LOCUS       NM_000678               2942 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens adrenoceptor alpha 1D (ADRA1D), mRNA.
ACCESSION   NM_000678
VERSION     NM_000678.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Wang,J., Ning,D., Xie,D., Chen,X., Cao,X. and Wan,C.
  TITLE     Functional Involvement of ADRA1D in Cutaneous Melanoma Progression
            and Angiogenesis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (5), 44-50 (2023)
   PUBMED   37571902
  REMARK    GeneRIF: Functional Involvement of ADRA1D in Cutaneous Melanoma
            Progression and Angiogenesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Gao,X., Enten,G.A., DeSantis,A.J., Volkman,B.F., Gaponenko,V. and
            Majetschak,M.
  TITLE     Characterization of heteromeric complexes between chemokine (C-X-C
            motif) receptor 4 and alpha1-adrenergic receptors utilizing
            intermolecular bioluminescence resonance energy transfer assays
  JOURNAL   Biochem Biophys Res Commun 528 (2), 368-375 (2020)
   PUBMED   32085899
  REMARK    GeneRIF: Characterization of heteromeric complexes between
            chemokine (C-X-C motif) receptor 4 and alpha1-adrenergic receptors
            utilizing intermolecular bioluminescence resonance energy transfer
            assays.
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Janezic,E.M., Lauer,S.M., Williams,R.G., Chungyoun,M., Lee,K.S.,
            Navaluna,E., Lau,H.T., Ong,S.E. and Hague,C.
  TITLE     N-glycosylation of alpha1D-adrenergic receptor N-terminal domain is
            required for correct trafficking, function, and biogenesis
  JOURNAL   Sci Rep 10 (1), 7209 (2020)
   PUBMED   32350295
  REMARK    GeneRIF: N-glycosylation of alpha1D-adrenergic receptor N-terminal
            domain is required for correct trafficking, function, and
            biogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Carmona-Rosas,G., Hernandez-Espinosa,D.A., Alcantara-Hernandez,R.,
            Alfonzo-Mendez,M.A. and Garcia-Sainz,J.A.
  TITLE     Distinct phosphorylation sites/clusters in the carboxyl terminus
            regulate alpha1D-adrenergic receptor subcellular localization and
            signaling
  JOURNAL   Cell Signal 53, 374-389 (2019)
   PUBMED   30419287
  REMARK    GeneRIF: The roles of adrenoceptor alpha 1D phosphorylation
            sites/clusters were investigated. Carboxyl terminus phosphorylation
            seems to control receptor's membrane localization. Intracellular
            loop 3 mutation caused agonist-induced sustained ERK1/2 activation.
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   Gao,X., Albee,L.J., Volkman,B.F., Gaponenko,V. and Majetschak,M.
  TITLE     Asymmetrical ligand-induced cross-regulation of chemokine (C-X-C
            motif) receptor 4 by alpha1-adrenergic receptors at the heteromeric
            receptor complex
  JOURNAL   Sci Rep 8 (1), 2730 (2018)
   PUBMED   29426850
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2942)
  AUTHORS   Esbenshade,T.A., Hirasawa,A., Tsujimoto,G., Tanaka,T., Yano,J.,
            Minneman,K.P. and Murphy,T.J.
  TITLE     Cloning of the human alpha 1d-adrenergic receptor and inducible
            expression of three human subtypes in SK-N-MC cells
  JOURNAL   Mol Pharmacol 47 (5), 977-985 (1995)
   PUBMED   7746284
REFERENCE   7  (bases 1 to 2942)
  AUTHORS   Schwinn,D.A., Johnston,G.I., Page,S.O., Mosley,M.J., Wilson,K.H.,
            Worman,N.P., Campbell,S., Fidock,M.D., Furness,L.M.,
            Parry-Smith,D.J. et al.
  TITLE     Cloning and pharmacological characterization of human alpha-1
            adrenergic receptors: sequence corrections and direct comparison
            with other species homologues
  JOURNAL   J Pharmacol Exp Ther 272 (1), 134-142 (1995)
   PUBMED   7815325
REFERENCE   8  (bases 1 to 2942)
  AUTHORS   Weinberg,D.H., Trivedi,P., Tan,C.P., Mitra,S., Perkins-Barrow,A.,
            Borkowski,D., Strader,C.D. and Bayne,M.
  TITLE     Cloning, expression and characterization of human alpha adrenergic
            receptors alpha 1a, alpha 1b and alpha 1c
  JOURNAL   Biochem Biophys Res Commun 201 (3), 1296-1304 (1994)
   PUBMED   8024574
REFERENCE   9  (bases 1 to 2942)
  AUTHORS   Schwinn,D.A. and Lomasney,J.W.
