LOCUS       NM_153207               5830 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens AE binding protein 2 (AEBP2), transcript variant 1,
            mRNA.
ACCESSION   NM_153207
VERSION     NM_153207.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5830)
  AUTHORS   Kasinath,V., Beck,C., Sauer,P., Poepsel,S., Kosmatka,J., Faini,M.,
            Toso,D., Aebersold,R. and Nogales,E.
  TITLE     JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and
            other histone modifications
  JOURNAL   Science 371 (6527) (2021)
   PUBMED   33479123
  REMARK    GeneRIF: JARID2 and AEBP2 regulate PRC2 in the presence of
            H2AK119ub1 and other histone modifications.
REFERENCE   2  (bases 1 to 5830)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5830)
  AUTHORS   Zhang,Q., Wang,W. and Gao,Q.
  TITLE     beta-TRCP-mediated AEBP2 ubiquitination and destruction controls
            cisplatin resistance in ovarian cancer
  JOURNAL   Biochem Biophys Res Commun 523 (1), 274-279 (2020)
   PUBMED   31864706
  REMARK    GeneRIF: beta-TRCP-mediated AEBP2 ubiquitination and destruction
            controls cisplatin resistance in ovarian cancer.
REFERENCE   4  (bases 1 to 5830)
  AUTHORS   Sun,A., Li,F., Liu,Z., Jiang,Y., Zhang,J., Wu,J. and Shi,Y.
  TITLE     Structural and biochemical insights into human zinc finger protein
            AEBP2 reveals interactions with RBBP4
  JOURNAL   Protein Cell 9 (8), 738-742 (2018)
   PUBMED   29134516
  REMARK    GeneRIF: The binding interface between AEBP and RBBP4 is relatively
            small compared with PHF6, histone H3 and FOG-1, indicating that
            AEBP may not have been the only region that participates in RBBP4
            recognition.
            Review article
REFERENCE   5  (bases 1 to 5830)
  AUTHORS   Kim,H., Bakshi,A. and Kim,J.
  TITLE     Retrotransposon-derived promoter of Mammalian Aebp2
  JOURNAL   PLoS One 10 (4), e0126966 (2015)
   PUBMED   25915901
  REMARK    GeneRIF: retrotransposons as promoter, which display partial DNA
            methylation pattern of allelic- or non-allelic origin during
            different stages of development
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5830)
  AUTHORS   Ciferri,C., Lander,G.C., Maiolica,A., Herzog,F., Aebersold,R. and
            Nogales,E.
  TITLE     Molecular architecture of human polycomb repressive complex 2
  JOURNAL   Elife 1, e00005 (2012)
   PUBMED   23110252
  REMARK    GeneRIF: The first three-dimensional structure of the human
            polycomb repressive complex 2 complex bound to its cofactor AEBP2
            has been presented.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5830)
  AUTHORS   Soler Artigas,M., Loth,D.W., Wain,L.V., Gharib,S.A., Obeidat,M.,
            Tang,W., Zhai,G., Zhao,J.H., Smith,A.V., Huffman,J.E., Albrecht,E.,
            Jackson,C.M., Evans,D.M., Cadby,G., Fornage,M., Manichaikul,A.,
            Lopez,L.M., Johnson,T., Aldrich,M.C., Aspelund,T., Barroso,I.,
            Campbell,H., Cassano,P.A., Couper,D.J., Eiriksdottir,G.,
            Franceschini,N., Garcia,M., Gieger,C., Gislason,G.K., Grkovic,I.,
