LOCUS       NM_000024               2013 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens adrenoceptor beta 2 (ADRB2), mRNA.
ACCESSION   NM_000024
VERSION     NM_000024.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Saha,P.P., Gogonea,V., Sweet,W., Mohan,M.L., Singh,K.D.,
            Anderson,J.T., Mallela,D., Witherow,C., Kar,N., Stenson,K.,
            Harford,T., Fischbach,M.A., Brown,J.M., Karnik,S.S., Moravec,C.S.,
            DiDonato,J.A., Naga Prasad,S.V. and Hazen,S.L.
  TITLE     Gut microbe-generated phenylacetylglutamine is an endogenous
            allosteric modulator of beta2-adrenergic receptors
  JOURNAL   Nat Commun 15 (1), 6696 (2024)
   PUBMED   39107277
  REMARK    GeneRIF: Gut microbe-generated phenylacetylglutamine is an
            endogenous allosteric modulator of beta2-adrenergic receptors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Liang,J., Seghiri,M., Singh,P.K., Seo,H.G., Lee,J.Y., Jo,Y.,
            Song,Y.B., Park,C., Zalicki,P., Jeong,J.Y., Huh,W.K.,
            Caculitan,N.G. and Smith,A.W.
  TITLE     The beta2-adrenergic receptor associates with CXCR4 multimers in
            human cancer cells
  JOURNAL   Proc Natl Acad Sci U S A 121 (14), e2304897121 (2024)
   PUBMED   38547061
  REMARK    GeneRIF: The beta2-adrenergic receptor associates with CXCR4
            multimers in human cancer cells.
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Lu,Y., Cheng,D., Pang,J., Peng,Y., Jin,S., Zhang,X., Li,Y. and
            Zuo,Y.
  TITLE     Chronic stress promotes gastric cancer progression via the
            adrenoceptor beta 2/PlexinA1 pathway
  JOURNAL   Cell Stress Chaperones 29 (1), 201-215 (2024)
   PUBMED   38331165
  REMARK    GeneRIF: Chronic stress promotes gastric cancer progression via the
            adrenoceptor beta 2/PlexinA1 pathway.
REFERENCE   4  (bases 1 to 2013)
  AUTHORS   Donato-Trancoso,A., Cristina de Souza Ribeiro,B., Barrozo do
            Canto,F., de Souza Nogueira,J. and Romana-Souza,B.
  TITLE     Chronic psychological stress aggravates psoriasis-like skin
            inflammation via overactivation of beta2-adrenoceptor and nuclear
            factor kappa B pathways
  JOURNAL   Scand J Immunol 97 (4), e13258 (2023)
   PUBMED   39007953
  REMARK    GeneRIF: Chronic psychological stress aggravates psoriasis-like
            skin inflammation via overactivation of beta2-adrenoceptor and
            nuclear factor kappa B pathways.
REFERENCE   5  (bases 1 to 2013)
  AUTHORS   Parola,A.L. and Kobilka,B.K.
  TITLE     The peptide product of a 5' leader cistron in the beta 2 adrenergic
            receptor mRNA inhibits receptor synthesis
  JOURNAL   J Biol Chem 269 (6), 4497-4505 (1994)
   PUBMED   8308019
REFERENCE   6  (bases 1 to 2013)
  AUTHORS   Gope,R., Gope,M.L., Thorson,A., Christensen,M., Smyrk,T., Chun,M.,
            Alvarez,L., Wildrick,D.M. and Boman,B.M.
  TITLE     Genetic changes at the beta-2-adrenergic receptor locus on
            chromosome 5 in human colorectal carcinomas
  JOURNAL   Anticancer Res 11 (6), 2047-2050 (1991)
   PUBMED   1663718
REFERENCE   7  (bases 1 to 2013)
  AUTHORS   Bouvier,M., Guilbault,N. and Bonin,H.
