LOCUS       NM_001394807            9722 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ADP-ribosylhydrolase like 1 (ADPRHL1), transcript
            variant 5, mRNA.
ACCESSION   NM_001394807
VERSION     NM_001394807.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9722)
  AUTHORS   Tian,L., Guo,T., Wu,F., Bai,R., Ai,S., Wang,H., Song,Y., Zhu,M.,
            Jiang,Y., Ma,S., Zhuang,X. and Guo,S.
  TITLE     The pseudoenzyme ADPRHL1 affects cardiac function by regulating the
            ROCK pathway
  JOURNAL   Stem Cell Res Ther 14 (1), 309 (2023)
   PUBMED   37880701
  REMARK    GeneRIF: The pseudoenzyme ADPRHL1 affects cardiac function by
            regulating the ROCK pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9722)
  AUTHORS   Targa,A., Larrimore,K.E., Wong,C.K., Chong,Y.L., Fung,R., Lee,J.,
            Choi,H. and Rancati,G.
  TITLE     Non-genetic and genetic rewiring underlie adaptation to hypomorphic
            alleles of an essential gene
  JOURNAL   EMBO J 40 (21), e107839 (2021)
   PUBMED   34528284
  REMARK    GeneRIF: Non-genetic and genetic rewiring underlie adaptation to
            hypomorphic alleles of an essential gene.
REFERENCE   3  (bases 1 to 9722)
  AUTHORS   Smith,S.J., Towers,N., Saldanha,J.W., Shang,C.A., Mahmood,S.R.,
            Taylor,W.R. and Mohun,T.J.
  TITLE     The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is
            essential for heart chamber outgrowth and acts on muscle actin
            filament assembly
  JOURNAL   Dev Biol 416 (2), 373-388 (2016)
   PUBMED   27217161
  REMARK    GeneRIF: Hybrid human-Xenopus Adprhl1 protein constructs were
            produced by utilizing restriction sites from one species and
            engineering the same site into the second species by PCR. Hearts
            containing human ADPRHL1 developed normally. Engineered
            human-Xenopus hybrid proteins cause extensive branching of
            myofibrils with sarcomere division occurring at the actin-Z-disc
            boundary.
REFERENCE   4  (bases 1 to 9722)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   5  (bases 1 to 9722)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   6  (bases 1 to 9722)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160251.29.
            
            Summary: ADP-ribosylation is a reversible posttranslational
            modification used to regulate protein function.
            ADP-ribosyltransferases (see ART1; MIM 601625) transfer ADP-ribose
            from NAD+ to the target protein, and ADP-ribosylhydrolases, such as
            ADPRHL1, reverse the reaction (Glowacki et al., 2002 [PubMed
            12070318]).[supplied by OMIM, Mar 2008].
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612156.3/ ENSP00000489048.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AL160251.29        58139-58403         c
            266-430             AL160251.29        49340-49504         c
