LOCUS       NM_000682               3696 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens adrenoceptor alpha 2B (ADRA2B), mRNA.
ACCESSION   NM_000682
VERSION     NM_000682.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3696)
  AUTHORS   Kachkovska,V.
  TITLE     ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Beta2 ADRENERGIC
            RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH EARLY-ONSET AND
            LATE-ONSET BRONCHIAL ASTHMA
  JOURNAL   Georgian Med News (340-341), 254-258 (2023)
   PUBMED   37805907
  REMARK    GeneRIF: ASSOCIATION BETWEEN GLN27GLU POLYMORPHISM IN THE Beta2
            ADRENERGIC RECEPTOR GENE AND OBESITY RISK IN PATIENTS WITH
            EARLY-ONSET AND LATE-ONSET BRONCHIAL ASTHMA.
REFERENCE   2  (bases 1 to 3696)
  AUTHORS   Papageorgiou,L., Christou,E., Louka,E., Papakonstantinou,E.,
            Diakou,I., Pierouli,K., Dragoumani,K., Bacopoulou,F.,
            Chrousos,G.P., Eliopoulos,E. and Vlachakis,D.
  TITLE     ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors
            Reveals Novel Conserved Motifs Which Play Key Role in Mental
            Disorders
  JOURNAL   Adv Exp Med Biol 1423, 79-99 (2023)
   PUBMED   37525034
  REMARK    GeneRIF: ADRA2B and HTR1A: An Updated Study of the Biogenic Amine
            Receptors Reveals Novel Conserved Motifs Which Play Key Role in
            Mental Disorders.
REFERENCE   3  (bases 1 to 3696)
  AUTHORS   Eldeeb,H.M., Elgharabawy,R.M., Abd Elmoniem,A.E. and Ahmed,A.A.
  TITLE     Alpha-2 beta-adrenergic receptor (301-303 I/D) gene polymorphism in
            hypertension and type 2 diabetes mellitus diseases among Saudi
            cases in the Qassim region
  JOURNAL   Sci Prog 104 (2), 368504211012162 (2021)
   PUBMED   33900865
  REMARK    GeneRIF: Alpha-2 beta-adrenergic receptor (301-303 I/D) gene
            polymorphism in hypertension and type 2 diabetes mellitus diseases
            among Saudi cases in the Qassim region.
REFERENCE   4  (bases 1 to 3696)
  AUTHORS   Potnuri,A.G., Allakonda,L. and Saheera,S.
  TITLE     Involvement of Histamine 2 Receptor in Alpha 1 Adrenoceptor
            Mediated Cardiac Hypertrophy and Oxidative Stress in H9c2 Cardio
            Myoblasts
  JOURNAL   J Cardiovasc Transl Res 14 (1), 184-194 (2021)
   PUBMED   32385805
  REMARK    GeneRIF: Involvement of Histamine 2 Receptor in Alpha 1
            Adrenoceptor Mediated Cardiac Hypertrophy and Oxidative Stress in
            H9c2 Cardio Myoblasts.
REFERENCE   5  (bases 1 to 3696)
  AUTHORS   Mulerova capital TE, Cyrilliccapital,A. Cyrillic, Filimonov,E.S.,
            Maksimov,S.A., Maksimov,V.N., Voevoda capital,E.M. CyrillicI,
            Ogarkov capital,E.M. CyrillicY and Ogarkov capital,E.M. CyrillicY.
  TITLE     Interrelation of cardiovascular risk factors with high albuminury
            among patients with arterial hypertension living in Mountain
            Shoriya
  JOURNAL   Ter Arkh 91 (1), 71-77 (2019)
   PUBMED   31090375
  REMARK    GeneRIF: In the group of shors with arterial hypertension, high
            albuminuria was associated with polymorphisms of the ACE genes
            (OR=2.05), ADRA2B (OR=6.00),-- The primary predictors determining
            the development of high albuminuria among patients with arterial
            hypertension in both ethnic groups were genetic ones.
