggcctgccta gccaggaccg ccaggaggag ctgtatgacg
     1561 acgtggacct gtcagagctc acagctgcgg tggagcctac cgaggaagcc acccctgttg
     1621 cagatgaccc aaatgagaga gaatctgacc gagtgtacct ggacctcaca cctgtcaagt
     1681 cctttctgca tggccccagc agtgcacagg cccaggcctc ctccccgacg ttgtcctgcc
     1741 tggacaatgc aactgaggcc ctcccggcag actcaggccc aggtcccacc ccagatgagc
     1801 cctgcataaa gtgtccagag aacctgggag aacagcagct ggagagtttg gagccagagg
     1861 atccttccct gagaatcacc accgtcaaaa tccagacgga acagcagaga atctccttcc
     1921 caccgagctg cccggatgcc gtggtggcca ccccacctgg tgccagccca cctgtgaagg
     1981 acaggttgcg cgtgaccagt gcagagatca agcttggcaa gaatcggaca gaagctgagg
     2041 tgaagcggta cacagaggag aaggagaggc ttgaaaagaa gaaggaagaa atccgggggc
     2101 acctggctca gctccggaaa gagaaacggg agctaaagga aaccctactg aaatgcacag
     2161 acaaggaagt cctggcgagc ctggagcaga agctgaagga aattgacgag gagtgccggg
     2221 gcgaggagag caggcgcgtg gacctggagc tcagcatcat ggaggtgaag gacaacctga
     2281 agaaggctga ggcagggcct gtgacgttag gcaccaccgt ggacaccacc cacctggaga
     2341 atgtgagccc ccgccccaaa gctgtcacac ctgcctctgc cccagactgt accccagtca
     2401 actctgcaac cacactcaag aacaggcctc tctcggtcgt ggtcacaggc aaaggcactg
     2461 tactccagaa agccaaggaa tgggagaaga aaggagcaag ttagaaaaca agcttcatct
     2521 aaagactctc atgtcaatgt ggaccttggt gacaatcctg ctttgttaaa gcaaaaacta
     2581 tgcgaaaggg tgagtctgtt tagaagaaaa agcaaagact gaggtactgt gaatggagag
     2641 cttcagctaa gaggaggctc tgtccctttt cagagccaaa ggaaataata caacaaaaag
     2701 gaggcttctt tggagaccta agtctattgg atgtaaacaa gacgttgtat ttagggatgt
     2761 tctgtgtttc tttctttttt gaagttgtca tcaattgctt tactaagatt tttaaatagt
     2821 gaaaacctcc tgtttagact ttggtggaag atgaatcaag gaagcagggc cctgtcttat
     2881 gggtcacgtg tctttggtga gtgagaagac ctaaactcct ggccatcatc tcttatccaa
     2941 tacttagcag ttggggatta aaccatcctt gccttcagtt ctctccaata ttaccaggcc
     3001 caactcagtc ttcagtgatt ttaaacagca ttgacatcat ctgtaaaacc atcatctgta
     3061 aaaccatcta tgacatgagt tttgagaaac aataatgggg aaaatatttg ggaccaagct
     3121 gaagcactaa tcccactaag ttaaagactt ctttccagtc caaggcaggc ctgaatcaac
     3181 tgtctttaaa taaaatttta agtgatgctg tattatatat aggaaaaaat gcttaaaatc
     3241 ctgtcattta gaacagtgaa aagtatcttt tgagattaaa gtgactcttt actgtaggaa
     3301 aaatattact ctgtgtttac agattcattg ctgtggtcag gccattttta agggaagagt
     3361 tatttaatat aaatagtctc tgattttaag ttctgtttaa tgttcattct ccttccaaga
     3421 acaaagtggt gatttttggt tagggtgatc gccctcttaa aattggcagt gctgttcctt
     3481 gtgctgcccc tgtcttttcc tctgatggca tttttttttt ttttttttta acacaggttg
     3541 aaacatttca tctattatct ctgcctcatt tctggagggt tgtgtatcag ttctctaaca
     3601 cttgttcctg agaactaaat gtctttttta ttcttatttc ctctctcata aacatttggt
     3661 gaccttttac caagtggtga gttagttagg ttttttaaaa taaaatgttc attgtatttg
     3721 aa
//
