LOCUS       NM_000680               3770 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens adrenoceptor alpha 1A (ADRA1A), transcript variant 1,
            mRNA.
ACCESSION   NM_000680 XM_005273414
VERSION     NM_000680.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3770)
  AUTHORS   Ren,C., Cui,L., Li,R., Song,X., Li,J., Xi,Q., Zhang,Z. and Zhao,L.
  TITLE     Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning
            as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A
            Pathway
  JOURNAL   Horm Metab Res 55 (12), 876-884 (2023)
   PUBMED   37820700
  REMARK    GeneRIF: Hsa_circ_0080608 Attenuates Lung Cancer Progression by
            Functioning as a Competitive Endogenous RNA to Regulate the
            miR-661/ADRA1A Pathway.
REFERENCE   2  (bases 1 to 3770)
  AUTHORS   Chechekhin,V., Ivanova,A., Kulebyakin,K., Sysoeva,V., Naida,D.,
            Arbatsky,M., Basalova,N., Karagyaur,M., Skryabina,M., Efimenko,A.,
            Grigorieva,O., Kalinina,N., Tkachuk,V. and Tyurin-Kuzmin,P.
  TITLE     Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent
            Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven
            Hypertension
  JOURNAL   Cells 12 (4), 585 (2023)
   PUBMED   36831252
  REMARK    GeneRIF: Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose
            Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of
            Obesity-Driven Hypertension.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3770)
  AUTHORS   Zhang,J., Fu,X., Lu,Y., Cheng,C., Wang,K., Zhu,Y. and Xie,Q.
  TITLE     Hypermethylation in the promoter region of the ADRA1A gene is
            associated with opioid use disorder in Han Chinese
  JOURNAL   Brain Res 1793, 148050 (2022)
   PUBMED   35964682
  REMARK    GeneRIF: Hypermethylation in the promoter region of the ADRA1A gene
            is associated with opioid use disorder in Han Chinese.
REFERENCE   4  (bases 1 to 3770)
  AUTHORS   Baranova,T., Podyacheva,E., Zemlyanukhina,T., Berlov,D.,
            Danilova,M., Glotov,O. and Glotov,A.
  TITLE     Vascular Reactions of the Diving Reflex in Men and Women Carrying
            Different ADRA1A Genotypes
  JOURNAL   Int J Mol Sci 23 (16), 9433 (2022)
   PUBMED   36012699
  REMARK    GeneRIF: Vascular Reactions of the Diving Reflex in Men and Women
            Carrying Different ADRA1A Genotypes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3770)
  AUTHORS   Zhao,W. and Liu,X.
  TITLE     MiR-3682 promotes the progression of hepatocellular carcinoma (HCC)
            via inactivating AMPK signaling by targeting ADRA1A
  JOURNAL   Ann Hepatol 27 Suppl 1, 100570 (2022)
   PUBMED   34706275
  REMARK    GeneRIF: MiR-3682 promotes the progression of hepatocellular
            carcinoma (HCC) via inactivating AMPK signaling by targeting
            ADRA1A.
REFERENCE   6  (bases 1 to 3770)
  AUTHORS   Coge,F., Guenin,S.P., Renouard-Try,A., Rique,H., Ouvry,C.,
            Fabry,N., Beauverger,P., Nicolas,J.P., Galizzi,J.P., Boutin,J.A.
            and Canet,E.
  TITLE     Truncated isoforms inhibit [3H]prazosin binding and cellular
            trafficking of native human alpha1A-adrenoceptors
  JOURNAL   Biochem J 343 Pt 1 (Pt 1), 231-239 (1999)
   PUBMED   10493934
REFERENCE   7  (bases 1 to 3770)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
REFERENCE   8  (bases 1 to 3770)
  AUTHORS   Hirasawa,A., Shibata,K., Horie,K., Takei,Y., Obika,K., Tanaka,T.,
            Muramoto,N., Takagaki,K., Yano,J. and Tsujimoto,G.
  TITLE     Cloning, functional expression and tissue distribution of human
            alpha 1c-adrenoceptor splice variants
  JOURNAL   FEBS Lett 363 (3), 256-260 (1995)
   PUBMED   7737411
REFERENCE   9  (bases 1 to 3770)
  AUTHORS   Hoehe,M.R., Berrettini,W.H., Schwinn,D.A. and Hsieh,W.T.
  TITLE     A two-allele PstI RFLP for the alpha-1C adrenergic receptor gene
            (ADRA1C)
  JOURNAL   Hum Mol Genet 1 (5), 349 (1992)
   PUBMED   1363873
REFERENCE   10 (bases 1 to 3770)
  AUTHORS   Schwinn,D.A., Lomasney,J.W., Lorenz,W., Szklut,P.J., Fremeau,R.T.
            Jr., Yang-Feng,T.L., Caron,M.G., Lefkowitz,R.J. and Cotecchia,S.
