LOCUS       NM_000679               2507 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens adrenoceptor alpha 1B (ADRA1B), mRNA.
ACCESSION   NM_000679
VERSION     NM_000679.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Masukawa,D., Takahagi,R., Nakao,Y. and Goshima,Y.
  TITLE     L-DOPA Receptor GPR143 Functionally Couples with Adrenergic alpha1B
            Receptor at the Second Transmembrane Interface
  JOURNAL   Biol Pharm Bull 46 (7), 869-873 (2023)
   PUBMED   37394637
  REMARK    GeneRIF: L-DOPA Receptor GPR143 Functionally Couples with
            Adrenergic alpha1B Receptor at the Second Transmembrane Interface.
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Renkhold,L., Kollmann,R., Inderwiedenstrasse,L. and Kienitz,M.C.
  TITLE     PKC-isoform specific regulation of receptor desensitization and
            KCNQ1/KCNE1 K+ channel activity by mutant alpha1B-adrenergic
            receptors
  JOURNAL   Cell Signal 91, 110228 (2022)
   PUBMED   34958868
  REMARK    GeneRIF: PKC-isoform specific regulation of receptor
            desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant
            alpha1B-adrenergic receptors.
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Gao,X., Enten,G.A., DeSantis,A.J., Volkman,B.F., Gaponenko,V. and
            Majetschak,M.
  TITLE     Characterization of heteromeric complexes between chemokine (C-X-C
            motif) receptor 4 and alpha1-adrenergic receptors utilizing
            intermolecular bioluminescence resonance energy transfer assays
  JOURNAL   Biochem Biophys Res Commun 528 (2), 368-375 (2020)
   PUBMED   32085899
  REMARK    GeneRIF: Characterization of heteromeric complexes between
            chemokine (C-X-C motif) receptor 4 and alpha1-adrenergic receptors
            utilizing intermolecular bioluminescence resonance energy transfer
            assays.
REFERENCE   4  (bases 1 to 2507)
  AUTHORS   Hernandez-Espinosa,D.A., Reyes-Cruz,G. and Garcia-Sainz,J.A.
  TITLE     Roles of the G protein-coupled receptor kinase 2 and Rab5 in
            alpha1B-adrenergic receptor function and internalization
  JOURNAL   Eur J Pharmacol 867, 172846 (2020)
   PUBMED   31811856
  REMARK    GeneRIF: Study data indicate that GRK2 and RAB5 play key roles in
            alpha1B-adrenergic receptor phosphorylation, internalization, and
            desensitization. The possibility that RAB5 might form part of a
            signaling complex is suggested, as well as that GDP-Rab5 might
            interfere with the ability of GRK2 to catalyze alpha1B-adrenergic
            receptor phosphorylation.
REFERENCE   5  (bases 1 to 2507)
  AUTHORS   Wijaya,L.K., Stumbles,P.A. and Drummond,P.D.
  TITLE     Tumor necrosis factor alpha induces alpha1B-adrenergic receptor
            expression in keratinocytes
  JOURNAL   Cytokine 125, 154851 (2020)
   PUBMED   31520851
  REMARK    GeneRIF: Tumor necrosis factor alpha induces alpha1B-adrenergic
            receptor expression in keratinocytes.
REFERENCE   6  (bases 1 to 2507)
  AUTHORS   Warrington,J.A. and Bengtsson,U.
  TITLE     High-resolution physical mapping of human 5q31-q33 using three
            methods: radiation hybrid mapping, interphase fluorescence in situ
            hybridization, and pulsed-field gel electrophoresis
  JOURNAL   Genomics 24 (2), 395-398 (1994)
   PUBMED   7698768
REFERENCE   7  (bases 1 to 2507)
  AUTHORS   Ramarao,C.S., Denker,J.M., Perez,D.M., Gaivin,R.J., Riek,R.P. and
            Graham,R.M.
  TITLE     Genomic organization and expression of the human alpha
            1B-adrenergic receptor
  JOURNAL   J Biol Chem 267 (30), 21936-21945 (1992)
   PUBMED   1328250
REFERENCE   8  (bases 1 to 2507)
  AUTHORS   Allen,L.F., Lefkowitz,R.J., Caron,M.G. and Cotecchia,S.
