LOCUS       NM_000025               2585 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens adrenoceptor beta 3 (ADRB3), mRNA.
ACCESSION   NM_000025
VERSION     NM_000025.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2585)
  AUTHORS   Hanh,N.T.H., Trang,D.T.N., Thu,N.T.T. and Tuyet,L.T.
  TITLE     Association between rs4994 variant in beta3-Adrenergic receptor and
            obesity in Vietnamese preschool-age children, independent of eating
            behaviors
  JOURNAL   BMC Pediatr 24 (1), 594 (2024)
   PUBMED   39294633
  REMARK    GeneRIF: Association between rs4994 variant in beta3-Adrenergic
            receptor and obesity in Vietnamese preschool-age children,
            independent of eating behaviors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2585)
  AUTHORS   Liang,C.C., Hsieh,W.C., Lo,T.S., Huang,T.X., Chou,Y.C., Huang,J.Y.
            and Huang,Y.H.
  TITLE     Urinary beta 3-adrenoceptor as a diagnostic biomarker for
            overactive bladder in women
  JOURNAL   Sci Rep 13 (1), 19368 (2023)
   PUBMED   37938600
  REMARK    GeneRIF: Urinary beta 3-adrenoceptor as a diagnostic biomarker for
            overactive bladder in women.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2585)
  AUTHORS   Potocka,N., Skrzypa,M., Zadarko-Domaradzka,M., Barabasz,Z.,
            Penar-Zadarko,B., Sakowicz,A., Zadarko,E. and Zawlik,I.
  TITLE     Effects of the Trp64Arg Polymorphism in the ADRB3 Gene on Body
            Composition, Cardiorespiratory Fitness, and Physical Activity in
            Healthy Adults
  JOURNAL   Genes (Basel) 14 (8), 1541 (2023)
   PUBMED   37628593
  REMARK    GeneRIF: Effects of the Trp64Arg Polymorphism in the ADRB3 Gene on
            Body Composition, Cardiorespiratory Fitness, and Physical Activity
            in Healthy Adults.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2585)
  AUTHORS   Cannavo,A., Jun,S., Rengo,G., Marzano,F., Agrimi,J., Liccardo,D.,
            Elia,A., Keceli,G., Altobelli,G.G., Marcucci,L., Megighian,A.,
            Gao,E., Feng,N., Kammers,K., Ferrara,N., Finos,L., Koch,W.J. and
            Paolocci,N.
  TITLE     beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF)
            Generation Limits Chronic Postischemic Heart Failure
  JOURNAL   Circ Res 132 (7), 867-881 (2023)
   PUBMED   36884028
  REMARK    GeneRIF: beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF)
            Generation Limits Chronic Postischemic Heart Failure.
REFERENCE   5  (bases 1 to 2585)
  AUTHORS   Zhang,J.Y., Zhao,Q., Li,X.M., Liu,F., Zhao,Q., Men,L., Chen,Q.J.,
            Zhai,H. and Yang,Y.N.
  TITLE     Association of an ADRB3 Variant with Coronary Artery Disease Within
            the Chinese Han Population: Construction of a Predictive Nomogram
            Model
  JOURNAL   Genet Test Mol Biomarkers 27 (3), 81-89 (2023)
   PUBMED   36989522
  REMARK    GeneRIF: Association of an ADRB3 Variant with Coronary Artery
            Disease Within the Chinese Han Population: Construction of a
            Predictive Nomogram Model.
REFERENCE   6  (bases 1 to 2585)
  AUTHORS   Susulic,V.S., Frederich,R.C., Lawitts,J., Tozzo,E., Kahn,B.B.,
            Harper,M.E., Himms-Hagen,J., Flier,J.S. and Lowell,B.B.
  TITLE     Targeted disruption of the beta 3-adrenergic receptor gene
  JOURNAL   J Biol Chem 270 (49), 29483-29492 (1995)
   PUBMED   7493988
REFERENCE   7  (bases 1 to 2585)
  AUTHORS   van Spronsen,A., Nahmias,C., Krief,S., Briend-Sutren,M.M.,
            Strosberg,A.D. and Emorine,L.J.
  TITLE     The promoter and intron/exon structure of the human and mouse beta
            3-adrenergic-receptor genes
  JOURNAL   Eur J Biochem 213 (3), 1117-1124 (1993)
   PUBMED   8389293
REFERENCE   8  (bases 1 to 2585)
  AUTHORS   Granneman,J.G., Lahners,K.N. and Rao,D.D.
