LOCUS       NM_001391992            4322 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens ADP-ribosylarginine hydrolase (ADPRH), transcript
            variant 5, mRNA.
ACCESSION   NM_001391992
VERSION     NM_001391992.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4322)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4322)
  AUTHORS   Rack,J.G.M., Ariza,A., Drown,B.S., Henfrey,C., Bartlett,E.,
            Shirai,T., Hergenrother,P.J. and Ahel,I.
  TITLE     (ADP-ribosyl)hydrolases: Structural Basis for Differential
            Substrate Recognition and Inhibition
  JOURNAL   Cell Chem Biol 25 (12), 1533-1546 (2018)
   PUBMED   30472116
REFERENCE   3  (bases 1 to 4322)
  AUTHORS   Kernstock,S., Koch-Nolte,F., Mueller-Dieckmann,J., Weiss,M.S. and
            Mueller-Dieckmann,C.
  TITLE     Cloning, expression, purification and crystallization as well as
            X-ray fluorescence and preliminary X-ray diffraction analyses of
            human ADP-ribosylhydrolase 1
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 65 (Pt 5), 529-532
            (2009)
   PUBMED   19407395
  REMARK    GeneRIF: prerequisite for obtaining well diffracting crystals was
            the performance of X-ray fluorescence analysis on poorly
            diffracting apo hARH1 crystals, which revealed the presence of
            trace amounts of K(+) in the crystal
REFERENCE   4  (bases 1 to 4322)
  AUTHORS   Weber,F., Aldred,M.A., Morrison,C.D., Plass,C., Frilling,A.,
            Broelsch,C.E., Waite,K.A. and Eng,C.
  TITLE     Silencing of the maternally imprinted tumor suppressor ARHI
            contributes to follicular thyroid carcinogenesis
  JOURNAL   J Clin Endocrinol Metab 90 (2), 1149-1155 (2005)
   PUBMED   15546898
  REMARK    GeneRIF: Silencing of the putative maternally imprinted tumor
            suppressor gene ARHI serves as a key early event in follicular
            thyroid carcinogenesis.
REFERENCE   5  (bases 1 to 4322)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   6  (bases 1 to 4322)
  AUTHORS   Zolkiewska,A. and Moss,J.
  TITLE     The alpha 7 integrin as a target protein for cell surface
            mono-ADP-ribosylation in muscle cells
  JOURNAL   Adv Exp Med Biol 419, 297-303 (1997)
   PUBMED   9193669
REFERENCE   7  (bases 1 to 4322)
  AUTHORS   Takada,T., Iida,K. and Moss,J.
  TITLE     Cloning and site-directed mutagenesis of human ADP-ribosylarginine
            hydrolase
  JOURNAL   J Biol Chem 268 (24), 17837-17843 (1993)
   PUBMED   8349667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073352.22.
            
            Summary: The enzyme encoded by this gene catalyzes removal of
            mono-ADP-ribose from arginine residues of proteins in the
            ADP-ribosylation cycle. Unlike the rat and mouse enzymes that
            require DTT for maximal activity, the human enzyme is
            DTT-independent. Alternatively spliced transcript variants that
            encode different protein isoforms have been described. [provided by
            RefSeq, May 2014].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020574.1, AK313369.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1145              AC073352.22        61919-63063         c
            1146-1479           AC073352.22        60088-60421         c
            1480-1840           AC073352.22        55910-56270         c
            1841-4322           AC073352.22        52610-55091         c
FEATURES             Location/Qualifiers
     source          1..4322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..4322
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /note="ADP-ribosylarginine hydrolase"