            Hammond,C.J., Hancock,D.B., Harris,T.B., Ramasamy,A.,
            Heckbert,S.R., Heliovaara,M., Homuth,G., Hysi,P.G., James,A.L.,
            Jankovic,S., Joubert,B.R., Karrasch,S., Klopp,N., Koch,B.,
            Kritchevsky,S.B., Launer,L.J., Liu,Y., Loehr,L.R., Lohman,K.,
            Loos,R.J., Lumley,T., Al Balushi,K.A., Ang,W.Q., Barr,R.G.,
            Beilby,J., Blakey,J.D., Boban,M., Boraska,V., Brisman,J.,
            Britton,J.R., Brusselle,G.G., Cooper,C., Curjuric,I., Dahgam,S.,
            Deary,I.J., Ebrahim,S., Eijgelsheim,M., Francks,C., Gaysina,D.,
            Granell,R., Gu,X., Hankinson,J.L., Hardy,R., Harris,S.E.,
            Henderson,J., Henry,A., Hingorani,A.D., Hofman,A., Holt,P.G.,
            Hui,J., Hunter,M.L., Imboden,M., Jameson,K.A., Kerr,S.M.,
            Kolcic,I., Kronenberg,F., Liu,J.Z., Marchini,J., McKeever,T.,
            Morris,A.D., Olin,A.C., Porteous,D.J., Postma,D.S., Rich,S.S.,
            Ring,S.M., Rivadeneira,F., Rochat,T., Sayer,A.A., Sayers,I.,
            Sly,P.D., Smith,G.D., Sood,A., Starr,J.M., Uitterlinden,A.G.,
            Vonk,J.M., Wannamethee,S.G., Whincup,P.H., Wijmenga,C.,
            Williams,O.D., Wong,A., Mangino,M., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., North,K.E., Omenaas,E., Palmer,L.J.,
            Pietilainen,K.H., Pin,I., Pola Sbreve Ek,O., Pouta,A., Psaty,B.M.,
            Hartikainen,A.L., Rantanen,T., Ripatti,S., Rotter,J.I., Rudan,I.,
            Rudnicka,A.R., Schulz,H., Shin,S.Y., Spector,T.D., Surakka,I.,
            Vitart,V., Volzke,H., Wareham,N.J., Warrington,N.M., Wichmann,H.E.,
            Wild,S.H., Wilk,J.B., Wjst,M., Wright,A.F., Zgaga,L., Zemunik,T.,
            Pennell,C.E., Nyberg,F., Kuh,D., Holloway,J.W., Boezen,H.M.,
            Lawlor,D.A., Morris,R.W., Probst-Hensch,N., Kaprio,J., Wilson,J.F.,
            Hayward,C., Kahonen,M., Heinrich,J., Musk,A.W., Jarvis,D.L.,
            Glaser,S., Jarvelin,M.R., Ch Stricker,B.H., Elliott,P.,
            O'Connor,G.T., Strachan,D.P., London,S.J., Hall,I.P., Gudnason,V.
            and Tobin,M.D.
  CONSRTM   International Lung Cancer Consortium; GIANT consortium
  TITLE     Genome-wide association and large-scale follow up identifies 16 new
            loci influencing lung function
  JOURNAL   Nat Genet 43 (11), 1082-1090 (2011)
   PUBMED   21946350
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5830)
  AUTHORS   Pasini,D., Cloos,P.A., Walfridsson,J., Olsson,L., Bukowski,J.P.,
            Johansen,J.V., Bak,M., Tommerup,N., Rappsilber,J. and Helin,K.
  TITLE     JARID2 regulates binding of the Polycomb repressive complex 2 to
            target genes in ES cells
  JOURNAL   Nature 464 (7286), 306-310 (2010)
   PUBMED   20075857
REFERENCE   9  (bases 1 to 5830)
  AUTHORS   Cao,R. and Zhang,Y.
  TITLE     SUZ12 is required for both the histone methyltransferase activity
            and the silencing function of the EED-EZH2 complex
  JOURNAL   Mol Cell 15 (1), 57-67 (2004)
   PUBMED   15225548
REFERENCE   10 (bases 1 to 5830)
  AUTHORS   He,G.P., Kim,S. and Ro,H.S.
