LOCUS       NM_032744               1692 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens androgen dependent TFPI regulating protein (ADTRP),
            transcript variant 2, mRNA.
ACCESSION   NM_032744
VERSION     NM_032744.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   Kee,Z., Ong,S.M., Heng,C.K. and Ooi,D.S.Q.
  TITLE     Androgen-dependent tissue factor pathway inhibitor regulating
            protein: a review of its peripheral actions and association with
            cardiometabolic diseases
  JOURNAL   J Mol Med (Berl) 100 (2), 185-196 (2022)
   PUBMED   34797389
  REMARK    GeneRIF: Androgen-dependent tissue factor pathway inhibitor
            regulating protein: a review of its peripheral actions and
            association with cardiometabolic diseases.
            Review article
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   Luo,C., Tang,B., Qin,S., Yuan,C., Du,Y. and Yang,J.
  TITLE     GATA2 regulates the CAD susceptibility gene ADTRP rs6903956 through
            preferential interaction with the G allele
  JOURNAL   Mol Genet Genomics 296 (4), 799-808 (2021)
   PUBMED   33856550
  REMARK    GeneRIF: GATA2 regulates the CAD susceptibility gene ADTRP
            rs6903956 through preferential interaction with the G allele.
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Luo,C., Pook,E., Wang,F., Archacki,S.R., Tang,B., Zhang,W.,
            Hu,J.S., Yang,J., Leineweber,K., Bechem,M., Huang,W., Song,Y.,
            Cheung,S.H., Laux,V., Ke,T., Ren,X., Tu,X., Chen,Q., Wang,Q.K. and
            Xu,C.
  TITLE     ADTRP regulates TFPI expression via transcription factor POU1F1
            involved in coronary artery disease
  JOURNAL   Gene 753, 144805 (2020)
   PUBMED   32445923
  REMARK    GeneRIF: Data identify POU1F1 as a transcription factor that
            regulates TFPI transcription in response to ADTRP, and link POU1F1
            variants to risk of CAD for the first time.
REFERENCE   4  (bases 1 to 1692)
  AUTHORS   Ooi,D.S.Q., Ong,S.M., Eng,M.H., Chan,Y.H., Lee,Y.S., Low,A.F.H.,
            Chan,M.Y. and Heng,C.K.
  TITLE     Detection of ADTRP in circulation and its role as a novel biomarker
            for coronary artery disease
  JOURNAL   PLoS One 15 (8), e0237074 (2020)
   PUBMED   32790694
  REMARK    GeneRIF: Detection of ADTRP in circulation and its role as a novel
            biomarker for coronary artery disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1692)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1692)
  AUTHORS   Lupu,C., Zhu,H., Popescu,N.I., Wren,J.D. and Lupu,F.
  TITLE     Novel protein ADTRP regulates TFPI expression and function in human
            endothelial cells in normal conditions and in response to androgen
  JOURNAL   Blood 118 (16), 4463-4471 (2011)
   PUBMED   21868574
  REMARK    GeneRIF: This study confirms ADTRP expression and colocalization
            with TFPI and caveolin-1 in endothelial cell.
REFERENCE   7  (bases 1 to 1692)
  AUTHORS   Beaty,T.H., Ruczinski,I., Murray,J.C., Marazita,M.L., Munger,R.G.,
            Hetmanski,J.B., Murray,T., Redett,R.J., Fallin,M.D., Liang,K.Y.,
            Wu,T., Patel,P.J., Jin,S.C., Zhang,T.X., Schwender,H.,
            Wu-Chou,Y.H., Chen,P.K., Chong,S.S., Cheah,F., Yeow,V., Ye,X.,
            Wang,H., Huang,S., Jabs,E.W., Shi,B., Wilcox,A.J., Lie,R.T.,
            Jee,S.H., Christensen,K., Doheny,K.F., Pugh,E.W., Ling,H. and
            Scott,A.F.