  TITLE     Molecular cloning and expression of the cDNA for a novel alpha
            1-adrenergic receptor subtype
  JOURNAL   J Biol Chem 265 (14), 8183-8189 (1990)
   PUBMED   1970822
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022839.8, AK289548.1,
            AK311558.1, D25235.1, AC091675.5, HY277084.1, BF475837.1 and
            AA383170.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_000680.3.
            
            Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of
            the G protein-coupled receptor superfamily. They activate mitogenic
            responses and regulate growth and proliferation of many cells.
            There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of
            which signal through the Gq/11 family of G-proteins and different
            subtypes show different patterns of activation. This gene encodes
            alpha-1A-adrenergic receptor. Alternative splicing of this gene
            generates four transcript variants, which encode four different
            isoforms with distinct C-termini but having similar ligand binding
            properties. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is alternatively spliced in
            the 3' end, compared to variant 3. It encodes isoform 1, which has
            a longer and distinct C-terminus compared to isoform 3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.45753.1,
                                           SRR1803613.221112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380573.4/ ENSP00000369947.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC022839.8         119573-119607
            36-109              AK289548.1         1-74
            110-299             AK289548.1         76-265
            300-300             AC022839.8         119872-119872
            301-499             AK289548.1         267-465
            500-523             AC022839.8         121352-121375
            524-1123            AK311558.1         441-1040
            1124-2063           D25235.1           531-1470
            2064-2326           AC091675.5         84566-84828
            2327-2874           D25235.1           1734-2281
            2875-3065           AC091675.5         85377-85567
            3066-3495           HY277084.1         21-450              c
            3496-3711           BF475837.1         57-272              c
            3712-3767           AA383170.1         1-56                c
            3768-3770           AC091675.5         86270-86272
FEATURES             Location/Qualifiers
     source          1..3770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.2"
     gene            1..3770
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /note="adrenoceptor alpha 1A"
                     /db_xref="GeneID:148"
                     /db_xref="HGNC:HGNC:277"
                     /db_xref="MIM:104221"
     exon            1..343
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /inference="alignment:Splign:2.1.0"
     exon            344..1912
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             1030..2430
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /note="isoform 1 is encoded by transcript variant 1; G
                     protein coupled receptor; alpha-1A adrenoceptor; alpha-1A
                     adrenoreceptor; alpha-1C adrenergic receptor"
                     /codon_start=1
                     /product="alpha-1A adrenergic receptor isoform 1"
                     /protein_id="NP_000671.2"
                     /db_xref="CCDS:CCDS6054.1"
                     /db_xref="GeneID:148"
                     /db_xref="HGNC:HGNC:277"
                     /db_xref="MIM:104221"
                     /translation="MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGN
                     ILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIW
                     AAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIG
                     PLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGL
                     KSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGI
                     VVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFK
                     KAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTD
                     GVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVP
                     TIKVHTISLSENGEEV"
     exon            1913..3770
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3770
                     /gene="ADRA1A"
                     /gene_synonym="ADRA1C; ADRA1L1; ALPHA1AAR"
                     /note="major polyA site"
ORIGIN      
        1 gagttacgtc agcgagagct gcaaagttcc ttgctattct tttctggtgt cggggagctg