            431-556             AL160251.29        38657-38782         c
            557-697             AL160251.29        33867-34007         c
            698-825             AL160251.29        29967-30094         c
            826-958             AL160251.29        29132-29264         c
            959-1112            AL160251.29        27741-27894         c
            1113-9722           AL160251.29        4526-13135          c
FEATURES             Location/Qualifiers
     source          1..9722
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q34"
     gene            1..9722
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /note="ADP-ribosylhydrolase like 1"
                     /db_xref="GeneID:113622"
                     /db_xref="HGNC:HGNC:21303"
                     /db_xref="MIM:610620"
     exon            1..265
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..5955
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /note="isoform 4 is encoded by transcript variant 5;
                     ADP-ribosyl-hydrolase; [Protein ADP-ribosylarginine]
                     hydrolase-like protein 1; ADP-ribosylhydrolase 2;
                     ADP-ribosylarginine hydrolase like 1;
                     ADP-ribosylhydrolase-like protein 1; inactive
                     ADP-ribosyltransferase ARH2"
                     /codon_start=1
                     /product="inactive ADP-ribosyltransferase ARH2 isoform 4"
                     /protein_id="NP_001381736.1"
                     /db_xref="CCDS:CCDS91841.1"
                     /db_xref="GeneID:113622"
                     /db_xref="HGNC:HGNC:21303"
                     /db_xref="MIM:610620"
                     /translation="MEKFKAAMLLGSVGDALGYRNVCKENSTVGMKIQEELQRSGGLD
                     HLVLSPGEWPVSDNTIMHIATAEALTTDYWCLDDLYREMVRCYVEIVEKLPERRPDPA
                     TIEGCAQLKPNNYLLAWHTPFNEKGSGFGAATKAMCIGLRYWKPERLETLIEVSVECG
                     RMTHNHPTGFLGSLCTALFVSFAAQGKPLVQWGRDMLRAVPLAEEYCRKTIRHTAEYQ
                     EHWFYFEAKWQFYLEERKISKDSENKAIFPDNYDAEEREKTYRKWSSEGRGGRRGHDA
                     PMIAYDALLAAGNSWTELCHRAMFHGGESAATGTIAGCLFGLLYGLDLVPKGLYQDLE
                     DKEKLEDLGAALYRLSTEENRKSSKTCSDVMSVDAQTLKKKMGKLACDPAAHSILSSL
                     LLYVTGRADRPPGTEAGGSRPSHQPQTQEATQRPTRFQLLQAKFLGTGRERYLKRTRE
                     VGRLISKDKQGPGGGLVGATINKLLEKTKEPAPKPCLSEKPRWGHPAGKSTVKNILKI
                     FLAAEEKEAKEKEAREKPPVERPKAARGLLPKIMGKSSVLSKLREKFEQNSCLCSEAS
                     ALRLHTQERKKRNLQRKRMHRPEVRVLHTATMASTCVKMPPARFLACTAEPLPALSIA
                     TVVCGPRSWLSHCTKISHSEARRPPRGEASVPPSARETGPSGNKAVGKGPLEEEPQRQ
                     PRPSKPVTPQVMAQRDGHAVPSLAFSCAPCTGGVLPGLVPASSPLGPASPWGTGSAGG
                     DGTADPTAESTAGGVQEVRGARLTWPPGPPGECAGEGPEITMTVCSSEDEREGAGFPD
                     PGRDPLFATQKYFPEQKVPEHIPPLNAPSVQAARRTQPATEPPRITVQIPVVHEMPAP
