LOCUS       NM_000674               2901 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens adenosine A1 receptor (ADORA1), transcript variant 1,
            mRNA.
ACCESSION   NM_000674 XM_005244900
VERSION     NM_000674.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2901)
  AUTHORS   Zhu,W., Hong,Y., Tong,Z., He,X., Li,Y., Wang,H., Gao,X., Song,P.,
            Zhang,X., Wu,X., Tan,Z., Huang,W., Liu,Z., Bao,Y., Ma,J., Zheng,N.,
            Xie,C., Ke,X., Zhou,W., Jia,W., Li,M., Zhong,J., Sheng,L. and Li,H.
  TITLE     Activation of hepatic adenosine A1 receptor ameliorates MASH via
            inhibiting SREBPs maturation
  JOURNAL   Cell Rep Med 5 (3), 101477 (2024)
   PUBMED   38508143
  REMARK    GeneRIF: Activation of hepatic adenosine A1 receptor ameliorates
            MASH via inhibiting SREBPs maturation.
            Erratum:[Cell Rep Med. 2024 May 21;5(5):101563. doi:
            10.1016/j.xcrm.2024.101563.. PMID: 38718795]
REFERENCE   2  (bases 1 to 2901)
  AUTHORS   Tzortzini,E., Corey,R.A. and Kolocouris,A.
  TITLE     Comparative Study of Receptor-, Receptor State-, and
            Membrane-Dependent Cholesterol Binding Sites in A2A and A1
            Adenosine Receptors Using Coarse-Grained Molecular Dynamics
            Simulations
  JOURNAL   J Chem Inf Model 63 (3), 928-949 (2023)
   PUBMED   36637988
  REMARK    GeneRIF: Comparative Study of Receptor-, Receptor State-, and
            Membrane-Dependent Cholesterol Binding Sites in A2A and A1
            Adenosine Receptors Using Coarse-Grained Molecular Dynamics
            Simulations.
REFERENCE   3  (bases 1 to 2901)
  AUTHORS   Sarasola,L.I., Del Torrent,C.L., Perez-Arevalo,A., Argerich,J.,
            Casajuana-Martin,N., Chevigne,A., Fernandez-Duenas,V., Ferre,S.,
            Pardo,L. and Ciruela,F.
  TITLE     The ADORA1 mutation linked to early-onset Parkinson's disease
            alters adenosine A1-A2A receptor heteromer formation and function
  JOURNAL   Biomed Pharmacother 156, 113896 (2022)
   PUBMED   36279718
  REMARK    GeneRIF: The ADORA1 mutation linked to early-onset Parkinson's
            disease alters adenosine A1-A2A receptor heteromer formation and
            function.
REFERENCE   4  (bases 1 to 2901)
  AUTHORS   Deluigi,M., Morstein,L., Schuster,M., Klenk,C., Merklinger,L.,
            Cridge,R.R., de Zhang,L.A., Klipp,A., Vacca,S., Vaid,T.M.,
            Mittl,P.R.E., Egloff,P., Eberle,S.A., Zerbe,O., Chalmers,D.K.,
            Scott,D.J. and Pluckthun,A.
  TITLE     Crystal structure of the alpha1B-adrenergic receptor reveals
            molecular determinants of selective ligand recognition
  JOURNAL   Nat Commun 13 (1), 382 (2022)
   PUBMED   35046410
  REMARK    GeneRIF: Crystal structure of the alpha1B-adrenergic receptor
            reveals molecular determinants of selective ligand recognition.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2901)
  AUTHORS   Tian,D., Li,J., Zou,L., Lin,M., Shi,X., Hu,Y., Lang,J., Xu,L.,
            Ye,W., Li,X. and Chen,L.
  TITLE     Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix
            Accumulation in Diabetic Nephropathy through Disturbance of
            Peritubular Microenvironment
  JOURNAL   J Diabetes Res 2021, 5584871 (2021)
   PUBMED   34671682
  REMARK    GeneRIF: Adenosine A1 Receptor Deficiency Aggravates Extracellular
            Matrix Accumulation in Diabetic Nephropathy through Disturbance of
            Peritubular Microenvironment.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2901)
  AUTHORS   Townsend-Nicholson,A. and Shine,J.
  TITLE     Molecular cloning and characterisation of a human brain A1
            adenosine receptor cDNA
  JOURNAL   Brain Res Mol Brain Res 16 (3-4), 365-370 (1992)
   PUBMED   1339301
REFERENCE   7  (bases 1 to 2901)
  AUTHORS   Libert,F., Van Sande,J., Lefort,A., Czernilofsky,A., Dumont,J.E.,
            Vassart,G., Ensinger,H.A. and Mendla,K.D.
