LOCUS       NM_000677               1757 bp    mRNA    linear   PRI 13-NOV-2024
DEFINITION  Homo sapiens adenosine A3 receptor (ADORA3), transcript variant A,
            mRNA.
ACCESSION   NM_000677
VERSION     NM_000677.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1757)
  AUTHORS   Zeng,X., Hu,Y., Qiao,S., Cao,X., Dai,Y., Wu,F. and Wei,Z.
  TITLE     ADORA3 activation promotes goblet cell differentiation via
            enhancing HMGCS2-mediated ketogenesis in ulcerative colitis
  JOURNAL   Int Immunopharmacol 140, 112729 (2024)
   PUBMED   39098229
  REMARK    GeneRIF: ADORA3 activation promotes goblet cell differentiation via
            enhancing HMGCS2-mediated ketogenesis in ulcerative colitis.
REFERENCE   2  (bases 1 to 1757)
  AUTHORS   Sapio,M.R., Staedtler,E.S., King,D.M., Maric,D., Jahanipour,J.,
            Ghetti,A., Jacobson,K.A., Mannes,A.J. and Iadarola,M.J.
  TITLE     Analgesic candidate adenosine A 3 receptors are expressed by
            perineuronal peripheral macrophages in human dorsal root ganglion
            and spinal cord microglia
  JOURNAL   Pain 165 (10), 2323-2343 (2024)
   PUBMED   38691673
  REMARK    GeneRIF: Analgesic candidate adenosine A 3 receptors are expressed
            by perineuronal peripheral macrophages in human dorsal root
            ganglion and spinal cord microglia.
REFERENCE   3  (bases 1 to 1757)
  AUTHORS   Xu,Y., Tang,L., Zhou,C., Sun,L., Hu,Y., Zhang,Z., Xia,S., Bao,X.,
            Yang,H. and Xu,Y.
  TITLE     Inhibition of ADORA3 promotes microglial phagocytosis and
            alleviates chronic ischemic white matter injury
  JOURNAL   CNS Neurosci Ther 30 (5), e14742 (2024)
   PUBMED   38715283
  REMARK    GeneRIF: Inhibition of ADORA3 promotes microglial phagocytosis and
            alleviates chronic ischemic white matter injury.
REFERENCE   4  (bases 1 to 1757)
  AUTHORS   Atkinson,M.R., Townsend-Nicholson,A., Nicholl,J.K., Sutherland,G.R.
            and Schofield,P.R.
  TITLE     Cloning, characterisation and chromosomal assignment of the human
            adenosine A3 receptor (ADORA3) gene
  JOURNAL   Neurosci Res 29 (1), 73-79 (1997)
   PUBMED   9293494
REFERENCE   5  (bases 1 to 1757)
  AUTHORS   Bouma,M.G., Jeunhomme,T.M., Boyle,D.L., Dentener,M.A.,
            Voitenok,N.N., van den Wildenberg,F.A. and Buurman,W.A.
  TITLE     Adenosine inhibits neutrophil degranulation in activated human
            whole blood: involvement of adenosine A2 and A3 receptors
  JOURNAL   J Immunol 158 (11), 5400-5408 (1997)
   PUBMED   9164961
REFERENCE   6  (bases 1 to 1757)
  AUTHORS   Murrison,E.M., Goodson,S.J., Edbrooke,M.R. and Harris,C.A.
  TITLE     Cloning and characterisation of the human adenosine A3 receptor
            gene
  JOURNAL   FEBS Lett 384 (3), 243-246 (1996)
   PUBMED   8617363
REFERENCE   7  (bases 1 to 1757)
  AUTHORS   Monitto,C.L., Levitt,R.C., DiSilvestre,D. and Holroyd,K.J.
  TITLE     Localization of the A3 adenosine receptor gene (ADORA3) to human
            chromosome 1p
  JOURNAL   Genomics 26 (3), 637-638 (1995)
   PUBMED   7607699
REFERENCE   8  (bases 1 to 1757)
  AUTHORS   Salvatore,C.A., Jacobson,M.A., Taylor,H.E., Linden,J. and
            Johnson,R.G.
  TITLE     Molecular cloning and characterization of the human A3 adenosine
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 90 (21), 10365-10369 (1993)
   PUBMED   8234299
REFERENCE   9  (bases 1 to 1757)
  AUTHORS   Sajjadi,F.G. and Firestein,G.S.
  TITLE     cDNA cloning and sequence analysis of the human A3 adenosine
            receptor
  JOURNAL   Biochim Biophys Acta 1179 (1), 105-107 (1993)
   PUBMED   8399349
REFERENCE   10 (bases 1 to 1757)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390195.10.
            
            On Aug 31, 2019 this sequence version replaced NM_000677.3.