REFERENCE   6  (bases 1 to 3696)
  AUTHORS   Weinshank,R.L., Zgombick,J.M., Macchi,M., Adham,N., Lichtblau,H.,
            Branchek,T.A. and Hartig,P.R.
  TITLE     Cloning, expression, and pharmacological characterization of a
            human alpha 2B-adrenergic receptor
  JOURNAL   Mol Pharmacol 38 (5), 681-688 (1990)
   PUBMED   2172775
REFERENCE   7  (bases 1 to 3696)
  AUTHORS   Chang,A.C., Ho,T.F. and Chang,N.C.
  TITLE     In vitro amplification by polymerase chain reaction of a partial
            gene encoding the third subtype of alpha-2 adrenergic receptor in
            humans
  JOURNAL   Biochem Biophys Res Commun 172 (2), 817-823 (1990)
   PUBMED   2173582
REFERENCE   8  (bases 1 to 3696)
  AUTHORS   McClue,S.J. and Milligan,G.
  TITLE     The alpha 2B adrenergic receptor of undifferentiated neuroblastoma
            x glioma hybrid NG108-15 cells, interacts directly with the guanine
            nucleotide binding protein, Gi2
  JOURNAL   FEBS Lett 269 (2), 430-434 (1990)
   PUBMED   2169434
REFERENCE   9  (bases 1 to 3696)
  AUTHORS   Lomasney,J.W., Lorenz,W., Allen,L.F., King,K., Regan,J.W.,
            Yang-Feng,T.L., Caron,M.G. and Lefkowitz,R.J.
  TITLE     Expansion of the alpha 2-adrenergic receptor family: cloning and
            characterization of a human alpha 2-adrenergic receptor subtype,
            the gene for which is located on chromosome 2
  JOURNAL   Proc Natl Acad Sci U S A 87 (13), 5094-5098 (1990)
   PUBMED   2164221
REFERENCE   10 (bases 1 to 3696)
  AUTHORS   Regan,J.W., Kobilka,T.S., Yang-Feng,T.L., Caron,M.G.,
            Lefkowitz,R.J. and Kobilka,B.K.
  TITLE     Cloning and expression of a human kidney cDNA for an alpha
            2-adrenergic receptor subtype
  JOURNAL   Proc Natl Acad Sci U S A 85 (17), 6301-6305 (1988)
   PUBMED   2842764
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092603.2 and BC133021.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000682.6.
            
            Summary: This intronless gene encodes a seven-pass transmembrane
            protein. This protein is a member of a subfamily of G
            protein-coupled receptors that regulate neurotransmitter release
            from sympathetic nerves and from adrenergic neurons in the central
            nervous system. [provided by RefSeq, Apr 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803613.98023.1, BC133021.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620793.2/ ENSP00000480573.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               AC092603.2         15427-15752         c
            327-1603            BC133021.1         1-1277
            1604-1604           AC092603.2         14158-14158         c
            1605-3613           BC133021.1         1279-3287
            3614-3696           AC092603.2         12066-12148         c
FEATURES             Location/Qualifiers
     source          1..3696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..3696
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR;
                     ALPHA2BAR; FAME2"
                     /note="adrenoceptor alpha 2B"
                     /db_xref="GeneID:151"
                     /db_xref="HGNC:HGNC:282"
                     /db_xref="MIM:104260"
     exon            1..3696
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR;
                     ALPHA2BAR; FAME2"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1775
