LOCUS       NM_000676               1522 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens adenosine A2b receptor (ADORA2B), mRNA.
ACCESSION   NM_000676
VERSION     NM_000676.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1522)
  AUTHORS   Oyama,M., Sakamoto,M., Kitabatake,K., Shiina,K., Kitahara,D.,
            Onozawa,S., Nishino,K., Sudo,Y. and Tsukimoto,M.
  TITLE     Involvement of Cannabinoid Receptors and Adenosine A2B Receptor in
            Enhanced Migration of Lung Cancer A549 Cells Induced by gamma-Ray
            Irradiation
  JOURNAL   Biol Pharm Bull 47 (1), 60-71 (2024)
   PUBMED   37926527
  REMARK    GeneRIF: Involvement of Cannabinoid Receptors and Adenosine A2B
            Receptor in Enhanced Migration of Lung Cancer A549 Cells Induced by
            gamma-Ray Irradiation.
REFERENCE   2  (bases 1 to 1522)
  AUTHORS   Strickland,L.N., Faraoni,E.Y., Ruan,W., Yuan,X., Eltzschig,H.K. and
            Bailey-Lundberg,J.M.
  TITLE     The resurgence of the Adora2b receptor as an immunotherapeutic
            target in pancreatic cancer
  JOURNAL   Front Immunol 14, 1163585 (2023)
   PUBMED   37187740
  REMARK    GeneRIF: The resurgence of the Adora2b receptor as an
            immunotherapeutic target in pancreatic cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1522)
  AUTHORS   Faraoni,E.Y., Singh,K., Chandra,V., Le Roux,O., Dai,Y., Sahin,I.,
            O'Brien,B.J., Strickland,L.N., Li,L., Vucic,E., Warner,A.N.,
            Pruski,M., Clark,T., Van Buren,G., Thosani,N.C., Bynon,J.S.,
            Wray,C.J., Bar-Sagi,D., Poulsen,K.L., Vornik,L.A., Savage,M.I.,
            Sei,S., Mohammed,A., Zhao,Z., Brown,P.H., Mills,T., Eltzschig,H.K.,
            McAllister,F. and Bailey-Lundberg,J.M.
  TITLE     CD73-Dependent Adenosine Signaling through Adora2b Drives
            Immunosuppression in Ductal Pancreatic Cancer
  JOURNAL   Cancer Res 83 (7), 1111-1127 (2023)
   PUBMED   36720042
  REMARK    GeneRIF: CD73-Dependent Adenosine Signaling through Adora2b Drives
            Immunosuppression in Ductal Pancreatic Cancer.
REFERENCE   4  (bases 1 to 1522)
  AUTHORS   Campos-Contreras,A.D.R., Gonzalez-Gallardo,A., Diaz-Munoz,M. and
            Vazquez-Cuevas,F.G.
  TITLE     Adenosine Receptor A2B Negatively Regulates Cell Migration in
            Ovarian Carcinoma Cells
  JOURNAL   Int J Mol Sci 23 (9), 4585 (2022)
   PUBMED   35562985
  REMARK    GeneRIF: Adenosine Receptor A2B Negatively Regulates Cell Migration
            in Ovarian Carcinoma Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1522)
  AUTHORS   Kim,J., Shin,J.Y., Choi,Y.H., Lee,S.Y., Jin,M.H., Kim,C.D.,
            Kang,N.G. and Lee,S.
  TITLE     Adenosine and Cordycepin Accelerate Tissue Remodeling Process
            through Adenosine Receptor Mediated Wnt/beta-Catenin Pathway
            Stimulation by Regulating GSK3b Activity
  JOURNAL   Int J Mol Sci 22 (11), 5571 (2021)
   PUBMED   34070360
  REMARK    GeneRIF: Adenosine and Cordycepin Accelerate Tissue Remodeling
            Process through Adenosine Receptor Mediated Wnt/beta-Catenin
            Pathway Stimulation by Regulating GSK3b Activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1522)
  AUTHORS   Jacobson,M.A., Johnson,R.G., Luneau,C.J. and Salvatore,C.A.
  TITLE     Cloning and chromosomal localization of the human A2b adenosine
            receptor gene (ADORA2B) and its pseudogene
  JOURNAL   Genomics 27 (2), 374-376 (1995)
   PUBMED   7558011
REFERENCE   7  (bases 1 to 1522)
  AUTHORS   Strohmeier,G.R., Reppert,S.M., Lencer,W.I. and Madara,J.L.
  TITLE     The A2b adenosine receptor mediates cAMP responses to adenosine
            receptor agonists in human intestinal epithelia
  JOURNAL   J Biol Chem 270 (5), 2387-2394 (1995)
   PUBMED   7836474
REFERENCE   8  (bases 1 to 1522)
  AUTHORS   Townsend-Nicholson,A., Baker,E., Sutherland,G.R. and Schofield,P.R.
  TITLE     Localization of the adenosine A2b receptor subtype gene (ADORA2B)
            to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell
            hybrids
  JOURNAL   Genomics 25 (2), 605-607 (1995)
   PUBMED   7790006
REFERENCE   9  (bases 1 to 1522)
  AUTHORS   Pierce,K.D., Furlong,T.J., Selbie,L.A. and Shine,J.
