LOCUS       NM_033302               4920 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens adrenoceptor alpha 1A (ADRA1A), transcript variant 3,
            mRNA.
ACCESSION   NM_033302
VERSION     NM_033302.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4920)
  AUTHORS   Ren,C., Cui,L., Li,R., Song,X., Li,J., Xi,Q., Zhang,Z. and Zhao,L.
  TITLE     Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning
            as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A
            Pathway
  JOURNAL   Horm Metab Res 55 (12), 876-884 (2023)
   PUBMED   37820700
  REMARK    GeneRIF: Hsa_circ_0080608 Attenuates Lung Cancer Progression by
            Functioning as a Competitive Endogenous RNA to Regulate the
            miR-661/ADRA1A Pathway.
REFERENCE   2  (bases 1 to 4920)
  AUTHORS   Chechekhin,V., Ivanova,A., Kulebyakin,K., Sysoeva,V., Naida,D.,
            Arbatsky,M., Basalova,N., Karagyaur,M., Skryabina,M., Efimenko,A.,
            Grigorieva,O., Kalinina,N., Tkachuk,V. and Tyurin-Kuzmin,P.
  TITLE     Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent
            Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven
            Hypertension
  JOURNAL   Cells 12 (4), 585 (2023)
   PUBMED   36831252
  REMARK    GeneRIF: Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose
            Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of
            Obesity-Driven Hypertension.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4920)
  AUTHORS   Zhang,J., Fu,X., Lu,Y., Cheng,C., Wang,K., Zhu,Y. and Xie,Q.
  TITLE     Hypermethylation in the promoter region of the ADRA1A gene is
            associated with opioid use disorder in Han Chinese
  JOURNAL   Brain Res 1793, 148050 (2022)
   PUBMED   35964682
  REMARK    GeneRIF: Hypermethylation in the promoter region of the ADRA1A gene
            is associated with opioid use disorder in Han Chinese.
REFERENCE   4  (bases 1 to 4920)
  AUTHORS   Baranova,T., Podyacheva,E., Zemlyanukhina,T., Berlov,D.,
            Danilova,M., Glotov,O. and Glotov,A.
  TITLE     Vascular Reactions of the Diving Reflex in Men and Women Carrying
            Different ADRA1A Genotypes
  JOURNAL   Int J Mol Sci 23 (16), 9433 (2022)
   PUBMED   36012699
  REMARK    GeneRIF: Vascular Reactions of the Diving Reflex in Men and Women
            Carrying Different ADRA1A Genotypes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4920)
  AUTHORS   Zhao,W. and Liu,X.
  TITLE     MiR-3682 promotes the progression of hepatocellular carcinoma (HCC)
            via inactivating AMPK signaling by targeting ADRA1A
  JOURNAL   Ann Hepatol 27 Suppl 1, 100570 (2022)
   PUBMED   34706275
  REMARK    GeneRIF: MiR-3682 promotes the progression of hepatocellular
            carcinoma (HCC) via inactivating AMPK signaling by targeting
            ADRA1A.
REFERENCE   6  (bases 1 to 4920)
  AUTHORS   Coge,F., Guenin,S.P., Renouard-Try,A., Rique,H., Ouvry,C.,
            Fabry,N., Beauverger,P., Nicolas,J.P., Galizzi,J.P., Boutin,J.A.
            and Canet,E.
  TITLE     Truncated isoforms inhibit [3H]prazosin binding and cellular
            trafficking of native human alpha1A-adrenoceptors
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 231-239 (1999)
   PUBMED   10493934
REFERENCE   7  (bases 1 to 4920)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   8  (bases 1 to 4920)
  AUTHORS   Hirasawa,A., Shibata,K., Horie,K., Takei,Y., Obika,K., Tanaka,T.,
            Muramoto,N., Takagaki,K., Yano,J. and Tsujimoto,G.
  TITLE     Cloning, functional expression and tissue distribution of human
            alpha 1c-adrenoceptor splice variants
  JOURNAL   FEBS Lett 363 (3), 256-260 (1995)
   PUBMED   7737411
REFERENCE   9  (bases 1 to 4920)
  AUTHORS   Hoehe,M.R., Berrettini,W.H., Schwinn,D.A. and Hsieh,W.T.
