LOCUS       NM_000681               3879 bp    mRNA    linear   PRI 03-AUG-2024
DEFINITION  Homo sapiens adrenoceptor alpha 2A (ADRA2A), mRNA.
ACCESSION   NM_000681
VERSION     NM_000681.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3879)
  AUTHORS   Jiang,R., Lu,Z., Wang,C., Xiao,J., Liu,Q., Xu,X., Shi,J., Shen,J.,
            Zhu,X., Gong,P., Zhuang,Q.X., Shi,K. and Shi,W.
  TITLE     Beta2 adrenergic receptor-mediated abnormal myelopoiesis drives
            neuroinflammation in aged patients with traumatic brain injury
  JOURNAL   Sci Adv 10 (29), eadp5239 (2024)
   PUBMED   39028822
  REMARK    GeneRIF: Beta2 adrenergic receptor-mediated abnormal myelopoiesis
            drives neuroinflammation in aged patients with traumatic brain
            injury.
REFERENCE   2  (bases 1 to 3879)
  AUTHORS   Hartmann,S., Yasmeen,S., Jacobs,B.M., Denaxas,S., Pirmohamed,M.,
            Gamazon,E.R., Caulfield,M.J., Hemingway,H., Pietzner,M. and
            Langenberg,C.
  CONSRTM   Genes & Health Research Team
  TITLE     ADRA2A and IRX1 are putative risk genes for Raynaud's phenomenon
  JOURNAL   Nat Commun 14 (1), 6156 (2023)
   PUBMED   37828025
  REMARK    GeneRIF: ADRA2A and IRX1 are putative risk genes for Raynaud's
            phenomenon.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3879)
  AUTHORS   Chen,Y., Cao,H., Pan,N., Long,Y., Zhou,J., Zhou,C., Wang,Y. and
            Gong,Q.
  TITLE     The alpha-2A-adrenergic receptor gene polymorphism modulates gray
            matter structural networks, visual memory, and inhibitory cognitive
            control in children with attention deficit/hyperactivity disorder
  JOURNAL   Cereb Cortex 33 (14), 9088-9094 (2023)
   PUBMED   37310179
  REMARK    GeneRIF: The alpha-2A-adrenergic receptor gene polymorphism
            modulates gray matter structural networks, visual memory, and
            inhibitory cognitive control in children with attention
            deficit/hyperactivity disorder.
REFERENCE   4  (bases 1 to 3879)
  AUTHORS   Handy,D.E. and Gavras,H.
  TITLE     Promoter region of the human alpha 2A adrenergic receptor gene
  JOURNAL   J Biol Chem 267 (33), 24017-24022 (1992)
   PUBMED   1385431
REFERENCE   5  (bases 1 to 3879)
  AUTHORS   Perala,M., Hirvonen,H., Kalimo,H., Ala-Uotila,S., Regan,J.W.,
            Akerman,K.E. and Scheinin,M.
  TITLE     Differential expression of two alpha 2-adrenergic receptor subtype
            mRNAs in human tissues
  JOURNAL   Brain Res Mol Brain Res 16 (1-2), 57-63 (1992)
   PUBMED   1334200
REFERENCE   6  (bases 1 to 3879)
  AUTHORS   Surprenant,A., Horstman,D.A., Akbarali,H. and Limbird,L.E.
  TITLE     A point mutation of the alpha 2-adrenoceptor that blocks coupling
            to potassium but not calcium currents
  JOURNAL   Science 257 (5072), 977-980 (1992)
   PUBMED   1354394
REFERENCE   7  (bases 1 to 3879)
  AUTHORS   Suryanarayana,S., Daunt,D.A., Von Zastrow,M. and Kobilka,B.K.
  TITLE     A point mutation in the seventh hydrophobic domain of the alpha 2
            adrenergic receptor increases its affinity for a family of beta
            receptor antagonists
  JOURNAL   J Biol Chem 266 (23), 15488-15492 (1991)
   PUBMED   1678390
REFERENCE   8  (bases 1 to 3879)
  AUTHORS   Wang,C.D., Buck,M.A. and Fraser,C.M.