  TITLE     Molecular cloning and expression of an adenosine A2b receptor from
            human brain
  JOURNAL   Biochem Biophys Res Commun 187 (1), 86-93 (1992)
   PUBMED   1325798
REFERENCE   10 (bases 1 to 1522)
  AUTHORS   Stiles,G.L.
  TITLE     Adenosine receptors
  JOURNAL   J Biol Chem 267 (10), 6451-6454 (1992)
   PUBMED   1551861
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006251.3.
            
            On Nov 20, 2020 this sequence version replaced NM_000676.3.
            
            Summary: This gene encodes an adenosine receptor that is a member
            of the G protein-coupled receptor superfamily. This integral
            membrane protein stimulates adenylate cyclase activity in the
            presence of adenosine. This protein also interacts with netrin-1,
            which is involved in axon elongation. The gene is located near the
            Smith-Magenis syndrome region on chromosome 17. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X68487.1, M97759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304222.3/ ENSP00000304501.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-454               AC006251.3         57134-57587
            455-1522            AC006251.3         86683-87750
FEATURES             Location/Qualifiers
     source          1..1522
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1522
                     /gene="ADORA2B"
                     /gene_synonym="ADORA2"
                     /note="adenosine A2b receptor"
                     /db_xref="GeneID:136"
                     /db_xref="HGNC:HGNC:264"
                     /db_xref="MIM:600446"
     exon            1..454
                     /gene="ADORA2B"
                     /gene_synonym="ADORA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1118
                     /gene="ADORA2B"
                     /gene_synonym="ADORA2"
                     /codon_start=1
                     /product="adenosine receptor A2b"
                     /protein_id="NP_000667.1"
                     /db_xref="CCDS:CCDS11173.1"
                     /db_xref="GeneID:136"
                     /db_xref="HGNC:HGNC:264"
                     /db_xref="MIM:600446"
                     /translation="MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNY
                     FLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVD
                     RYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDG
                     TTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTEL
                     MDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAI
                     LLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL"
     exon            455..1522
                     /gene="ADORA2B"
                     /gene_synonym="ADORA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADORA2B"
                     /gene_synonym="ADORA2"
                     /note="hexamer: AATAAA"
     polyA_site      1522
                     /gene="ADORA2B"
                     /gene_synonym="ADORA2"
                     /note="major polyA site"
ORIGIN      
        1 agaagcggca ggcggaggcg cggtccgggc gctatggcca tgcccggcgg gtctcacgcg
       61 gctgcccctc gcccggcgcg ccttcggtag ggggcgcccg gggcccagct ggcccggcca
      121 tgctgctgga gacacaggac gcgctgtacg tggcgctgga gctggtcatc gccgcgcttt
      181 cggtggcggg caacgtgctg gtgtgcgccg cggtgggcac ggcgaacact ctgcagacgc
      241 ccaccaacta cttcctggtg tccctggctg cggccgacgt ggccgtgggg ctcttcgcca
      301 tcccctttgc catcaccatc agcctgggct tctgcactga cttctacggc tgcctcttcc
      361 tcgcctgctt cgtgctggtg ctcacgcaga gctccatctt cagccttctg gccgtggcag
      421 tcgacagata cctggccatc tgtgtcccgc tcaggtataa aagtttggtc acggggaccc
      481 gagcaagagg ggtcattgct gtcctctggg tccttgcctt tggcatcgga ttgactccat
      541 tcctggggtg gaacagtaaa gacagtgcca ccaacaactg cacagaaccc tgggatggaa
      601 ccacgaatga aagctgctgc cttgtgaagt gtctctttga gaatgtggtc cccatgagct
      661 acatggtata tttcaatttc tttgggtgtg ttctgccccc actgcttata atgctggtga
      721 tctacattaa gatcttcctg gtggcctgca ggcagcttca gcgcactgag ctgatggacc
      781 actcgaggac caccctccag cgggagatcc atgcagccaa gtcactggcc atgattgtgg
      841 ggatttttgc cctgtgctgg ttacctgtgc atgctgttaa ctgtgtcact cttttccagc
      901 cagctcaggg taaaaataag cccaagtggg caatgaatat ggccattctt ctgtcacatg
      961 ccaattcagt tgtcaatccc attgtctatg cttaccggaa ccgagacttc cgctacactt
     1021 ttcacaaaat tatctccagg tatcttctct gccaagcaga tgtcaagagt gggaatggtc
     1081 aggctggggt acagcctgct ctcggtgtgg gcctatgatc taggctctcg cctcttccag
     1141 gagaagatac aaatccacaa gaaacaaaga ggacacggct ggttttcatt gtgaaagata
     1201 gctacacctc acaaggaaat ggactgcctc tcttgagcac ttccctggag ctaccacgta
     1261 tctagctaat atgtatgtgt cagtagtagg ctccaaggat tgacaaatat atttatgatc
     1321 tattcagctg cttttactgt gtggattatg ccaacagctt gaatggattc taacagactc
     1381 ttttgttttt aaaagtctgc cttgtttatg gtggaaaatt actgaaacta ttttactgtg
     1441 aaacagtgtg aactattata atgcaaatac tttttaactt agaggcaatg gaaaaataaa
     1501 agttgactgt actaaaaatg ta
//
