LOCUS       NM_032804               3760 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens 2-aminoethanethiol dioxygenase (ADO), mRNA.
ACCESSION   NM_032804
VERSION     NM_032804.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3760)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3760)
  AUTHORS   Wang,Y., Shin,I., Li,J. and Liu,A.
  TITLE     Crystal structure of human cysteamine dioxygenase provides a
            structural rationale for its function as an oxygen sensor
  JOURNAL   J Biol Chem 297 (4), 101176 (2021)
   PUBMED   34508780
  REMARK    GeneRIF: Crystal structure of human cysteamine dioxygenase provides
            a structural rationale for its function as an oxygen sensor.
REFERENCE   3  (bases 1 to 3760)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3760)
  AUTHORS   Wang,Y., Davis,I., Chan,Y., Naik,S.G., Griffith,W.P. and Liu,A.
  TITLE     Characterization of the nonheme iron center of cysteamine
            dioxygenase and its interaction with substrates
  JOURNAL   J Biol Chem 295 (33), 11789-11802 (2020)
   PUBMED   32601061
  REMARK    GeneRIF: Characterization of the nonheme iron center of cysteamine
            dioxygenase and its interaction with substrates.
REFERENCE   5  (bases 1 to 3760)
  AUTHORS   Sakono,T., Meguro,A., Takeuchi,M., Yamane,T., Teshigawara,T.,
            Kitaichi,N., Horie,Y., Namba,K., Ohno,S., Nakao,K., Sakamoto,T.,
            Sakai,T., Nakano,T., Keino,H., Okada,A.A., Takeda,A., Ito,T.,
            Mashimo,H., Ohguro,N., Oono,S., Enaida,H., Okinami,S., Horita,N.,
            Ota,M. and Mizuki,N.
  TITLE     Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with
            susceptibility to Vogt-Koyanagi-Harada disease in Japanese
            population
  JOURNAL   PLoS One 15 (5), e0233464 (2020)
   PUBMED   32437414
  REMARK    GeneRIF: Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are
            associated with susceptibility to Vogt-Koyanagi-Harada disease in
            Japanese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3760)
  AUTHORS   Eriksson,N., Benton,G.M., Do,C.B., Kiefer,A.K., Mountain,J.L.,
            Hinds,D.A., Francke,U. and Tung,J.Y.
  TITLE     Genetic variants associated with breast size also influence breast
            cancer risk
  JOURNAL   BMC Med Genet 13, 53 (2012)
   PUBMED   22747683
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3760)
  AUTHORS   Postel-Vinay,S., Veron,A.S., Tirode,F., Pierron,G., Reynaud,S.,
            Kovar,H., Oberlin,O., Lapouble,E., Ballet,S., Lucchesi,C.,
            Kontny,U., Gonzalez-Neira,A., Picci,P., Alonso,J.,
            Patino-Garcia,A., de Paillerets,B.B., Laud,K., Dina,C., Froguel,P.,
            Clavel-Chapelon,F., Doz,F., Michon,J., Chanock,S.J., Thomas,G.,
            Cox,D.G. and Delattre,O.
  TITLE     Common variants near TARDBP and EGR2 are associated with
            susceptibility to Ewing sarcoma
  JOURNAL   Nat Genet 44 (3), 323-327 (2012)
   PUBMED   22327514
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3760)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   9  (bases 1 to 3760)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3760)
  AUTHORS   Dominy,J.E. Jr., Simmons,C.R., Hirschberger,L.L., Hwang,J.,
            Coloso,R.M. and Stipanuk,M.H.
  TITLE     Discovery and characterization of a second mammalian thiol
            dioxygenase, cysteamine dioxygenase
  JOURNAL   J Biol Chem 282 (35), 25189-25198 (2007)
   PUBMED   17581819
  REMARK    GeneRIF: when endogenous expression of the human ADO ortholog
            C10orf22 in HepG2/C3A cells was reduced by RNA-mediated
            interference, hypotaurine production decreased
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL133417.11, AK127694.1, BC028589.2 and BC067740.1.
            
            On May 17, 2019 this sequence version replaced NM_032804.5.