                     PTRLQNMSSGENKPCICGGENVVENAHTEFPTVTENRRGHRAPVELSKLSGMQAGLSA
                     SSPQGPRAAPRLAAARGAVGADHSVPETLLTQRLQTDPAGGKENKGSFENSHGPRNPD
                     DISGERTSELRDVKHPLPESNEISMQKKGSATNDPAASQNLLRGNTSHASSSQQVPSP
                     TGRNPTGAPTSLAASSKGRTGPEGVTPMGMTVPGALEECRRPLLIESSQPLKAAEEIT
                     SHDVRENPLSSLNEPPKPGMKACGAMAAAGSVASRATPAPAPGSTQSPGDRTAGEPET
                     LGQWGSRALSESHPRGEALPRDPHSHGLLAPGGSLEPKSGAAGRSLLRGVALVQHPED
                     IATLARHPEDAAALARHPEAARLYISNTSAASRHTAAVGGRKDVAVEGNLLGFSTESG
                     IPASDHPRPQARSVAESPSYGPGLPPSPPENPQAKGREGVRFPRGAEPDHLLPAVPPA
                     EVDMGWVGGTHQRGPPHLQAHLPPTAGDTQAKLRASVPEPRTQAGESQERPLTQADLG
                     RQQSHQAQEETPQPGDAGKRVAPSGSKVVLNPAKEPQTWWAQDLAGDKGMAIGVGGAC
                     QRSDQGQQHLQGPWEERGRSTAWGEGTRAARNPAVPPGEPEGPGSPAAQGQAQKQVQE
                     WDRGQVQGHAQEQAQWQTQIEAQGQAQEQAQGGTQGHSQGQAQKQFQNWAQGQAQGHA
                     QEQAQWQTQIEAQGQAQEPAQGGAQGQVQGQAQKWAQGQIQGQAQKQVQGEVQKWAQE
                     EAQGQAQWQTQIKAQKWAQEQTQKGAQERVQGQAQKGAQERAQEQAQEQTQIEAQGQA
                     QKGAQERAREQAQKGAQERAREQAQKGAQERAREQAQKGAQERAREQAQKGAQERARE
                     QAQKGAQERAREQAQKGAQERAQEQGREQTHIEAQGQAQKGAQEWARDRARDQGWEQT
                     QIETQRQTQKGAQERAWEQGREQALTSGMAPRAWEQPISGIAEGVDAAGRSGGSRSPA
                     PRDGGQSGGSGLGEPSAGYPPPGSRPLRGKSIATSPLGLGKSPTEPKPEAGGCGTPQA
                     PAQEGSPDHPGAERALQDRMEASEPERRGRSRHLAKYKAQSFRDQRAFDLSFRPMSVR
                     ASDTSELPK"
     exon            266..430
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..556
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..697
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..825
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /inference="alignment:Splign:2.1.0"
     exon            826..958
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1112
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..9722
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9702..9707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /note="hexamer: AATAAA"
     polyA_site      9722
                     /gene="ADPRHL1"
                     /gene_synonym="ARH2"
                     /note="major polyA site"
ORIGIN      
        1 caaaggccag gacgctccgc agctgttggg gaagaggagc tgcctcctgg gatggagaaa
       61 tttaaggctg cgatgttgct ggggagcgtc ggcgatgctc ttggctacag aaatgtctgc
      121 aaggagaaca gcactgtagg catgaagatc caggaggagc tgcaacgttc cgggggcctg
      181 gaccacctcg tactctcgcc aggagaatgg cccgtgagtg acaacaccat catgcacatc
      241 gcaaccgccg aggccctcac cacagactac tggtgcctgg atgatctgta ccgggagatg
      301 gtgagatgct atgtggaaat cgttgagaag cttccagaac gccggccaga cccagctacc
      361 attgaaggct gtgctcagct aaagcccaat aactaccttc tcgcctggca cacaccgttc
      421 aatgaaaaag gctcagggtt tggagcggcc accaaggcca tgtgcatcgg cctgcggtac