  TITLE     G-protein-coupled receptor genes as protooncogenes: constitutively
            activating mutation of the alpha 1B-adrenergic receptor enhances
            mitogenesis and tumorigenicity
  JOURNAL   Proc Natl Acad Sci U S A 88 (24), 11354-11358 (1991)
   PUBMED   1662393
REFERENCE   9  (bases 1 to 2507)
  AUTHORS   Lomasney,J.W., Cotecchia,S., Lorenz,W., Leung,W.Y., Schwinn,D.A.,
            Yang-Feng,T.L., Brownstein,M., Lefkowitz,R.J. and Caron,M.G.
  TITLE     Molecular cloning and expression of the cDNA for the alpha
            1A-adrenergic receptor. The gene for which is located on human
            chromosome 5
  JOURNAL   J Biol Chem 266 (10), 6365-6369 (1991)
   PUBMED   1706716
REFERENCE   10 (bases 1 to 2507)
  AUTHORS   Yang-Feng,T.L., Xue,F.Y., Zhong,W.W., Cotecchia,S., Frielle,T.,
            Caron,M.G., Lefkowitz,R.J. and Francke,U.
  TITLE     Chromosomal organization of adrenergic receptor genes
  JOURNAL   Proc Natl Acad Sci U S A 87 (4), 1516-1520 (1990)
   PUBMED   2154750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011343.3, U03865.1,
            BQ576306.1 and AC068657.6.
            
            On Nov 24, 2018 this sequence version replaced NM_000679.3.
            
            Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of
            the G protein-coupled receptor superfamily. They activate mitogenic
            responses and regulate growth and proliferation of many cells.
            There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of
            which signal through the Gq/11 family of G-proteins and different
            subtypes show different patterns of activation. This gene encodes
            alpha-1B-adrenergic receptor, which induces neoplastic
            transformation when transfected into NIH 3T3 fibroblasts and other
            cell lines. Thus, this normal cellular gene is identified as a
            protooncogene. This gene comprises 2 exons and a single large
            intron of at least 20 kb that interrupts the coding region.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U03865.1, BC136568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306675.5/ ENSP00000306662.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC011343.3         80861-81111
            252-401             AC011343.3         81112-81261
            402-2039            U03865.1           101-1738
            2040-2505           BQ576306.1         19-484              c
            2506-2507           AC068657.6         53735-53736
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..2507
                     /gene="ADRA1B"
                     /gene_synonym="ADRA1; ALPHA1BAR"
                     /note="adrenoceptor alpha 1B"
                     /db_xref="GeneID:147"
                     /db_xref="HGNC:HGNC:278"
                     /db_xref="MIM:104220"
     exon            1..1373
                     /gene="ADRA1B"
                     /gene_synonym="ADRA1; ALPHA1BAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..1987
                     /gene="ADRA1B"
                     /gene_synonym="ADRA1; ALPHA1BAR"
                     /note="alpha-1B adrenoceptor; alpha-1B adrenoreceptor;
                     adrenergic, alpha-1B-, receptor"
                     /codon_start=1
                     /product="alpha-1B adrenergic receptor"
                     /protein_id="NP_000670.1"
                     /db_xref="CCDS:CCDS4347.1"
                     /db_xref="GeneID:147"
                     /db_xref="HGNC:HGNC:278"
                     /db_xref="MIM:104220"
                     /translation="MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITR
                     AISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFS
                     AALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRR
                     KAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAV
                     ILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPR
