LOCUS       NM_001282531            6672 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens activity dependent neuroprotector homeobox (ADNP),
            transcript variant 3, mRNA.
ACCESSION   NM_001282531 XM_005260354
VERSION     NM_001282531.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6672)
  AUTHORS   Neuhaus,E., Rea,H., Jones,E., Benavidez,H., Miles,C., Whiting,A.,
            Johansson,M., Eayrs,C., Kurtz-Nelson,E.C., Earl,R., Bernier,R.A.
            and Eichler,E.E.
  TITLE     Shared and divergent mental health characteristics of ADNP-, CHD8-
            and DYRK1A-related neurodevelopmental conditions
  JOURNAL   J Neurodev Disord 16 (1), 15 (2024)
   PUBMED   38622540
  REMARK    GeneRIF: Shared and divergent mental health characteristics of
            ADNP-, CHD8- and DYRK1A-related neurodevelopmental conditions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6672)
  AUTHORS   Levine,J., Lobyntseva,A., Shazman,S., Hakim,F. and Gozes,I.
  TITLE     Longitudinal Genotype-Phenotype (Vineland Questionnaire)
            Characterization of 15 ADNP Syndrome Cases Highlights Mutated
            Protein Length and Structural Characteristics Correlation with
            Communicative Abilities Accentuated in Males
  JOURNAL   J Mol Neurosci 74 (1), 15 (2024)
   PUBMED   38282129
  REMARK    GeneRIF: Longitudinal Genotype-Phenotype (Vineland Questionnaire)
            Characterization of 15 ADNP Syndrome Cases Highlights Mutated
            Protein Length and Structural Characteristics Correlation with
            Communicative Abilities Accentuated in Males.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6672)
  AUTHORS   Ge,C., Tian,Y., Hu,C., Mei,L., Li,D., Dong,P., Zhang,Y., Li,H.,
            Sun,D., Peng,W., Xu,X., Jiang,Y. and Xu,Q.
  TITLE     Clinical impact and in vitro characterization of ADNP variants in
            pediatric patients
  JOURNAL   Mol Autism 15 (1), 5 (2024)
   PUBMED   38254177
  REMARK    GeneRIF: Clinical impact and in vitro characterization of ADNP
            variants in pediatric patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6672)
  AUTHORS   Zhao,X., Su,Z., Xu,Z., Su,H. and Zheng,R.
  TITLE     [Helsmoortel-Van der Aa syndrome due to hotspot mutation of ADNP
            gene and a literature review]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 40 (11), 1382-1386 (2023)
   PUBMED   37906146
  REMARK    GeneRIF: [Helsmoortel-Van der Aa syndrome due to hotspot mutation
            of ADNP gene and a literature review].
            Review article
REFERENCE   5  (bases 1 to 6672)
  AUTHORS   Braitch,M., Kawabe,K., Nyirenda,M., Gilles,L.J., Robins,R.A.,
            Gran,B., Murphy,S., Showe,L. and Constantinescu,C.S.
  TITLE     Expression of activity-dependent neuroprotective protein in the
            immune system: possible functions and relevance to multiple
            sclerosis
  JOURNAL   Neuroimmunomodulation 17 (2), 120-125 (2010)
   PUBMED   19923857
  REMARK    GeneRIF: ADNP is expressed in many immune system cells. ADNP mRNA
            is reduced in PBMCs in MS. The peptide NAP, which plays an
            important role in neuroprotection, has potential immunomodulatory
            properties.
REFERENCE   6  (bases 1 to 6672)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 6672)
  AUTHORS   Mandel,S. and Gozes,I.
  TITLE     Activity-dependent neuroprotective protein constitutes a novel
            element in the SWI/SNF chromatin remodeling complex
  JOURNAL   J Biol Chem 282 (47), 34448-34456 (2007)
   PUBMED   17878164
  REMARK    GeneRIF: Activity-dependent neuroprotective protein constitutes a
            novel element in the SWI/SNF chromatin remodeling complex.
REFERENCE   8  (bases 1 to 6672)
  AUTHORS   Kankova,K., Stejskalova,A., Pacal,L., Tschoplova,S., Hertlova,M.,
            Krusova,D., Izakovicova-Holla,L., Beranek,M., Vasku,A., Barral,S.
            and Ott,J.