  TITLE     Evidence for gene-environment interaction in a genome wide study of
            nonsyndromic cleft palate
  JOURNAL   Genet Epidemiol 35 (6), 469-478 (2011)
   PUBMED   21618603
REFERENCE   8  (bases 1 to 1692)
  AUTHORS   Wang,F., Xu,C.Q., He,Q., Cai,J.P., Li,X.C., Wang,D., Xiong,X.,
            Liao,Y.H., Zeng,Q.T., Yang,Y.Z., Cheng,X., Li,C., Yang,R.,
            Wang,C.C., Wu,G., Lu,Q.L., Bai,Y., Huang,Y.F., Yin,D., Yang,Q.,
            Wang,X.J., Dai,D.P., Zhang,R.F., Wan,J., Ren,J.H., Li,S.S.,
            Zhao,Y.Y., Fu,F.F., Huang,Y., Li,Q.X., Shi,S.W., Lin,N., Pan,Z.W.,
            Li,Y., Yu,B., Wu,Y.X., Ke,Y.H., Lei,J., Wang,N., Luo,C.Y., Ji,L.Y.,
            Gao,L.J., Li,L., Liu,H., Huang,E.W., Cui,J., Jia,N., Ren,X., Li,H.,
            Ke,T., Zhang,X.Q., Liu,J.Y., Liu,M.G., Xia,H., Yang,B., Shi,L.S.,
            Xia,Y.L., Tu,X. and Wang,Q.K.
  TITLE     Genome-wide association identifies a susceptibility locus for
            coronary artery disease in the Chinese Han population
  JOURNAL   Nat Genet 43 (4), 345-349 (2011)
   PUBMED   21378986
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1692)
  AUTHORS   Park,J.W., Cai,J., McIntosh,I., Jabs,E.W., Fallin,M.D.,
            Ingersoll,R., Hetmanski,J.B., Vekemans,M., Attie-Bitach,T.,
            Lovett,M., Scott,A.F. and Beaty,T.H.
  TITLE     High throughput SNP and expression analyses of candidate genes for
            non-syndromic oral clefts
  JOURNAL   J Med Genet 43 (7), 598-608 (2006)
   PUBMED   16415175
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1692)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC007011.1, AJ420520.1, AI147084.1, AI336841.1 and AL022724.2.
            
            On Feb 27, 2020 this sequence version replaced NM_032744.3.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The resulting isoform (2) has the same
            N- and C-termini but is shorter compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007011.1, AJ420520.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000414691.8/ ENSP00000404416.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-808               BC007011.1         31-838
            809-1232            AJ420520.1         822-1245
            1233-1557           AI147084.1         9-333               c
            1558-1560           AI336841.1         9-11                c
            1561-1692           AL022724.2         108465-108596
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p24.1"
     gene            1..1692
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /note="androgen dependent TFPI regulating protein"
                     /db_xref="GeneID:84830"
                     /db_xref="HGNC:HGNC:21214"
                     /db_xref="MIM:614348"
     exon            1..197
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..737
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     androgen-dependent TPF1-regulating protein; FAHFA
                     hydrolase ADTRP; fatty acid esters of hydroxy fatty acids
                     hydrolase ADTRP"
                     /codon_start=1
                     /product="androgen-dependent TFPI-regulating protein
                     isoform 2"
                     /protein_id="NP_116133.1"
                     /db_xref="CCDS:CCDS4521.1"
                     /db_xref="GeneID:84830"
                     /db_xref="HGNC:HGNC:21214"
                     /db_xref="MIM:614348"
