LOCUS       NM_007002               1379 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens ADRM1 26S proteasome ubiquitin receptor (ADRM1),
            transcript variant 1, mRNA.
ACCESSION   NM_007002
VERSION     NM_007002.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1379)
  AUTHORS   Shao,Z., Wang,Y., He,Y., Zhang,C., Zhao,Y., Zhang,M., Li,Q. and
            Wang,J.
  TITLE     The high expression of ADRM1 in hepatocellular carcinoma is closely
            related to tumor immune infiltration and is regulated by
            miR-891a-5p
  JOURNAL   Sci Rep 14 (1), 14002 (2024)
   PUBMED   38890391
  REMARK    GeneRIF: The high expression of ADRM1 in hepatocellular carcinoma
            is closely related to tumor immune infiltration and is regulated by
            miR-891a-5p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1379)
  AUTHORS   Osei-Amponsa,V., Chandravanshi,M., Lu,X., Magidson,V., Das,S.,
            Andresson,T., Dyba,M., Sabbasani,V.R., Swenson,R.E., Fromont,C.,
            Shrestha,B., Zhao,Y., Clapp,M.E., Chari,R. and Walters,K.J.
  TITLE     hRpn13 shapes the proteome and transcriptome through epigenetic
            factors HDAC8, PADI4, and transcription factor NF-kappaB p50
  JOURNAL   Mol Cell 84 (3), 522-537 (2024)
   PUBMED   38151017
  REMARK    GeneRIF: hRpn13 shapes the proteome and transcriptome through
            epigenetic factors HDAC8, PADI4, and transcription factor NF-kappaB
            p50.
REFERENCE   3  (bases 1 to 1379)
  AUTHORS   Zhu,D. and Zhong,Q.
  TITLE     Potential of adhesion-regulating molecule 1 (ADRM1) as a biomarker
            for patients with renal clear-cell carcinoma or papillary-cell
            carcinoma
  JOURNAL   Asian J Surg 46 (10), 4666-4668 (2023)
   PUBMED   37268471
  REMARK    GeneRIF: Potential of adhesion-regulating molecule 1 (ADRM1) as a
            biomarker for patients with renal clear-cell carcinoma or
            papillary-cell carcinoma.
REFERENCE   4  (bases 1 to 1379)
  AUTHORS   Xiao,J., Xie,Y., Duan,Q., Liu,T., Ye,R., Duan,X., Le,Z., Deng,N.
            and Liu,F.
  TITLE     LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1
            Transcription to Facilitate the Pathological Progression of
            Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell
            Models
  JOURNAL   Int Heart J 64 (4), 750-758 (2023)
   PUBMED   37518356
  REMARK    GeneRIF: LIM Homeobox 2 Increases Adhesion-Regulating Molecule 1
            Transcription to Facilitate the Pathological Progression of
            Oxidized Low-Density Lipoprotein-Stimulated Atherosclerotic Cell
            Models.
REFERENCE   5  (bases 1 to 1379)
  AUTHORS   Lu,X., Sabbasani,V.R., Osei-Amponsa,V., Evans,C.N., King,J.C.,
            Tarasov,S.G., Dyba,M., Das,S., Chan,K.C., Schwieters,C.D.,
            Choudhari,S., Fromont,C., Zhao,Y., Tran,B., Chen,X., Matsuo,H.,
            Andresson,T., Chari,R., Swenson,R.E., Tarasova,N.I. and
            Walters,K.J.
  TITLE     Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13
            species upregulated in multiple myeloma
  JOURNAL   Nat Commun 12 (1), 7318 (2021)
   PUBMED   34916494
  REMARK    GeneRIF: Structure-guided bifunctional molecules hit a
            DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1379)
  AUTHORS   Yao,T., Song,L., Xu,W., DeMartino,G.N., Florens,L., Swanson,S.K.,
            Washburn,M.P., Conaway,R.C., Conaway,J.W. and Cohen,R.E.
