LOCUS       NM_001365225            2608 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens ADP dependent glucokinase (ADPGK), transcript variant
            4, mRNA.
ACCESSION   NM_001365225 XM_006720712
VERSION     NM_001365225.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2608)
  AUTHORS   Herrera-Morande,A., Vallejos-Baccelliere,G., Cea,P.A., Zamora,R.A.,
            Cid,D., Maturana,P., Gonzalez-Ordenes,F., Castro-Fernandez,V. and
            Guixe,V.
  TITLE     Kinetic characterization and phylogenetic analysis of human
            ADP-dependent glucokinase reveal new insights into its regulatory
            properties
  JOURNAL   Arch Biochem Biophys 741, 109602 (2023)
   PUBMED   37084804
  REMARK    GeneRIF: Kinetic characterization and phylogenetic analysis of
            human ADP-dependent glucokinase reveal new insights into its
            regulatory properties.
REFERENCE   2  (bases 1 to 2608)
  AUTHORS   Tandon,A., Birkenhagen,J., Nagalla,D., Kolker,S. and Sauer,S.W.
  TITLE     ADP-dependent glucokinase as a novel onco-target for haematological
            malignancies
  JOURNAL   Sci Rep 10 (1), 13584 (2020)
   PUBMED   32788680
  REMARK    GeneRIF: ADP-dependent glucokinase as a novel onco-target for
            haematological malignancies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2608)
  AUTHORS   Jiang,H.Y. and Wang,Z.J.
  TITLE     ADPGK-AS1 promotes the progression of colorectal cancer via
            sponging miR-525 to upregulate FUT1
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (5), 2380-2386 (2020)
   PUBMED   32196589
  REMARK    GeneRIF: ADPGK-AS1 promotes the progression of colorectal cancer
            via sponging miR-525 to upregulate FUT1.
REFERENCE   4  (bases 1 to 2608)
  AUTHORS   Imle,R., Wang,B.T., Stutzenberger,N., Birkenhagen,J., Tandon,A.,
            Carl,M., Himmelreich,N., Thiel,C., Grone,H.J., Poschet,G.,
            Volkers,M., Gulow,K., Schroder,A., Carillo,S., Mittermayr,S.,
            Bones,J., Kaminski,M.M., Kolker,S. and Sauer,S.W.
  TITLE     ADP-dependent glucokinase regulates energy metabolism via
            ER-localized glucose sensing
  JOURNAL   Sci Rep 9 (1), 14248 (2019)
   PUBMED   31582762
  REMARK    GeneRIF: ADP-dependent glucokinase regulates energy metabolism via
            ER-localized glucose sensing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2608)
  AUTHORS   Richter,J.P., Goroncy,A.K., Ronimus,R.S. and Sutherland-Smith,A.J.
  TITLE     The Structural and Functional Characterization of Mammalian
            ADP-dependent Glucokinase
  JOURNAL   J Biol Chem 291 (8), 3694-3704 (2016)
   PUBMED   26555263
  REMARK    GeneRIF: ADPGK is substrate inhibited by high glucose concentration
            and shows high specificity for glucose, with no activity for other
            sugars, as determined by NMR spectroscopy, including 2-deoxyglucose
REFERENCE   6  (bases 1 to 2608)
  AUTHORS   Cuesta-Munoz,A.L., Tuomi,T., Cobo-Vuilleumier,N., Koskela,H.,
            Odili,S., Stride,A., Buettger,C., Otonkoski,T., Froguel,P.,
            Grimsby,J., Garcia-Gimeno,M. and Matschinsky,F.M.
  TITLE     Clinical heterogeneity in monogenic diabetes caused by mutations in
            the glucokinase gene (GCK-MODY)
  JOURNAL   Diabetes Care 33 (2), 290-292 (2010)
   PUBMED   19903754
  REMARK    GeneRIF: Glucose and insulin response to oral glucose is higher in
            GCK(261) carriers, indicating clinical heterogeneity in GCK
            maturity diabetes carriers.
REFERENCE   7  (bases 1 to 2608)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 2608)
  AUTHORS   Codner,E., Rocha,A., Deng,L., Martinez-Aguayo,A., Godoy,C.,
            Mericq,V. and Chung,W.K.