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR;
                     ALPHA2BAR; FAME2"
                     /note="alpha-2-adrenergic receptor-like 1; ADRA2B
                     adrenergic, alpha-2B-, receptor; G-protein coupled
                     receptor; alpha-2B adrenoreceptor; alpha-2 adrenergic
                     receptor subtype C2"
                     /codon_start=1
                     /product="alpha-2B adrenergic receptor"
                     /protein_id="NP_000673.2"
                     /db_xref="CCDS:CCDS56129.1"
                     /db_xref="GeneID:151"
                     /db_xref="HGNC:HGNC:282"
                     /db_xref="MIM:104260"
                     /translation="MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLR
                     APQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVH
                     LCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRG
                     RPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGES
                     KQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAA
                     LPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSR
                     VLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYS
                     LGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
                     "
     regulatory      2655..2660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR;
                     ALPHA2BAR; FAME2"
                     /note="hexamer: TATAAA"
     polyA_site      2687
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR;
                     ALPHA2BAR; FAME2"
                     /note="major polyA site"
     regulatory      3675..3680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR;
                     ALPHA2BAR; FAME2"
                     /note="hexamer: AATAAA"
     polyA_site      3696
                     /gene="ADRA2B"
                     /gene_synonym="ADRA2L1; ADRA2RL1; ADRARL1; alpha-2BAR;
                     ALPHA2BAR; FAME2"
                     /note="major polyA site"
ORIGIN      
        1 actcccctgc aggcgcggct ggggcgaaag cctgcgagct gagcgggcgc aaggtcctcc
       61 gcgcctcctt taagaaccgg cccagcccgg cccgcgcccc cagagcgtac ggcatccgcg
      121 tggcgggagg gcgcgacttt ctccggtccc gggcgggacg gggacggcgg cgggacaact
      181 tgggaaactt ctctggggcg gacggcaggg accccgggca ccggtggagg aggatgtagg
      241 agggcggctg ctggtcctgg gtgttcccga cctcctaggc cccgctcgtc caggccatgg
      301 ggctccagcg ccctcggcgc cgcccgaggg gcgacgctct tgtctagccg agccgggcag
      361 cgctgtcgtc cacggtgcgc actgggcggg cagcgctccc tctgcccacc tcccgccccg
      421 tcatggacca ccaggacccc tactccgtgc aggccacagc ggccatagcg gcggccatca
      481 ccttcctcat tctctttacc atcttcggca acgctctggt catcctggct gtgttgacca
      541 gccgctcgct gcgcgcccct cagaacctgt tcctggtgtc gctggccgcc gccgacatcc
      601 tggtggccac gctcatcatc cctttctcgc tggccaacga gctgctgggc tactggtact
      661 tccggcgcac gtggtgcgag gtgtacctgg cgctcgacgt gctcttctgc acctcgtcca
      721 tcgtgcacct gtgcgccatc agcctggacc gctactgggc cgtgagccgc gcgctggagt
      781 acaactccaa gcgcaccccg cgccgcatca agtgcatcat cctcactgtg tggctcatcg
      841 ccgccgtcat ctcgctgccg cccctcatct acaagggcga ccagggcccc cagccgcgcg
      901 ggcgccccca gtgcaagctc aaccaggagg cctggtacat cctggcctcc agcatcggat
      961 ctttctttgc tccttgcctc atcatgatcc ttgtctacct gcgcatctac ctgatcgcca