  TITLE     Proteasome recruitment and activation of the Uch37 deubiquitinating
            enzyme by Adrm1
  JOURNAL   Nat Cell Biol 8 (9), 994-1002 (2006)
   PUBMED   16906146
  REMARK    GeneRIF: Neither Uch37 alone nor the Uch37-Adrm1 or Uch37-Adrm1-S1
            complexes can hydrolyse di-ubiquitin efficiently; rather,
            incorporation into the 19S complex is required to enable processing
            of polyubiquitin chains.
REFERENCE   7  (bases 1 to 1379)
  AUTHORS   Jorgensen,J.P., Lauridsen,A.M., Kristensen,P., Dissing,K.,
            Johnsen,A.H., Hendil,K.B. and Hartmann-Petersen,R.
  TITLE     Adrm1, a putative cell adhesion regulating protein, is a novel
            proteasome-associated factor
  JOURNAL   J Mol Biol 360 (5), 1043-1052 (2006)
   PUBMED   16815440
  REMARK    GeneRIF: Adrm1 has a specialised role in proteasome function.
            Identified Adrm1 as a novel component of the regulatory ATPase
            complex of the 26 S proteasome
REFERENCE   8  (bases 1 to 1379)
  AUTHORS   Lamerant,N. and Kieda,C.
  TITLE     Adhesion properties of adhesion-regulating molecule 1 protein on
            endothelial cells
  JOURNAL   FEBS J 272 (8), 1833-1844 (2005)
   PUBMED   15819879
  REMARK    GeneRIF: ARM-1 is a cytosolic protein associated with the plasma
            membrane. However, no cell surface expression of the protein was
            observed. These results suggest an indirect role of ARM-1 in
            adhesion rather than a direct role as an adhesion molecule
            itself.[ARM-1]
REFERENCE   9  (bases 1 to 1379)
  AUTHORS   Simins,A.B., Weighardt,H., Weidner,K.M., Weidle,U.H. and
            Holzmann,B.
  TITLE     Functional cloning of ARM-1, an adhesion-regulating molecule
            upregulated in metastatic tumor cells
  JOURNAL   Clin Exp Metastasis 17 (8), 641-648 (1999)
   PUBMED   10919708
REFERENCE   10 (bases 1 to 1379)
  AUTHORS   Shimada,S., Ogawa,M., Takahashi,M., Schlom,J. and Greiner,J.W.
  TITLE     Molecular cloning and characterization of the complementary DNA of
            an M(r) 110,000 antigen expressed by human gastric carcinoma cells
            and upregulated by gamma-interferon
  JOURNAL   Cancer Res 54 (14), 3831-3836 (1994)
   PUBMED   8033103
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354836.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007002.3.
            
            Summary: This gene encodes a member of the adhesion regulating
            molecule 1 protein family. The encoded protein is a component of
            the proteasome where it acts as a ubiquitin receptor and recruits
            the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase
            L5. Increased levels of the encoded protein are associated with
            increased cell adhesion, which is likely an indirect effect of this
            intracellular protein. Dysregulation of this gene has been
            implicated in carcinogenesis. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC093021.1, SRR3476690.381698.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253003.7/ ENSP00000253003.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL354836.13        67422-67474
            54-267              AL354836.13        67993-68206
            268-384             AL354836.13        68886-69002
            385-508             AL354836.13        70622-70745
            509-595             AL354836.13        71073-71159
            596-677             AL354836.13        71796-71877
            678-910             AL354836.13        72021-72253
            911-1068            AL354836.13        72446-72603
            1069-1171           AL354836.13        72793-72895
            1172-1379           AL354836.13        73080-73287
FEATURES             Location/Qualifiers
     source          1..1379
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1379
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /note="ADRM1 26S proteasome ubiquitin receptor"
                     /db_xref="GeneID:11047"
                     /db_xref="HGNC:HGNC:15759"
                     /db_xref="MIM:610650"
