LOCUS       NM_014913               5157 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ADNP homeobox 2 (ADNP2), mRNA.
ACCESSION   NM_014913 XM_377498
VERSION     NM_014913.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5157)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 5157)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5157)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5157)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (bases 1 to 5157)
  AUTHORS   Merenlender-Wagner,A., Malishkevich,A., Shemer,Z., Udawela,M.,
            Gibbons,A., Scarr,E., Dean,B., Levine,J., Agam,G. and Gozes,I.
  TITLE     Autophagy has a key role in the pathophysiology of schizophrenia
  JOURNAL   Mol Psychiatry 20 (1), 126-132 (2015)
   PUBMED   24365867
  REMARK    GeneRIF: This study showed ADNP2 that deregulated in postmortem
            hippocampal samples from schizophrenia patients, but that now
            showed a significantly increased expression in lymphocytes from
            related patients.
REFERENCE   6  (bases 1 to 5157)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   7  (bases 1 to 5157)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   8  (bases 1 to 5157)
  AUTHORS   Dresner,E., Agam,G. and Gozes,I.
  TITLE     Activity-dependent neuroprotective protein (ADNP) expression level
            is correlated with the expression of the sister protein ADNP2:
            deregulation in schizophrenia
  JOURNAL   Eur Neuropsychopharmacol 21 (5), 355-361 (2011)
   PUBMED   20598862
  REMARK    GeneRIF: In the prefrontal cortex of schizophrenia patients the
            correlation between ADNP and ADNP2 mRNA levels was apparently
            higher than in the hippocampus (r=0.854, p<0.001), but did not
            reach a significant difference (p=0.25).
REFERENCE   9  (bases 1 to 5157)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (bases 1 to 5157)
  AUTHORS   Kushnir,M., Dresner,E., Mandel,S. and Gozes,I.
  TITLE     Silencing of the ADNP-family member, ADNP2, results in changes in
            cellular viability under oxidative stress
  JOURNAL   J Neurochem 105 (2), 537-545 (2008)
   PUBMED   18179478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139100.4 and KC877689.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014913.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071589.1, SRR1803612.220130.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262198.9/ ENSP00000262198.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC139100.4         127529-127739
            212-332             AC139100.4         135797-135917
            333-422             AC139100.4         151370-151459
            423-4378            AC139100.4         153879-157834
            4379-4915           KC877689.1         1-537
            4916-5157           AC139100.4         158372-158613
FEATURES             Location/Qualifiers
     source          1..5157
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..5157
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /note="ADNP homeobox 2"
                     /db_xref="GeneID:22850"
                     /db_xref="HGNC:HGNC:23803"