      481 tggaagcctg agcggctgga gaccctcatc gaggtcagcg tggagtgcgg ccggatgacc
      541 cacaaccatc ccacaggctt cctgggctcc ctgtgcacgg ccctgtttgt gtcgttcgcc
      601 gcacaaggaa agcccctggt ccagtggggg agagacatgc tgcgggcggt gcctctggca
      661 gaagagtact gcaggaagac catccggcac acggcagaat accaggagca ctggttttac
      721 tttgaagcta aatggcaatt ttatttggag gagaggaaaa tcagtaaaga ctcagaaaat
      781 aaagccatct tccccgacaa ttatgatgca gaagagaggg aaaagaccta caggaagtgg
      841 agctcggaag gtcgaggggg aagacgaggc cacgatgccc ccatgatagc ctatgacgcc
      901 ctccttgcag caggaaacag ctggactgag ctgtgtcacc gggccatgtt tcatggaggg
      961 gagagcgcgg ccacgggcac cattgcaggc tgcctgttcg ggttgctgta cggcctggac
     1021 ctcgttccca aaggcttgta ccaggacctg gaggacaagg agaagctgga ggacctgggc
     1081 gcggctctct accgcctgtc cacagaggag aaccggaaga gcagcaagac ctgcagtgac
     1141 gtcatgtctg tggacgccca aaccctgaag aagaagatgg gcaagctggc ctgtgacccg
     1201 gccgcccact ccatcctcag cagcctgctg ctctacgtca cgggccgcgc agaccggccc
     1261 ccggggacag aggccggggg gagcaggccc agccaccagc cccagaccca ggaggccacc
     1321 cagcggccca cgcgcttcca gctcctgcag gccaagttcc tgggcactgg ccgggagcgc
     1381 tacctcaaga ggaccaggga ggtgggccgg ctgatctcca aggacaagca ggggccgggt
     1441 gggggcctcg tgggtgccac catcaacaag ctcctggaga agaccaagga gccggcccca
     1501 aagccctgcc tcagcgagaa gccccgctgg ggccacccgg ccgggaagag caccgtgaaa
     1561 aacatcctga agatattctt ggccgccgag gagaaggagg cgaaggagaa agaagcacgc
     1621 gagaagcccc ctgtggagcg gcccaaagcc gccaggggcc tcttgccgaa gatcatgggc
     1681 aagagctcgg tgctgtccaa gctgcgggag aagttcgagc agaacagctg cctgtgctcc
     1741 gaggccagtg cgctgaggct gcacacgcag gagcggaaga agaggaacct gcagaggaag
     1801 aggatgcacc ggccggaggt gcgcgtgctg cacacggcca ccatggccag cacctgcgtc
     1861 aagatgcccc ctgcccgctt tctggcctgc acggctgagc ccctgccggc cctcagcatc
     1921 gccaccgtcg tctgtggccc caggagctgg ctgtcccact gcaccaaaat cagccactcg
     1981 gaggcaaggc gtccacccag aggagaagcc agcgtgcccc ctagtgccag ggagacgggg
     2041 cccagtggga acaaagcagt gggaaagggg cccctggagg aggagcccca aagacagcca
     2101 aggccctcga agcccgtgac accccaggtg atggctcaga gggacggcca cgctgtcccc
     2161 tcgctggcct tctcttgtgc tccctgcaca ggtggagtcc ttcctggcct tgtgcctgca
     2221 tcatccccac tgggaccggc cagcccttgg ggcaccggat cagccggagg tgatgggact
     2281 gcagacccca ccgcagagag caccgcagga ggcgtccagg aggtgagggg agccaggctc
     2341 acgtggcctc ctgggccccc aggcgagtgt gcaggggagg gccctgaaat caccatgact
     2401 gtttgcagtt cagaggatga aagggaagga gcaggcttcc cagacccagg gagagacccc
     2461 ctctttgcca cccagaagta tttcccagaa cagaaggtgc cggagcacat cccacccctg
     2521 aacgctccat cggtccaggc tgctcggaga acacagcctg ccacggagcc tccacggata
     2581 actgtccaaa ttccagttgt ccatgaaatg ccagcccctc ccaccaggct gcaaaatatg
     2641 tcaagtggtg aaaacaaacc ttgtatttgt ggaggagaga atgtggttga aaatgcccac
     2701 acagaatttc ccaccgtgac tgagaacaga aggggtcacc gagccccagt ggaactgagc
     2761 aagctttcag ggatgcaggc gggactcagc gcctcttcgc cgcaggggcc acgggcagct