  TITLE     Rodent and human beta 3-adrenergic receptor genes contain an intron
            within the protein-coding block
  JOURNAL   Mol Pharmacol 42 (6), 964-970 (1992)
   PUBMED   1336117
REFERENCE   9  (bases 1 to 2585)
  AUTHORS   Nahmias,C., Blin,N., Elalouf,J.M., Mattei,M.G., Strosberg,A.D. and
            Emorine,L.J.
  TITLE     Molecular characterization of the mouse beta 3-adrenergic receptor:
            relationship with the atypical receptor of adipocytes
  JOURNAL   EMBO J 10 (12), 3721-3727 (1991)
   PUBMED   1718744
REFERENCE   10 (bases 1 to 2585)
  AUTHORS   Emorine,L.J., Marullo,S., Briend-Sutren,M.M., Patey,G., Tate,K.,
            Delavier-Klutchko,C. and Strosberg,A.D.
  TITLE     Molecular characterization of the human beta 3-adrenergic receptor
  JOURNAL   Science 245 (4922), 1118-1121 (1989)
   PUBMED   2570461
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA904248.1, X70811.1,
            AC144573.2 and BQ024407.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 20, 2018 this sequence version replaced NM_000025.2.
            
            Summary: The protein encoded by this gene belongs to the family of
            beta adrenergic receptors, which mediate catecholamine-induced
            activation of adenylate cyclase through the action of G proteins.
            This receptor is located mainly in the adipose tissue and is
            involved in the regulation of lipolysis and thermogenesis. Obesity
            and bodyweight-related disorders are correlated with certain
            polymorphisms in three subtypes of beta-adrenoceptor, among them,
            the ADRB3 gene.[provided by RefSeq, Oct 2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X70811.1, AK293033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345060.5/ ENSP00000343782.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               DA904248.1         367-568
            203-2022            X70811.1           198-2017
            2023-2023           AC144573.2         19628-19628
            2024-2577           X70811.1           2019-2572
            2578-2580           BQ024407.1         14-16               c
            2581-2585           AC144573.2         20186-20190
FEATURES             Location/Qualifiers
     source          1..2585
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.23"
     gene            1..2585
                     /gene="ADRB3"
                     /gene_synonym="BETA3AR"
                     /note="adrenoceptor beta 3"
                     /db_xref="GeneID:155"
                     /db_xref="HGNC:HGNC:288"
                     /db_xref="MIM:109691"
     exon            1..1335
                     /gene="ADRB3"
                     /gene_synonym="BETA3AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1357
                     /gene="ADRB3"
                     /gene_synonym="BETA3AR"
                     /note="beta-3 adrenoceptor; beta-3 adrenoreceptor;
                     adrenergic, beta-3-, receptor"
                     /codon_start=1
                     /product="beta-3 adrenergic receptor"
                     /protein_id="NP_000016.1"
                     /db_xref="CCDS:CCDS6099.1"
                     /db_xref="GeneID:155"
                     /db_xref="HGNC:HGNC:288"
                     /db_xref="MIM:109691"
                     /translation="MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALL
                     ALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGH
                     WPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVL
                     VWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLL
                     VMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACG
                     RRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWL
                     GYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPA
                     QPRLCQRLDGASWGVS"
     exon            1336..2585
                     /gene="ADRB3"