  TITLE     Phorbol-ester-induced phosphorylation of the beta 2-adrenergic
            receptor decreases its coupling to Gs
  JOURNAL   FEBS Lett 279 (2), 243-248 (1991)
   PUBMED   1848190
REFERENCE   8  (bases 1 to 2013)
  AUTHORS   Yang-Feng,T.L., Xue,F.Y., Zhong,W.W., Cotecchia,S., Frielle,T.,
            Caron,M.G., Lefkowitz,R.J. and Francke,U.
  TITLE     Chromosomal organization of adrenergic receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1516-1520 (1990)
   PUBMED   2154750
REFERENCE   9  (bases 1 to 2013)
  AUTHORS   Emorine,L.J., Marullo,S., Delavier-Klutchko,C., Kaveri,S.V.,
            Durieu-Trautmann,O. and Strosberg,A.D.
  TITLE     Structure of the gene for human beta 2-adrenergic receptor:
            expression and promoter characterization
  JOURNAL   Proc Natl Acad Sci U S A 84 (20), 6995-6999 (1987)
   PUBMED   2823249
REFERENCE   10 (bases 1 to 2013)
  AUTHORS   Bucens,D. and Pain,M.C.
  TITLE     Influence of hematocrit, blood gas tensions, and pH on
            pressure-flow relations in the isolated canine lung
  JOURNAL   Circ Res 37 (5), 588-596 (1975)
   PUBMED   154
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313151.1, AC011354.4,
            BC073856.1 and CA440083.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 15, 2020 this sequence version replaced NM_000024.5.
            
            Summary: This gene encodes beta-2-adrenergic receptor which is a
            member of the G protein-coupled receptor superfamily. This receptor
            is directly associated with one of its ultimate effectors, the
            class C L-type calcium channel Ca(V)1.2. This receptor-channel
            complex also contains a G protein, an adenylyl cyclase,
            cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A.
            The assembly of the signaling complex provides a mechanism that
            ensures specific and rapid signaling by this G protein-coupled
            receptor. This receptor is also a transcription regulator of the
            alpha-synuclein gene, and together, both genes are believed to be
            associated with risk of Parkinson's Disease. This gene is
            intronless. Different polymorphic forms, point mutations, and/or
            downregulation of this gene are associated with nocturnal asthma,
            obesity, type 2 diabetes and cardiovascular disease. [provided by
            RefSeq, Oct 2019].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X04827.1, AK313151.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305988.6/ ENSP00000305372.4
            RefSeq Select criteria :: based on single protein-coding transcript
            regulatory uORF        :: PMID: 8308019
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-431               AK313151.1         1-431
            432-432             AC011354.4         127997-127997
            433-1463            AK313151.1         433-1463
            1464-1553           BC073856.1         1433-1522
            1554-2013           CA440083.1         19-478              c
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..2013
                     /gene="ADRB2"
                     /gene_synonym="ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR"
                     /note="adrenoceptor beta 2"
                     /db_xref="GeneID:154"
                     /db_xref="HGNC:HGNC:286"
                     /db_xref="MIM:109690"
     exon            1..2013
                     /gene="ADRB2"
                     /gene_synonym="ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      121..180
                     /regulatory_class="uORF"
                     /gene="ADRB2"
                     /gene_synonym="ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:8308019]"
                     /note="regulatory uORF; this uORF encodes a 19 aa peptide
                     (PMID:8308019)"
     CDS             222..1463
                     /gene="ADRB2"
                     /gene_synonym="ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR"