  TITLE     Genetic risk factors for diabetic nephropathy on chromosomes 6p and
            7q identified by the set-association approach
  JOURNAL   Diabetologia 50 (5), 990-999 (2007)
   PUBMED   17345061
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 6672)
  AUTHORS   Zamostiano,R., Pinhasov,A., Gelber,E., Steingart,R.A., Seroussi,E.,
            Giladi,E., Bassan,M., Wollman,Y., Eyre,H.J., Mulley,J.C.,
            Brenneman,D.E. and Gozes,I.
  TITLE     Cloning and characterization of the human activity-dependent
            neuroprotective protein
  JOURNAL   J Biol Chem 276 (1), 708-714 (2001)
   PUBMED   11013255
REFERENCE   10 (bases 1 to 6672)
  AUTHORS   Van Dijck,A., Vandeweyer,G. and Kooy,F.
  TITLE     ADNP-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27054228
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034553.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001282531.2.
            
            Summary: Vasoactive intestinal peptide is a neuroprotective factor
            that has a stimulatory effect on the growth of some tumor cells and
            an inhibitory effect on others. This gene encodes a protein that is
            upregulated by vasoactive intestinal peptide and may be involved in
            its stimulatory effect on certain tumor cells. The encoded protein
            contains one homeobox and nine zinc finger domains, suggesting that
            it functions as a transcription factor. This gene is also
            upregulated in normal proliferative tissues. Finally, the encoded
            protein may increase the viability of certain cell types through
            modulation of p53 activity. Alternatively spliced transcript
            variants encoding the same protein have been described. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) represents the longest
            transcript. All five variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3118279.1,
                                           SRR14038193.3610261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621696.5/ ENSP00000483881.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-612               AL034553.12        52273-52884         c
            613-787             AL034553.12        50098-50272         c
            788-871             AL034553.12        26213-26296         c
            872-984             AL034553.12        25336-25448         c
            985-1077            AL034553.12        23464-23556         c
            1078-6672           AL034553.12        10365-15959         c
FEATURES             Location/Qualifiers
     source          1..6672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..6672
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /note="activity dependent neuroprotector homeobox"
                     /db_xref="GeneID:23394"
                     /db_xref="HGNC:HGNC:15766"
                     /db_xref="MIM:611386"
     exon            1..612
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /inference="alignment:Splign:2.1.0"
     exon            613..787
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /inference="alignment:Splign:2.1.0"
     exon            788..871
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /inference="alignment:Splign:2.1.0"
     exon            872..984
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /inference="alignment:Splign:2.1.0"
     CDS             877..4185
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /note="ADNP homeobox 1; activity-dependent neuroprotective
                     protein; activity-dependent neuroprotector"
                     /codon_start=1
                     /product="activity-dependent neuroprotector homeobox
                     protein"
                     /protein_id="NP_001269460.1"
                     /db_xref="CCDS:CCDS13433.1"
                     /db_xref="GeneID:23394"
                     /db_xref="HGNC:HGNC:15766"
