LOCUS       NM_020233               1534 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ADP-ribose/CDP-alcohol diphosphatase, manganese
            dependent (ADPRM), mRNA.
ACCESSION   NM_020233
VERSION     NM_020233.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Cabezas,A., Ribeiro,J.M., Rodrigues,J.R., Lopez-Villamizar,I.,
            Fernandez,A., Canales,J., Pinto,R.M., Costas,M.J. and
            Cameselle,J.C.
  TITLE     Molecular bases of catalysis and ADP-ribose preference of human
            Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion
            by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase
  JOURNAL   PLoS One 10 (2), e0118680 (2015)
   PUBMED   25692488
  REMARK    GeneRIF: Results from homology modeling and simulation studies of
            docking and molecular dynamics revealed the structural and dynamic
            information on human ADPRibase-Mn with the catalytic sites.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Canales,J., Fernandez,A., Ribeiro,J.M., Cabezas,A., Rodrigues,J.R.,
            Cameselle,J.C. and Costas,M.J.
  TITLE     Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel
            metallophosphoesterase family preferentially expressed in rodent
            immune cells
  JOURNAL   Biochem J 413 (1), 103-113 (2008)
   PUBMED   18352857
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC002347.3, DA305828.1, AB073393.1 and DA280275.1.
            
            On May 17, 2019 this sequence version replaced NM_020233.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.79953.1,
                                           SRR1803614.170385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379774.5/ ENSP00000369099.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC002347.3         46775-46790         c
            17-50               DA305828.1         1-34
            51-1209             AB073393.1         6-1164
            1210-1534           DA280275.1         235-559
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1534
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
                     /note="ADP-ribose/CDP-alcohol diphosphatase, manganese
                     dependent"
                     /db_xref="GeneID:56985"
                     /db_xref="HGNC:HGNC:30925"
     exon            1..74
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
                     /inference="alignment:Splign:2.1.0"
     exon            75..692
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1120
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
                     /EC_number="3.6.1.13"
                     /EC_number="3.6.1.16"
                     /EC_number="3.6.1.53"
                     /note="ADP-ribose/CDP-alcohol pyrophosphatase;
                     ADPRibase-Mn; CDP-choline phosphohydrolase"
                     /codon_start=1
                     /product="manganese-dependent ADP-ribose/CDP-alcohol
                     diphosphatase"
                     /protein_id="NP_064618.3"
                     /db_xref="CCDS:CCDS11159.2"
                     /db_xref="GeneID:56985"
                     /db_xref="HGNC:HGNC:30925"
                     /translation="MDDKPNPEALSDSSERLFSFGVIADVQFADLEDGFNFQGTRRRY
                     YRHSLLHLQGAIEDWNNESSMPCCVLQLGDIIDGYNAQYNASKKSLELVMDMFKRLKV
                     PVHHTWGNHEFYNFSREYLTHSKLNTKFLEDQIVHHPETMPSEDYYAYHFVPFPKFRF
                     ILLDAYDLSVLGVDQSSPKYEQCMKILREHNPNTELNSPQGLSEPQFVQFNGGFSQEQ
                     LNWLNEVLTFSDTNQEKVVIVSHLPIYPDASDNVCLAWNYRDALAVIWSHECVVCFFA
                     GHTHDGGYSEDPFGVYHVNLEGVIETAPDSQAFGTVHVYPDKMMLKGRGRVPDRIMNY
                     KKERAFHC"
     exon            693..809
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1534
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1180..1185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
                     /note="hexamer: AATAAA"
     polyA_site      1199
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
                     /note="major polyA site"
     polyA_site      1228
                     /gene="ADPRM"
                     /gene_synonym="C17orf48; MDS006; NBLA03831"
ORIGIN      
        1 gtccgtcccg ctcgttggtg gcgctgttac atagcccgta gtcagaggcc tttcagccca
       61 ggggccggcg cacgaaacct gtttggaggt tatggatgat aaacccaatc ctgaagccct
      121 aagtgacagt tcagagcgtc ttttctcctt tggcgtcatc gcagatgttc aatttgcaga
      181 cttagaagat ggctttaatt tccaaggaac caggcggcga tactacagac atagtcttct
      241 tcacttacag ggtgccattg aagactggaa taatgaaagc agcatgccct gttgtgtcct
      301 tcagcttgga gatatcatcg atggatataa tgcacagtat aatgcatcca aaaagtccct
      361 agaacttgtt atggacatgt tcaagaggct taaagttcca gttcatcata catggggaaa
      421 ccatgaattc tataacttca gtagagagta tttaacacac tctaaactta acactaagtt
      481 tctagaagat cagattgtac atcatcctga gaccatgcct tcagaagatt attatgctta
      541 tcattttgta ccattcccta aattccggtt cattttactt gatgcatatg acttgagtgt
      601 cttgggcgtg gatcagtctt ctccaaaata cgagcagtgt atgaagatat tgagggagca
      661 caatccaaat acggaactga atagtcctca aggactttct gagccccagt ttgtccagtt
      721 taatggagga ttcagccaag aacagctaaa ctggttgaat gaagtgctaa cattctctga
      781 cacaaaccaa gaaaaggtgg tgattgtgag ccatcttccc atttacccgg acgcctctga
      841 caatgtgtgc ctggcctgga actacagaga tgccctggca gtcatttggt ctcatgagtg
      901 tgtggtgtgt ttctttgctg gtcacaccca tgatggtggc tactctgagg atccttttgg
      961 tgtataccac gtcaacctag aaggagttat tgaaacagct ccagacagcc aagcctttgg
     1021 cacagttcat gtctatcctg acaaaatgat gttgaaaggg agaggcagag ttccagatag
     1081 aattatgaat tacaagaaag aaagagcctt ccattgttag tctaatttat tttaacttga
     1141 tagaaaatga gctttgtgtt tgtccctcct aaacaaaaaa ataaaaatcc tctgtctcat
     1201 tgtttagtat tcagcttgca taacaaaatg tatttatagt ttcagtgtgt gatggttgat
     1261 aaaatactca gaaatgttat tttggatcat gtatccattg taagttagaa acaaaccagg
     1321 gaggaaactg aggcaggggt gtatagtcct cataaggggc atatagtcct catgagggat
     1381 cttatttggc cctacctgat tttttttaac tttttacaag gagattgtat tcacatgtgt
     1441 taactatgta acttcaagtt cagcatataa gctcaggtaa gctttttcta ttcaccctgc
     1501 tgtgtaaatg agctttggac aatttctgct caga
//