                     /note="catecholamine receptor; beta-2 adrenoceptor; beta-2
                     adrenoreceptor; adrenergic, beta-2-, receptor, surface;
                     adrenoceptor beta 2 surface"
                     /codon_start=1
                     /product="beta-2 adrenergic receptor"
                     /protein_id="NP_000015.2"
                     /db_xref="CCDS:CCDS4292.1"
                     /db_xref="GeneID:154"
                     /db_xref="HGNC:HGNC:286"
                     /db_xref="MIM:109690"
                     /translation="MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIV
                     LAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFG
                     NFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIV
                     SGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFV
                     YSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLG
                     IIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRI
                     AFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQG
                     TVPSDNIDSQGRNCSTNDSLL"
     regulatory      1995..2000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRB2"
                     /gene_synonym="ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR"
                     /note="hexamer: AATAAA"
     polyA_site      2013
                     /gene="ADRB2"
                     /gene_synonym="ADRB2R; ADRBR; ARB2; B2AR; BAR; BETA2AR"
                     /note="major polyA site"
ORIGIN      
        1 gcactgcgaa gcggcttctt cagagcacgg gctggaactg gcaggcaccg cgagccccta
       61 gcacccgaca agctgagtgt gcaggacgag tccccaccac acccacacca cagccgctga
      121 atgaggcttc caggcgtccg ctcgcggccc gcagagcccc gccgtgggtc cgcccgctga
      181 ggcgccccca gccagtgcgc tcacctgcca gactgcgcgc catggggcaa cccgggaacg
      241 gcagcgcctt cttgctggca cccaatggaa gccatgcgcc ggaccacgac gtcacgcagg
      301 aaagggacga ggtgtgggtg gtgggcatgg gcatcgtcat gtctctcatc gtcctggcca
      361 tcgtgtttgg caatgtgctg gtcatcacag ccattgccaa gttcgagcgt ctgcagacgg
      421 tcaccaacta cttcatcact tcactggcct gtgctgatct ggtcatgggc ctggcagtgg
      481 tgccctttgg ggccgcccat attcttatga aaatgtggac ttttggcaac ttctggtgcg
      541 agttttggac ttccattgat gtgctgtgcg tcacggccag cattgagacc ctgtgcgtga
      601 tcgcagtgga tcgctacttt gccattactt cacctttcaa gtaccagagc ctgctgacca
      661 agaataaggc ccgggtgatc attctgatgg tgtggattgt gtcaggcctt acctccttct
      721 tgcccattca gatgcactgg taccgggcca cccaccagga agccatcaac tgctatgcca
      781 atgagacctg ctgtgacttc ttcacgaacc aagcctatgc cattgcctct tccatcgtgt
      841 ccttctacgt tcccctggtg atcatggtct tcgtctactc cagggtcttt caggaggcca
      901 aaaggcagct ccagaagatt gacaaatctg agggccgctt ccatgtccag aaccttagcc
      961 aggtggagca ggatgggcgg acggggcatg gactccgcag atcttccaag ttctgcttga
     1021 aggagcacaa agccctcaag acgttaggca tcatcatggg cactttcacc ctctgctggc
     1081 tgcccttctt catcgttaac attgtgcatg tgatccagga taacctcatc cgtaaggaag
     1141 tttacatcct cctaaattgg ataggctatg tcaattctgg tttcaatccc cttatctact
     1201 gccggagccc agatttcagg attgccttcc aggagcttct gtgcctgcgc aggtcttctt
     1261 tgaaggccta tgggaatggc tactccagca acggcaacac aggggagcag agtggatatc
     1321 acgtggaaca ggagaaagaa aataaactgc tgtgtgaaga cctcccaggc acggaagact
     1381 ttgtgggcca tcaaggtact gtgcctagcg ataacattga ttcacaaggg aggaattgta
     1441 gtacaaatga ctcactgctg taaagcagtt tttctacttt taaagacccc cccccccaac
     1501 agaacactaa acagactatt taacttgagg gtaataaact tagaataaaa ttgtaaaatt
     1561 gtatagagat atgcagaagg aagggcatcc ttctgccttt tttatttttt taagctgtaa
     1621 aaagagagaa aacttatttg agtgattatt tgttatttgt acagttcagt tcctctttgc
     1681 atggaatttg taagtttatg tctaaagagc tttagtccta gaggacctga gtctgctata
     1741 ttttcatgac ttttccatgt atctacctca ctattcaagt attaggggta atatattgct
     1801 gctggtaatt tgtatctgaa ggagattttc cttcctacac ccttggactt gaggattttg
     1861 agtatctcgg acctttcagc tgtgaacatg gactcttccc ccactcctct tatttgctca
     1921 cacggggtat tttaggcagg gatttgagga gcagcttcag ttgttttccc gagcaaagtc
     1981 taaagtttac agtaaataaa ttgtttgacc atg
//