                     /db_xref="MIM:611386"
                     /translation="MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPN
                     DFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACPFSSKFFSAYKSHFRNVHSEDFE
                     NRILLNCPYCTFNADKKTLETHIKIFHAPNASAPSSSLSTFKDKNKNDGLKPKQADSV
                     EQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPLGSNAREE
                     SSIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQ
                     DKKSMGLPPRIGSLASGNVRSLPSQQMVNRLSIPKPNLNSTGVNMMSSVHLQQNNYGV
                     KSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARY
                     SLQSANASSLSSGQLKSPSLSQSQASRVLGQSSSKPAAAATGPPPGNTSSTQKWKICT
                     ICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHML
                     IHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQGSHTNIHLLV
                     TTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLC
                     PLCFSILKGPISDALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITL
                     HLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKRTYEQMEFPLLKKRKLDDDSDSPS
                     FFEEKPEEPVVLALDPKGHEDDSYEARKSFLTKYFNKQPYPTRREIEKLAASLWLWKS
                     DIASHFSNKRKKCVRDCEKYKPGVLLGFNMKELNKVKHEMDFDAEWLFENHDEKDSRV
                     NASKTADKKLNLGKEDDSSSDSFENLEEESNESGSPFDPVFEVEPKISNDNPEEHVLK
                     VIPEDASESEEKLDQKEDGSKYETIHLTEEPTKLMHNASDSEVDQDDVVEWKDGASPS
                     ESGPGSQQVSDFEDNTCEMKPGTWSDESSQSEDARSSKPAAKKKATMQGDREQLKWKN
                     SSYGKVEGFWSKDQSQWKNASENDERLSNPQIEWQNSTIDSEDGEQFDNMTDGVAEPM
                     HGSLAGVKLSSQQA"
     exon            985..1077
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..6672
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5218..5223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /note="hexamer: AATAAA"
     polyA_site      5247
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /note="major polyA site"
     regulatory      6521..6526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /note="hexamer: AATAAA"
     polyA_site      6542
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
                     /note="major polyA site"
     polyA_site      6672
                     /gene="ADNP"
                     /gene_synonym="ADNP1; HVDAS; MRD28"
ORIGIN      
        1 ctttctcggc cgccattttg gctagggcag gttcggggac tcggtccgag gcgcttgtat
       61 tgtctgctga ggggagacgc gggatcagcc ccctcccccg cccgttgccg ccgccgcctc
      121 cgccggcccg gtctcccctc cgccgcccgc cgggatccat gagctgaact cccgcccccc
      181 cccccccggc cgccgccatc ttgtgccccc tccccctccc gcaggcagcg ctaaggggga
      241 ttttggcgtc ttctcagaca cagctccctc tctcggtccc cgctgctgag gagcgagagg
      301 agcgcggccg ccgccgcccg cgccggtgaa gccgcctctc ccacaccctc cgtctcctcc
      361 ctccgcccct cctttgtctg caccgctcga cgacgccgcc gccgcccgcc gctctgctgc
      421 gcccgccgcg ccccccggca gcacccgcgg ccgcggcgcg agccggagtc cgccgagccg
      481 gagcgcgacg aggccccggg cgcgccctcc ccgctgccgc caccgccgtg ccgccgccat
      541 ccgcccgccg ccgccgccgc tgtccggccc ccgagcacgc cggccccgcg cgcgcctcga
      601 ggccgagtca aggtgtgaga tgcacaatgc gaaacctagg ccccagcttt tacaccatga
      661 tgcgcagggt tgtacttttt gtactgaact gataggtggc ctagtggtta tgccctgtac
      721 taccattttg aggatctgga ctccgtttcc tgccttgctc tttggaccac attgtcaatt
      781 cacaccgaat accgtagcag taggcaggac agttccaatt caacaaaaac ctctttaccc
      841 tggcactcaa aactgtaatg atgatgaact gaaactatgt tccaacttcc tgtcaacaat
      901 cttggcagtt taagaaaagc ccggaaaact gtgaaaaaaa tacttagtga cattgggttg
      961 gaatactgta aagaacatat agaagatttt aaacaatttg aacctaatga cttttatttg
     1021 aaaaacacta catgggagga tgtaggactg tgggacccat cacttacgaa aaaccaggac
     1081 tatcggacaa aacctttctg ctgcagcgct tgtccatttt cctcaaaatt cttctctgcc
     1141 tacaaaagtc atttccgcaa tgtccatagt gaagactttg aaaataggat tctccttaat
     1201 tgcccctact gtaccttcaa tgcagacaaa aagactttgg aaacacacat taaaatattt
