LOCUS       NM_001125               3623 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens ADP-ribosylarginine hydrolase (ADPRH), transcript
            variant 1, mRNA.
ACCESSION   NM_001125
VERSION     NM_001125.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3623)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3623)
  AUTHORS   Rack,J.G.M., Ariza,A., Drown,B.S., Henfrey,C., Bartlett,E.,
            Shirai,T., Hergenrother,P.J. and Ahel,I.
  TITLE     (ADP-ribosyl)hydrolases: Structural Basis for Differential
            Substrate Recognition and Inhibition
  JOURNAL   Cell Chem Biol 25 (12), 1533-1546 (2018)
   PUBMED   30472116
REFERENCE   3  (bases 1 to 3623)
  AUTHORS   Kernstock,S., Koch-Nolte,F., Mueller-Dieckmann,J., Weiss,M.S. and
            Mueller-Dieckmann,C.
  TITLE     Cloning, expression, purification and crystallization as well as
            X-ray fluorescence and preliminary X-ray diffraction analyses of
            human ADP-ribosylhydrolase 1
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 65 (Pt 5), 529-532
            (2009)
   PUBMED   19407395
  REMARK    GeneRIF: prerequisite for obtaining well diffracting crystals was
            the performance of X-ray fluorescence analysis on poorly
            diffracting apo hARH1 crystals, which revealed the presence of
            trace amounts of K(+) in the crystal
REFERENCE   4  (bases 1 to 3623)
  AUTHORS   Weber,F., Aldred,M.A., Morrison,C.D., Plass,C., Frilling,A.,
            Broelsch,C.E., Waite,K.A. and Eng,C.
  TITLE     Silencing of the maternally imprinted tumor suppressor ARHI
            contributes to follicular thyroid carcinogenesis
  JOURNAL   J Clin Endocrinol Metab 90 (2), 1149-1155 (2005)
   PUBMED   15546898
  REMARK    GeneRIF: Silencing of the putative maternally imprinted tumor
            suppressor gene ARHI serves as a key early event in follicular
            thyroid carcinogenesis.
REFERENCE   5  (bases 1 to 3623)
  AUTHORS   Glowacki,G., Braren,R., Firner,K., Nissen,M., Kuhl,M., Reche,P.,
            Bazan,F., Cetkovic-Cvrlje,M., Leiter,E., Haag,F. and Koch-Nolte,F.
  TITLE     The family of toxin-related ecto-ADP-ribosyltransferases in humans
            and the mouse
  JOURNAL   Protein Sci 11 (7), 1657-1670 (2002)
   PUBMED   12070318
REFERENCE   6  (bases 1 to 3623)
  AUTHORS   Zolkiewska,A. and Moss,J.
  TITLE     The alpha 7 integrin as a target protein for cell surface
            mono-ADP-ribosylation in muscle cells
  JOURNAL   Adv Exp Med Biol 419, 297-303 (1997)
   PUBMED   9193669
REFERENCE   7  (bases 1 to 3623)
  AUTHORS   Takada,T., Iida,K. and Moss,J.
  TITLE     Cloning and site-directed mutagenesis of human ADP-ribosylarginine
            hydrolase
  JOURNAL   J Biol Chem 268 (24), 17837-17843 (1993)
   PUBMED   8349667
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073352.22, BC063883.1 and
            BC074769.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001125.3.