       61 aatattaaaa gggtgattgt ggagttaccg gttatctgca tttttttttc ttttcttatt
      121 ttgactcttt ttaaaaaatg caggtaaagt gacagcggtt caggagctta aagacatcag
      181 tggtggaggg gtgagtcagc gggtgcaaaa ggacaaggat ttggtgcctc ggagacacgg
      241 tcccctctcc gcctccagag aagagcaggc aggcagctcc cgggaccgaa gccgggtcca
      301 catcccccgc gcgcgagctg gtggctcagc agcggcgctt caggtggacg cggtcaaacg
      361 atgccccgca gcctcctggg tctcagcaca tattccacac ctacgtcccc tgacctgtgc
      421 tcctagaagc tggagagagc aggagccttc ggtggggcag ctcaaaatgt aggtaactgc
      481 gggccaggag cagcgcccaa cctgtagcgc tgcgctaccc aaccatcggt ccctgccttt
      541 gagcgtcgac ggctgatctt ttggtttgag ggagagactg gcgctggagt tttgaattcc
      601 gaatcatgtg cagaatgctg aatcttcccc cagccaggac gaataagaca gcgcggaaaa
      661 gcagattctc gtaattctgg aattgcatgt tgcaaggagt ctcctggatc ttcgcaccca
      721 gcttcgggta gggagggagt ccgggtcccg ggctaggcca gcccggcagg tggagagggt
      781 ccccggcagc cccgcgcgcc cctggccatg tctttaatgc cctgcccctt catgtggcct
      841 tctgagggtt cccagggctg gccagggttg tttcccaccc gcgcgcgcgc tctcaccccc
      901 agccaaaccc acctggcagg gctccctcca gccgagacct tttgattccc ggctcccgcg
      961 ctcccgcctc cgcgccagcc cgggaggtgg ccctggacag ccggacctcg cccggccccg
     1021 gctgggacca tggtgtttct ctcgggaaat gcttccgaca gctccaactg cacccaaccg
     1081 ccggcaccgg tgaacatttc caaggccatt ctgctcgggg tgatcttggg gggcctcatt
     1141 cttttcgggg tgctgggtaa catcctagtg atcctctccg tagcctgtca ccgacacctg
     1201 cactcagtca cgcactacta catcgtcaac ctggcggtgg ccgacctcct gctcacctcc
     1261 acggtgctgc ccttctccgc catcttcgag gtcctaggct actgggcctt cggcagggtc
     1321 ttctgcaaca tctgggcggc agtggatgtg ctgtgctgca ccgcgtccat catgggcctc
     1381 tgcatcatct ccatcgaccg ctacatcggc gtgagctacc cgctgcgcta cccaaccatc
     1441 gtcacccaga ggaggggtct catggctctg ctctgcgtct gggcactctc cctggtcata
     1501 tccattggac ccctgttcgg ctggaggcag ccggcccccg aggacgagac catctgccag
     1561 atcaacgagg agccgggcta cgtgctcttc tcagcgctgg gctccttcta cctgcctctg
     1621 gccatcatcc tggtcatgta ctgccgcgtc tacgtggtgg ccaagaggga gagccggggc
     1681 ctcaagtctg gcctcaagac cgacaagtcg gactcggagc aagtgacgct ccgcatccat
     1741 cggaaaaacg ccccggcagg aggcagcggg atggccagcg ccaagaccaa gacgcacttc
     1801 tcagtgaggc tcctcaagtt ctcccgggag aagaaagcgg ccaaaacgct gggcatcgtg
     1861 gtcggctgct tcgtcctctg ctggctgcct tttttcttag tcatgcccat tgggtctttc
     1921 ttccctgatt tcaagccctc tgaaacagtt tttaaaatag tattttggct cggatatcta
     1981 aacagctgca tcaaccccat catataccca tgctccagcc aagagttcaa aaaggccttt
     2041 cagaatgtct tgagaatcca gtgtctctgc agaaagcagt cttccaaaca tgccctgggc
     2101 tacaccctgc acccgcccag ccaggccgtg gaagggcaac acaaggacat ggtgcgcatc
     2161 cccgtgggat caagagagac cttctacagg atctccaaga cggatggcgt ttgtgaatgg
     2221 aaatttttct cttccatgcc ccgtggatct gccaggatta cagtgtccaa agaccaatcc
     2281 tcctgtacca cagcccgggt gagaagtaaa agctttttgc aggtctgctg ctgtgtaggg
     2341 ccctcaaccc ccagccttga caagaaccat caagttccaa ccattaaggt ccacaccatc
     2401 tccctcagtg agaacgggga ggaagtctag gacaggaaag atgcagagga aaggggaata
     2461 atcttaggta cccaccccac ttccttctcg gaaggccagc tcttcttgga ggacaagaca
     2521 ggaccaatca aagaggggac ctgctgggaa tggggtgggt ggtagaccca actcatcagg
     2581 cagcgggtag ggcacaggga agagggaggg tgtctcacaa ccaaccagtt cagaatgata
     2641 cggaacagca tttccctgca gctaatgctt tcttggtcac tctgtgccca cttcaacgaa
     2701 aaccaccatg ggaaacagaa tttcatgcac aatccaaaag actataaata taggattatg
     2761 atttcatcat gaatattttg agcacacact ctaagtttgg agctatttct tgatggaagt
     2821 gaggggattt tattttcagg ctcaacctac tgacagccac atttgacatt tatggggaga
     2881 gggcctagag aggaagagca ttaagatggt ggccgagatc cagacacatt atttttagag
     2941 caagtcctga aactccaccc tttctgatac atccaatttc tcagcttgag ggaaacttgg
     3001 cagtgaggtt tacctttgac tgcactttga atggatgctg ctcctcattt cccaaagatg
     3061 agagtgaggg gcactcatga tgtcttggaa tgtagtgttc tctatccttg ggtcaggaga
     3121 gggttgaaag aaccaaccag ggtggtatgg cttttcccaa gagaaaacaa tagacctgag
     3181 catcattctt tcaatttaac tactagagag aaaatccatt aaacagttcc aagatcagat
     3241 gatgataggc tttctctcta atatctttaa agagcaagag gttggtgtgg ctgttaattt
     3301 cttgcaaaga tagaggctgt tcacttactg cacagccatt tcaacatggc ttacaaaagc
     3361 ctttcttgac aaatcactta cctgttccag aactctgtta tgaaaatcca gagcttataa
     3421 tattttgaaa ggcaaaagat tgtctcccat tacttcttat ctgcttcact attgcataat
     3481 gaatgagctt cacctgtggc atgttggaat gagccttatg atccaagtac attattcccg
     3541 aactttgaaa aatactaatg cttagcttca gacaatactg atggatcacc aaagaactgt
     3601 ctaacgcagg agtttgcaaa cattttttga tagaaggcca tttgttctgg taaaagatcc
     3661 agtagtcaac tcaacttcat ctattcctac ttttctgcaa gagcttgggg aacatgctat
     3721 attttgcttt atgtatacca aattttggta aaccataata actcagtaca
//