                     /db_xref="MIM:617422"
     exon            1..211
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /inference="alignment:Splign:2.1.0"
     exon            212..332
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..3620
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /note="zinc finger protein 508; ADNP homeobox protein 2"
                     /codon_start=1
                     /product="activity-dependent neuroprotector homeobox
                     protein 2"
                     /protein_id="NP_055728.1"
                     /db_xref="CCDS:CCDS32853.1"
                     /db_xref="GeneID:22850"
                     /db_xref="HGNC:HGNC:23803"
                     /db_xref="MIM:617422"
                     /translation="MFQIPVENLDNIRKVRKKVKGILVDIGLDSCKELLKDLKGFDPG
                     EKYFHNTSWGDVSLWEPSGKKVRYRTKPYCCGLCKYSTKVLTSFKNHLHRYHEDEIDQ
                     ELVIPCPNCVFASQPKVVGRHFRMFHAPVRKVQNYTVNILGETKSSRSDVISFTCLKC
                     NFSNTLYYSMKKHVLVAHFHYLINSYFGLRTEEMGEQPKTNDTVSIEKIPPPDKYYCK
                     KCNANASSQDALMYHILTSDIHRDLENKLRSVISEHIKRTGLLKQTHIAPKPAAHLAA
                     PANGSAPSAPAQPPCFHLALPQNSPSPAAGQPVTVAQGAPGSLTHSPPAAGQSHMTLV
                     SSPLPVGQNSLTLQPPAPQPVFLSHGVPLHQSVNPPVLPLSQPVGPVNKSVGTSVLPI
                     NQTVRPGVLPLTQPVGPINRPVGPGVLPVSPSVTPGVLQAVSPGVLSVSRAVPSGVLP
                     AGQMTPAGQMTPAGVIPGQTATSGVLPTGQMVQSGVLPVGQTAPSRVLPPGQTAPLRV
                     ISAGQVVPSGLLSPNQTVSSSAVVPVNQGVNSGVLQLSQPVVSGVLPVGQPVRPGVLQ
                     LNQTVGTNILPVNQPVRPGASQNTTFLTSGSILRQLIPTGKQVNGIPTYTLAPVSVTL
                     PVPPGGLATVAPPQMPIQLLPSGAAAPMAGSMPGMPSPPVLVNAAQSVFVQASSSAAD
                     TNQVLKQAKQWKTCPVCNELFPSNVYQVHMEVAHKHSESKSGEKLEPEKLAACAPFLK
                     WMREKTVRCLSCKCLVSEEELIHHLLMHGLGCLFCPCTFHDIKGLSEHSRNRHLGKKK
                     LPMDYSNRGFQLDVDANGNLLFPHLDFITILPKEKLGEREVYLAILAGIHSKSLVPVY
                     VKVRPQAEGTPGSTGKRVSTCPFCFGPFVTTEAYELHLKERHHIMPTVHTVLKSPAFK
                     CIHCCGVYTGNMTLAAIAVHLVRCRSAPKDSSSDLQAQPGFIHNSELLLVSGEVMHDS
                     SFSVKRKLPDGHLGAEDQRHGEEQPPILNADAAPGPEKVTSVVPFKRQRNESRTEGPI
                     VKDEALQILALDPKKYEGRSYEEKKQFLKDYFHKKPYPSKKEIELLSSLFWVWKIDVA
                     SFFGKRRYICMKAIKNHKPSVLLGFDMSELKNVKHRLNFEYEP"
     exon            333..422
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /inference="alignment:Splign:2.1.0"
     exon            423..5157
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4328..4333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /note="hexamer: AATAAA"
     polyA_site      4354
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
     regulatory      5132..5137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /note="hexamer: ATTAAA"
     polyA_site      5157
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /note="major polyA site"
ORIGIN      
        1 aatcgagcgc cattttctct ttctggctgc gcgggaggag gggaccagtc gcgctggggg
       61 tgggcgcgcg ctgaggcggg ggtcccgccg cgcggggcgg aggcgcgggc gggcgcaggc
      121 ggccccacgg gacgcggctg cgctcggcgg aagacgcggc agccctgcga gaggcagcag