  TITLE     A two-allele PstI RFLP for the alpha-1C adrenergic receptor gene
            (ADRA1C)
  JOURNAL   Hum Mol Genet 1 (5), 349 (1992)
   PUBMED   1363873
REFERENCE   10 (bases 1 to 4920)
  AUTHORS   Schwinn,D.A., Lomasney,J.W., Lorenz,W., Szklut,P.J., Fremeau,R.T.
            Jr., Yang-Feng,T.L., Caron,M.G., Lefkowitz,R.J. and Cotecchia,S.
  TITLE     Molecular cloning and expression of the cDNA for a novel alpha
            1-adrenergic receptor subtype
  JOURNAL   J Biol Chem 265 (14), 8183-8189 (1990)
   PUBMED   1970822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289548.1, AC022839.8,
            AK311558.1, D32201.1, AC091675.5, AC015564.13, BX101935.1 and
            AA568306.1.
            
            On Apr 13, 2016 this sequence version replaced NM_033302.2.
            
            Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of
            the G protein-coupled receptor superfamily. They activate mitogenic
            responses and regulate growth and proliferation of many cells.
            There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of
            which signal through the Gq/11 family of G-proteins and different
            subtypes show different patterns of activation. This gene encodes
            alpha-1A-adrenergic receptor. Alternative splicing of this gene
            generates four transcript variants, which encode four different
            isoforms with distinct C-termini but having similar ligand binding
            properties. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) encodes isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.214636.1,
                                           SRR1803614.116008.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AK289548.1         310-465
            157-180             AC022839.8         121352-121375
            181-250             AK311558.1         441-510
            251-1722            D32201.1           1-1472
            1723-1728           AC091675.5         84568-84573
            1729-2339           D32201.1           1479-2089
            2340-4123           AC015564.13        191642-193425       c
            4124-4510           BX101935.1         1-387
            4511-4920           AA568306.1         34-443
FEATURES             Location/Qualifiers
     source          1..4920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..4920
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /note="adrenoceptor alpha 1A"
                     /db_xref="GeneID:148"
                     /db_xref="HGNC:HGNC:277"
                     /db_xref="MIM:104221"
     exon            1..1569
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             687..1976
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /note="isoform 3 is encoded by transcript variant 3; G
                     protein coupled receptor; alpha-1A adrenoceptor; alpha-1A
                     adrenoreceptor; alpha-1C adrenergic receptor"
                     /codon_start=1
                     /product="alpha-1A adrenergic receptor isoform 3"
                     /protein_id="NP_150645.2"
                     /db_xref="CCDS:CCDS6052.1"
                     /db_xref="GeneID:148"
                     /db_xref="HGNC:HGNC:277"
                     /db_xref="MIM:104221"
                     /translation="MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGN
                     ILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIW
                     AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIG
                     PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGL
                     KSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGI
                     VVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK
                     KAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTD
                     GVCEWKFFSSMPRGSARITVSKDQSSCTTARGHTPMT"
     exon            1570..1955
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1956..4920
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtggacgcgg tcaaacgatg ccccgcagcc tcctgggtct cagcacatat tccacaccta
       61 cgtcccctga cctgtgctcc tagaagctgg agagagcagg agccttcggt ggggcagctc
      121 aaaatgtagg taactgcggg ccaggagcag cgcccaacct gtagcgctgc gctacccaac
      181 catcggtccc tgcctttgag cgtcgacggc tgatcttttg gtttgaggga gagactggcg
      241 ctggagtttt gaattccgaa tcatgtgcag aatgctgaat cttcccccag ccaggacgaa
      301 taagacagcg cggaaaagca gattctcgta attctggaat tgcatgttgc aaggagtctc
      361 ctggatcttc gcacccagct tcgggtaggg agggagtccg ggtcccgggc taggccagcc
      421 cggcaggtgg agagggtccc cggcagcccc gcgcgcccct ggccatgtct ttaatgccct
      481 gccccttcat gtggccttct gagggttccc agggctggcc agggttgttt cccacccgcg
      541 cgcgcgctct cacccccagc caaacccacc tggcagggct ccctccagcc gagacctttt
      601 gattcccggc tcccgcgctc ccgcctccgc gccagcccgg gaggtggccc tggacagccg
      661 gacctcgccc ggccccggct gggaccatgg tgtttctctc gggaaatgct tccgacagct
      721 ccaactgcac ccaaccgccg gcaccggtga acatttccaa ggccattctg ctcggggtga
      781 tcttgggggg cctcattctt ttcggggtgc tgggtaacat cctagtgatc ctctccgtag
      841 cctgtcaccg acacctgcac tcagtcacgc actactacat cgtcaacctg gcggtggccg
      901 acctcctgct cacctccacg gtgctgccct tctccgccat cttcgaggtc ctaggctact
      961 gggccttcgg cagggtcttc tgcaacatct gggcggcagt ggatgtgctg tgctgcaccg
     1021 cgtccatcat gggcctctgc atcatctcca tcgaccgcta catcggcgtg agctacccgc
     1081 tgcgctaccc aaccatcgtc acccagagga ggggtctcat ggctctgctc tgcgtctggg
     1141 cactctccct ggtcatatcc attggacccc tgttcggctg gaggcagccg gcccccgagg
     1201 acgagaccat ctgccagatc aacgaggagc cgggctacgt gctcttctca gcgctgggct
     1261 ccttctacct gcctctggcc atcatcctgg tcatgtactg ccgcgtctac gtggtggcca
     1321 agagggagag ccggggcctc aagtctggcc tcaagaccga caagtcggac tcggagcaag
     1381 tgacgctccg catccatcgg aaaaacgccc cggcaggagg cagcgggatg gccagcgcca
     1441 agaccaagac gcacttctca gtgaggctcc tcaagttctc ccgggagaag aaagcggcca
     1501 aaacgctggg catcgtggtc ggctgcttcg tcctctgctg gctgcctttt ttcttagtca
     1561 tgcccattgg gtctttcttc cctgatttca agccctctga aacagttttt aaaatagtat
     1621 tttggctcgg atatctaaac agctgcatca accccatcat atacccatgc tccagccaag
     1681 agttcaaaaa ggcctttcag aatgtcttga gaatccagtg tctctgcaga aagcagtctt
     1741 ccaaacatgc cctgggctac accctgcacc cgcccagcca ggccgtggaa gggcaacaca
     1801 aggacatggt gcgcatcccc gtgggatcaa gagagacctt ctacaggatc tccaagacgg
     1861 atggcgtttg tgaatggaaa tttttctctt ccatgccccg tggatctgcc aggattacag
     1921 tgtccaaaga ccaatcctcc tgtaccacag cccggggaca cacacccatg acatgaagcc
     1981 agcttcccgt ccacgactgt tgtccttact gcccaaggaa ggggagcatg aaacccacca
     2041 ctggtcctgc gacccactgt ctttggaatc caccccagga gcccaggagc cttgcctgac
     2101 acttggattt acttctttat caagcatcca tctgactaag gcacaaatcc aacatgttac
     2161 tgttactgat acaggaaaaa cagtaactta aggaatgatc atgaatgcaa agggaaagag