  TITLE     Cloning and functional characterization of a human A1 adenosine
            receptor
  JOURNAL   Biochem Biophys Res Commun 187 (2), 919-926 (1992)
   PUBMED   1530647
REFERENCE   8  (bases 1 to 2901)
  AUTHORS   Stiles,G.L.
  TITLE     Adenosine receptors
  JOURNAL   J Biol Chem 267 (10), 6451-6454 (1992)
   PUBMED   1551861
  REMARK    Review article
REFERENCE   9  (bases 1 to 2901)
  AUTHORS   Libert,F., Passage,E., Parmentier,M., Simons,M.J., Vassart,G. and
            Mattei,M.G.
  TITLE     Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor,
            and a new subtype of serotonin receptor
  JOURNAL   Genomics 11 (1), 225-227 (1991)
   PUBMED   1662665
  REMARK    Erratum:[Genomics 1994 Sep 1;23(1):305]
REFERENCE   10 (bases 1 to 2901)
  AUTHORS   Libert,F., Parmentier,M., Lefort,A., Dinsart,C., Van Sande,J.,
            Maenhaut,C., Simons,M.J., Dumont,J.E. and Vassart,G.
  TITLE     Selective amplification and cloning of four new members of the G
            protein-coupled receptor family
  JOURNAL   Science 244 (4904), 569-572 (1989)
   PUBMED   2541503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB171678.1, L22214.1,
            AC105940.2 and BU740906.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 24, 2018 this sequence version replaced NM_000674.2.
            
            Summary: The protein encoded by this gene is an adenosine receptor
            that belongs to the G-protein coupled receptor 1 family. There are
            3 types of adenosine receptors, each with a specific pattern of
            ligand binding and tissue distribution, and together they regulate
            a diverse set of physiologic functions. The type A1 receptors
            inhibit adenylyl cyclase, and play a role in the fertilization
            process. Animal studies also suggest a role for A1 receptors in
            kidney function and ethanol intoxication. Transcript variants with
            alternative splicing in the 5' UTR have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.1943214.1, AK289928.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337894.9/ ENSP00000338435.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               DB171678.1         22-408
            388-1692            L22214.1           383-1687
            1693-2891           AC105940.2         107558-108756
            2892-2901           BU740906.1         19-28               c
FEATURES             Location/Qualifiers
     source          1..2901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2901
                     /gene="ADORA1"
                     /gene_synonym="RDC7"
                     /note="adenosine A1 receptor"
                     /db_xref="GeneID:134"
                     /db_xref="HGNC:HGNC:262"
                     /db_xref="MIM:102775"
     exon            1..203
                     /gene="ADORA1"
                     /gene_synonym="RDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            204..358
                     /gene="ADORA1"
                     /gene_synonym="RDC7"
                     /inference="alignment:Splign:2.1.0"
     exon            359..756
                     /gene="ADORA1"
                     /gene_synonym="RDC7"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1396
                     /gene="ADORA1"
                     /gene_synonym="RDC7"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="adenosine receptor A1 isoform 1"
                     /protein_id="NP_000665.1"
                     /db_xref="CCDS:CCDS1434.1"
                     /db_xref="GeneID:134"
                     /db_xref="HGNC:HGNC:262"
                     /db_xref="MIM:102775"
                     /translation="MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDAT
                     FCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIA
                     VDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANG
                     SMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSAS
                     SGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFL
                     THGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD"