     2821 ccgcgtctgg cagcagcaag aggggctgtg ggcgccgacc acagtgtccc agagacactt
     2881 ctgacacaga gactccagac agatcctgct ggcgggaagg aaaacaaagg cagctttgag
     2941 aattcacacg gtcccaggaa tcctgacgat atttcaggag agaggacctc tgagctcaga
     3001 gatgtgaagc atccgttgcc ggaatctaat gaaatatcaa tgcagaagaa gggctccgca
     3061 acaaatgatc ctgcagcctc acaaaacctt ctgaggggaa acaccagcca tgcctccagc
     3121 agccagcaag tgccgtcccc gactgggaga aacccaacag gagcccccac gtcactggcg
     3181 gcatcatcca aggggcgtac ggggcctgag ggtgtcaccc cgatgggcat gacagtgccc
     3241 ggtgcgctgg aggaatgcag aaggccgctg ctaatagagt cttctcagcc cctgaaggct
     3301 gccgaggaaa tcaccagcca tgatgttcgc gagaacccac tgtcctcatt aaatgaacca
     3361 cccaaaccag gtatgaaagc ctgtggggcg atggcagctg cagggagcgt tgcgagccgc
     3421 gccacgcctg caccagcgcc aggcagcacc cagagccctg gagaccgcac agcgggagag
     3481 ccagagacgc tgggccagtg gggaagcaga gccttgtccg aaagccaccc cagaggagag
     3541 gctctccctc gagaccctca cagccacggc ctcctggccc ctgggggatc cttggagccc
     3601 aagagtggag cagcagggag gagcctcctg agaggcgtgg ccctcgtcca gcacccagag
     3661 gacattgcga ccctcgcccg ccacccggag gatgctgcgg ccctcgcccg gcacccagag
     3721 gcggcccgat tatacatttc aaacacatca gcagccagca gacatacagc agctgtagga
     3781 ggcagaaagg atgtggctgt ggaaggaaac cttttgggtt tcagcacaga gtctggaatt
     3841 cctgcttctg atcatcctag gccacaggca aggagcgtgg cagagtcccc cagctatggc
     3901 cctggcctcc cgccgtcgcc tcctgagaac ccacaggcaa agggcaggga gggcgtcagg
     3961 tttccccgtg gggcggagcc tgaccatctg cttcccgcag tgcctcccgc ggaggtggac
     4021 atggggtggg taggtggcac ccaccagcgg ggccctcccc atctacaggc acacctgccc
     4081 cctactgctg gtgacacaca ggcaaagctc cgggccagtg tccccgagcc taggacgcag
     4141 gcaggtgaat cccaggagcg tcccctgaca caggcggacc tggggaggca acagagtcac
     4201 caggcacagg aggagacccc ccagcccggg gatgcgggga agagggtggc gccgtcgggc
     4261 tcgaaggttg tgctgaaccc agcaaaagag cctcagacat ggtgggcaca ggatctggcc
     4321 ggggacaaag ggatggccat tggggttggg ggcgcctgcc agcgcagtga ccaaggtcag
     4381 cagcatctgc agggaccctg ggaggagcgg gggcggagca cggcgtgggg agagggcacc
     4441 agggctgcca ggaacccagc tgtgcctcca ggggagcccg aggggccggg aagcccggca
     4501 gcccaaggac aggcccagaa acaggttcag gaatgggacc ggggacaggt tcagggacac
     4561 gctcaagaac aggcccagtg gcagacccag atagaggccc aggggcaggc acaggaacag
     4621 gctcagggtg ggacccaggg acacagtcag ggacaggccc agaaacagtt tcagaattgg
     4681 gcccagggac aggctcaggg acacgctcaa gaacaggccc agtggcagac ccagatagag
     4741 gcccaggggc aggcacagga accagctcag ggtggggccc agggacaggt tcagggacag
     4801 gcccagaaat gggctcaggg gcagattcag ggacaggccc agaaacaggt tcaaggagag
     4861 gttcagaaat gggcccagga agaggctcag ggacaggccc agtggcagac ccagataaag
     4921 gcccagaaat gggctcagga acagacccag aaaggggctc aggaacgggt tcagggtcag
     4981 gcccagaaag gggctcagga acgggcccag gaacaggctc aggagcagac ccagatagag
     5041 gctcagggtc aggcccagaa gggggctcag gaacgggctc gggaacaggc ccagaaaggg