  TITLE     Site-directed mutagenesis of alpha 2A-adrenergic receptors:
            identification of amino acids involved in ligand binding and
            receptor activation by agonists
  JOURNAL   Mol Pharmacol 40 (2), 168-179 (1991)
   PUBMED   1678850
REFERENCE   9  (bases 1 to 3879)
  AUTHORS   Fraser,C.M., Arakawa,S., McCombie,W.R. and Venter,J.C.
  TITLE     Cloning, sequence analysis, and permanent expression of a human
            alpha 2-adrenergic receptor in Chinese hamster ovary cells.
            Evidence for independent pathways of receptor coupling to adenylate
            cyclase attenuation and activation
  JOURNAL   J Biol Chem 264 (20), 11754-11761 (1989)
   PUBMED   2568356
REFERENCE   10 (bases 1 to 3879)
  AUTHORS   Kobilka,B.K., Matsui,H., Kobilka,T.S., Yang-Feng,T.L., Francke,U.,
            Caron,M.G., Lefkowitz,R.J. and Regan,J.W.
  TITLE     Cloning, sequencing, and expression of the gene coding for the
            human platelet alpha 2-adrenergic receptor
  JOURNAL   Science 238 (4827), 650-656 (1987)
   PUBMED   2823383
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158163.11, AF284095.1 and
            BM682651.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000681.3.
            
            Summary: Alpha-2-adrenergic receptors are members of the G
            protein-coupled receptor superfamily. The alpha-2-adrenergic
            receptors are a type of adrenergic receptors (for adrenaline or
            epinephrine), which inhibit adenylate cyclase. These receptors
            include 3 highly homologous subtypes: alpha2A, alpha2B, and
            alpha2C. They are involved in regulating the release of
            neurotransmitter molecules from sympathetic nerves and from
            adrenergic neurons in the central nervous system. The sympathetic
            nervous system regulates cardiovascular function by activating
            adrenergic receptors in the heart, blood vessels and kidney.
            Studies in mouse revealed that both the alpha2A and alpha2C
            receptor subtypes were required for presynaptic transmitter release
            from the sympathetic nervous system in the heart and from central
            noradrenergic neurons. The alpha-2-adrenergic receptors are also
            involved in catecholamine signaling by extracellular regulated
            protein kinase 1 and 2 (ERK1/2) pathways. A clear association
            between the alpha-2-adrenergic receptor and disease has not been
            yet established. [provided by RefSeq, Sep 2019].
            
            Sequence Note: The 5'-most in-frame translation initiation codon is
            selected for this RefSeq based on good conservation across
            mammalian species. A possible downstream start codon would result
            in a protein that is 15 aa shorter at the N-terminus. The
            literature, including PMIDs:2823383, 2568356, 1354394 and 1678390,
            assumes the use of the downstream start codon based on initial
            cloning reports, but there is no experimental evidence indicating
            which start codon is preferentially used in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF284095.1, BC050414.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280155.4/ ENSP00000280155.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL158163.11        194557-194559
            4-134               AL158163.11        194560-194690
            135-286             AF284095.1         1-152
            287-303             AL158163.11        194843-194859
            304-2792            AF284095.1         170-2658
            2793-2793           AL158163.11        197349-197349
            2794-3784           AF284095.1         2660-3650