  TITLE     Pharmacologic characterization of cloned alpha 1-adrenoceptor
            subtypes: selective antagonists suggest the existence of a fourth
            subtype
  JOURNAL   Eur J Pharmacol 227 (4), 433-436 (1992)
   PUBMED   1359975
REFERENCE   10 (bases 1 to 2942)
  AUTHORS   Bruno,J.F., Whittaker,J., Song,J.F. and Berelowitz,M.
  TITLE     Molecular cloning and sequencing of a cDNA encoding a human alpha
            1A adrenergic receptor
  JOURNAL   Biochem Biophys Res Commun 179 (3), 1485-1490 (1991)
   PUBMED   1656955
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357040.14, S70782.1, U03864.1
            and AL121675.36.
            
            On May 17, 2019 this sequence version replaced NM_000678.3.
            
            Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of
            the G protein-coupled receptor superfamily. They activate mitogenic
            responses and regulate growth and proliferation of many cells.
            There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of
            which signal through the Gq/11 family of G-proteins and different
            subtypes show different patterns of activation. This gene encodes
            alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic
            receptor gene, this gene comprises 2 exons and a single intron that
            interrupts the coding region. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L31772.1, U03864.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379453.6/ ENSP00000368766.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AL357040.14        15738-16012         c
            276-321             S70782.1           4-49
            322-1199            U03864.1           49-926
            1200-1894           S70782.1           927-1621
            1895-2941           AL121675.36        100424-101470       c
            2942-2942           AL121675.36        100423-100423       c
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2942
                     /gene="ADRA1D"
                     /gene_synonym="ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR;
                     dJ779E11.2"
                     /note="adrenoceptor alpha 1D"
                     /db_xref="GeneID:146"
                     /db_xref="HGNC:HGNC:280"
                     /db_xref="MIM:104219"
     exon            1..1441
                     /gene="ADRA1D"
                     /gene_synonym="ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR;
                     dJ779E11.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..2049
                     /gene="ADRA1D"
                     /gene_synonym="ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR;
                     dJ779E11.2"
                     /note="adrenergic, alpha -1D-, receptor; adrenergic,
                     alpha-1A-, receptor; alpha-1D adrenoceptor; alpha-1D
                     adrenoreceptor; alpha-1A adrenergic receptor;
                     alpha-adrenergic receptor 1a"
                     /codon_start=1
                     /product="alpha-1D adrenergic receptor"
                     /protein_id="NP_000669.1"
                     /db_xref="CCDS:CCDS13079.1"
                     /db_xref="GeneID:146"
                     /db_xref="HGNC:HGNC:280"
                     /db_xref="MIM:104219"
                     /translation="MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVG
                     GVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVF
                     LAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLG
                     FWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILA
                     LLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCR
                     VYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLS
                     VRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGY
                     FNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCA
                     PSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTT
                     QLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSN
                     LRETDI"
     exon            1442..2942
                     /gene="ADRA1D"
                     /gene_synonym="ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR;
                     dJ779E11.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2862..2867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA1D"
