LOCUS       NM_000683               2142 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adrenoceptor alpha 2C (ADRA2C), mRNA.
ACCESSION   NM_000683 XM_938284
VERSION     NM_000683.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Amar,J., Brunel,J., Cardot Bauters,C., Jacques,V., Delmas,C.,
            Odou,M.F. and Savagner,F.
  TITLE     Genetic biomarkers of life-threatening pheochromocytoma-induced
            cardiomyopathy
  JOURNAL   Endocr Relat Cancer 29 (5), 267-272 (2022)
   PUBMED   35258481
  REMARK    GeneRIF: Genetic biomarkers of life-threatening
            pheochromocytoma-induced cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Brocos-Mosquera,I., Gabilondo,A.M., Diez-Alarcia,R., Muguruza,C.,
            Erdozain,A.M., Meana,J.J. and Callado,L.F.
  TITLE     alpha2A- and alpha2C-adrenoceptor expression and functionality in
            postmortem prefrontal cortex of schizophrenia subjects
  JOURNAL   Eur Neuropsychopharmacol 52, 3-11 (2021)
   PUBMED   34237656
  REMARK    GeneRIF: alpha2A- and alpha2C-adrenoceptor expression and
            functionality in postmortem prefrontal cortex of schizophrenia
            subjects.
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2142)
  AUTHORS   Rivero,E.M., Martinez,L.M., Bruque,C.D., Gargiulo,L., Bruzzone,A.
            and Luthy,I.A.
  TITLE     Prognostic significance of alpha- and beta2-adrenoceptor gene
            expression in breast cancer patients
  JOURNAL   Br J Clin Pharmacol 85 (9), 2143-2154 (2019)
   PUBMED   31218733
  REMARK    GeneRIF: Prognostic significance of alpha- and beta2-adrenoceptor
            gene expression in breast cancer patients.
REFERENCE   5  (bases 1 to 2142)
  AUTHORS   Motawea,H.K.B., Chotani,M.A., Ali,M., Ackerman,W., Zhao,G.,
            Ahmed,A.A.E., Buhimschi,C.S. and Buhimschi,I.A.
  TITLE     Human Placenta Expresses alpha2-Adrenergic Receptors and May Be
            Implicated in Pathogenesis of Preeclampsia and Fetal Growth
            Restriction
  JOURNAL   Am J Pathol 188 (12), 2774-2785 (2018)
   PUBMED   30273604
  REMARK    GeneRIF: High alpha2-Adrenergic Receptor expression is associated
            with Pathogenesis of Preeclampsia and Fetal Growth Restriction.
REFERENCE   6  (bases 1 to 2142)
  AUTHORS   Riess,O., Thies,U., Siedlaczck,I., Potisek,S., Graham,R.,
            Theilmann,J., Grimm,T., Epplen,J.T. and Hayden,M.R.
  TITLE     Precise mapping of the brain alpha 2-adrenergic receptor gene
            within chromosome 4p16
  JOURNAL   Genomics 19 (2), 298-302 (1994)
   PUBMED   8188260
REFERENCE   7  (bases 1 to 2142)
  AUTHORS   Eason,M.G. and Liggett,S.B.
  TITLE     Human alpha 2-adrenergic receptor subtype distribution: widespread
            and subtype-selective expression of alpha 2C10, alpha 2C4, and
            alpha 2C2 mRNA in multiple tissues
  JOURNAL   Mol Pharmacol 44 (1), 70-75 (1993)
   PUBMED   7688069
REFERENCE   8  (bases 1 to 2142)
  AUTHORS   Coupry,I., Duzic,E. and Lanier,S.M.
  TITLE     Factors determining the specificity of signal transduction by
            guanine nucleotide-binding protein-coupled receptors. II.
            Preferential coupling of the alpha 2C-adrenergic receptor to the
            guanine nucleotide-binding protein, Go
  JOURNAL   J Biol Chem 267 (14), 9852-9857 (1992)
   PUBMED   1349607
REFERENCE   9  (bases 1 to 2142)
  AUTHORS   Chhajlani,V., Rangel,N., Uhlen,S. and Wikberg,J.E.
  TITLE     Identification of an additional gene belonging to the alpha 2
            adrenergic receptor family in the human genome by PCR
  JOURNAL   FEBS Lett 280 (2), 241-244 (1991)
   PUBMED   1849485
REFERENCE   10 (bases 1 to 2142)
  AUTHORS   Regan,J.W., Kobilka,T.S., Yang-Feng,T.L., Caron,M.G.,
            Lefkowitz,R.J. and Kobilka,B.K.
  TITLE     Cloning and expression of a human kidney cDNA for an alpha
            2-adrenergic receptor subtype
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6301-6305 (1988)
   PUBMED   2842764
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC141928.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000683.3.