                     /translation="MTKTSTCIYHFLVLSWYTFLNYYISQEGKDEVKPKILANGARWK
                     YMTLLNLLLQTIFYGVTCLDDVLKRTKGGKDIKFLTAFRDLLFTTLAFPVSTFVFLAF
                     WILFLYNRDLIYPKVLDTVIPVWLNHAMHTFIFPITLAEVVLRPHSYPSKKTGLTLLA
                     AASIAYISRILWLYFETGTWVYPVFAKLSLLGLAAFFSLSYVFIASIYLLGEKLNHWK
                     WGDMRQPRKKRK"
     exon            198..332
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            333..434
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..550
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..702
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..1692
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1523..1528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /note="hexamer: AATAAA"
     regulatory      1538..1543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /note="hexamer: AATAAA"
     polyA_site      1543
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /note="major polyA site"
     polyA_site      1560
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
     regulatory      1666..1671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
                     /note="hexamer: AACAAG"
     polyA_site      1692
                     /gene="ADTRP"
                     /gene_synonym="AIG1L; C6orf105; dJ413H6.1"
ORIGIN      
        1 agaaagtact caagacattc acggtgcccc ggtcagcact cgccatgacg aagacttcta
       61 catgcatata ccacttcctt gttctgagct ggtatacttt cctcaattat tacatctcac
      121 aggaaggaaa agacgaggtg aaacccaaaa tcttggcaaa tggtgcaagg tggaaatata
      181 tgacgctgct taatctgctc ttgcagacca ttttctacgg ggtcacctgc ctggatgatg
      241 tgctgaaaag aaccaaaggg ggaaaagaca ttaagttcct aactgccttc agagacctgc
      301 ttttcaccac tctggctttt cctgtatcca cgtttgtatt tttggcattc tggatcctct
      361 ttctctacaa tcgagatctc atttacccca aggtcctaga tactgtcatc cccgtgtggc
      421 tgaatcatgc aatgcacact ttcatattcc ccatcacatt ggctgaagtc gtcctcaggc
      481 ctcactccta tccatcaaag aagacaggac tcaccttgct ggctgctgcc agcattgctt
      541 acatcagccg catcctatgg ctctactttg agacgggtac ctgggtgtat cctgtgtttg
      601 ccaaactcag cctcttgggt ctagcagctt tcttctctct cagctacgtc ttcatcgcca
      661 gcatctacct acttggagag aagctcaacc actggaaatg gggtgacatg aggcagccac
      721 ggaagaagag gaagtaattg cacaccattt tccaagaacc aagaaagaag aaaacacaag
      781 agatttttct catctttttt ttttttttct ggtggaggga ggtggtggag gaacatagca
      841 aagtaggagg gacagagagt gatacttaaa tttaataaga ggttcgtgaa ggtagcttaa
      901 cttgagaact cttggttttt tgaaaggttg actgcacatg ccaaaaacaa ctcctgctat
      961 ctcagaatta attatctttg accttcgtgg aggatggtct ctggttaaaa tctggccaaa
     1021 gaaactcaca taaacttggt gttagagaac atctagagag agagagagga acttagagtc
     1081 atttaaactc ttcagtttac agagaaggat gctgaggacc tagatgagaa gttacctgca
     1141 aaaggcaaaa gggttactta gtgtcagaac caaggcaatg acttctctct cccagatctc
     1201 ctagctactg gtcctgggcc attttttttt ttttaaataa tcccaacttt ctttaaaaga
     1261 caagcatttc agtaagctag ttattttcat gggttgctca tccatttttt tcagtgatct
     1321 aaaaatgtag ggagatggct actactgaag ttgtctgtct acttgggata atagcaaatt
     1381 aattgaagac aatgggaaag taagttataa aaaatactgg gaaatctgtt tctcttctga
     1441 gcaagcattc agggcaggta taaacatcaa acatagtgac attgtcaaaa cctcttccat
     1501 ttgaacattg attaattcat caaataaatg gtatagtaat aaattttgct tgcagaagaa
     1561 tctggatggg aagtgataga attataaggg ctgttgagat tgctttgcta caaagcactt
     1621 ttctgaatta gtgtgtggtt taacaaagct gatttccaga tgcttaacaa ggattcatga
     1681 tccctgctgt ga
//
