LOCUS       NM_017825               1651 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ADP-ribosylserine hydrolase (ADPRS), mRNA.
ACCESSION   NM_017825
VERSION     NM_017825.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1651)
  AUTHORS   Oz Yildiz,S., Yalnizoglu,D., Simsek Kiper,P.O., Gocmen,R.,
            Sogukpinar,M., Utine,G.E. and Haliloglu,G.
  TITLE     Delineation of ADPRHL2 Variants: Report of Two New Patients with
            Review of the Literature
  JOURNAL   Neuropediatrics 55 (3), 156-165 (2024)
   PUBMED   38365196
  REMARK    GeneRIF: Delineation of ADPRHL2 Variants: Report of Two New
            Patients with Review of the Literature.
            Review article
REFERENCE   2  (bases 1 to 1651)
  AUTHORS   Fontana,P., Buch-Larsen,S.C., Suyari,O., Smith,R., Suskiewicz,M.J.,
            Schutzenhofer,K., Ariza,A., Rack,J.G.M., Nielsen,M.L. and Ahel,I.
  TITLE     Serine ADP-ribosylation in Drosophila provides insights into the
            evolution of reversible ADP-ribosylation signalling
  JOURNAL   Nat Commun 14 (1), 3200 (2023)
   PUBMED   37268618
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1651)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1651)
  AUTHORS   Hendriks,I.A., Buch-Larsen,S.C., Prokhorova,E., Elsborg,J.D.,
            Rebak,A.K.L.F.S., Zhu,K., Ahel,D., Lukas,C., Ahel,I. and
            Nielsen,M.L.
  TITLE     The regulatory landscape of the human HPF1- and ARH3-dependent
            ADP-ribosylome
  JOURNAL   Nat Commun 12 (1), 5893 (2021)
   PUBMED   34625544
  REMARK    GeneRIF: The regulatory landscape of the human HPF1- and
            ARH3-dependent ADP-ribosylome.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1651)
  AUTHORS   Beijer,D., Agnew,T., Rack,J.G.M., Prokhorova,E., Deconinck,T.,
            Ceulemans,B., Peric,S., Milic Rasic,V., De Jonghe,P., Ahel,I. and
            Baets,J.
  TITLE     Biallelic ADPRHL2 mutations in complex neuropathy affect ADP
            ribosylation and DNA damage response
  JOURNAL   Life Sci Alliance 4 (11), e202101057 (2021)
   PUBMED   34479984
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1651)
  AUTHORS   Ono,T., Kasamatsu,A., Oka,S. and Moss,J.
  TITLE     The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes
            O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone
            deacetylases
  JOURNAL   Proc Natl Acad Sci U S A 103 (45), 16687-16691 (2006)
   PUBMED   17075046
  REMARK    GeneRIF: poly(ADP-ribose) glycohydrolase ARH3 hydrolyzed
            O-acetyl-ADP-ribose to produce ADP-ribose in a time- and
            Mg(2+)-dependent reaction and thus could participate in two
            signaling pathways
REFERENCE   7  (bases 1 to 1651)
  AUTHORS   Mueller-Dieckmann,C., Kernstock,S., Lisurek,M., von Kries,J.P.,
            Haag,F., Weiss,M.S. and Koch-Nolte,F.
  TITLE     The structure of human ADP-ribosylhydrolase 3 (ARH3) provides
            insights into the reversibility of protein ADP-ribosylation
  JOURNAL   Proc Natl Acad Sci U S A 103 (41), 15026-15031 (2006)
   PUBMED   17015823
  REMARK    GeneRIF: The molecular architecture of human ARH3 constitutes the
            archetype of an all-alpha-helical protein fold and suggests
            reversibility mechanisms of protein ADP-ribosylation.
REFERENCE   8  (bases 1 to 1651)
  AUTHORS   Kernstock,S., Koch-Nolte,F., Mueller-Dieckmann,J., Weiss,M.S. and
            Mueller-Dieckmann,C.
  TITLE     Cloning, expression, purification, crystallization and preliminary
            X-ray diffraction analysis of human ARH3, the first eukaryotic
            protein-ADP-ribosylhydrolase
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 62 (Pt 3), 224-227
            (2006)
   PUBMED   16511307
  REMARK    GeneRIF: cloning, recombinant production, purification and
            crystallization of ARH3 consisting of 347 amino-acid residues
REFERENCE   9  (bases 1 to 1651)
  AUTHORS   Oka,S., Kato,J. and Moss,J.
  TITLE     Identification and characterization of a mammalian 39-kDa
            poly(ADP-ribose) glycohydrolase
  JOURNAL   J Biol Chem 281 (2), 705-713 (2006)
   PUBMED   16278211
  REMARK    GeneRIF: ARH3 has poly(ADP-ribose) glycohydrolase activity but is
            structurally unrelated to poly(ADP-ribose) glycohydrolase
REFERENCE   10 (bases 1 to 1651)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014169.2.
            
            On Nov 23, 2018 this sequence version replaced NM_017825.2.