  TITLE     Cloning and characterization of a novel zinc finger transcriptional
            repressor. A direct role of the zinc finger motif in repression
  JOURNAL   J Biol Chem 274 (21), 14678-14684 (1999)
   PUBMED   10329662
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091805.16, DB244333.1, BC022220.1, BC015624.2 and AA195771.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153207.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform A.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022220.1, SRR1803615.203006.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266508.14/ ENSP00000266508.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC091805.16        107863-108044       c
            183-207             DB244333.1         1-25
            208-1836            BC022220.1         1-1629
            1837-1841           BC015624.2         1142-1146
            1842-3827           BC022220.1         1630-3615
            3828-4248           BC015624.2         3135-3555
            4249-4355           AA195771.1         61-167
            4356-5830           AC091805.16        25309-26783         c
FEATURES             Location/Qualifiers
     source          1..5830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..5830
                     /gene="AEBP2"
                     /note="AE binding protein 2"
                     /db_xref="GeneID:121536"
                     /db_xref="HGNC:HGNC:24051"
                     /db_xref="MIM:617934"
     exon            1..879
                     /gene="AEBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1720
                     /gene="AEBP2"
                     /note="isoform a is encoded by transcript variant 1;
                     AE(adipocyte enhancer)-binding protein 2; zinc finger
                     protein AEBP2; adipocyte enhancer-binding protein 2"
                     /codon_start=1
                     /product="zinc finger protein AEBP2 isoform a"
                     /protein_id="NP_694939.2"
                     /db_xref="CCDS:CCDS44842.1"
                     /db_xref="GeneID:121536"
                     /db_xref="HGNC:HGNC:24051"
                     /db_xref="MIM:617934"
                     /translation="MAAAITDMADLEELSRLSPLPPGSPGSAARGRAEPPEEEEEEEE
                     EEEEAEAEAVAALLLNGGSGGGGGGGGGGVGGGEAETMSEPSPESASQAGEDEDEEED
                     DEEEEDESSSSGGGEEESSAESLVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEE
                     PKGPRGSQGGGGGGSSSSSVVSSGGDEGYGTGGGGSSATSGGRRGSLEMSSDGEPLSR
                     MDSEDSISSTIMDVDSTISSGRSTPAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSP
                     DLADHIRSIHVDGQRGGVFVCLWKGCKVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGG
                     CNASFASQGGLARHVPTHFSQQNSSKVSSQPKAKEESPSKAGMNKRRKLKNKRRRSLP
                     RPHDFFDAQTLDAIRHRAICFNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLH
                     WMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALLLDPNIYRTMPQKRLKR"
     exon            880..1087
                     /gene="AEBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1195
                     /gene="AEBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1382
                     /gene="AEBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1507
                     /gene="AEBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1575
                     /gene="AEBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1689
                     /gene="AEBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..5830
                     /gene="AEBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3807..3812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AEBP2"
                     /note="hexamer: AATAAA"
     regulatory      3812..3817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AEBP2"
                     /note="hexamer: AACAAA"
     polyA_site      3827
                     /gene="AEBP2"
                     /note="major polyA site"
     polyA_site      3839
                     /gene="AEBP2"
     polyA_site      4229
                     /gene="AEBP2"