      181 cggagacgcg gtgctcctcg ggcgccaagc ggaaaatttc aaaaatgttt caaattcctg
      241 tggaaaatct tgacaacatc agaaaggtgc gaaaaaaggt gaaaggtatt cttgtggata
      301 ttgggcttga cagctgcaag gagttactga aggaccttaa aggctttgat ccaggagaga
      361 aatactttca taacacatca tggggtgatg tttctctctg ggaaccttct ggaaagaaag
      421 tgagatatcg aacaaagcca tactgttgtg gcctctgtaa atactctaca aaggtgctta
      481 cttcattcaa gaatcattta catcgttacc atgaagatga aattgaccaa gagctggtga
      541 tcccttgccc aaactgtgta tttgcatctc agcccaaagt tgtgggaagg cacttcagaa
      601 tgttccatgc acctgtccgg aaagtccaga actacacagt gaatatttta ggtgaaacta
      661 aatcatctag gagcgatgtg ataagtttca catgtctaaa atgtaacttt tcaaacactt
      721 tgtactacag catgaagaag catgtgctgg tagcccattt tcactactta attaactcct
      781 actttggcct aagaactgag gaaatgggtg agcaaccgaa aactaacgat actgtttcta
      841 tagagaagat cccaccacct gacaaatatt actgtaaaaa gtgcaacgcc aatgccagca
      901 gccaggatgc gttaatgtat cacattttga catcagacat acacagagat ttggagaata
      961 agcttagatc tgtgatttca gaacatatta agaggactgg actcttgaag caaacgcaca
     1021 ttgctccaaa accagcagca catttggctg caccagcaaa tggcagtgct ccaagcgctc
     1081 cagcgcagcc tccttgcttc catcttgctt tgccacagaa cagtccaagc ccagccgcag
     1141 gacagccagt gactgtggcc cagggtgccc ctggaagcct cactcattcc ccccctgctg
     1201 ctggccaatc ccacatgact ctggtctcca gccctctgcc tgtgggccag aacagcctca
     1261 ccctgcagcc cccagcacct cagcccgtct ttctttctca cggggttcca cttcatcagt
     1321 ctgtgaatcc tcctgtgttg cccttgagtc agccagtcgg acctgtcaat aagtctgttg
     1381 gaactagtgt cctccccata aatcagactg ttcgccctgg ggttttaccc ctcacccagc
     1441 ctgtgggacc cataaacaga cctgttgggc ctggtgttct tcctgtgagc ccctctgtca
     1501 cccctggggt cctgcaggct gtctcgccag gggtgctttc tgtgagtcgg gcggtcccgt
     1561 ctggagtcct tcctgcaggc cagatgactc ctgcaggcca gatgactcct gcaggggtta
     1621 tccctgggca aacagcaact tctggggttc ttcctactgg ccagatggtc cagtcaggag
     1681 ttctccctgt gggccagaca gctccgtcac gggttcttcc cccaggccag acagccccat
     1741 tgagggttat ctctgcaggc caggtggtcc cgtctgggct tctttctccc aaccagacag
     1801 tctcctcctc agctgttgtg cctgtaaacc agggtgtgaa ttctggtgtt ctgcagctta
     1861 gtcagcctgt tgtgtcggga gttcttcctg tgggccagcc agtgaggcct ggggtcttgc
     1921 aactcaacca gactgtgggc accaacattc tgcctgtgaa tcagccagtg agacctggtg
     1981 cttcgcagaa caccaccttc ctgacatcag gctctattct cagacagctc atccctacag
     2041 ggaaacaagt gaatgggatt ccaacctaca cgctggcccc cgtgtctgtc actctgccgg
     2101 ttccccctgg aggccttgcg actgtcgctc cgccccagat gcccatccag ctcctgccgt
     2161 caggtgcagc tgcaccaatg gccggttcca tgcccggcat gccctctcct ccagtgctgg
     2221 tgaatgctgc tcagagcgtg tttgttcagg cctcctcctc tgcagcagac acaaaccagg
     2281 tgctcaaaca ggccaagcag tggaagacct gccctgtctg caacgagctc tttccgtcca
     2341 acgtctacca ggtccacatg gaggtagcgc ataagcacag cgagtccaag tctggtgaga
     2401 aacttgagcc tgaaaaactg gcagcgtgtg caccatttct aaagtggatg agagagaaaa
     2461 cggtgcgatg tctgtcttgt aagtgcttgg tctctgagga agagcttata caccacttgc
     2521 tgatgcatgg cttggggtgc ttgttctgtc catgcacctt ccatgatatc aaaggtcttt
     2581 cagagcacag caggaatagg cacctgggga agaagaagtt gcctatggat tatagcaaca
