LOCUS       NM_001129               4097 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens AE binding protein 1 (AEBP1), mRNA.
ACCESSION   NM_001129
VERSION     NM_001129.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4097)
  AUTHORS   Liu,S., Gu,Y., Shi,Y., Yu,S., Li,W. and Lv,W.
  TITLE     AEBP1 upregulation contributes to cervical cancer progression by
            facilitating cell proliferation, migration, and invasion
  JOURNAL   J Obstet Gynaecol Res 50 (7), 1166-1174 (2024)
   PUBMED   38684171
  REMARK    GeneRIF: AEBP1 upregulation contributes to cervical cancer
            progression by facilitating cell proliferation, migration, and
            invasion.
REFERENCE   2  (bases 1 to 4097)
  AUTHORS   Asadie,M., Miri,A., Badri,T., Hosseini Nejad,J. and Gharechahi,J.
  TITLE     Dysregulated AEBP1 and COLEC12 Genes in Late-Onset Alzheimer's
            Disease: Insights from Brain Cortex and Peripheral Blood Analysis
  JOURNAL   J Mol Neurosci 74 (2), 37 (2024)
   PUBMED   38568322
  REMARK    GeneRIF: Dysregulated AEBP1 and COLEC12 Genes in Late-Onset
            Alzheimer's Disease: Insights from Brain Cortex and Peripheral
            Blood Analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4097)
  AUTHORS   Ju,G., Xing,T., Xu,M., Zhang,X., Sun,Y., Mu,Z., Sun,D., Miao,S.,
            Li,L., Liang,J. and Lin,Y.
  TITLE     AEBP1 promotes papillary thyroid cancer progression by activating
            BMP4 signaling
  JOURNAL   Neoplasia 49, 100972 (2024)
   PUBMED   38237535
  REMARK    GeneRIF: AEBP1 promotes papillary thyroid cancer progression by
            activating BMP4 signaling.
REFERENCE   4  (bases 1 to 4097)
  AUTHORS   Corano Scheri,K., Lavine,J.A., Tedeschi,T., Thomson,B.R. and
            Fawzi,A.A.
  TITLE     Single-cell transcriptomics analysis of proliferative diabetic
            retinopathy fibrovascular membranes reveals AEBP1 as fibrogenesis
            modulator
  JOURNAL   JCI Insight 8 (23), e172062 (2023)
   PUBMED   37917183
  REMARK    GeneRIF: Single-cell transcriptomics analysis of proliferative
            diabetic retinopathy fibrovascular membranes reveals AEBP1 as
            fibrogenesis modulator.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4097)
  AUTHORS   Li,Y.X., Zhu,X.X., Wu,X., Li,J.H., Ni,X.H., Li,S.J., Zhao,W. and
            Yin,X.Y.
  TITLE     ACLP promotes activation of cancer-associated fibroblasts and tumor
            metastasis via ACLP-PPARgamma-ACLP feedback loop in pancreatic
            cancer
  JOURNAL   Cancer Lett 544, 215802 (2022)
   PUBMED   35732215
  REMARK    GeneRIF: ACLP promotes activation of cancer-associated fibroblasts
            and tumor metastasis via ACLP-PPARgamma-ACLP feedback loop in
            pancreatic cancer.
REFERENCE   6  (bases 1 to 4097)
  AUTHORS   Layne,M.D., Yet,S.F., Maemura,K., Hsieh,C.M., Bernfield,M.,
            Perrella,M.A. and Lee,M.E.
  TITLE     Impaired abdominal wall development and deficient wound healing in
            mice lacking aortic carboxypeptidase-like protein
  JOURNAL   Mol Cell Biol 21 (15), 5256-5261 (2001)
   PUBMED   11438679
  REMARK    GeneRIF: Most ACLP knockout mice die perinatally due to abdominal
            issues.
REFERENCE   7  (bases 1 to 4097)
  AUTHORS   Muise,A.M. and Ro,H.S.
  TITLE     Enzymic characterization of a novel member of the regulatory B-like
            carboxypeptidase with transcriptional repression function:
            stimulation of enzymic activity by its target DNA
  JOURNAL   Biochem J 343 Pt 2 (Pt 2), 341-345 (1999)
   PUBMED   10510298
REFERENCE   8  (bases 1 to 4097)
  AUTHORS   Layne,M.D., Endege,W.O., Jain,M.K., Yet,S.F., Hsieh,C.M.,
            Chin,M.T., Perrella,M.A., Blanar,M.A., Haber,E. and Lee,M.E.