            
            Summary: This gene encodes a member of the
            ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the
            removal of ADP-ribose from ADP-ribosylated proteins. This enzyme
            localizes to the mitochondria, in addition to the nucleus and
            cytoplasm.[provided by RefSeq, Feb 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014169.2, AJ427295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000373178.5/
                                                  ENSP00000362273.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1651              BC014169.2         3-1653
FEATURES             Location/Qualifiers
     source          1..1651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..1651
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /note="ADP-ribosylserine hydrolase"
                     /db_xref="GeneID:54936"
                     /db_xref="HGNC:HGNC:21304"
                     /db_xref="MIM:610624"
     exon            1..224
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1105
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /EC_number="3.2.1.143"
                     /note="ADP-ribosylhydrolase 3; protein ADP-ribosylarginine
                     hydrolase-like protein 2; poly(ADP-ribose) glycohydrolase
                     ARH3; [Protein ADP-ribosylarginine] hydrolase-like protein
                     2; ADP-ribosylarginine hydrolase like 2;
                     O-acetyl-ADP-ribose deacetylase ARH3; [Protein
                     ADP-ribosylserine] hydrolase; ADP-ribose glycohydrolase
                     ARH3; ADP-ribosylhydrolase like 2"
                     /codon_start=1
                     /product="ADP-ribosylhydrolase ARH3"
                     /protein_id="NP_060295.1"
                     /db_xref="CCDS:CCDS402.1"
                     /db_xref="GeneID:54936"
                     /db_xref="HGNC:HGNC:21304"
                     /db_xref="MIM:610624"
                     /translation="MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHD
                     TVDLTSVLRHVQSLEPDPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAH
                     RFAQEYKKDPDRGYGAGVVTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGI
                     SLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGH
                     MEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFES
                     VPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQ
                     VPESWQQSCEGYEETDILAQSLHRVFQKS"
     exon            225..321
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /inference="alignment:Splign:2.1.0"
     exon            322..529
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /inference="alignment:Splign:2.1.0"
     exon            530..714
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /inference="alignment:Splign:2.1.0"
     exon            715..815
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1651
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /note="hexamer: AATAAA"
     polyA_site      1651
                     /gene="ADPRS"
                     /gene_synonym="ADPRHL2; ARH3; CONDSIAS"
                     /note="major polyA site"
ORIGIN      
        1 agtctgcgcg cggatggccg cagcggcgat ggcggcagcg gcaggtggag gggctggcgc
       61 ggcccgctcc ctctcgcgct tccgaggctg cctggctggc gcgctgctcg gggactgcgt
      121 gggctccttc tacgaggccc acgacaccgt cgacctgacg tcagtcctgc gtcatgtcca
      181 gagtctggag ccggaccccg gcacgcccgg gagtgagcgg acagaagcct tgtactacac
      241 agatgacaca gccatggcca gggccctggt gcagtccctg ctagccaagg aggcctttga
      301 cgaggtggac atggctcaca gatttgctca ggagtacaag aaagaccctg acaggggcta
      361 tggtgctgga gtagtcactg tcttcaagaa gctcctgaac cccaaatgtc gcgatgtctt
      421 tgagcctgcc cgggcccagt ttaacgggaa aggctcctat ggcaatggag gtgccatgcg
      481 ggtggctggc atctccctgg cctatagcag tgtccaggat gtgcagaagt ttgcccggct
      541 ctcggcccag ctgacacacg cctcctccct gggttacaat ggcgccatcc tgcaggccct
      601 ggctgtgcac ctggccttgc agggcgagtc ttccagcgag cactttctca agcaactcct
      661 gggccacatg gaggatctgg agggtgatgc ccagtccgtc ttggatgcca gggagttggg
      721 catggaggag cgtccatact ccagccgcct gaagaagatt ggagagcttc tagaccaggc
      781 atcggtgacc agggaggaag tggtgtctga gctagggaat ggcattgctg cctttgagtc
      841 ggtacccacc gccatctact gcttcctacg ctgcatggag ccagaccctg agatcccttc
      901 tgccttcaat agcctccaaa ggactctcat ttattccatc tcacttggtg gggacacaga
      961 caccattgcc accatggctg gggccattgc tggtgcctac tatgggatgg atcaggtgcc
     1021 agagagctgg cagcaaagct gtgaaggcta cgaggagaca gacatcctgg cccaaagcct
     1081 gcaccgtgtc ttccagaaga gttgatgagg gctacagctg ttggggctct gccaggtccc
     1141 ctgggaccaa ctacagctcc aatcagaaac cctgcgcttc cttgagtgtg gcttcccact
     1201 tttcctgcat tgtggagctg actgagtaca ccggtgaggc tggggtctct gcaggggagg
     1261 tcactggaac agcgagcaag ggactggtgc ctcgctggtg ctgggtctct ggtttgctgc
     1321 agagccgtag gacactcctg gctcctcagt aggacagaca gacgcaggcg ggtttatttt
     1381 ggaggggtac ttgtggcatt ttcctgtatt gtcttggaca tgggatgtgg ggaggtggaa
     1441 atgatgagca gtagcatcat ttctccctgt tgggttttag ccagtttgcc agcaagcgca
     1501 tcctagcagg gtccccgagc agcaggttgt gtggatgaag ggacaggcac ttgcatccag
     1561 ctgatctagg tcacacctgg ctcttggctg ccatgtggct tattaacagc ttccagtgga
     1621 agtcgcaata aacagttttt ggtaaatctc a
//