                     /db_xref="GeneID:141"
                     /db_xref="HGNC:HGNC:269"
                     /db_xref="MIM:603081"
     exon            1..1145
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1479
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1182..2255
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /EC_number="3.2.2.19"
                     /note="isoform 1 is encoded by transcript variant 5;
                     ADP-ribose-L-arginine cleaving enzyme; [Protein
                     ADP-ribosylarginine] hydrolase; ADP-ribosylhydrolase ARH1"
                     /codon_start=1
                     /product="ADP-ribosylarginine hydrolase isoform 1"
                     /protein_id="NP_001378921.1"
                     /db_xref="CCDS:CCDS2990.1"
                     /db_xref="GeneID:141"
                     /db_xref="HGNC:HGNC:269"
                     /db_xref="MIM:603081"
                     /translation="MEKYVAAMVLSAAGDALGYYNGKWEFLQDGEKIHRQLAQLGGLD
                     ALDVGRWRVSDDTVMHLATAEALVEAGKAPKLTQLYYLLAKHYQDCMEDMDGRAPGGA
                     SVHNAMQLKPGKPNGWRIPFNSHEGGCGAAMRAMCIGLRFPHHSQLDTLIQVSIESGR
                     MTHHHPTGYLGALASALFTAYAVNSRPPLQWGKGLMELLPEAKKYIVQSGYFVEENLQ
                     HWSYFQTKWENYLKLRGILDGESAPTFPESFGVKERDQFYTSLSYSGWGGSSGHDAPM
                     IAYDAVLAAGDSWKELAHRAFFHGGDSDSTAAIAGCWWGVMYGFKGVSPSNYEKLEYR
                     NRLEETARALYSLGSKEDTVISL"
     exon            1480..1840
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..4322
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4298..4303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /note="hexamer: AATAAA"
     polyA_site      4322
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /note="major polyA site"
ORIGIN      
        1 acagccaggc gagagccggc tttccggtgc cgccacattc cgggcaccag gctccgggct
       61 cttcagagca tttggggcgg gcgacggagg tcccgtccac tctcgcttgg gtgcagaagg
      121 gcgcggcggt gccaggaagc cgccttggag gctccaagat tagctcactc agcgcggcca
      181 agcgcaggtg cgggggccct cgccgccacc ctgcttatct ggggacagtc ccggaacccg
      241 gtgacccggc tccgccccaa cccgcgccct cgtccacccg cagcagccaa ggcctcttcc
      301 ccggccccgg gagcccgcgc cacgcccgtc gctcgcgcgt tccagtccag gctacagcag
      361 gtatcgcgat cccggccctc ggccccgcgc tcccctcccc cgcccctggc gctctccgag
      421 tgtggccgac catgaggatt cccagtcttg caaatcgtgg gagcgtgtca accgccccgt
      481 ttctttccaa agccgggcat ggcccggaag cagctgatca gatcttagtt ctgaatgtat
      541 agttcgggta cgagaatgtg acccgtgaaa gttcagagga gttaagtaat tacagcgttc
      601 tgaaagcgaa cgttaaaggg aatttacaac cgaaaaaaga tgccggtctt cttcccccat
      661 cccagcttgc aattcacaga agcacacatt agggtggagc cagaaggaat tacggaaagg
      721 acaatgagga cattgagagg gagggtatgg ggggttaaag ttagtcctcc gaggccaaga
      781 agcagagtgt cttggcctag tgtctgaaaa tcgcagcgca ggacggaact tccgagagcc
      841 tatacctccc cacttccccc tccagtttac agatgggcaa accgctgtcc cgggtgtctg
      901 tcaggtctag tagcccagaa tctcagtgcc taggcttcac tgtaaataat aaactatgta
      961 aataacattt acaaatatcc tttgtgagct cagaaactca gcattaccag taactgggta
     1021 gtggaacgca tccatcttcg tcgtttactc cttctccagg ggctctccag cctgcattcc
     1081 atggccaaca gcagtgcagc tgcagaagca cttctggaag cctcctgact tgaactagac
     1141 cttggacacc ctctccagag cccagcaatt gtgagggact gatggagaag tatgtggctg
     1201 ctatggtgct gagtgcagct ggagatgccc tggggtacta caatgggaag tgggagttcc
     1261 tccaggatgg ggagaagata caccggcagt tggcccagct gggcggcttg gatgccctag
     1321 acgtgggaag gtggagagtt agtgacgaca cagtgatgca cttggccaca gcagaagctc
     1381 ttgtggaagc tgggaaagcc cctaagttga ctcaactgta ttacctcctt gctaagcatt