     regulatory      5139..5144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AEBP2"
                     /note="hexamer: AATAAA"
     polyA_site      5164
                     /gene="AEBP2"
     regulatory      5209..5214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AEBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      5237
                     /gene="AEBP2"
     regulatory      5321..5326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AEBP2"
                     /note="hexamer: AATAAA"
     polyA_site      5355
                     /gene="AEBP2"
     regulatory      5765..5770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AEBP2"
                     /note="hexamer: AAGAAA"
     polyA_site      5781
                     /gene="AEBP2"
     regulatory      5809..5814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AEBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      5830
                     /gene="AEBP2"
ORIGIN      
        1 agtctccgtg tgagtgcgcg tagtcgcgcg cctgtccccg cgcgggctcc gtagcgcgtg
       61 tgcaggctga cgcagctcgc gggccctcct cctgctctgc agcggcgtcg gcggagtttt
      121 gggcgtttgg gaggggggcg agggagagag agtcgagaga gggaggcggc ggtggggagg
      181 aggaggagga ggaggagcag gcgccgccat ggccgccgct atcaccgaca tggccgacct
      241 ggaggagctc tcccgcctga gccctctgcc ccccggcagc ccgggttcgg cggcgcgggg
      301 ccgggctgag ccccccgagg aggaggagga agaggaggag gaggaagagg aggcggaggc
      361 cgaggcggtg gcggcgctgc tgctgaacgg cggcagcggt gggggcggcg gaggcggcgg
      421 cggaggagtg gggggcggcg aggcagagac gatgtcggag ccgagccccg agagcgccag
      481 ccaggccggg gaggacgaag acgaggagga ggacgacgag gaggaggaag atgagagcag
      541 cagcagcggc gggggtgagg aggagagtag cgccgagagc ctggtgggca gcagcggcgg
      601 gagcagcagc gacgagaccc gctcgttgag ccccggcgcc gccagcagca gcagcgggga
      661 tggggacggc aaggagggcc tggaggagcc caagggaccg cggggcagcc agggcggcgg
      721 cgggggcggc agcagtagca gcagcgtagt ctccagcggc ggcgacgagg gctacgggac
      781 tgggggaggc ggaagcagcg cgacctccgg gggccggcgg ggcagcttgg agatgtcgtc
      841 ggatggggaa cccctgagcc gcatggactc ggaggacagc ataagcagta ctataatgga
      901 tgtagacagc acaatttcca gtgggcgttc aactccagca atgatgaatg gacaaggaag
      961 cactacttct tcaagcaaaa atattgccta taattgttgt tgggaccagt gccaggcttg
     1021 cttcaactct agcccagatc tggcagatca catccgttcc atacatgtag atggtcagcg
     1081 aggaggggta tttgtttgct tatggaaagg ttgtaaagta tataacactc catctaccag
     1141 tcaaagttgg ttacaaaggc atatgctgac acacagtgga gacaaacctt tcaagtgtgt
     1201 tgttggtggc tgcaatgcca gctttgcttc tcagggaggg ctagctcgtc atgtacccac
     1261 acacttcagt cagcagaact cctcaaaagt ttctagccag ccaaaggcca aagaagaatc
     1321 tccttctaaa gctggaatga acaaaaggag gaaattaaag aacaaaagac gacgctcatt
     1381 accacggcca catgatttct tcgatgcaca aacactggat gcgataagac atcgagccat
     1441 atgctttaac ctctcagctc atatagaaag tttagggaag ggacacagtg ttgtttttca
     1501 tagtactgta atagctaaga gaaaagaaga ttctgggaag atcaaacttt tgcttcattg
     1561 gatgcctgaa gacattctgc ctgatgtgtg ggtgaatgaa agtgaacgac atcagttaaa
     1621 aactaaagta gttcatttat caaagctacc caaagatact gccttgcttt tggacccaaa
     1681 catatacaga acaatgccgc agaagaggtt gaagaggtaa aaaataaata aatacataaa
     1741 aagcaaacaa gcggggacac ctgcagtctt agtcactgac aatgggttta gggaaagttg
     1801 cacattagag tcaacccctt cttttttttt tttttttttt taaatccagt atttaggata
     1861 atatttatgc ttagtgtaaa cattctgtga atgaagtaga ctcttcggtg gaatatatta
     1921 atatattact gtatatccac attttcatgg aatggtactg tgggagactg agcaaacact
     1981 cttttggcaa cttagtagaa cagcttctta aaggctttgc atgcttgctg ctttaagctg
     2041 cttttttttt tcttttcttc cctttagtga tttcagtagt ttatattgga aagaaaaaca
     2101 attacaacat gtgcccttac aaataccaaa agcactgtaa ggatatttgt cttgacagtg
     2161 tttattgatt tgaagtcata ttaggaaata tttagacaat gaaaattatc aagagataat
     2221 ttacctttca attatgataa atagatgtga ttggttgcca tttgtgttct tttgcagaac
     2281 tctgataaga aaagtgttca atttgtattt aagcaaacag tgaacgacgt ttgcaatcaa
     2341 ctaaaaattc gtctatcgaa ttagggctga aaattactgt taaagagtgt tgcagtatgt
     2401 ctggtggctc ccttttcagg actagggctt tctcatggag tacagtatgt taatatttac
     2461 ctatataact aatctgttaa cggtttttga aaaacctttc aaattatttg aataatcttc
