LOCUS       NP_055728               1131 aa            linear   PRI 27-APR-2025
DEFINITION  activity-dependent neuroprotector homeobox protein 2 [Homo
            sapiens].
ACCESSION   NP_055728 XP_377498
VERSION     NP_055728.1
DBSOURCE    REFSEQ: accession NM_014913.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1131)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (residues 1 to 1131)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 1131)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (residues 1 to 1131)
  AUTHORS   Hauri,S., Comoglio,F., Seimiya,M., Gerstung,M., Glatter,T.,
            Hansen,K., Aebersold,R., Paro,R., Gstaiger,M. and Beisel,C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (residues 1 to 1131)
  AUTHORS   Merenlender-Wagner,A., Malishkevich,A., Shemer,Z., Udawela,M.,
            Gibbons,A., Scarr,E., Dean,B., Levine,J., Agam,G. and Gozes,I.
  TITLE     Autophagy has a key role in the pathophysiology of schizophrenia
  JOURNAL   Mol Psychiatry 20 (1), 126-132 (2015)
   PUBMED   24365867
  REMARK    GeneRIF: This study showed ADNP2 that deregulated in postmortem
            hippocampal samples from schizophrenia patients, but that now
            showed a significantly increased expression in lymphocytes from
            related patients.
REFERENCE   6  (residues 1 to 1131)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   7  (residues 1 to 1131)
  AUTHORS   Rosnoblet,C., Vandamme,J., Volkel,P. and Angrand,P.O.
  TITLE     Analysis of the human HP1 interactome reveals novel binding
            partners
  JOURNAL   Biochem Biophys Res Commun 413 (2), 206-211 (2011)
   PUBMED   21888893
REFERENCE   8  (residues 1 to 1131)
  AUTHORS   Dresner,E., Agam,G. and Gozes,I.
  TITLE     Activity-dependent neuroprotective protein (ADNP) expression level
            is correlated with the expression of the sister protein ADNP2:
            deregulation in schizophrenia
  JOURNAL   Eur Neuropsychopharmacol 21 (5), 355-361 (2011)
   PUBMED   20598862
  REMARK    GeneRIF: In the prefrontal cortex of schizophrenia patients the
            correlation between ADNP and ADNP2 mRNA levels was apparently
            higher than in the hippocampus (r=0.854, p<0.001), but did not
            reach a significant difference (p=0.25).
REFERENCE   9  (residues 1 to 1131)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   10 (residues 1 to 1131)
  AUTHORS   Kushnir,M., Dresner,E., Mandel,S. and Gozes,I.
  TITLE     Silencing of the ADNP-family member, ADNP2, results in changes in
            cellular viability under oxidative stress
  JOURNAL   J Neurochem 105 (2), 537-545 (2008)
   PUBMED   18179478
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139100.4 and KC877689.1.
            
            On Aug 30, 2004 this sequence version replaced XP_377498.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071589.1, SRR1803612.220130.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262198.9/ ENSP00000262198.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1131
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     Protein         1..1131
                     /product="activity-dependent neuroprotector homeobox
                     protein 2"
                     /note="zinc finger protein 508; ADNP homeobox protein 2"
                     /calculated_mol_wt=122703
     Region          1..984
                     /region_name="ADNP_N"
                     /note="Activity-dependent neuroprotector homeobox protein
                     N-terminal; pfam19627"
                     /db_xref="CDD:466132"
     Region          <268..514
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          274..329
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IQ32.1)"
     Site            1024
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q6IQ32.1)"
     Region          1043..1096
                     /region_name="HOX"
                     /note="Homeodomain; smart00389"
                     /db_xref="CDD:197696"
     Site            order(1044..1048,1050,1067,1073,1086,1088..1089,
                     1092..1093,1095..1097,1099..1100)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     Site            order(1046,1049,1089,1092..1093,1096)
                     /site_type="other"
                     /note="specific DNA base contacts [nucleotide binding]"
                     /db_xref="CDD:238039"
     CDS             1..1131
                     /gene="ADNP2"
                     /gene_synonym="ZNF508"
                     /coded_by="NM_014913.4:225..3620"
                     /db_xref="CCDS:CCDS32853.1"
                     /db_xref="GeneID:22850"
                     /db_xref="HGNC:HGNC:23803"
                     /db_xref="MIM:617422"
ORIGIN      
        1 mfqipvenld nirkvrkkvk gilvdiglds ckellkdlkg fdpgekyfhn tswgdvslwe
       61 psgkkvryrt kpyccglcky stkvltsfkn hlhryhedei dqelvipcpn cvfasqpkvv
      121 grhfrmfhap vrkvqnytvn ilgetkssrs dvisftclkc nfsntlyysm kkhvlvahfh
      181 ylinsyfglr teemgeqpkt ndtvsiekip ppdkyyckkc nanassqdal myhiltsdih
      241 rdlenklrsv isehikrtgl lkqthiapkp aahlaapang sapsapaqpp cfhlalpqns
      301 pspaagqpvt vaqgapgslt hsppaagqsh mtlvssplpv gqnsltlqpp apqpvflshg
      361 vplhqsvnpp vlplsqpvgp vnksvgtsvl pinqtvrpgv lpltqpvgpi nrpvgpgvlp
      421 vspsvtpgvl qavspgvlsv sravpsgvlp agqmtpagqm tpagvipgqt atsgvlptgq
      481 mvqsgvlpvg qtapsrvlpp gqtaplrvis agqvvpsgll spnqtvsssa vvpvnqgvns
      541 gvlqlsqpvv sgvlpvgqpv rpgvlqlnqt vgtnilpvnq pvrpgasqnt tfltsgsilr
      601 qliptgkqvn giptytlapv svtlpvppgg latvappqmp iqllpsgaaa pmagsmpgmp
      661 sppvlvnaaq svfvqasssa adtnqvlkqa kqwktcpvcn elfpsnvyqv hmevahkhse
      721 sksgeklepe klaacapflk wmrektvrcl sckclvseee lihhllmhgl gclfcpctfh
      781 dikglsehsr nrhlgkkklp mdysnrgfql dvdangnllf phldfitilp keklgerevy
      841 lailagihsk slvpvyvkvr pqaegtpgst gkrvstcpfc fgpfvtteay elhlkerhhi
      901 mptvhtvlks pafkcihccg vytgnmtlaa iavhlvrcrs apkdsssdlq aqpgfihnse
      961 lllvsgevmh dssfsvkrkl pdghlgaedq rhgeeqppil nadaapgpek vtsvvpfkrq
     1021 rnesrtegpi vkdealqila ldpkkyegrs yeekkqflkd yfhkkpypsk keiellsslf
     1081 wvwkidvasf fgkrryicmk aiknhkpsvl lgfdmselkn vkhrlnfeye p
//