                     /gene_synonym="ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR;
                     dJ779E11.2"
                     /note="hexamer: ATTAAA"
     polyA_site      2890
                     /gene="ADRA1D"
                     /gene_synonym="ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR;
                     dJ779E11.2"
                     /note="major polyA site"
     regulatory      2902..2907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA1D"
                     /gene_synonym="ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR;
                     dJ779E11.2"
                     /note="hexamer: ACTAAA"
     polyA_site      2921
                     /gene="ADRA1D"
                     /gene_synonym="ADRA1; ADRA1A; ADRA1R; ALPHA1; DAR;
                     dJ779E11.2"
ORIGIN      
        1 gggagcgccg cagtggccgc tgcctgcacc gcccggcccc ggagccgccg ctttgcccgc
       61 ttgccgggca cgctcagagc gccgcgcgcg tagcgggccc cggctcttcg gtgctactcc
      121 acggccggcc tcggggagcc cggccgccgc ccgggccagg cagctccgct ctcggacagc
      181 cgcgctccgc gtcacaggaa cttgggcagg accccgacgg gacccgtgcg cggagctgca
      241 tctggagccc cgcggctatg ccctgtgctc ccctccctgc cggccgctcg ttctgtgccc
      301 cggcccggcc accgacggcc gcgcgttgag atgactttcc gcgatctcct gagcgtcagt
      361 ttcgagggac cccgcccgga cagcagcgca gggggctcca gcgcgggcgg cggcgggggc
      421 agcgcgggcg gcgcggcccc ctcggagggc ccggcggtgg gcggcgtgcc ggggggcgcg
      481 ggcggcggcg gcggcgtggt gggcgcaggc agcggcgagg acaaccggag ctccgcgggg
      541 gagccgggga gcgcgggcgc gggcggcgac gtgaatggca cggcggccgt cgggggactg
      601 gtggtgagcg cgcagggcgt gggcgtgggc gtcttcctgg cagccttcat ccttatggcc
      661 gtggcaggta acctgcttgt catcctctca gtggcctgca accgccacct gcagaccgtc
      721 accaactatt tcatcgtgaa cctggccgtg gccgacctgc tgctgagcgc caccgtactg
      781 cccttctcgg ccaccatgga ggttctgggc ttctgggcct ttggccgcgc cttctgcgac
      841 gtatgggccg ccgtggacgt gctgtgctgc acggcctcca tcctcagcct ctgcaccatc
      901 tccgtggacc ggtacgtggg cgtgcgccac tcactcaagt acccagccat catgaccgag
      961 cgcaaggcgg ccgccatcct ggccctgctc tgggtcgtag ccctggtggt gtccgtaggg
     1021 cccctgctgg gctggaagga gcccgtgccc cctgacgagc gcttctgcgg tatcaccgag
     1081 gaggcgggct acgctgtctt ctcctccgtg tgctccttct acctgcccat ggcggtcatc
     1141 gtggtcatgt actgccgcgt gtacgtggtc gcgcgcagca ccacgcgcag cctcgaggcg
     1201 ggcgtcaagc gcgagcgagg caaggcctcc gaggtggtgc tgcgcatcca ctgtcgcggc
     1261 gcggccacgg gcgccgacgg ggcgcacggc atgcgcagcg ccaagggcca caccttccgc
     1321 agctcgctct ccgtgcgcct gctcaagttc tcccgtgaga agaaagcggc caagactctg
     1381 gccatcgtcg tgggtgtctt cgtgctctgc tggttccctt tcttctttgt cctgccgctc
     1441 ggctccttgt tcccgcagct gaagccatcg gagggcgtct tcaaggtcat cttctggctc
     1501 ggctacttca acagctgcgt gaacccgctc atctacccct gttccagccg cgagttcaag
     1561 cgcgccttcc tccgtctcct gcgctgccag tgccgtcgtc gccggcgccg ccgccctctc
     1621 tggcgtgtct acggccacca ctggcgggcc tccaccagcg gcctgcgcca ggactgcgcc
     1681 ccgagttcgg gcgacgcgcc ccccggagcg ccgctggccc tcaccgcgct ccccgacccc
     1741 gaccccgaac ccccaggcac gcccgagatg caggctccgg tcgccagccg tcgaaagcca
     1801 cccagcgcct tccgcgagtg gaggctgctg gggccgttcc ggagacccac gacccagctg
     1861 cgcgccaaag tctccagcct gtcgcacaag atccgcgccg ggggcgcgca gcgcgcagag
     1921 gcagcgtgcg cccagcgctc agaggtggag gctgtgtccc taggcgtccc acacgaggtg
     1981 gccgagggcg ccacctgcca ggcctacgaa ttggccgact acagcaacct acgggagacc
     2041 gatatttaag gaccccagag ctaggccgcg gagtgtgctg ggcttggggg taagggggac
     2101 cagagaggcg ggctggtgtt ctaagagccc ccgtgcaaat cggagacccg gaaactgatc
     2161 agggcagctg ctctgtgaca tccctgagga actgggcaga gcttgaggct ggagcccttg
     2221 aaaggtgaaa agtagtgggg ccccctgctg gactcaggtg cccagaactc ttttcttaga
     2281 agggagaggc tgcgggctcc gtggggcctt ttgctcccaa tccctatttg agaaacactg
     2341 ccccatcctc catgccctga accctgagta gacagcccca agcatggcca ggaaggcctg
     2401 cccctcctct tctgggaaat aggcacagaa gctttggccg gctaccccag tgcctccctt
     2461 agggaaaaag tcagtgggac cagggctcct cagtggacaa atttctcctt cttactgcca
     2521 actggaggaa cccagtggac ctaccaccac ccacaagctt tggtggcaga ttgtatagcc
     2581 gtcatacaag cctgctgtat ttatccatgg gcccgctgtc cgccacccag gctcctccgt
     2641 gcacacccca tcacctggcc cctacccctt attacttccc ctcaagggcc ttactgttta
     2701 cactctgtac atagctcatc gtgcctgtgc ccatcacttc ttgctgggat tccaagccac
     2761 caattggaga gctttatttg tcattttgag acatatttat tggtaagagt acttctattt
     2821 tgtccaagct gtgcaaactg tccctcttta gcccataacc cattaaaaaa aaaatacttt
     2881 ttcccctaaa gtctgtcaag aactaaaggc ccgcaacaga atagattggg tctacatttg
     2941 cc
//