            
            Summary: Human thiol dioxygenases include cysteine dioxygenase
            (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase
            (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine,
            whereas ADO adds 2 oxygen atoms to free cysteamine to form
            hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by
            OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC028589.2, SRR1803613.253940.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373783.3/ ENSP00000362888.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL133417.11        16207-16242
            37-166              AK127694.1         3-132
            167-412             BC028589.2         1-246
            413-1778            BC067740.1         185-1550
            1779-3760           BC028589.2         1613-3594
FEATURES             Location/Qualifiers
     source          1..3760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..3760
                     /gene="ADO"
                     /gene_synonym="C10orf22"
                     /note="2-aminoethanethiol dioxygenase"
                     /db_xref="GeneID:84890"
                     /db_xref="HGNC:HGNC:23506"
                     /db_xref="MIM:611392"
     exon            1..3760
                     /gene="ADO"
                     /gene_synonym="C10orf22"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..1153
                     /gene="ADO"
                     /gene_synonym="C10orf22"
                     /EC_number="1.13.11.19"
                     /note="cysteamine (2-aminoethanethiol) dioxygenase (ADO);
                     cysteamine dioxygenase; 2-aminoethanethiol (cysteamine)
                     dioxygenase"
                     /codon_start=1
                     /product="2-aminoethanethiol dioxygenase"
                     /protein_id="NP_116193.2"
                     /db_xref="CCDS:CCDS7266.2"
                     /db_xref="GeneID:84890"
                     /db_xref="HGNC:HGNC:23506"
                     /db_xref="MIM:611392"
                     /translation="MPRDNMASLIQRIARQACLTFRGSGGGRGASDRDAASGPEAPMQ
                     PGFPENLSKLKSLLTQLRAEDLNIAPRKATLQPLPPNLPPVTYMHIYETDGFSLGVFL
                     LKSGTSIPLHDHPGMHGMLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPR
                     EREAVRPGVLRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGR
                     DCHYYRVLEPVRPKEASSSACDLPREVWLLETPQADDFWCEGEPYPGPKVFP"
     regulatory      2598..2603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADO"
                     /gene_synonym="C10orf22"
                     /note="hexamer: AATAAA"
     polyA_site      2617
                     /gene="ADO"
                     /gene_synonym="C10orf22"
                     /note="major polyA site"
     regulatory      3732..3737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADO"
                     /gene_synonym="C10orf22"
                     /note="hexamer: AATAAA"
     polyA_site      3760
                     /gene="ADO"
                     /gene_synonym="C10orf22"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcccgg ccaccgtcgt aggtgcgggc cgcatgaatg gagcgccggg cgtaaggcaa
       61 agcctggcac cgtctgcgcg gccgctatct gctcccggag cgtgagtgcg gggtgtgggg
      121 cgtgcgcgtg cgcgctcaga gggggctcaa ggcgagcgcg ccgggcagtt gcgggcgcgt
      181 ggctgctgag gttggcggcg gtgccgcgcg cccgacgggc cggtggttgc ggggcctccc
      241 gcctcgaccc gggctggggg cagccgtggc ggccgccggg gaccgcaagg ggcggaggaa
      301 aggagggggc cggtcccggc acgcagagga gcagccgacc atgccccgag acaacatggc
      361 ctccttgatc caacggatcg cccgccaggc ttgcctcacc ttccggggca gcgggggcgg
      421 ccgcggcgct tccgatcgcg acgcggcttc tggcccggag gcgccgatgc agccgggctt
      481 ccccgagaac ctgagcaagc tgaagagcct cctgacccag ctccgcgccg aggacttgaa
      541 catcgccccg cgcaaggcca cactgcagcc gctgccgccc aacctgccgc cagtcaccta
      601 catgcacatc tacgagacgg acggcttcag cctgggcgtg ttcctgctca agagcggcac