            
            Summary: The enzyme encoded by this gene catalyzes removal of
            mono-ADP-ribose from arginine residues of proteins in the
            ADP-ribosylation cycle. Unlike the rat and mouse enzymes that
            require DTT for maximal activity, the human enzyme is
            DTT-independent. Alternatively spliced transcript variants that
            encode different protein isoforms have been described. [provided by
            RefSeq, May 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer protein. Variants 1, 2 and 4
            encode the same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063883.1, SRR1660809.34822.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357003.8/ ENSP00000349496.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC073352.22        62880-63063         c
            185-1027            BC063883.1         1-843
            1028-1582           BC074769.2         585-1139
            1583-3623           BC063883.1         1399-3439
FEATURES             Location/Qualifiers
     source          1..3623
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..3623
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /note="ADP-ribosylarginine hydrolase"
                     /db_xref="GeneID:141"
                     /db_xref="HGNC:HGNC:269"
                     /db_xref="MIM:603081"
     exon            1..360
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     exon            361..446
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..780
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             483..1556
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /EC_number="3.2.2.19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribose-L-arginine cleaving enzyme; [Protein
                     ADP-ribosylarginine] hydrolase; ADP-ribosylhydrolase ARH1"
                     /codon_start=1
                     /product="ADP-ribosylarginine hydrolase isoform 1"
                     /protein_id="NP_001116.1"
                     /db_xref="CCDS:CCDS2990.1"
                     /db_xref="GeneID:141"
                     /db_xref="HGNC:HGNC:269"
                     /db_xref="MIM:603081"
                     /translation="MEKYVAAMVLSAAGDALGYYNGKWEFLQDGEKIHRQLAQLGGLD
                     ALDVGRWRVSDDTVMHLATAEALVEAGKAPKLTQLYYLLAKHYQDCMEDMDGRAPGGA
                     SVHNAMQLKPGKPNGWRIPFNSHEGGCGAAMRAMCIGLRFPHHSQLDTLIQVSIESGR
                     MTHHHPTGYLGALASALFTAYAVNSRPPLQWGKGLMELLPEAKKYIVQSGYFVEENLQ
                     HWSYFQTKWENYLKLRGILDGESAPTFPESFGVKERDQFYTSLSYSGWGGSSGHDAPM
                     IAYDAVLAAGDSWKELAHRAFFHGGDSDSTAAIAGCWWGVMYGFKGVSPSNYEKLEYR
                     NRLEETARALYSLGSKEDTVISL"
     exon            781..1141
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..3623
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3599..3604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /note="hexamer: AATAAA"
     polyA_site      3623
                     /gene="ADPRH"
                     /gene_synonym="ARH1; hARH1"
                     /note="major polyA site"
ORIGIN      
        1 acagccaggc gagagccggc tttccggtgc cgccacattc cgggcaccag gctccgggct
       61 cttcagagca tttggggcgg gcgacggagg tcccgtccac tctcgcttgg gtgcagaagg
      121 gcgcggcggt gccaggaagc cgccttggag gctccaagat tagctcactc agcgcggcca
      181 agcgcaggtg cgggggccct cgccgccacc ctgcttatct ggggacagtc ccggaacccg
      241 gtgacccggc tccgccccaa cccgcgccct cgtccacccg cagcagccaa ggcctcttcc
      301 ccggccccgg gagcccgcgc cacgcccgtc gctcgcgcgt tccagtccag gctacagcag
      361 gggctctcca gcctgcattc catggccaac agcagtgcag ctgcagaagc acttctggaa
      421 gcctcctgac ttgaactaga ccttggacac cctctccaga gcccagcaat tgtgagggac
      481 tgatggagaa gtatgtggct gctatggtgc tgagtgcagc tggagatgcc ctggggtact
      541 acaatgggaa gtgggagttc ctccaggatg gggagaagat acaccggcag ttggcccagc