     2521 atattttcat ttaacctata tgactctaat tttttttctg aggaaatcat ttggtttttg
     2581 agttgttttt tcttaatgta agaaaaattg tatttttttt acaagtatct tcaaactgaa
     2641 tcttttatgc accaaagttg gtcttgaaaa ggaaaataaa atcactttct tgcttggtaa
     2701 gcaagaagcc atatcgattt tttttaactt acagaaatgg aaatatgtgt aacttgttag
     2761 tattgtatta aacaaatgtt gcatagagat aatagaacat tgcttgtaaa taattcagca
     2821 gatttgtaat atatttttat attttgaaat gtactgtaga tgttttctag aggcatgaaa
     2881 gttaaatgta tatattatgg tagaaataat attgaaggat attgtacttc actagtgctg
     2941 ccagaggaat tgttaataaa agcaccttct ttaacaataa atgtctttca cagacttaag
     3001 ggactatgta ctactgttaa tatctctaag aacaaaacac attgaacatc cttccagaaa
     3061 gtctttgagg gaggacctat acccataata gaattatggc actcatttct gacagtgatc
     3121 aagaaatcag ttatttcctt actgttggaa ggacattgta aagtatgtgg ttatatgcag
     3181 tgaaactgca gaaaatactc ctggttgagg agttttcact ttactacagt gatataaaaa
     3241 ccagcagttt ttacactaaa ttttttaaag aaatattaga caaaaatata gaattaaaac
     3301 ctttggttcc aaaatgggaa aggttccacg atacataaat catttctcat ttgctttaaa
     3361 aaatttaaaa gtgtaaaaat tatgagagac tttattcgtt aacaatgggg gtaaagagct
     3421 atatacatga aaatgagtct tataaaatta agtgaagtgc aaataaaagc actgctacta
     3481 taagacattc tggaatggtt gtttaataag ggtattatcc atttgatcta tagcaatgtg
     3541 attttatttt taaaaagaaa agcagtgtgt tttctttttt tgttgttttc ttttgcttaa
     3601 gcacttcatc aattgcttta ttctgtatct gcgaagtaat ctgcaatctc ttttgttctt
     3661 tttaaaattt gatttgttat aaaattgcca aatagaagtg tttcagatac atagtttgta
     3721 cctgtatttt tattttattg cctcatgttc ttgtaagtca ttcttaattg accaatgatt
     3781 gtagaccttg cttgagtatt ttttctaata aaacaaagca aatcacattt agcttcaaat
     3841 tgtaacaatt caattgaatt ttaaaatgac acctgaaaag atacatctga tattttctat
     3901 atagagcaca gtaaataagt tttttcattg tgtagaaata cttagatgtc aaaaccagat
     3961 ttcgtgatcc ttgattaact tctgagtact caatcaatca taatcctttt gctgcttatc
     4021 tgatgttggt ttgatactgt taacacacca aaaagaatat ggaattgaaa tgagctagct
     4081 ttataacttg tatgtataca tatatacaca taacatccaa ttatgactgg gtaataagtg
     4141 tgaaaatttt aatttgtggt tttcatttat taatgtctgc ccatctgtat tgttgctcct
     4201 accttcaaat atgacacctg aaataataag tctgttgtcc agaatttatg tattgttcag
     4261 catcaagcaa actacagctc acaagcatac ccatttatat gttgtctatg cctgctttct
     4321 cctgcagtgg cagaattgag tggtgagacc ttaggtcctg caagccccca atttttacta
     4381 caggttggca atccctaatc caaaaatctg acataaaaaa tgctccaaag ttcaaaactt
     4441 tctgagtgct gacatcatgc tgcaagtgga aaattccacg cctgacctca tgtgactggt
     4501 catagtcaaa acaattaaga ctttgtttca tgcacaaaat tattaaaact gttgtataaa
     4561 attaccttca gtctatgtgt ataaggtgtt tgtgagatat aaatgaactt tatgtttagt
     4621 cttggatcgc atttctgagt ctcattatgt atatgcagat actcaaaaat ctgaaaaaaa
     4681 tcaaaaatct gaaatacttc tggtcccaag catttcggat aagggatact cagcctgtct
     4741 ctggtccttt aagaaaaagt tttcgattcc tttgtctagt tgacaaaaag tttggaaaca
     4801 taaacttaga ccacacaact tgcattttaa tatgacaatg ttgatcttgg taataagcca
     4861 gtacattaaa ttttagtgaa agctgtttca tgtattttac agtaaatact gccatattag
     4921 gtacctacaa caaatggtgg tttttggaaa cttttacggt gggtttttaa agttattaat
     4981 agtccatcat ttcatcattt gtgtttctgt atttattttg ctaagaacta aataagattt
     5041 tgtacatcag attgtgtttg aaccgtaagg cacatctgct ttatctaaaa gaatcttaag
     5101 gtggaaatag tgtaaaattt aaaatttttt atatttctaa taaacttttt atatataaat
     5161 gttacctaaa gtggacacat gttacttctg aatttcacat gaaaggaaat taaagatgga
     5221 caataattat ctctcaatat tttaagattt gttttactaa ttgaaaacag tatgtcagta
     5281 aatctttggc cttagtgctt ttttccccct tttacacatt aataaaatgt tttaaatatg
     5341 gtaatactct taaaacggta gaatttgcca cagttgttta aagcattttt attttttctt
     5401 tgaattctta attcatggtg aacagatgtt gggttcttaa aatataaaaa tgagaaaata
     5461 tgtattaaaa atacttgata gagggttttc tctttaatca caacttaaaa aaagaaacct
     5521 ttaatacctc tgcataagtt ctctgaaaga acttaaattc ttagtttata tgaaaactga
     5581 tatgtatgtc tgtgtaacaa agcctgttgg gtacaggtct acaaggagat actttgtttc
     5641 taaaaaagga gttaaatcgt gtcacctgaa tttttttttt ttgagataag tggacatttt
     5701 ggggattttg gttaaaacat atttctctat tctaaaaatt acagaatatg tattcataaa
     5761 agggaagaaa ttgttagaaa atttcctgtg tacgtagttt gtttttaaat taaagaatct
     5821 tgtgacctgg
//