     exon            757..2901
                     /gene="ADORA1"
                     /gene_synonym="RDC7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2881..2886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADORA1"
                     /gene_synonym="RDC7"
                     /note="hexamer: AATAAA"
     polyA_site      2901
                     /gene="ADORA1"
                     /gene_synonym="RDC7"
                     /note="major polyA site"
ORIGIN      
        1 actcagctcc tgcgccgggg gcgacagagc cgcaggcgcc cgagtcgagt cccagccagc
       61 taccatccct ctggagctta ccggccggcc ttggcttccc caggaatccc tggagctagc
      121 ggctgctgaa ggcgtcgagg tgtgggggca cttggacaga acagtcaggc agccgggagc
      181 tctgccagct ttggtgacct tgggccgggc tgggagcgct gcggcgggag ccggaggact
      241 atgagctgcc gcgcgttgtc cagagcccag cccagcccta ccgcgcgcgg cccggagctc
      301 tgttccctgg aactttgggc actgcctctg ggacccctgc cggccagcag gcaggatggt
      361 gcttgcctcg tgccccttgg tgcccgtctg ctgatgtgcc cagcctgtgc ccgccatgcc
      421 gccctccatc tcagctttcc aggccgccta catcggcatc gaggtgctca tcgccctggt
      481 ctctgtgccc gggaacgtgc tggtgatctg ggcggtgaag gtgaaccagg cgctgcggga
      541 tgccaccttc tgcttcatcg tgtcgctggc ggtggctgat gtggccgtgg gtgccctggt
      601 catccccctc gccatcctca tcaacattgg gccacagacc tacttccaca cctgcctcat
      661 ggttgcctgt ccggtcctca tcctcaccca gagctccatc ctggccctgc tggcaattgc
      721 tgtggaccgc tacctccggg tcaagatccc tctccggtac aagatggtgg tgaccccccg
      781 gagggcggcg gtggccatag ccggctgctg gatcctctcc ttcgtggtgg gactgacccc
      841 tatgtttggc tggaacaatc tgagtgcggt ggagcgggcc tgggcagcca acggcagcat
      901 gggggagccc gtgatcaagt gcgagttcga gaaggtcatc agcatggagt acatggtcta
      961 cttcaacttc tttgtgtggg tgctgccccc gcttctcctc atggtcctca tctacctgga
     1021 ggtcttctac ctaatccgca agcagctcaa caagaaggtg tcggcctcct ccggcgaccc
     1081 gcagaagtac tatgggaagg agctgaagat cgccaagtcg ctggccctca tcctcttcct
     1141 ctttgccctc agctggctgc ctttgcacat cctcaactgc atcaccctct tctgcccgtc
     1201 ctgccacaag cccagcatcc ttacctacat tgccatcttc ctcacgcacg gcaactcggc
     1261 catgaacccc attgtctatg ccttccgcat ccagaagttc cgcgtcacct tccttaagat
     1321 ttggaatgac catttccgct gccagcctgc acctcccatt gacgaggatc tcccagaaga
     1381 gaggcctgat gactagaccc cgccttccgc tcccaccagc ccacatccag tggggtctca
     1441 gtccagtcct cacatgcccg ctgtcccagg ggtctccctg agcctgcccc agctgggctg
     1501 ttggctgggg gcatggggga ggctctgaag agatacccac agagtgtggt ccctccacta
     1561 ggagttaact accctacacc tctgggccct gcaggaggcc tgggagggca agggtcctac
     1621 ggagggacca ggtgtctaga ggcaacagtg ttctgagccc ccacctgcct gaccatccca
     1681 tgagcagtcc agagcttcag ggctgggcag gtcctgggga ggctgagact gcagaggagc
     1741 cacctgggct gggagaaggt gcttgggctt ctgcggtgag gcaggggagt ctgcttgtct
     1801 tagatgttgg tggtgcagcc ccaggaccaa gcttaaggag aggagagcat ctgctctgag
     1861 acggatggaa ggagagaggt tgaggatgca ctggcctgtt ctgtaggaga gactggccag
     1921 aggcagctaa ggggcaggaa tcaaggagcc tccgttccca cctctgagga ctctggaccc
     1981 caggccatac caggtgctag ggtgcctgct ctccttgccc tgggccagcc caggattgta
     2041 cgtgggagag gcagaaaggg taggttcagt aatcatttct gatatttgct ggagtgctgg
     2101 ctccacgccc tggggagtga gcttggtgcg gtaggtgctg gcctcaaaca gccacgaggt
     2161 ggtagctctg agccctcctt cttgccctga gctttccggg gaggagcctt ggagtgtaat
     2221 tacctgtcat ctgggccacc agctccactg gcctgcccgt tgccgggcct ggactgtcct
     2281 aggtgacccc atctctgctg cttctgggcc tgatggagag gagaacacta gacatgccaa
     2341 ctcgggagca ttctgcctgc ctgggaacgg ggtggacgag ggagtgtctg taaggactca
     2401 gtgttgactg taggcgcccc tggggtgggt ttagcaggct gcagcaggca gaggagagta
     2461 cccccctgag agcatgtggg ggaaggcctt gctgtcatgt gaatccctca atacccctag
     2521 tatctggctg ggttttcagg ggctttggaa gctctgttgc aggtgtccgg gggtctagga
     2581 ctttagggat ctggggaagg accaacccat gccctgccaa gcctggagcc cctgtgttgg
     2641 ggggcaaggt gggggagcct ggagcccctg tgtgggaggg cgaggcgggg gagcctggag
     2701 cccctgtgtg ggagggcgag gcgggggatc ctggagcccc tgtgtcgggg ggcgagggag
     2761 gggaggtggc cgtcgagttg accttctgaa catgagtgtc aactccagga cttgcttcca
     2821 agcccttccc tctgttggaa attgggtgtg ccctggctcc caagggaggc ccatgtgact
     2881 aataaaaaac tgtgaaccct g
//