     1021 aacgcagcaa ccgcagaggt cccagggcca agggggggcc tgggcagggt gagtccaagc
     1081 agccccgacc cgaccatggt ggggctttgg cctcagccaa actgccagcc ctggcctctg
     1141 tggcttctgc cagagaggtc aacggacact cgaagtccac tggggagaag gaggaggggg
     1201 agacccctga agatactggg acccgggcct tgccacccag ttgggctgcc cttcccaact
     1261 caggccaggg ccagaaggag ggtgtttgtg gggcatctcc agaggatgaa gctgaagagg
     1321 aggaagagga ggaggaggag gaggaagagt gtgaacccca ggcagtgcca gtgtctccgg
     1381 cctcagcttg cagccccccg ctgcagcagc cacagggctc ccgggtgctg gccaccctac
     1441 gtggccaggt gctcctgggc aggggcgtgg gtgctatagg tgggcagtgg tggcgtcgac
     1501 gggcgcagct gacccgggag aagcgcttca ccttcgtgct ggctgtggtc attggcgttt
     1561 ttgtgctctg ctggttcccc ttcttcttca gctacagcct gggagccatc tgcccgaagc
     1621 actgcaaggt gccccatggc ctcttccagt tcttcttctg gatcggctac tgcaacagct
     1681 cactgaaccc tgttatctac accatcttca accaggactt ccgccgtgcc ttccggagga
     1741 tcctgtgccg cccgtggacc cagacggcct ggtgagcccg cctgcgctgc ccctgtgggg
     1801 ttggtgcggt ggcgccgggg tcaccctgct tcttgccctg ctgtgtgtgg ctgcctcccc
     1861 tgggctttct gctccctgcc cagatcctgt aggcctcatc ttaggaaccc cttgggaggg
     1921 gtgggcaggg gggctgctag caagggtccc agtgaagctt ccccttgccg gcttagctgt
     1981 gggggacccc ttctccaccc tctccctgag cacaggccga tggaggtggt tcaaatcctc
     2041 tggaacatag ccaagaccag gagaagagag agcactttct tcccagagcc ccatgctctc
     2101 cagaccaatg tctgggcttc cctttcttga ggaccttgtg ttcctggcag gtcacttgct
     2161 tgtggtgttt tcgtttcttt ttcatctccc ccccacccac aaagagcacg gagccagcct
     2221 tccacttttc ccagtggggc ctgctgctga gggggaggaa gaaacgaaga ctgatcaccc
     2281 acgctaggca ctcgcggtcc ctggcaggcg ctgggatggg ggcttatggg gtggcatcgt
     2341 ctctgggccc tcctttcccc ctttgcctgt tttcggatct gtggttcctt tgaaagccag
     2401 aacaatggat cggcttcctt acccagcacc cctccggtag gtgggtggcc acgtggatgc
     2461 ctcgctgggg cggtcttgga ggcctggtct ctgcctcgac gggagatccc cgatcactgg
     2521 cattcacccc ctgcaaaaat cggggcgaca atagctcact gcctacttgc tgcagggaga
     2581 tgaaaggctt tgcagaaagc tttgagctct gtgggggaac acactagaga accaaaaatg
     2641 tgattatatg gtgatataaa aatccctttc ctctgtgttt accaccacct gtcttcctgt
     2701 agacttttgt tctgtccctg gggtgtgtga attcctaccc cgaactggaa gccgggagtg
     2761 gcagacagaa tcactatttc aagttaaagg atctctttga gaatgtgttc ttctggctgc
     2821 aaaggtctga gttattacgc tacatgacaa cgtttcgaca tttcaccggc aacaccaaga
     2881 gggtttttag tggcttgggt ctccccagtg ggggataagt cttttgtcat caaggaggca
     2941 aattgtctcc ccaagacagc tcaaaatatc cacacctcgg caacagtcta agatgagagc
     3001 ctgtgacagg tggcagcgcc cccaggtggg gtactggcat cagagcctgg tgcgccccta
     3061 ggggagcctc ccactggagt gcccggccag gtctccaagc cccaaatgag tccttgtgaa
     3121 ccacaactga tccccccagg tgggtgcttg tggactgcct cggacccagc cacgctgctc
     3181 cccgcaatgc tgatggggct gtgcattgag gacccctgct tcctggttct cagtcccacc
     3241 ccaaaacctg gcacccagaa cagttggaag tgtggaaagg aggtttatcg gccttccctt
     3301 ggagagggcc tggcttcaac attgggccag taggcatctt agcttggcag gtgtcggggg
     3361 aatgggccag atggacctgc tagatttgga agggcaccga gggagttttc tgggtgtaga
     3421 gagaatggag gggaccaaaa agagtccttc ctggggtgtg ggaggcttcc cagcttggtc
     3481 ctcagtgggt tgttgaggcc agagtatcgc cctgggatgt ggtggggagc tgggccagga
     3541 gagggactga ctgtgaccct ctgctggccg gtcttgtgtg cgccccatgg gacccccagt
     3601 gttcttgcct gtgacctctt attgcgacat gcaggtggtg tttttttttt ttttaaactc
     3661 tgagctattt tatcaataaa ggatattttg taataa
//