  TITLE     Mild fasting hyperglycemia in children: high rate of glucokinase
            mutations and some risk of developing type 1 diabetes mellitus
  JOURNAL   Pediatr Diabetes 10 (6), 382-388 (2009)
   PUBMED   19309449
  REMARK    GeneRIF: The presence of mild persistent hyperglycemia in any
            patient without autoantibodies should lead to genetic analysis of
            glucokinase, particularly if there is a positive family history.
REFERENCE   9  (bases 1 to 2608)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   10 (bases 1 to 2608)
  AUTHORS   Ronimus,R.S. and Morgan,H.W.
  TITLE     Cloning and biochemical characterization of a novel mouse
            ADP-dependent glucokinase
  JOURNAL   Biochem Biophys Res Commun 315 (3), 652-658 (2004)
   PUBMED   14975750
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA031990.1, AC009712.22 and BC006112.1.
            
            On Aug 9, 2018 this sequence version replaced XM_006720712.4.
            
            Summary: ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent
            phosphorylation of glucose to glucose-6-phosphate and may play a
            role in glycolysis, possibly during ischemic conditions (Ronimus
            and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.264894.1,
                                           SRR1803614.277659.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456471.3/ ENSP00000397694.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-504               DA031990.1         28-531
            505-505             AC009712.22        160427-160427       c
            506-1648            BC006112.1         475-1617
            1649-2608           AC009712.22        136828-137787       c
FEATURES             Location/Qualifiers
     source          1..2608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q24.1"
     gene            1..2608
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /note="ADP dependent glucokinase"
                     /db_xref="GeneID:83440"
                     /db_xref="HGNC:HGNC:25250"
                     /db_xref="MIM:611861"
     exon            1..300
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1561
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /EC_number="2.7.1.147"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; ATP-dependent glucokinase; rbBP-35"
                     /codon_start=1
                     /product="ADP-dependent glucokinase isoform 4 precursor"
                     /protein_id="NP_001352154.1"
                     /db_xref="CCDS:CCDS92041.1"
                     /db_xref="GeneID:83440"
                     /db_xref="HGNC:HGNC:25250"
                     /db_xref="MIM:611861"
                     /translation="MALWRGSAYAGFLALAVGCVFLLEPELPGSALRSLWSSLCLGPA
                     PAPPGPVSPEGRLAAAWDALIVRPVRRWRRVAVGVNACVDVVLSGVKLLQALGLSPGN
                     GKDHSILHSRNDLEEAFIHFMGKGAAAERFFSDKETFHDIAQVASEFPGAQHYVGGNA
                     ALIGQKFAANSDLKVLLCGPVGPKLHELLDDNVFVPPESLQEVDEFHLILEYQAGEEW
                     GQLKAPHANRFIFSHDLSNGAMNMLEVFVSSLEEFQPDLVVLSGLHMMEGQSKELQRK
                     RLLEVVTSISDIPTGIPVHLELASMTNRELMSSIVHQQVFPAVTSLGLNEQELLFLTQ
                     SASGPHSSLSSWNGVPDVGMVSDILFWILKEHGRSKSRASDLTRIHFHTLVYHILATV
                     DGHWANQLAAVAAGARVAGTQACATETIDTSRVSLRAPQEFMTSHSEAGSRIVLNPNK
                     PVVEWHREGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSEVHPHY"
     exon            301..526
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /inference="alignment:Splign:2.1.0"
     exon            527..589
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /inference="alignment:Splign:2.1.0"
     exon            590..710
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /inference="alignment:Splign:2.1.0"
     exon            711..907
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1006