     2221 gaaaagagcc ttcagggaca aatagctcga ttttttgtaa atcagtttca tacaacctcc
     2281 ctcccccatt tcattcttaa aagttaattg agaatcatca gccacgtgta gggtgtgagg
     2341 aattccataa ggcaccccag tttcttcaat aagtaaatgg catttttaaa aggggaactt
     2401 ttatgggtta aaatattctt aagagatgta ttcatcaagt atactgtaca agccttgttc
     2461 atttagattg aaacaaagtg taaaaagaca tttttgaagt aattggagaa aattaagcat
     2521 aggctgtgtc ctattagatg ttagataatt agatcgttat tttaaatttt gttggatgtg
     2581 ataatggcat tgtccttaac tggtaagtgc atatcgaagt atgtttgcaa tttgctttaa
     2641 agttttattg ccaaaagtgg ggaagcaagt gtgatagatg aaataagaat ggcaggcaag
     2701 gccacatgcc gttcttccat gtttgtgcat gtttgaaatt tttcagaata aaatatttta
     2761 aaagaaaaaa aaagttaggc acatttaact tgtaaaagtt agtgtccctc aaattctaga
     2821 acattcatag acatgaaaat caccctgcaa aacaaaatcc ccttcgttca aagagagctg
     2881 ctcttgcagt ctctgctctc tcatttcttt attcactcta taatattcag tgtggggtta
     2941 ctgtgctcca gcgccaagtc cagggggtgg agaataacaa gggcagagac atagtccttg
     3001 ccctccaagc acctgtgatg gtaatacagt gccatgggag cttggtgaag ggcctcagcc
     3061 ggctgcagag ttaggcttat caaaagtggt gatctctacg gtgaatcctg gaggacacaa
     3121 tggggtgggg aacagaaaca gttgttccag gcaaagaagg gaggaatctg tgccaaggcc
     3181 caggggctgg tgaacctcag gcgtgtgctg ggggtgctgc ctcctcccaa atgtcggggc
     3241 acagggaagt cagtctcgct tatcatggtg gccacttggc tctacaaacc cccattgccc
     3301 aagtccccac aggcaaacca cacaactgct cttcttctca ctcttttttt taagccaaga
     3361 aagaactcac tgaaacagcc agtcagtcag ggatgagtcc aaggctttcc tgacagagtg
     3421 accatgtttg gcttggctga aaatcacaaa gccttggttt cccagttgcg tgattctctt
     3481 tgttctcaag gcttagtgca gcattacagt gggatggcta aacagagaaa aaaaaaaaaa
     3541 ggaggtctat ttctttctct tcatacaaat aaatatttgc ccaagaatgg aagtgcttaa
     3601 ttcttaagaa taaccaaatg ctttggactt cttaacaagc aaatcatata caaagcaatt
     3661 cagtgttcct actaattgag aaattgtttt tagcaagaag atgttatgca gcatgttttt
     3721 aaaaaacaag tttttccaac aacaacaaca acaacaaaaa gaaaaaacag aaaataactg
     3781 aatcactata atatccccaa aggctggctt tcacaccatc caagggtcac agctcacgct
     3841 acattgaagc gtatgaaaga gtgtctgctt gtgttacaaa cctgatggag cagaggtggg
     3901 gcagggggga aatgaaagca aaagggacag acttgaagct gcacttttgc aatcaactaa
     3961 cagttaggaa ggacttgact tgctggggct aaggaaaaca aatctggagg ttcattttgc
     4021 ctgtgaaatt aaaattatac tttagtaaat aaagctgacg ccatttaacc atgaacccgg
     4081 tgacatttcc tggcttgctg cagcgtttct gcttgtctcc ttgttacatt tgtttaaaat
     4141 acaaacacag catttccatg ttgccagaga agcaaatgtg ggctgactgg ctgattttag
     4201 ctgctatggt ttttctgtaa cctttaacaa ttgttgtgac aaataagatt ccatgtaagg
     4261 tgcaatttct aactgtgcag tgtttgtgaa ccacatccac cttctccagg tttggtattt
     4321 ggtcgactaa gttgacgatg tcattacctt tccttccatt taaaaaaaaa agttaatctg
     4381 aatcgtgctg agagtttggt atgcacgcta tactattcaa gggagcattc tcttctgtgt
     4441 cagaataata tatttatgtg tgtgaatcat tatacttgaa tttgtggcaa cattttgtat
     4501 caatgaatat atatgacacc caggctgact acaatggctt caaagagttt aatttctctt
     4561 aaatggactc agtatccttg gaatgtgctg tttaagtgtt tctgaatttt ctacacgcca
     4621 tttttacagg tccatctgtt tatgatgtga tgagataaac aatcacgttg attttatgtt
     4681 tcttttcaaa gaaaatgaat gtatatagta ctaagcagat gaataaatta ttgaaaaaat
     4741 atacttcatg gatcatgccc actgataaaa atgaatttat tttatttgtt gaacaaactg
     4801 actgttcaaa ttataagaat ttatattgtc cttattaata tgaatgccat ctatttaagt
     4861 gttgttcaat attgatatgt gttctctaat aaaatatttt aaacctcttt ctttaaacac
//