     1441 accaagactg catggaagac atggatgggc gggcaccagg tggtgcctcg gtgcacaacg
     1501 ccatgcagct gaagccgggc aagcccaatg gctggaggat tcccttcaac agccatgagg
     1561 gcggctgtgg ggctgccatg cgggccatgt gcatcggtct caggttccca caccatagcc
     1621 aactggacac actgatccaa gtgagcatcg agagtggtcg gatgacccac caccacccaa
     1681 caggctacct gggggccctt gcgtctgctc tttttacagc ctatgctgtg aatagcagac
     1741 cacccttgca gtggggaaaa ggactgatgg agctgctacc agaagctaaa aagtacattg
     1801 tccaatcagg ctactttgta gaggaaaatc ttcaacactg gtcctacttc caaaccaaat
     1861 gggaaaatta cctaaaactt agagggattt tggatggaga atcagcccct accttccctg
     1921 agtctttcgg tgtgaaggag agggatcagt tctacacctc cctgagctac tctggctggg
     1981 gtggcagcag tgggcacgat gcccccatga ttgcctacga tgctgttctt gctgcaggag
     2041 actcctggaa ggagcttgcc caccgagcct ttttccatgg tggagacagt gattctacag
     2101 ctgccattgc tggctgctgg tggggagtta tgtatggttt taaaggagtg agtccctcca
     2161 actatgagaa actagaatac agaaaccggc tggaagagac agctagggct ttatattctc
     2221 tcgggtcaaa agaagacact gtaatttccc tttagggaga cgtgatgttc acttctgatg
     2281 gattcttctt ttgtgtattt ccttttctgc tatttctttt cagtttttcc aaagtcaaga
     2341 gtcttaacct tgtactcagg gaattttgag ataacaagtc ccttgggcac cttaagctca
     2401 gttttttcag gctcatcctg ttcttccaga atctatccct tttcttacac tgaagagtcc
     2461 tttagctcaa ttgatagggt cagcgtctcg caagcaaaaa atctcatgac ctcatatttg
     2521 agtcttcatt ttcatcatct acttgttcta aaagtttttt ctgtttgtct caagttgggt
     2581 tcccacaaag tggactttga gacaaagatc tgaatgcaag cagtttatat gggagatgat
     2641 tccaggaaat accgatatga gaatggggaa atgaaaccag gaagggaaga gagctagtat
     2701 ggggtatgtt aatgagcagg tttccactgt gggcggttgg cactctgcca tctgagtcct
     2761 ctgcctaaag cattcctcag aactgtccca tttgaagggc aagcaaacct ggggtattta
     2821 tccactgact tccatctgac actggttgag gaccactgcc agggatgcta actccctggt
     2881 aattcttggc ttaccctttg tacaaaccaa accttagtgt cttcaggtaa agactcagag
     2941 atacttgcag gggcaagctg taaagggcat gggaacagtg agggacatat gtggggtcct
     3001 aacaatatct gctaggctgg tctacctcct aaatatactc tgaatctatc acctctattg
     3061 ccttcttgca ctgaggattt ttcagctgga tttctgcaat ccaagctact caagtctggg
     3121 agatgctgct ctgagctgct ctcagtactc tcctcatcat ggcagttaac acattaccaa
     3181 ttttgttatt gtctgtttgc ttgtttgcat tatttctaaa cagaacctag cacagtgctt
     3241 gggcagccaa taggcattaa tcagtatcta ttgagtgtta tgaactagcc tcctagctcg
     3301 tgcttccctc attaccctcc agagttatgt ttacgaataa caaattgacc atgctaaact
     3361 aatcatgttc caatgaatac atcacctttc ttcatttctt gatgctcttc ccaatccttg
     3421 tctacctgat aataaattct tacttgtcct tcaagaccca actcagatag atagagcttc
     3481 ctgagtgaaa cctgctttga ttgttcaggc acttggccac cttctcctca ctcctcccac
     3541 agccttctgt cttggccttg tcatcacatc aatcctgttg tgtggtgctg tgtgtcttct
     3601 gggtcagtcc taggcacatg ctgcccagca catgtccacc tgggaaatga gatgccatcg
     3661 tcacattcat ttggtcaccc tcagtccagc cagtgggctt gctctcattt ggcctgttct
     3721 caggggtggg aaggaagagc gtcccttcct tctccttttg agaaaaccac agaactatga
     3781 ctctcatgat ttttcctttg tgaaatccct ggttttcagc tggaagcggt gggtaaatga
     3841 ggtctgatga tagcagtcct gccaccttct agttcatccc ataggaatgt ttttccaagt
     3901 ccttccagtc tttttagaac gtggtggagg agggttgtgt gtgccccagg gggtcggggg
     3961 taggggatgc agggaggatc ttagcatttg ttgttttcta gtgcagggct ttagccacaa
     4021 ttgtaaacaa caggaaaagg ctctttagag atcctattag atttgctttg ccgattgtca
     4081 ctcttcatca caggcacatt tcaaaaagag gttagacttt cagacttctt ttttctcaaa
     4141 cctcaaaact tccaccccaa acttcgctct cagctggtga ctttgcttct ttatgtgtgt
     4201 gtatgtgtgt cagagaaaga gagagagaga gagagaaggg aggatgagaa cgaatggggg
     4261 gaagagataa actttatgca taacattagg gtaaatcaat aaagatggtc tgacacatcg
     4321 ta
//