            
            Summary: Alpha-2-adrenergic receptors are members of the G
            protein-coupled receptor superfamily. They include 3 highly
            homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
            have a critical role in regulating neurotransmitter release from
            sympathetic nerves and from adrenergic neurons in the central
            nervous system. The mouse studies revealed that both the alpha2A
            and alpha2C subtypes were required for normal presynaptic control
            of transmitter release from sympathetic nerves in the heart and
            from central noradrenergic neurons. The alpha2A subtype inhibited
            transmitter release at high stimulation frequencies, whereas the
            alpha2C subtype modulated neurotransmission at lower levels of
            nerve activity. This gene encodes the alpha2C subtype, which
            contains no introns in either its coding or untranslated sequences.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC142625.1, J03853.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330055.7/ ENSP00000386069.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC141928.2         12432-12615
            185-2142            AC141928.2         12616-14573
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..2142
                     /gene="ADRA2C"
                     /gene_synonym="ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR"
                     /note="adrenoceptor alpha 2C"
                     /db_xref="GeneID:152"
                     /db_xref="HGNC:HGNC:283"
                     /db_xref="MIM:104250"
     exon            1..2142
                     /gene="ADRA2C"
                     /gene_synonym="ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1611
                     /gene="ADRA2C"
                     /gene_synonym="ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR"
                     /note="alpha2-AR-C4; alpha-2CAR; alpha-2C adrenoceptor;
                     alpha-2C adrenoreceptor; alpha-2 adrenergic receptor
                     subtype C4; adrenergic, alpha-2C-, receptor"
                     /codon_start=1
                     /product="alpha-2C adrenergic receptor"
                     /protein_id="NP_000674.2"
                     /db_xref="CCDS:CCDS47004.1"
                     /db_xref="GeneID:152"
                     /db_xref="HGNC:HGNC:283"
                     /db_xref="MIM:104250"
                     /translation="MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRG
                     QYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVAT
                     LVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYN
                     LKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGS
                     FFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHC
                     APPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALT
                     ASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFV
                     LCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKH
                     ILFRRRRRGFRQ"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA2C"
                     /gene_synonym="ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR"
                     /note="hexamer: AATAAA"
     polyA_site      2142
                     /gene="ADRA2C"
                     /gene_synonym="ADRA2L2; ADRA2RL2; ADRARL2; ALPHA2CAR"
                     /note="major polyA site"
ORIGIN      
        1 acttacacgc tcggcagctg cggggagccc ggcagccacg ctctccggcg cgccgcccgc
       61 ggagccacca cggccgaggg ccggctgctg ggcgccgcgg tccccggcgg gcgcgcccga
      121 gcagcaggcg gcgatgcggg cgccgacccc ggctgggggg cgcccgagct gccgcggctg
      181 cgccccggct ccaggaggga cggcgtagct cgcgggagga ccatggcgtc cccggcgctg
      241 gcggcggcgc tggcggtggc ggcagcggcg ggccccaatg cgagcggcgc gggcgagagg
      301 ggcagcggcg gggttgccaa tgcctcgggg gcttcctggg ggccgccgcg cggccagtac
      361 tcggcgggcg cggtggcagg gctggctgcc gtggtgggct tcctcatcgt cttcaccgtg
      421 gtgggcaacg tgctggtggt gatcgccgtg ctgaccagcc gggcgctgcg cgcgccacag
      481 aacctcttcc tggtgtcgct ggcctcggcc gacatcctgg tggccacgct ggtcatgccc
      541 ttctcgttgg ccaacgagct catggcctac tggtacttcg ggcaggtgtg gtgcggcgtg
      601 tacctggcgc tcgatgtgct gttttgcacc tcgtcgatcg tgcatctgtg tgccatcagc
      661 ctggaccgct actggtcggt gacgcaggcc gtcgagtaca acctgaagcg cacaccacgc
      721 cgcgtcaagg ccaccatcgt ggccgtgtgg ctcatctcgg ccgtcatctc cttcccgccg
      781 ctggtctcgc tctaccgcca gcccgacggc gccgcctacc cgcagtgcgg cctcaacgac
      841 gagacctggt acatcctgtc ctcctgcatc ggctccttct tcgcgccctg cctcatcatg
      901 ggcctggtct acgcgcgcat ctaccgagtg gccaagctgc gcacgcgcac gctcagcgag
      961 aagcgcgccc ccgtgggccc cgacggtgcg tccccgacta ccgaaaacgg gctgggcgcg
     1021 gcggcaggcg caggcgagaa cgggcactgc gcgcccccgc ccgccgacgt ggagccggac
     1081 gagagcagcg cagcggccga gaggcggcgg cgccggggcg cgttgcggcg gggcgggcgg
     1141 cggcgagcgg gcgcggaggg gggcgcgggc ggtgcggacg ggcagggggc ggggccgggg
     1201 gcggctgagt cgggggcgct gaccgcctcc aggtccccgg ggcccggtgg ccgcctgtcg
     1261 cgcgccagct cgcgctccgt cgagttcttc ctgtcgcgcc ggcgccgggc gcgcagcagc
     1321 gtgtgccgcc gcaaggtggc ccaggcgcgc gagaagcgct tcacctttgt gctggctgtg
     1381 gtcatgggcg tgttcgtgct ctgctggttc cccttcttct tcagctacag cctgtacggc
     1441 atctgccgcg aggcctgcca ggtgcccggc ccgctcttca agttcttctt ctggatcggc
     1501 tactgcaaca gctcgctcaa cccggtcatc tacacggtct tcaaccagga tttccggcga
     1561 tcctttaagc acatcctctt ccgacggagg agaaggggct tcaggcagtg actcgcaccc
     1621 gtctgggaat cctggacagc tccgcgctcg gggctgggca gaaggggcgg cccggacggg
     1681 ggagctttcc cagagacccg gggatggatt ggcctccagg gcgcagggga gggtgcggca
     1741 gggcaggagc ttggcagaga gatagccggg ctccagggag tggggaggag agagggggag
     1801 acccctttgc cttcccccct cagcaagggg ctgcttctgg ggctccctgc ctggatccag
     1861 ctctgggagc cctgccgagg tgtggctgtg aggtcagggt tttagagagc agtggcagag
     1921 gtagccccct aaatgggcaa gcaaggagcc ccccaaagac actaccactc cccatccccg
     1981 tctgaccaag ggctgacttc tccaggacct agtcgggggg tggctgccag ggggcaagga
     2041 gaaagcaccg acaatctttg attactgaaa gtatttaaat gtttgccaaa aacaacagcc
     2101 aaaacaacca aactattttc taaataaacc tttgtaatct aa
//