                     SSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVF
                     WLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWT
                     RGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAP
                     GALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPG
                     FKSNMPLAPGQF"
     exon            1374..2507
                     /gene="ADRA1B"
                     /gene_synonym="ADRA1; ALPHA1BAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2486..2491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADRA1B"
                     /gene_synonym="ADRA1; ALPHA1BAR"
                     /note="hexamer: ATTAAA"
     polyA_site      2507
                     /gene="ADRA1B"
                     /gene_synonym="ADRA1; ALPHA1BAR"
                     /note="major polyA site"
ORIGIN      
        1 agtcagccca gaagcggctc attgaaagca gaccctcttc ggcgctcgct gggcggagga
       61 cgcgccgcgg tccgcagacc cgagcgagct gggcaccgcc gggcgccccc ggccctgccg
      121 ccccctcctc cccgccgctc ccccgcgagc ccggccaggc gcgcctgacg tggaccatta
      181 aacttggagc tgccgcctcg tcccctctcc tcctcctcct ccctctgaca ggcgagcgag
      241 cgactcggtg caggcaggag acgtgctgcc gggctgggct gcccggggga gatgactcct
      301 cgccaggagg gcgcctctgg gaagaagacc acgggggaag caaagtttca gggcagctga
      361 ggagccttcg ccgcagccct tccgagccca atcatccccc tggctatgga gggcggactc
      421 taagatgaat cccgacctgg acaccggcca caacacatca gcacctgccc actggggaga
      481 gttgaaaaat gccaacttca ctggccccaa ccagacctcg agcaactcca cactgcccca
      541 gctggacatc accagggcca tctctgtggg cctggtgctg ggcgccttca tcctctttgc
      601 catcgtgggc aacatcctag tcatcttgtc tgtggcctgc aaccggcacc tgcggacgcc
      661 caccaactac ttcattgtca acctggccat ggccgacctg ctgttgagct tcaccgtcct
      721 gcccttctca gcggccctag aggtgctcgg ctactgggtg ctggggcgga tcttctgtga
      781 catctgggca gccgtggatg tcctgtgctg cacagcgtcc attctgagcc tgtgcgccat
      841 ctccatcgat cgctacatcg gggtgcgcta ctctctgcag tatcccacgc tggtcacccg
      901 gaggaaggcc atcttggcgc tgctcagtgt ctgggtcttg tccaccgtca tctccatcgg
      961 gcctctcctt gggtggaagg agccggcacc caacgatgac aaggagtgcg gggtcaccga
     1021 agaacccttc tatgccctct tctcctctct gggctccttc tacatccctc tggcggtcat
     1081 tctagtcatg tactgccgtg tctatatagt ggccaagaga accaccaaga acctagaggc
     1141 aggagtcatg aaggagatgt ccaactccaa ggagctgacc ctgaggatcc attccaagaa
     1201 ctttcacgag gacaccctta gcagtaccaa ggccaagggc cacaacccca ggagttccat
     1261 agctgtcaaa ctttttaagt tctccaggga aaagaaagca gctaagacgt tgggcattgt
     1321 ggtcggtatg ttcatcttgt gctggctacc cttcttcatc gctctaccgc ttggctcctt
     1381 gttctccacc ctgaagcccc ccgacgccgt gttcaaggtg gtgttctggc tgggctactt
     1441 caacagctgc ctcaacccca tcatctaccc atgctccagc aaggagttca agcgcgcttt
     1501 cgtgcgcatc ctcgggtgcc agtgccgcgg ccgcggccgc cgccgacgcc gccgccgccg
     1561 tcgcctgggc ggctgcgcct acacctaccg gccgtggacg cgcggcggct cgctggagcg
     1621 ctcgcagtcg cgcaaggact cgctggacga cagcggcagc tgcctgagcg gcagccagcg
     1681 gaccctgccc tcggcctcgc cgagcccggg ctacctgggc cgcggcgcgc caccgccagt
     1741 cgagctgtgc gccttccccg agtggaaggc gcccggcgcc ctcctgagcc tgcccgcgcc
     1801 tgagcccccc ggccgccgcg gccgccacga ctcgggcccg ctcttcacct tcaagctcct
     1861 gaccgagccc gagagccccg ggaccgacgg cggcgccagc aacggaggct gcgaggccgc
     1921 ggccgacgtg gccaacgggc agccgggctt caaaagcaac atgcccctgg cgcccgggca
     1981 gttttagggc ccccgtgcgc agctttcttt ccctggggag gaaaacatcg tgggggggag
     2041 gggagggcgg ggcggagggg ggaggggagc gtccacgccg ggtagacgcg cgccccaagg
     2101 ggaaccgggg ggagggccgg ggagaggggc agctgctttt ctggcagggg catgggtgcc
     2161 aggtaccacg cggaaagccg ggccgagcat gctgagagcc tgggggaccc gacgccgccg
     2221 ggatttacct ctctctctcc ctctgtgtat atataaacga gtccctctct acttgtattt
     2281 aaccgtgggt gcacgtgagt gtgactgtgc ggtgtgcgtg tgttccgctt gtgtgtgtgc
     2341 gtggggccgc cctgtgaggg cgcggcgact gtgcgcccag gaggcaaccg ggggcgttgt
     2401 gtgtgtcgtg acttcgtacc tctcaagccc ctccttgtac ttcactgaag gatggcactt
     2461 tggtggggtt ggaaacaaag tcgacattaa aggtcatttc tcctgtt
//