  TITLE     Aortic carboxypeptidase-like protein, a novel protein with
            discoidin and carboxypeptidase-like domains, is up-regulated during
            vascular smooth muscle cell differentiation
  JOURNAL   J Biol Chem 273 (25), 15654-15660 (1998)
   PUBMED   9624159
REFERENCE   9  (bases 1 to 4097)
  AUTHORS   Song,L. and Fricker,L.D.
  TITLE     Cloning and expression of human carboxypeptidase Z, a novel
            metallocarboxypeptidase
  JOURNAL   J Biol Chem 272 (16), 10543-10550 (1997)
   PUBMED   9099699
REFERENCE   10 (bases 1 to 4097)
  AUTHORS   Ohno,I., Hashimoto,J., Shimizu,K., Takaoka,K., Ochi,T.,
            Matsubara,K. and Okubo,K.
  TITLE     A cDNA cloning of human AEBP1 from primary cultured osteoblasts and
            its expression in a differentiating osteoblastic cell line
  JOURNAL   Biochem Biophys Res Commun 228 (2), 411-414 (1996)
   PUBMED   8920928
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006454.4, BC038588.1 and
            DB213495.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001129.4.
            
            Summary: This gene encodes a member of carboxypeptidase A protein
            family. The encoded protein may function as a transcriptional
            repressor and play a role in adipogenesis and smooth muscle cell
            differentiation. Studies in mice suggest that this gene functions
            in wound healing and abdominal wall development. Overexpression of
            this gene is associated with glioblastoma. [provided by RefSeq, May
            2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038588.1, AB209744.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223357.8/ ENSP00000223357.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC006454.4         148240-148255       c
            17-1316             BC038588.1         1-1300
            1317-1317           DB213495.1         382-382
            1318-4097           BC038588.1         1302-4081
FEATURES             Location/Qualifiers
     source          1..4097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..4097
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /note="AE binding protein 1"
                     /db_xref="GeneID:165"
                     /db_xref="HGNC:HGNC:303"
                     /db_xref="MIM:602981"
     exon            1..574
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..3798
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /note="aortic carboxypeptidase-like protein; adipocyte
                     enhancer-binding protein 1"
                     /codon_start=1
                     /product="adipocyte enhancer-binding protein 1 precursor"
                     /protein_id="NP_001120.3"
                     /db_xref="CCDS:CCDS5476.1"
                     /db_xref="GeneID:165"
                     /db_xref="HGNC:HGNC:303"
                     /db_xref="MIM:602981"
                     /translation="MAAVRGAPLLSCLLALLALCPGGRPQTVLTDDEIEEFLEGFLSE
                     LEPEPREDDVEAPPPPEPTPRVRKAQAGGKPGKRPGTAAEVPPEKTKDKGKKGKKDKG
                     PKVPKESLEGSPRPPKKGKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKA
                     TKKPPSGKRPPILAPSETLEWPLPPPPSPGPEELPQEGGAPLSNNWQNPGEETHVEAR
                     EHQPEPEEETEQPTLDYNDQIEREDYEDFEYIRRQKQPRPPPSRRRRPERVWPEPPEE
                     KAPAPAPEERIEPPVKPLLPPLPPDYGDGYVIPNYDDMDYYFGPPPPQKPDAERQTDE
                     EKEELKKPKKEDSSPKEETDKWAVEKGKDHKEPRKGEELEEEWTPTEKVKCPPIGMES
                     HRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEVDTRR
                     TTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFHGNVDKDTPVL
                     SELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVAPVYSYYAQNEVVATDDLDFRHHS