                     /gene_synonym="BETA3AR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1988..1993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRB3"
                     /gene_synonym="BETA3AR"
                     /note="hexamer: AATAAA"
     polyA_site      2012
                     /gene="ADRB3"
                     /gene_synonym="BETA3AR"
     regulatory      2561..2566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRB3"
                     /gene_synonym="BETA3AR"
                     /note="hexamer: AGTAAA"
     polyA_site      2585
                     /gene="ADRB3"
                     /gene_synonym="BETA3AR"
                     /note="major polyA site"
ORIGIN      
        1 gggacagcta gagaagatgg cccaggctgg ggaagtcgct ctcatgcctt gctgtcccct
       61 cccctgagcc aggtgatttg ggagaccccc tccttccttc tttccctacc gccccacgcg
      121 cgacccgggg atggctccgt ggcctcacga gaacagctct cttgccccat ggccggacct
      181 ccccaccctg gcgcccaata ccgccaacac cagtgggctg ccaggggttc cgtgggaggc
      241 ggccctagcc ggggccctgc tggcgctggc ggtgctggcc accgtgggag gcaacctgct
      301 ggtcatcgtg gccatcgcct ggactccgag actccagacc atgaccaacg tgttcgtgac
      361 ttcgctggcc gcagccgacc tggtgatggg actcctggtg gtgccgccgg cggccacctt
      421 ggcgctgact ggccactggc cgttgggcgc cactggctgc gagctgtgga cctcggtgga
      481 cgtgctgtgt gtgaccgcca gcatcgaaac cctgtgcgcc ctggccgtgg accgctacct
      541 ggctgtgacc aacccgctgc gttacggcgc actggtcacc aagcgctgcg cccggacagc
      601 tgtggtcctg gtgtgggtcg tgtcggccgc ggtgtcgttt gcgcccatca tgagccagtg
      661 gtggcgcgta ggggccgacg ccgaggcgca gcgctgccac tccaacccgc gctgctgtgc
      721 cttcgcctcc aacatgccct acgtgctgct gtcctcctcc gtctccttct accttcctct
      781 tctcgtgatg ctcttcgtct acgcgcgggt tttcgtggtg gctacgcgcc agctgcgctt
      841 gctgcgcggg gagctgggcc gctttccgcc cgaggagtct ccgccggcgc cgtcgcgctc
      901 tctggccccg gccccggtgg ggacgtgcgc tccgcccgaa ggggtgcccg cctgcggccg
      961 gcggcccgcg cgcctcctgc ctctccggga acaccgggcc ctgtgcacct tgggtctcat
     1021 catgggcacc ttcactctct gctggttgcc cttctttctg gccaacgtgc tgcgcgccct
     1081 ggggggcccc tctctagtcc cgggcccggc tttccttgcc ctgaactggc taggttatgc
     1141 caattctgcc ttcaacccgc tcatctactg ccgcagcccg gactttcgca gcgccttccg
     1201 ccgtcttctg tgccgctgcg gccgtcgcct gcctccggag ccctgcgccg ccgcccgccc
     1261 ggccctcttc ccctcgggcg ttcctgcggc ccggagcagc ccagcgcagc ccaggctttg
     1321 ccaacggctc gacggggctt cttggggagt ttcttaggcc tgaaggacaa gaagcaacaa
     1381 ctctgttgat cagaacctgt ggaaaacctc tggcctctgt tcagaatgag tcccatggga
     1441 ttccccggct gtgacactct accctccaga acctgacgac tgggccatgt gacccaagga
     1501 gggatcctta ccaagtgggt tttcaccatc ctcttgctct ctgtctgaga gatgttttct
     1561 aaaccccagc cttgaacttc actcctccct cagtggtagt gtccaggtgc cgtggagcag
     1621 caggctggct ttggtagggg cacccatcac ccggcttgcc tgtgcagtca gtgagtgctt
     1681 agggcaaaga gagctcccct ggttccattc cttctgccac ccaaaccctg atgagacctt
     1741 agtgttctcc aggctctgtg gcccaggctg agagcagcag ggtagaaaag accaagattt
     1801 ggggttttat ctctggttcc cttattactg ctctcaagca gtggcctctc tcactttagc
     1861 catggaatgg ctccgatcta cctcacagca gtgtcagaag gacttcgcca gggttttggg
     1921 agctccaggg ttcataagaa ggtgaaccat tagaacagat cccttctttt ccttttgcaa
     1981 tcagataaat aaatatcact gaatgcagtt catcctcggc cccctttccc tccgtttgtt
     2041 ttcttttcat aatccactta ctcccttccc ttctactctg cgctggcttt tgacagaggc
     2101 agtaaattag gcctaatcct cactcttttc ttcctaatct tcatcaaaca aaaaatgaaa
     2161 agtctgtctg gacgaagggg agtgagcttg agcctttgat atcttgctcc cccacccttc
     2221 ctgaaactct tgaaatccag ttgccattga gtagcaaagc cacgctcccc acaggacttg
     2281 gacagagggc ccacaggggg atgggctggc tgtggccagg tttagggcag ggggcatttg
     2341 tcccctccat gctataatcc agtggtgcct tacatggtgt gtgtgtgtgt gtgtgcgtgt
     2401 gtgtgtgtgt gtgtgtgtct ggaggcacag gcacaaagca ttgcttgggt tggtcaaatg
     2461 tcttgtgtca taaatatatt ctgatgtttc ccagcctttc cacaacctct accttcccac
     2521 tcaccttccc cagctacaaa aatctgtatt atcctcttaa agtaaaactg gagttacaaa
     2581 tttga
//