     5101 gctcaggaac gggctcggga acaggcccag aaaggggctc aggaacgggc tcgggaacag
     5161 gcccagaaag gggctcagga gcgggctcgg gaacaggccc agaaaggggc tcaggaacgg
     5221 gctcgggaac aggcccagaa aggggctcag gaacgggctc gggaacaggc ccagaaaggg
     5281 gctcaggaac gggctcagga acagggtcgg gagcagaccc acatagaggc tcagggtcag
     5341 gcccagaaag gggctcagga atgggctcgg gatcgggctc gggatcaggg ctgggagcag
     5401 acccagatag agactcagag gcagacccag aaaggggctc aggaacgggc ttgggaacag
     5461 ggtcgggaac aggccttgac aagtgggatg gcgcctcggg cctgggagca gcccattagt
     5521 ggcatagctg agggagtgga tgctgctggc aggagtgggg ggtccagaag cccagccccc
     5581 agggatggtg gacagtcagg gggcagtggc ctgggggagc ccagcgccgg gtacccaccc
     5641 ccaggaagcc gccccctcag gggcaagagc attgccacct ctcccctggg gctgggaaag
     5701 agcccaactg agcccaagcc tgaggctggg ggctgcggga ctccccaggc cccggcccag
     5761 gaggggtccc cagaccaccc tggggctgag agggccctgc aggacaggat ggaggcatcg
     5821 gagcccgagc gtcgcgggag gtccaggcac ctggccaagt acaaagccca gagcttccgt
     5881 gaccagaggg ccttcgattt gtccttcaga ccaatgagcg tcagggccag cgacacgtct
     5941 gagctcccaa agtgaggccc cgagtacaca ccgtggctcg cccagcactg tgacatccgc
     6001 ccattgaggg acttcaggca ttttcctgcc tccaaatgcg tcttggagca tcccctacag
     6061 agacgcctgt ttccataatt ttctttccct tcttcacaag ctgaccttgg gaggattgag
     6121 ctacatgtgg gtcgggttcc tgtcacccca cagagccacg aggccatggg ggtgggaggt
     6181 gcgggcctgt ggcctcacca ggccctcggg attctttgtg tcttcactcg ggggcgccgg
     6241 ctcacccctc tctcacacag cctgcagcgt ggagctcaca cctcccgcag tggcacggtg
     6301 tgtgcgtccc cttcgatctg caggatgctg gcactttggg acacctcccc agctctcaca
     6361 gggccacctc ccactgctcc ctgcccacac cccaccatgc cctgctctga cgtggccgca
     6421 tggcacccac catccatggg cccaaagtga tgcacaccgc cccaccccca tgactcgaaa
     6481 gaaagggcag agcttcctcc agcctcagac gcccaggtgg gtgccgggtg ctgtgtggct
     6541 gctgggccat gtggtggtca ccagagggtg tggggacgct gggatcccag gccgaaacca
     6601 gctcatccgg aggaagaggc ctcaggaaat gcccacgtta agttctgaga aagggacagt
     6661 gcagagccgt gggaagccag gatcccaggg aggcttcgtc tggaaactgg gtgctgggag
     6721 aacgaacggg agcctgcccg cccttccctg cagtccctgt gggtggtgcc actggtgccg
     6781 gtgacctgag agcctcgctg tctgtcctcc gtcctcccga acagcataga agtgtttcct
     6841 gccctggccc gagacggccc acgactccgg ccctgttcag gtactgaggt aatgcatgtt
     6901 caggctggaa tatttgaatg ctgtctagag gcacaagaag gaaatcaaag ccacctgtgg
     6961 tcacattgcc tcgagatggt ttttgttgct actctggact attttttagg ctcttcctcc
     7021 atgcacctat tttaaagcac attcttcccc atgatggagc catgcacctc cgtgtcgcga
     7081 tccatcgtcc caggccactc ggtggcctct gaaacccgga cccgtgaggc cacacggctg
     7141 cctgagtggc cccggagcag ctggattttc agcgtgaacc gatgcagcct gtcgccctac
     7201 agccccgcac ccttgttttt ggtggtgccc tccctgtgga aagttaattc ctgctttttg
     7261 aaggtgtctt ggcatcttct gcctttgcta ctgagcggtt tcctgaaaca gccctaagcg
     7321 ttcgcaaagg cgctttggtg cctgctgcga gcacctgttt tctgactcgg atgttccttt
     7381 agaggaaggt gttttccagt gtcggccctg agagggcgtt cagcaggcgc gtcctaccca