            3785-3879           BM682651.1         14-108              c
FEATURES             Location/Qualifiers
     source          1..3879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..3879
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
                     /note="adrenoceptor alpha 2A"
                     /db_xref="GeneID:150"
                     /db_xref="HGNC:HGNC:281"
                     /db_xref="MIM:104210"
     exon            1..3879
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
                     /inference="alignment:Splign:2.1.0"
     CDS             969..2366
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
                     /note="alpha-2AAR subtype C10; alpha-2-adrenergic
                     receptor, platelet type; alpha-2A adrenoceptor; alpha-2A
                     adrenoreceptor; alpha-2 adrenergic receptor subtype C10;
                     adrenergic, alpha-2A-, receptor"
                     /codon_start=1
                     /product="alpha-2A adrenergic receptor"
                     /protein_id="NP_000672.3"
                     /db_xref="CCDS:CCDS7569.2"
                     /db_xref="GeneID:150"
                     /db_xref="HGNC:HGNC:281"
                     /db_xref="MIM:104210"
                     /translation="MFRQEQPLAEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYS
                     LQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVI
                     PFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKR
                     TPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIG
                     SFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGP
                     GGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKG
                     KARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLA
                     VVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRR
                     AFKKILCRGDRKRIV"
     regulatory      3735..3740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
                     /note="hexamer: AATAAA"
     regulatory      3763..3768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
                     /note="hexamer: AATAAA"
     polyA_site      3768
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
                     /note="major polyA site"
     polyA_site      3784
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
     regulatory      3856..3861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
                     /note="hexamer: AATAAA"
     polyA_site      3879
                     /gene="ADRA2A"
                     /gene_synonym="ADRA2; ADRA2R; ADRAR; ALPHA2AAR; FPLD8;
                     ZNF32"
ORIGIN      
        1 gagcagcagc agctccagct cggtgcagaa gcccagcagc cggcgtgccg ccgcccggcc
       61 actccagcgc cttcttcccc gccttgcgct cctgccccaa ctcgcgctgt cgtcggaccc
      121 cggcccatcc agcagcgctc ggcgcccacc aggcggacgc ccaggagaac ccctgcctcc
      181 gtcgcggctc ctggagagct gatcgttcac ctgccccggc ccgcctgagg acgggggtgc
      241 cttcatgcgg cccccacact cctcaccccg ccgccgccgc cgtcccggag ctccgcacag
      301 tgtgccccag ccccagcagg gcgcacaact ttggaagtct cgcggcgctc cgagaggcgg
      361 cagagtccgc gccccagccc cgggccgggc cgggccagaa ccgcagcgtc tgggggaagc
      421 cagagagtcg gtaatcgctt cggggatgta aggcgacaga cataggaccc ccgagctcgc
      481 atcagcaccc ttcggctgcc tcccggggtg ggggcgggcc ccgcacacgg taagacctct
      541 tgctttcgct caggctcaag attcaagata cagatattga tatgtatata tatatttaat
      601 ttcctgtcat ccttccaagt tatcaggcca ccgatgattt ttgttctccc ttcttgaaga
      661 ataaatctct ctttacccat cggctctccc tactctctcc cgccgcttag aaataaaact
      721 tggctgtatt aggagctcgg agcaagaagg cgcccaccga gagcgtctga agcgcgagcc
      781 aggcgcagtt cgcgggaccc gggccatggg ccgctagcgg tcctccagtt cgggcccggc
      841 ctccctgcgg ccccctccct atgtgagccg cagccaggcg agcggggcgc cggaggaaga