      601 tgggcggctt ggatgcccta gacgtgggaa ggtggagagt tagtgacgac acagtgatgc
      661 acttggccac agcagaagct cttgtggaag ctgggaaagc ccctaagttg actcaactgt
      721 attacctcct tgctaagcat taccaagact gcatggaaga catggatggg cgggcaccag
      781 gtggtgcctc ggtgcacaac gccatgcagc tgaagccggg caagcccaat ggctggagga
      841 ttcccttcaa cagccatgag ggcggctgtg gggctgccat gcgggccatg tgcatcggtc
      901 tcaggttccc acaccatagc caactggaca cactgatcca agtgagcatc gagagtggtc
      961 ggatgaccca ccaccaccca acaggctacc tgggggccct tgcgtctgct ctttttacag
     1021 cctatgctgt gaatagcaga ccacccttgc agtggggaaa aggactgatg gagctgctac
     1081 cagaagctaa aaagtacatt gtccaatcag gctactttgt agaggaaaat cttcaacact
     1141 ggtcctactt ccaaaccaaa tgggaaaatt acctaaaact tagagggatt ttggatggag
     1201 aatcagcccc taccttccct gagtctttcg gtgtgaagga gagggatcag ttctacacct
     1261 ccctgagcta ctctggctgg ggtggcagca gtgggcacga tgcccccatg attgcctacg
     1321 atgctgttct tgctgcagga gactcctgga aggagcttgc ccaccgagcc tttttccatg
     1381 gtggagacag tgattctaca gctgccattg ctggctgctg gtggggagtt atgtatggtt
     1441 ttaaaggagt gagtccctcc aactatgaga aactagaata cagaaaccgg ctggaagaga
     1501 cagctagggc tttatattct ctcgggtcaa aagaagacac tgtaatttcc ctttagggag
     1561 acgtgatgtt cacttctgat ggattcttct tttgtgtatt tccttttctg ctatttcttt
     1621 tcagtttttc caaagtcaag agtcttaacc ttgtactcag ggaattttga gataacaagt
     1681 cccttgggca ccttaagctc agttttttca ggctcatcct gttcttccag aatctatccc
     1741 ttttcttaca ctgaagagtc ctttagctca attgataggg tcagcgtctc gcaagcaaaa
     1801 aatctcatga cctcatattt gagtcttcat tttcatcatc tacttgttct aaaagttttt
     1861 tctgtttgtc tcaagttggg ttcccacaaa gtggactttg agacaaagat ctgaatgcaa
     1921 gcagtttata tgggagatga ttccaggaaa taccgatatg agaatgggga aatgaaacca
     1981 ggaagggaag agagctagta tggggtatgt taatgagcag gtttccactg tgggcggttg
     2041 gcactctgcc atctgagtcc tctgcctaaa gcattcctca gaactgtccc atttgaaggg
     2101 caagcaaacc tggggtattt atccactgac ttccatctga cactggttga ggaccactgc
     2161 cagggatgct aactccctgg taattcttgg cttacccttt gtacaaacca aaccttagtg
     2221 tcttcaggta aagactcaga gatacttgca ggggcaagct gtaaagggca tgggaacagt
     2281 gagggacata tgtggggtcc taacaatatc tgctaggctg gtctacctcc taaatatact
     2341 ctgaatctat cacctctatt gccttcttgc actgaggatt tttcagctgg atttctgcaa
     2401 tccaagctac tcaagtctgg gagatgctgc tctgagctgc tctcagtact ctcctcatca
     2461 tggcagttaa cacattacca attttgttat tgtctgtttg cttgtttgca ttatttctaa
     2521 acagaaccta gcacagtgct tgggcagcca ataggcatta atcagtatct attgagtgtt
     2581 atgaactagc ctcctagctc gtgcttccct cattaccctc cagagttatg tttacgaata
     2641 acaaattgac catgctaaac taatcatgtt ccaatgaata catcaccttt cttcatttct
     2701 tgatgctctt cccaatcctt gtctacctga taataaattc ttacttgtcc ttcaagaccc
     2761 aactcagata gatagagctt cctgagtgaa acctgctttg attgttcagg cacttggcca
     2821 ccttctcctc actcctccca cagccttctg tcttggcctt gtcatcacat caatcctgtt
     2881 gtgtggtgct gtgtgtcttc tgggtcagtc ctaggcacat gctgcccagc acatgtccac
     2941 ctgggaaatg agatgccatc gtcacattca tttggtcacc ctcagtccag ccagtgggct
     3001 tgctctcatt tggcctgttc tcaggggtgg gaaggaagag cgtcccttcc ttctcctttt
     3061 gagaaaacca cagaactatg actctcatga tttttccttt gtgaaatccc tggttttcag
     3121 ctggaagcgg tgggtaaatg aggtctgatg atagcagtcc tgccaccttc tagttcatcc
     3181 cataggaatg tttttccaag tccttccagt ctttttagaa cgtggtggag gagggttgtg
     3241 tgtgccccag ggggtcgggg gtaggggatg cagggaggat cttagcattt gttgttttct
     3301 agtgcagggc tttagccaca attgtaaaca acaggaaaag gctctttaga gatcctatta
     3361 gatttgcttt gccgattgtc actcttcatc acaggcacat ttcaaaaaga ggttagactt
     3421 tcagacttct tttttctcaa acctcaaaac ttccacccca aacttcgctc tcagctggtg
     3481 actttgcttc tttatgtgtg tgtatgtgtg tcagagaaag agagagagag agagagaagg
     3541 gaggatgaga acgaatgggg ggaagagata aactttatgc ataacattag ggtaaatcaa
     3601 taaagatggt ctgacacatc gta
//