     7441 cgcggggctg aggtctctcc ttccagggaa ggtccatccc ggcagacgcc agtggctttg
     7501 gctctgcagc gccaaggagg cggcgtggcg tcatgctccg gggagcgcac aggtttcctt
     7561 ccagtcgaac aattaacttc agatccagca ggtttgaccc accctcacct gctgggacat
     7621 gcgagtgctg gtgtctggaa ggagggccgg gctgtgctga gctctggggg gccggtcccc
     7681 acagctcccc cgacagggcc cccggggcct cctctataaa tcaggggtcc gtgctcccag
     7741 cccgcttcga ggggtttctg cttggcgtgt gggttctaag tgcgagctgc tgtgtgtgga
     7801 ggctcctgag caccgggtgc ccctcgcgcg tgtgggtccc ggggcagccc agctgcacac
     7861 aggatggtcc gggggtgcgg gtgggggcag agctgagcat ggcgtgtact tggccacaga
     7921 agtcttgctg tggtgccgct ggacccctgc taggaggaca gggtcccctc tctcacgaag
     7981 cacacggacc tccagagtcc ctgcccctgc agtcctggga gcctgcagtt ggggctggag
     8041 ttggcctctc ggagccaccc aaacggagag gcccatgaga ggggagctca ggggtccagc
     8101 agaggctgac agagtggcct ctttgtcctg ttggcggccc ctgctcatgc ctggggcgtc
     8161 ctccctggag ctgggggagc tcagggaccc ccaggtctgt gtggctgccc ctgccactcc
     8221 aggcacagcg gcacggccct cactctttac ctatttggaa ttggaggcaa tgagtggcaa
     8281 gaacatgatg acagacacgg gaggtaaaaa tatgttcact ggctgttccc tttataaata
     8341 agaagtggtg ggacttgcgc tgctattttt aaatagacca gagagtacac tggagaaggc
     8401 attgagtggt tttattttaa gtggtggaaa aaatgatgag aatctcctcc agatgacagc
     8461 tccggaagtg tcgtgcctga acccctctca cagtctggcg ggcgcagagt ctgtgagcgg
     8521 ccaggaggcc acctgctcga ctggcccgtc ctctccatgt gccagatgca gcccagcatg
     8581 acactgccct cagctcaaaa acagcacagc tactctgtgt gcaggaaaaa actgccagtg
     8641 acttcaccag gatttgagaa cggtccgtac gttcacacta agctgagaca gcgcaggtta
     8701 gaagatagcg cggggaagta ttcacacttc agatacgacc atcacggcca catggctaag
     8761 gcccacaccc tcccggggtg aaataactac agcagaagaa tggggcgcta accacctcca
     8821 cgggcatttt aaataaaacc caaagttgtt ttgttttttt aaaaaaaaaa aaaaagaaag
     8881 aaagaaagtg gccgggcacg gtggctcatg cctgtaatcc cagcactttg ggaggccgag
     8941 gcagacagat cacgaggtca ggagatcaag accatcctgg ctaacacagt gaaaccctgt
     9001 ctctactaaa aatacaaaaa ttagccgggc gtggtggtgg gtgcctgtag tcccagctac
     9061 tcgggagcct gagacaggag aatggcgtga acccgggagg tggagcttgc agtgagccga
     9121 gattgcgcca ctgcactcca gcctgggtga cagagcgaga ctccgtcaaa aaaaaaaaaa
     9181 aaaagaagaa aagaaaagaa aagaaaacag gatatttatt ttagcttctt agttaacatc
     9241 attaattttg tgtagttgag cgactcgttg actgcctcct ccctgcagtt ttttacggtg
     9301 cctccggctg tcgacaggcc cactgtgagc cgcaggtctg tgggtgcaag tgacaacagc
     9361 cgggcgggag gcggtgcact caggcggcag gaaggtcccg agacggcgac gagaatgtgg
     9421 tcatgttcag gacactcgct cagggagggt cgttgtctgg gattttacac gctcagcacc
     9481 acctccttat tctgttctca gggtatctct gctgttggag ttacggtctt tcggttgtgt
     9541 attaggctac agctatttat taaatttgtt cttgttcata ttcttctttg tatataaaca
     9601 accctaaaat gggttagtca gaaaaaatta ctaaatgtca tttgttgtat tctctctgta
     9661 tttttactaa catcattcag ctggaaataa tttcaaaaag aaataaaata cctttcccat
     9721 ta
//