            
            Summary: This gene encodes a protein that belongs to the family of
            adenosine receptors, which are G-protein-coupled receptors that are
            involved in a variety of intracellular signaling pathways and
            physiological functions. The receptor encoded by this gene mediates
            a sustained cardioprotective function during cardiac ischemia, it
            is involved in the inhibition of neutrophil degranulation in
            neutrophil-mediated tissue injury, it has been implicated in both
            neuroprotective and neurodegenerative effects, and it may also
            mediate both cell proliferation and cell death. Alternative
            splicing results in multiple transcript variants. This gene shares
            its 5' terminal exon with some transcripts from overlapping
            GeneID:57413, which encodes an immunoglobulin domain-containing
            protein. [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (A) encodes the longest isoform
            (A).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L22607.1, X76981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000241356.5/ ENSP00000241356.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               AL390195.10        102047-102675       c
            630-1757            AL390195.10        98471-99598         c
FEATURES             Location/Qualifiers
     source          1..1757
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..1757
                     /gene="ADORA3"
                     /gene_synonym="A3AR"
                     /note="adenosine A3 receptor"
                     /db_xref="GeneID:140"
                     /db_xref="HGNC:HGNC:268"
                     /db_xref="MIM:600445"
     exon            1..629
                     /gene="ADORA3"
                     /gene_synonym="A3AR"
                     /inference="alignment:Splign:2.1.0"
     CDS             280..1236
                     /gene="ADORA3"
                     /gene_synonym="A3AR"
                     /note="isoform A is encoded by transcript variant A"
                     /codon_start=1
                     /product="adenosine receptor A3 isoform A"
                     /protein_id="NP_000668.1"
                     /db_xref="CCDS:CCDS839.1"
                     /db_xref="GeneID:140"
                     /db_xref="HGNC:HGNC:268"
                     /db_xref="MIM:600445"
                     /translation="MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQ
                     TTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLL
                     AIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRN
                     VTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKET
                     GAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSM
                     MNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE"
     exon            630..1757
                     /gene="ADORA3"
                     /gene_synonym="A3AR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1739..1744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADORA3"
                     /gene_synonym="A3AR"
                     /note="hexamer: AATAAA"
     polyA_site      1757
                     /gene="ADORA3"
                     /gene_synonym="A3AR"
                     /note="major polyA site"
ORIGIN      
        1 agtccatata gagctgtcct acagcattct ggaaacttga ggatgtgcgg tgcataaagg
       61 ggctggaagt gacccacctg tgatgagccc tttctaagga gaagggtttc caagagatca
      121 ccccaccaga aaagggtagg aatgagcaag ttgggaattt tagactgtca ctgcacatgg
      181 acctctggga agacgtctgg cgagagctag gcccactggc cctacagacg gatcttgctg
      241 gctcacctgt ccctgtggag gttcccctgg gaaggcaaga tgcccaacaa cagcactgct
      301 ctgtcattgg ccaatgttac ctacatcacc atggaaattt tcattggact ctgcgccata
      361 gtgggcaacg tgctggtcat ctgcgtggtc aagctgaacc ccagcctgca gaccaccacc
      421 ttctatttca ttgtctctct agccctggct gacattgctg ttggggtgct ggtcatgcct
      481 ttggccattg ttgtcagcct gggcatcaca atccacttct acagctgcct ttttatgact
      541 tgcctactgc ttatctttac ccacgcctcc atcatgtcct tgctggccat cgctgtggac
      601 cgatacttgc gggtcaagct taccgtcaga tacaagaggg tcaccactca cagaagaata
      661 tggctggccc tgggcctttg ctggctggtg tcattcctgg tgggattgac ccccatgttt
      721 ggctggaaca tgaaactgac ctcagagtac cacagaaatg tcaccttcct ttcatgccaa
      781 tttgtttccg tcatgagaat ggactacatg gtatacttca gcttcctcac ctggattttc
      841 atccccctgg ttgtcatgtg cgccatctat cttgacatct tttacatcat tcggaacaaa
      901 ctcagtctga acttatctaa ctccaaagag acaggtgcat tttatggacg ggagttcaag
      961 acggctaagt ccttgtttct ggttcttttc ttgtttgctc tgtcatggct gcctttatct
     1021 atcatcaact gcatcatcta ctttaatggt gaggtaccac agcttgtgct gtacatgggc
     1081 atcctgctgt cccatgccaa ctccatgatg aaccctatcg tctatgccta taaaataaag
     1141 aagttcaagg aaacctacct tttgatcctc aaagcttgtg tggtctgcca tccctctgat
     1201 tctttggaca caagcattga gaagaattct gagtagttat ccatcagaga tgactctgtc
     1261 tcattgacct tcagattccc catcaacaaa cacttgaggg cctgtatgcc tgggccaagg
     1321 gatttttaca tccttgatta cttccactga ggtgggagca tctccagtgc tccccaatta
     1381 tatctccccc actccactac tctcttcctc cacttcattt ttcccttgtc ctttctctct
     1441 aattcagtgt tttggaggcc tgacttgggg acaacgtatt attgatatta ttgtctgttt
     1501 tccttcttcc caatagaaga ataagtcatg gagcctgaag ggtgcctagt tgacttactg
     1561 acaaaaggct ccagttgggc tgaacatgtg tgtggtggtg actcatttcc ataccattgt
     1621 ggaattgagc agagaacctg ctctcggagg atgcctagga gatgttggga acagaaaaaa
     1681 taaactgagt ttaaggggga cttaaactgc tgaattcacc tgtggatgtt tttgagtaaa
     1741 taaaagctaa tagctaa
//