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..2608
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2510..2515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /note="hexamer: ATTAAA"
     polyA_site      2535
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /note="major polyA site"
     regulatory      2586..2591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
                     /note="hexamer: GATAAA"
     polyA_site      2608
                     /gene="ADPGK"
                     /gene_synonym="2610017G09Rik; ADP-GK"
ORIGIN      
        1 gccgagcccg gaagaggcgc gggctaggaa aggagttggt tcgcgcaggt gcggcgcctg
       61 ggtccccatg gcgctgtggc gcggctccgc gtacgcgggc ttcctggcgc tggccgtggg
      121 ctgcgtcttc ctgctggagc cagagctgcc aggctcggcg ctgcgctctc tctggagctc
      181 gctgtgtctg gggcccgcgc ctgcgccccc gggacccgtc tcccccgagg gccggttggc
      241 ggcagcctgg gacgcgctta tcgtgcggcc agtccggcgc tggcgccgcg tggcagtggg
      301 agtcaatgca tgtgttgatg tggtgctctc aggggtgaag ctcttgcagg cacttggcct
      361 tagtcctggg aatgggaaag atcacagcat tctgcattca aggaatgatc tggaagaagc
      421 cttcattcac ttcatgggga agggagcagc tgctgagcgc ttcttcagtg ataaggaaac
      481 ttttcacgac attgcccagg ttgcatcaga gttcccagga gcccagcact atgtaggagg
      541 aaatgcagct ttaattggac agaaatttgc agccaactca gatttaaagg ttcttctttg
      601 cggtccagtt ggtccaaagc tacatgagct tcttgatgac aatgtctttg ttccaccaga
      661 gtcattgcag gaagtggatg agttccacct cattttagag tatcaagcag gggaggagtg
      721 gggccagtta aaagctcccc atgccaaccg attcatcttc tctcacgacc tctccaacgg
      781 ggccatgaat atgctggagg tgtttgtgtc tagcctggag gagtttcagc cagacctggt
      841 ggtcctctct ggattgcaca tgatggaggg acaaagcaag gagctccaga ggaagagact
      901 cttggaggtt gtaacctcca tttctgacat ccccactggt attccagttc acctagagct
      961 ggccagtatg actaacaggg agctcatgag cagcattgtc catcagcagg tctttcccgc
     1021 ggtgacttcc cttgggctga atgaacagga gctgttattt ctcacccagt cagcctctgg
     1081 acctcactct tctctctctt cctggaacgg tgttcctgat gtgggcatgg tcagtgacat
     1141 cctcttctgg atcttgaaag aacatgggag gagtaaaagc agagcctcgg atctcaccag
     1201 gatccatttc cacacgctgg tctaccacat cctggcaact gtggatggac actgggccaa
     1261 ccagctggca gccgtggctg caggagctcg tgtggctggg acacaggcct gcgccacaga
     1321 aaccatagac accagccgag tgtctctgag ggcaccccaa gagttcatga cttcccattc
     1381 ggaggcaggc tccaggattg tattaaaccc aaacaagcca gtagtagaat ggcacagaga
     1441 gggaatatcc ttccacttca caccagtatt ggtgtgtaaa gaccccattc gaactgtagg
     1501 ccttggagat gccatttcag ccgaaggact cttctattcg gaagtacacc ctcactatta
     1561 ggaagattct taggggtaat ttttctgagg aaggagaact agccaactta agaattacag
     1621 gaagaaagtg gtttggaaga cagccaaaga aataaaagca gattaaactg tatcaggtac
     1681 attccagcct gttggcaact ccataaaaac atttcagatt ttaatccgaa tttagctaat
     1741 gagactggat ttttgttttt tatgttgtgt gtcacagagc taaaaactca gttcccaaat
     1801 ccccagttta tgcagcgcca tcaggtattt taagctaaac ttcttcaccc ctgagagcat
     1861 gtcagctgga gaaaagcagt tcttccttgc ccacttgaga agtgcacgcc cactcaccca
     1921 acatcctggt ctctaggaaa gcctcatgtg aggttcctct ttctttcagc tcagtgccca
     1981 tgggcaagga tcatgatttc cattccgtgt tacaatgaca atatttaatg agcataacct
     2041 tctcagtctc ctgctctcaa atttaggaca gagccgctaa ggacaaaaca atccctcccg
     2101 tgctttatga tggcagcagg ggctggggag cctctgaggg actctttcat tctgcagttg
     2161 tctggaagcc tgggtggcgt catgagctga aggatcatgc tttcctgtcc tggctccata
     2221 ggttataggc tggctggtga aaggttcacg tggcccaggc tgaacttcat tgcctagctt
     2281 tggatgtgct ttctgccata aagactgatt tttgttcgtt ctgagccttc aaggaatttg
     2341 ttttttacaa ctggaatatg ctcctgtgtg tgttaacaga tcatggatgt tttatgtttt
     2401 cactgatcat ttaaagagtt tgacctcaga gctccaggat catcagtaaa tttgtcatgt
     2461 tatatattta tttttttata aatcaagact tctgtgtgct cttaaatata ttaaaaacaa
     2521 tttacatttc aggaattctg tctgtaattg atttttgtct ccatcaccac tctggaacca
     2581 gataagataa aaatcattct gatcttca
//