     exon            1..53
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     exon            54..267
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1278
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /note="isoform 1 is encoded by transcript variant 1; 110
                     kDa cell membrane glycoprotein; M(r) 110,000 surface
                     antigen; proteasomal ubiquitin receptor ADRM1; rpn13
                     homolog; proteasome regulatory particle non-ATPase 13;
                     proteasome ubiquitin receptor; adhesion regulating
                     molecule 1"
                     /codon_start=1
                     /product="proteasomal ubiquitin receptor ADRM1 isoform 1"
                     /protein_id="NP_008933.2"
                     /db_xref="CCDS:CCDS13496.1"
                     /db_xref="GeneID:11047"
                     /db_xref="HGNC:HGNC:15759"
                     /db_xref="MIM:610650"
                     /translation="MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRK
                     GLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGS
                     KRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLL
                     GNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTP
                     SSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNV
                     PAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSP
                     QFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEG
                     DTKDKKDEEEDMSLD"
     exon            268..384
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     exon            385..508
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     exon            509..595
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     exon            596..677
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     exon            678..910
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1068
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1171
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1379
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1353..1358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /note="hexamer: AATAAA"
     polyA_site      1379
                     /gene="ADRM1"
                     /gene_synonym="ARM-1; ARM1; GP110; PSMD16"
                     /note="major polyA site"
ORIGIN      
        1 gaggaagagc gagcccggac ggcgcctctc gaacgagtgt gggcgcgagg caggatgacg
       61 acctcaggcg cgctctttcc aagcctggtg ccaggctctc ggggcgcctc caacaagtac
      121 ttggtggagt ttcgggcggg aaagatgtcc ctgaagggga ccaccgtgac tccggataag
      181 cggaaagggc tggtgtacat tcagcagacg gacgactcgc ttattcactt ctgctggaag
      241 gacaggacgt ccgggaacgt ggaagacgac ttgatcatct tccctgacga ctgtgagttc
      301 aagcgggtgc cgcagtgccc cagcgggagg gtctacgtgc tgaagttcaa ggcagggtcc
      361 aagcggcttt tcttctggat gcaggaaccc aagacagacc aggatgagga gcattgccgg
      421 aaagtcaacg agtatctgaa caaccccccg atgcctgggg cgctgggggc cagcggaagc
      481 agcggccacg aactctctgc gctaggcggt gagggtggcc tgcagagcct gctgggaaac
      541 atgagccaca gccagctcat gcagctcatc ggaccagccg gccttggagg actgggtggg
      601 ctgggggccc tgactggacc tggcctggcc agcttactgg ggagcagtgg gcctccaggg
      661 agcagctcct cctccagctc ccggagccag tcggcagcgg tcaccccgtc atccaccacc
      721 tcttccaccc gtgccacccc agccccttct gctccagcag ctgcctcagc aactagcccg
      781 agccccgcgc ccagttccgg gaatggagcc agcacagcag ccagcccgac ccagcccatc
      841 cagctgagcg acctccagag catcctggcc acgatgaacg taccagccgg gccagcaggc
      901 ggccagcaag tggacctggc cagtgtgctg acgccggaga taatggctcc catcctcgcc
      961 aacgcggatg tccaggagcg cctgcttccc tacttgccat ctggggagtc gctgccgcag
     1021 accgcggatg agatccagaa taccctgacc tcgccccagt tccagcaggc cctgggcatg
     1081 ttcagcgcag ccttggcctc ggggcagctg ggccccctca tgtgccagtt cggtctgcct
     1141 gcagaggctg tggaggccgc caacaagggc gatgtggaag cgtttgccaa agccatgcag
     1201 aacaacgcca agcccgagca gaaagagggc gacacgaagg acaagaagga cgaagaggag
     1261 gacatgagcc tggactgagc cacgcgccgt cctccgagga actgggcgct tgcagtgcgt
     1321 tgcacaccct cacctcccac ccactgatta ttaataaagt cttttctttt acctgccaa
//