                     YKDMRQLMKVVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGEHELGEPEFRYTAGI
                     HGNEVLGRELLLLLMQYLCREYRDGNPRVRSLVQDTRIHLVPSLNPDGYEVAAQMGSE
                     FGNWALGLWTEEGFDIFEDFPDLNSVLWGAEERKWVPYRVPNNNLPIPERYLSPDATV
                     STEVRAIIAWMEKNPFVLGANLNGGERLVSYPYDMARTPTQEQLLAAAMAAARGEDED
                     EVSEAQETPDHAIFRWLAISFASAHLTLTEPYRGGCQAQDYTGGMGIVNGAKWNPRTG
                     TINDFSYLHTNCLELSFYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTD
                     EQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTPSAKTCNVDYD
                     IGATQCNFILARSNWKRIREIMAMNGNRPIPHIDPSRPMTPQQRRLQQRRLQHRLRLR
                     AQMRLRRLNATTTLGPHTVPPTLPPAPATTLSTTIEPWGLIPPTTAGWEESETETYTE
                     VVTEFGTEVEPEFGTKVEPEFETQLEPEFETQLEPEFEEEEEEEKEEEIATGQAFPFT
                     TVETYTVNFGDF"
     exon            575..916
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            917..988
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1060
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1183
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1261
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1339
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1417
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1471
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1581
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1721
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1806
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1951
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2037
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2161
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2358
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2538
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2539..2890
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3030
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3130
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..4097
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4078..4083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /note="hexamer: AATAAA"
     polyA_site      4097
                     /gene="AEBP1"
                     /gene_synonym="ACLP"
                     /note="major polyA site"
ORIGIN      
        1 gccagcgctt tggagacggc tatccgcgcg ggagtgcgcc acgcggggcc ggagcgccta
       61 ttagccgcca ggacctcgga gcgccccgac cacccctgag cccctctggc ttcggagccc
      121 cccagcaccc cttcccgggt cccctcgccc accctaatcc actctccctc cctttcccgg
      181 attccctcgc tcaccccatc ctctctcccg ccccttcctg gattccctca cccgtctcga
      241 tcccctctcc gccctttccc agagacccag agcccctgac cccccgcgcc ctccccggag
      301 ccccccgcgc gtgccgcggc catggcggcc gtgcgcgggg cgcccctgct cagctgcctc
      361 ctggcgttgc tggccctgtg ccctggaggg cgcccgcaga cggtgctgac cgacgacgag
      421 atcgaggagt tcctcgaggg cttcctgtca gagctagaac ctgagccccg ggaggacgac
      481 gtggaggccc cgccgcctcc cgagcccacc ccgcgggtcc gaaaagccca ggcggggggc
      541 aagccaggga agcggccagg gacggccgca gaagtgcctc cggaaaagac caaagacaaa
      601 gggaagaaag gcaagaaaga caaaggcccc aaggtgccca aggagtcctt ggaggggtcc
      661 cccaggccgc ccaagaaggg gaaggagaag ccacccaagg ccaccaagaa gcccaaggag
      721 aagccaccta aggccaccaa gaagcccaag gagaagccac ccaaggccac caagaagccc
      781 aaagagaagc cacccaaggc caccaagaag cccccgtcag ggaagaggcc ccccattctg
      841 gctccctcag aaaccctgga gtggccactg cccccacccc ccagccctgg ccccgaggag
      901 ctaccccagg agggaggggc gcccctctca aataactggc agaatccagg agaggagacc
      961 catgtggagg cacgggagca ccagcctgag ccggaggagg agaccgagca acccacactg
     1021 gactacaatg accagatcga gagggaggac tatgaggact ttgagtacat tcggcgccag
     1081 aagcaaccca ggccaccccc aagcagaagg aggaggcccg agcgggtctg gccagagccc