      661 gtccatcccg ctgcacgacc acccgggcat gcacggcatg ctcaaggtgc tgtacggcac
      721 cgtgcgcatc agctgcatgg acaagctaga cgcgggcggc gggcaacggc cgcgggcctt
      781 gccgcccgag cagcagttcg agccgccgct gcagccccgg gagcgagaag ccgtgcggcc
      841 gggcgtgctg cgttcgcggg ccgagtacac cgaggccagc ggcccctgca tcctcacacc
      901 gcaccgggac aacctgcacc agatcgacgc cgtggaaggg cctgccgcct tcctggacat
      961 cctggccccg ccctacgacc cggacgatgg ccgggactgc cactattacc gggtgctgga
     1021 gccggtcagg cccaaggagg cctccagctc ggcctgtgac ctgcctcgag aggtgtggct
     1081 cctggagacc ccacaggccg atgacttctg gtgcgaggga gaaccctatc caggtcccaa
     1141 ggtcttccct tgaagccact ggcgcccagg agcggtgggc cgaagacgtg ccctacccta
     1201 ccacaagggc tgtgtctcta ccccctagcc tgggcgttgg atctactgga atgagcagca
     1261 gccgcttcct cggcagcctt gggaagcacg ggcgactgga cagcagccgc cgggcacggt
     1321 tatgggggcg gggtgggcgg ggaggctaga ttgtttcctg gtactgtcac tgccactggg
     1381 gctttgattt ggaggaatgg ggcaggggac tatctgaagc gcttccatcc taaagccata
     1441 atgaaaatat cttcctctct tccccattct atacaaaata ctaagtggtt ttcttgctcc
     1501 cactccctac cccttagtta aatagggttt attttccact catgccctta tgcctttttt
     1561 tcttatagtt ttttaactta ttgactgtgc atgacccagt ggtttgaatt gtttttagtt
     1621 caagtcattg gtaaaaacta ggtttaagga gatgagctac tgtttaaagt gagctggcct
     1681 gcctaattaa ttccttgtga aaactaaatg attttttcag tttggggatc attctcacaa
     1741 cataactatg catgtagagg acaagattta ttttctttcc tccctttgcc cagtagccac
     1801 atctggttta ctcaggcagc atctactaag aaattcagca cctgcatatc tctgtgacat
     1861 ggtcacttag agcttatctt ccctatgaat ctccagatct gtgagtcgag cagatttcat
     1921 gttgcagatt cacctttaat gcaaagactg tattatcctc acatgacttt ttttcttgtc
     1981 ttactgtacc ttaaaaggtg atagagtaat tctgtatttt ctaacgggaa gattcaaagg
     2041 agctgaatgt gttatgcttc caaacaactg aatgtaaaac actcctagcc agttgttgca
     2101 ttccctatat ttatttactt ccaatatttt actgtaaaag tagggagaaa tattatgttg
     2161 atagttgttt catattctct caggaacttt aatgttcccg actcgggtga ttccagctgt
     2221 gttgctggca gtgttgtctc aaccctctcc ctaaaatgac tgagccctgg gttcatctaa
     2281 tgtggttttc cttaggaaga gatagaaggc acagaagatc acagctagag aattgagaat
     2341 taactatact actagccatt ttagggcacc aaaacttggg attaaacact tcctacttcc
     2401 cactcccaac tcctgaaatg aagtcttgct atctgtgact agttttattt ttgtgctttt
     2461 aatagtccga gcagtcttac cttgtttaca catgtattga caccatttgc ttcaggccat
     2521 ggagcactgt ttctcccttt ttactattta taggattccg ttttttcaca agacttttaa
     2581 taaaaagaaa ttgtagaaat aaacacatta aaatttgccc agctgtcgtc taagccctct
     2641 tgattgactt gcccaagtgg caatagagtt ctaatatcta taataaaggg agatttgcta
     2701 ttattagtgg aatgttgacc ccgtatgtag agaaacagta cgtgcctttg cctctttatg
     2761 cacacagaga cccagggtga gggagtattt gttcccagtt tttaagatag tataaaaaag
     2821 caaatacttg gtgagtgatt taaaaataaa accaaaacaa aacacaaaaa gatattccac
     2881 aggacatgcc actttattat aaaacctgac acaggcatag taccaagtat ttcctgcatt
     2941 gttgctaaaa ttgttttatt gtagctccac attctggtgt agtttaaaat gcctttgggg
     3001 gcagtttgaa gcagttcttc atgccactta gtttgaaaat aaaattctag atatgcaaat
     3061 gattttctta gaaaacttca caaaataaaa gatcttgttt ttttttccat agcacagtaa
     3121 tgaatgtggt tatcaatcac atactttttt ggattatatt gtagcaaaaa gttgattagc
     3181 ttaccaagat tattaatagc aatgtatgtg ttataataca acttagtaca ttaaagctac
     3241 gaaaactcat cctggctgta ggatagtaat aaaggaagaa ttatgacttc attatgaaaa
     3301 aaagaagttt taaagttttc aattacgagc aatttggaag aaaaaaccta aggtgctttt
     3361 caaaagagta actgaaattg ttgcaggcca aaacagcaat atgatatctc agatttagtt
     3421 caataagaac agtgaaactt ttggttcact aataaattct gagtaaatta gtggtgaaga
     3481 caaaatataa cttgttttag tgagccactg aggaaagaat atgcttatta caaagacaaa
     3541 atgtggtgca gaaactatct tgcacctgtg tgcataaact gttagtcgtg actgacttgg
     3601 tgtgttgcta ttgtgtttct atatactccg tccaatatag ataatgtttt aataacaact
     3661 gtgggataaa agttatcttc cccttggaaa gactaatgag cacaatgata ttaatcactt
     3721 ttatggtgaa taataaatgc aataattgcc tcatgggtga
//