      901 ggaggaccca cgggcgccgg gccggaaggc agctggcagc aggcccaggc cagcgggcgc
      961 ccgcgttcat gttccgccag gagcagccgt tggccgaggg cagctttgcg cccatgggct
     1021 ccctgcagcc ggacgcgggc aacgcgagct ggaacgggac cgaggcgccg gggggcggcg
     1081 cccgggccac cccttactcc ctgcaggtga cgctgacgct ggtgtgcctg gccggcctgc
     1141 tcatgctgct caccgtgttc ggcaacgtgc tcgtcatcat cgccgtgttc acgagccgcg
     1201 cgctcaaggc gccccaaaac ctcttcctgg tgtctctggc ctcggccgac atcctggtgg
     1261 ccacgctcgt catccctttc tcgctggcca acgaggtcat gggctactgg tacttcggca
     1321 aggcttggtg cgagatctac ctggcgctcg acgtgctctt ctgcacgtcg tccatcgtgc
     1381 acctgtgcgc catcagcctg gaccgctact ggtccatcac acaggccatc gagtacaacc
     1441 tgaagcgcac gccgcgccgc atcaaggcca tcatcatcac cgtgtgggtc atctcggccg
     1501 tcatctcctt cccgccgctc atctccatcg agaagaaggg cggcggcggc ggcccgcagc
     1561 cggccgagcc gcgctgcgag atcaacgacc agaagtggta cgtcatctcg tcgtgcatcg
     1621 gctccttctt cgctccctgc ctcatcatga tcctggtcta cgtgcgcatc taccagatcg
     1681 ccaagcgtcg cacccgcgtg ccacccagcc gccggggtcc ggacgccgtc gccgcgccgc
     1741 cggggggcac cgagcgcagg cccaacggtc tgggccccga gcgcagcgcg ggcccggggg
     1801 gcgcagaggc cgaaccgctg cccacccagc tcaacggcgc ccctggcgag cccgcgccgg
     1861 ccgggccgcg cgacaccgac gcgctggacc tggaggagag ctcgtcttcc gaccacgccg
     1921 agcggcctcc agggccccgc agacccgagc gcggtccccg gggcaaaggc aaggcccgag
     1981 cgagccaggt gaagccgggc gacagcctgc cgcggcgcgg gccgggggcg acggggatcg
     2041 ggacgccggc tgcagggccg ggggaggagc gcgtcggggc tgccaaggcg tcgcgctggc
     2101 gcgggcggca gaaccgcgag aagcgcttca cgttcgtgct ggccgtggtc atcggagtgt
     2161 tcgtggtgtg ctggttcccc ttcttcttca cctacacgct cacggccgtc gggtgctccg
     2221 tgccacgcac gctcttcaaa ttcttcttct ggttcggcta ctgcaacagc tcgttgaacc
     2281 cggtcatcta caccatcttc aaccacgatt tccgccgcgc cttcaagaag atcctctgtc
     2341 ggggggacag gaagcggatc gtgtgaggtt tccgctggcg cccgcgtaga ctcacgctga
     2401 ctgcaggcag cggggggcat cgaggggtgc ttagccccag ggcactcaga aacccgggcg
     2461 ctgcctgctc tgcgtttcct cgtctggggt ggctctgcag cctcctgcgg gcgggcgtct
     2521 gctgctccta caagggaagc ttcttgctgc caggcccaca catccccagt tgttggtttg
     2581 gccactcttg acctggagcc atcttcctag tgggccaccc ctaatcacta ttgcttccta
     2641 aaggtatttt caccctcttc gcctggtaca gccctcacag ctcttcagag caagcactgg
     2701 actacaaggg catggctcac aaaaggttaa tggatggggg ttacctagcc ctggctaatt
     2761 ccccttccat tcccaactct ctctctcttt ttaaagaaaa atgctaaggg cagccctgcc
     2821 tgccctcccc atcccccgct gtaaatatac actatttttg atagcacaca tggggccccc
     2881 atatctcttg gccttggttt tgatgttgaa atcctggcct tgggagagat gccttccagg
     2941 cagacacagc tgtctggttc aggccaagcc cctttgcaat gcaagccctt tctggtgtta
     3001 tgaagtccct ctatgtcgtc gttttcacca gcaactggtg actgtccctt cgacacggac
     3061 ctgctttgag atttcctgac agggaaaaga tttctgtcca tttttttcct gtgcctaaca
     3121 gcataattgc cttttcctat gtaaatatta tgatggtgga tcaagacata agtaaatgag
     3181 cctttctgcc tcacatcagc cctgtgtata aagccattat tctctgatgc actgtttgcc
     3241 ccagtaactc actttaaaac ctctctttcc agtgttccct ctctccctcc agggccactg
     3301 cttgaagaag aatatgtatg tttctatctt gtatgtctgt gtgcccctcc tgccccgaaa
     3361 gtgctgacta tggggaaatc ttttagctgc tgtttttaga ctccaaggag tggaaattat
     3421 gtggaagaag caaacctgat acaatttgcc caaggtaaac agtttgaaaa gacaaatggg
     3481 cctgccaaac tgtacagttt cttccccaag agctgttagg tatcaaaatg ttgtcctttc
     3541 ccccctccgt gcttttctgg ttgagatcat gtcattgatg aactgccaaa gtcaggggag
     3601 gagggcagag actttgtgtt tacatctgca tttctacatg ttttagacag agacaattta
     3661 aggcctgcac tcttatttca ctaaagaaaa actaatgtca gcacatgttg ctaatgacag
     3721 tggatttttt tttaaataaa aaagtttaca gatcaaatgt gaaataaata tgaatggagt
     3781 ggtcctcttg tctgttatct gagttttcaa aagctttaag actctgggaa catctgattt
     3841 tatggatttt ttaaaaataa aaaatgtaca ttataaaaa
//