     1141 cctgaggaga aggccccggc cccagccccg gaggagagga ttgagcctcc tgtgaagcct
     1201 ctgctgcccc cgctgccccc tgactatggt gatggttacg tgatccccaa ctacgatgac
     1261 atggactatt actttgggcc tcctccgccc cagaagcccg atgctgagcg ccagacagac
     1321 gaagagaagg aggagctgaa gaaacccaaa aaggaggaca gcagccccaa ggaggagacc
     1381 gacaagtggg cagtggagaa gggcaaggac cacaaagagc cccgaaaggg cgaggagttg
     1441 gaggaggagt ggacgcctac ggagaaagtc aagtgtcccc ccattgggat ggagtcacac
     1501 cgtattgagg acaaccagat ccgagcctcc tccatgctgc gccacggcct gggggcacag
     1561 cgcggccggc tcaacatgca gaccggtgcc actgaggacg actactatga tggtgcgtgg
     1621 tgtgccgagg acgatgccag gacccagtgg atagaggtgg acaccaggag gactacccgg
     1681 ttcacaggcg tcatcaccca gggcagagac tccagcatcc atgacgattt tgtgaccacc
     1741 ttcttcgtgg gcttcagcaa tgacagccag acatgggtga tgtacaccaa cggctatgag
     1801 gaaatgacct ttcatgggaa cgtggacaag gacacacccg tgctgagtga gctcccagag
     1861 ccggtggtgg ctcgtttcat ccgcatctac ccactcacct ggaatggcag cctgtgcatg
     1921 cgcctggagg tgctggggtg ctctgtggcc cctgtctaca gctactacgc acagaatgag
     1981 gtggtggcca ccgatgacct ggatttccgg caccacagct acaaggacat gcgccagctc
     2041 atgaaggtgg tgaacgagga gtgccccacc atcacccgca cttacagcct gggcaagagc
     2101 tcacgaggcc tcaagatcta tgccatggag atctcagaca accctgggga gcatgaactg
     2161 ggggagcccg agttccgcta cactgctggg atccatggca acgaggtgct gggccgagag
     2221 ctgttgctgc tgctcatgca gtacctgtgc cgagagtacc gcgatgggaa cccacgtgtg
     2281 cgcagcctgg tgcaggacac acgcatccac ctggtgccct cactgaaccc tgatggctac
     2341 gaggtggcag cgcagatggg ctcagagttt gggaactggg cgctgggact gtggactgag
     2401 gagggctttg acatctttga agatttcccg gatctcaact ctgtgctctg gggagctgag
     2461 gagaggaaat gggtccccta ccgggtcccc aacaataact tgcccatccc tgaacgctac
     2521 ctttcgccag atgccacggt atccacggag gtccgggcca tcattgcctg gatggagaag
     2581 aaccccttcg tgctgggagc aaatctgaac ggcggcgagc ggctagtatc ctacccctac
     2641 gatatggccc gcacgcctac ccaggagcag ctgctggccg cagccatggc agcagcccgg
     2701 ggggaggatg aggacgaggt ctccgaggcc caggagactc cagaccacgc catcttccgg
     2761 tggcttgcca tctccttcgc ctccgcacac ctcaccttga ccgagcccta ccgcggaggc
     2821 tgccaagccc aggactacac cggcggcatg ggcatcgtca acggggccaa gtggaacccc
     2881 cggaccggga ctatcaatga cttcagttac ctgcatacca actgcctgga gctctccttc
     2941 tacctgggct gtgacaagtt ccctcatgag agtgagctgc cccgcgagtg ggagaacaac
     3001 aaggaggcgc tgctcacctt catggagcag gtgcaccgcg gcattaaggg ggtggtgacg
     3061 gacgagcaag gcatccccat tgccaacgcc accatctctg tgagtggcat taatcacggc
     3121 gtgaagacag ccagtggtgg tgattactgg cgaatcttga acccgggtga gtaccgcgtg
     3181 acagcccacg cggagggcta caccccgagc gccaagacct gcaatgttga ctatgacatc
     3241 ggggccactc agtgcaactt catcctggct cgctccaact ggaagcgcat ccgggagatc
     3301 atggccatga acgggaaccg gcctatccca cacatagacc catcgcgccc tatgaccccc
     3361 caacagcgac gcctgcagca gcgacgccta caacaccgcc tgcggcttcg ggcacagatg
     3421 cggctgcggc gcctcaacgc caccaccacc ctaggccccc acactgtgcc tcccacgctg
     3481 ccccctgccc ctgccaccac cctgagcact accatagagc cctggggcct cataccgcca
     3541 accaccgctg gctgggagga gtcggagact gagacctaca cagaggtggt gacagagttt
     3601 gggaccgagg tggagcccga gtttgggacc aaggtggagc ccgagtttga gacccagttg
     3661 gagcctgagt ttgagaccca gctggaaccc gagtttgagg aagaggagga ggaggagaaa
     3721 gaggaggaga tagccactgg ccaggcattc cccttcacaa cagtagagac ctacacagtg
     3781 aactttgggg acttctgaga tcagcgtcct accaagaccc cagcccaact caagctacag
     3841 cagcagcact tcccaagcct gctgaccaca gtcacatcac ccatcagcac atggaaggcc
     3901 cctggtatgg acactgaaag gaagggctgg tcctgcccct ttgagggggt gcaaacatga
     3961 ctgggaccta agagccagag gctgtgtaga ggctcctgct ccacctgcca gtctcgtaag
     4021 agatggggtt gctgcagtgt tggagtaggg gcagagggag ggagccaagg tcactccaat
     4081 aaaacaagct catggca
//