     2641 gaggttttca attagatgtc gatgccaatg gcaacctgct ctttccccac cttgatttca
     2701 tcaccatatt gccaaaggag aagcttgggg agcgggaagt ctacttggca atcctggctg
     2761 ggatacactc caagtcactg gtgcctgtgt atgtgaaggt gaggcctcag gctgagggca
     2821 cccccgggag caccggcaag cgagtgtcca cctgcccctt ttgctttggc ccctttgtga
     2881 caactgaggc ctatgagctg catttgaagg agaggcacca catcatgccc acagtccaca
     2941 cggtcctgaa gtctcccgcc ttcaagtgca tccactgctg tggggtctac acgggaaata
     3001 tgaccctggc tgccatcgcc gtccatttgg tgcgctgcag aagtgctccc aaggacagca
     3061 gctcagacct gcaggcccag ccgggtttta ttcacaacag tgaactgctt ttagtcagtg
     3121 gtgaagtgat gcatgattcc agtttttctg ttaagagaaa gctgcctgac ggccacttag
     3181 gggccgaaga ccagcggcat ggggaggagc agcctcccat cctaaatgcc gatgcagccc
     3241 cgggtccaga aaaggtgacg agtgttgtgc cttttaaaag acaaaggaat gaaagcagaa
     3301 cagagggacc tattgtcaag gacgaggctc ttcagatttt agcattagat cctaaaaaat
     3361 atgaaggccg ttcttatgaa gaaaagaagc aatttcttaa agattatttc cataagaaac
     3421 catatcctag taaaaaggaa atagaactgt tgtcctcact cttttgggtg tggaaaattg
     3481 atgtggcttc attttttgga aaaagaaggt atatttgcat gaaagcaata aaaaatcaca
     3541 agccttctgt acttttaggc tttgatatgt ctgaacttaa aaatgtgaaa catagattga
     3601 actttgaata tgaaccataa aacttgcaaa aaaaaaaaaa agtaactcta aagtagtagg
     3661 tagatttttt tcagttgaaa tttcacagtg ttgtcctcac tgtgttggtg aatcaacctc
     3721 agtggtcact gtgctgctct gcagagttac ttcaggtgct ggagagaccc ctgttaccag
     3781 gaagccagta gttatttcac atctattgtt tcctgcagtt tgatttgtaa cagaacagtt
     3841 gttttcaggt ttttttctct gtcatgtaaa tgaaatcttt tgatatttca tgcacgcctt
     3901 gttttcccac tagtgtcagt atcgtatgat aagaaactga aatctataaa taatttgctt
     3961 tttcattaag gacatttcag cctttttcag aatacttgat ttaactgcga gtggaagcat
     4021 cgatctcctt cagctttccc tgtagcagca gatggtacag tgagtgttca gagacgtggg
     4081 tacaaaccct gtgatgtatg tataaggctc cctgaggatg cactgcatta acttacgctg
     4141 acttctttgt aagatctttg cttatagatt ataatttaga tctgtatttt tttaggttta
     4201 tcctaatagc tgtttttttt tttaaccata actcatagaa aatcaaatgt ttttatttgt
     4261 taaaagtaga ctgaatttga catctggtat gctggtatgt agctcataca tcaagagtta
     4321 ttttacaaat aaatttattc tgtagatgca gaaatatttt tcagtgtaga ttttcccttt
     4381 tgatatgcta agtcatttct ccgttcagag gtaaaacaat aaatttttag tgcctttaga
     4441 ataaacattg aaagaataca ccccaaaact cttctcctaa cttaactact cataaactag
     4501 tgaaagggaa ggtctatgat actcaggaat aagattattg cccctgagtg tgaaaactaa
     4561 cttaaatttc agcatagggt ttcaggggac atggcgaagt ttacagactg agatctcagt
     4621 ctccatggtt ggtacagtaa gtctttgacc acattttctg aaggtcatgt ttagtggaga
     4681 aacgggcttt tctctagctg gtttaggctg gaagctgtgt ccgggtcgat gggatggcat
     4741 attgttaaag aatctccatt gtcgtcactg tcctgtggat gttaaacctc gtttttttcc
     4801 ccacacgata ttaaaactta aagcaccaga accagtcatg gagaccagcc agtttagatg
     4861 gtaagtcata tttctggtgg tacacagcag aggaacccct tcactctatc tttaggtaga
     4921 aatatttgga ggatgtgaca gcctctgaga aacataatgt tactatgtgg attttaaaaa
     4981 atataatact tgcatgtaat tgctataatg ttcatatttg aggcagttgt gaaactggtt
     5041 tatgattgtt ggtgtactct gttgtaaatt caaagagagc ttgttgaaca tttttttttt
     5101 ttacctattg ttttcagagt gtctattttg aattaaaatt tgttacaccg ctgcaaa
//