     1261 catgctccga acgccagcgc accaagtagc agcctcagca ctttcaaaga taaaaacaaa
     1321 aatgatggcc ttaaacctaa gcaggctgac agtgtagagc aagctgttta ttactgtaag
     1381 aagtgcactt accgagatcc tctttatgaa atagttagga agcacattta cagggaacat
     1441 tttcagcatg tggcagcacc ttacatagca aaggcaggag aaaaatcact caatggggca
     1501 gtccccttag gctcgaatgc ccgagaagag agtagtattc actgcaagcg atgccttttc
     1561 atgccaaagt cctatgaagc tttggtacag catgtcatcg aagaccatga acgtataggc
     1621 tatcaggtca ctgccatgat tgggcacaca aatgtagtgg ttccccgatc caaacccttg
     1681 atgctaattg ctcccaaacc tcaagacaag aagagcatgg gactcccacc aaggatcggt
     1741 tcccttgctt ctggaaatgt ccggtcttta ccatcacagc agatggtgaa tcgactctca
     1801 ataccaaagc ctaacttaaa ttctacagga gtcaacatga tgtccagtgt tcatctgcag
     1861 cagaacaact atggagtcaa atctgtaggc cagggttaca gtgttggtca gtcaatgaga
     1921 ctgggtctag gtggcaacgc accagtttcc attcctcaac aatctcagtc tgtaaagcag
     1981 ttacttccaa gtggaaacgg aaggtcttat gggcttgggt cagagcagag gtcccaggca
     2041 ccagcaagat actccctgca gtctgctaat gcctcttctc tctcatcggg ccagttaaag
     2101 tctccttccc tctctcagtc acaggcatcc agagtgttag gtcagtccag ttccaaacct
     2161 gctgcagctg ccacaggccc tcccccaggt aacacttcct caactcaaaa gtggaaaata
     2221 tgtacaatct gtaatgagct ttttcctgaa aatgtctata gtgtgcactt cgaaaaagaa
     2281 cataaagctg agaaagtccc agcagtagcc aactacatta tgaaaataca caattttact
     2341 agcaaatgcc tctactgtaa tcgctattta cccacagata ctctgctcaa ccatatgtta
     2401 attcatggtc tgtcttgtcc atattgccgt tcaactttca atgatgtgga aaagatggcc
     2461 gcacacatgc ggatggttca cattgatgaa gagatgggac ctaaaacaga ttctactttg
     2521 agttttgatt tgacattgca gcagggtagt cacactaaca tccatctcct ggtaactaca
     2581 tacaatctga gggatgcccc agctgaatct gttgcttacc atgcccaaaa taatcctcca
     2641 gttcctccaa agccacagcc aaaggttcag gaaaaggcag atatccctgt aaaaagttca
     2701 cctcaagctg cagtgcccta taaaaaagat gttgggaaaa ccctttgtcc tctttgcttt
     2761 tcaatcctaa aaggacccat atctgatgca cttgcacatc acttacgaga gaggcaccaa
     2821 gttattcaga cggttcatcc agttgagaaa aagctcacct acaaatgtat ccattgcctt
     2881 ggtgtgtata ccagcaacat gaccgcctca actatcactc tgcatctagt tcactgcagg
     2941 ggcgttggaa agacccaaaa tggccaggat aagacaaatg caccctctcg gcttaatcag
     3001 tctccaagtc tggcacctgt gaagcgcact tacgagcaaa tggaatttcc cttactgaaa
     3061 aaacgaaagt tagatgatga tagtgattca cccagcttct ttgaagagaa gcctgaagag
     3121 cctgttgttt tagctttaga ccccaagggt catgaagatg attcctatga agccaggaaa
     3181 agctttctaa caaagtattt caacaaacag ccctatccca ccaggagaga aattgagaag
     3241 ctagcagcca gtttatggtt atggaagagt gacatcgctt cccattttag taacaaaagg
     3301 aagaagtgtg tccgtgattg tgaaaagtac aagcctggcg tgttgctggg gtttaacatg
     3361 aaagaattaa ataaagtcaa gcatgagatg gattttgatg ctgagtggct atttgaaaat
     3421 catgatgaga aggattccag agtcaatgct agtaagactg ctgacaaaaa gctcaacctt
     3481 gggaaggaag atgacagttc ctcagacagt tttgaaaatt tggaagaaga atccaatgaa
     3541 agtggtagcc cttttgaccc tgtttttgaa gttgaaccta aaatctctaa cgataaccca
     3601 gaggaacatg tactgaaggt aattcctgag gatgcttcag aatctgagga gaagctagac
     3661 caaaaagagg atggttcaaa atacgaaact attcatttga ctgaggaacc aaccaaacta
     3721 atgcacaatg catctgatag tgaggttgac caagacgatg ttgttgagtg gaaagacggt
     3781 gcttctccat ctgagagtgg gcctggatcc caacaagtgt cagactttga ggacaatacc
     3841 tgcgaaatga aaccaggaac ctggtctgac gagtcttccc aaagcgaaga tgcaaggagc
     3901 agtaagccag ctgccaaaaa aaaggctacc atgcaaggtg acagagagca gttgaaatgg
     3961 aagaatagtt cctatggaaa agttgaaggg ttttggtcta aggaccagtc acagtggaag
     4021 aatgcatctg agaatgatga gcgcttatct aacccccaga ttgagtggca gaatagcaca
     4081 attgacagtg aggatgggga acagtttgac aacatgactg atggagtagc tgagcccatg
     4141 catggcagct tagccggagt taaactgagc agccaacagg cctaagtgcc aggttccctg
     4201 gcgttggtga catgctgcag cctggaactc tgatatccag tgtgactgca aagctgtctt
     4261 ctcactggta ctgccttgtg agtactggtt ggactgtggg gcatgtggcc gctgcagttc
     4321 cagtggttat ttctaagtct atgacaggac aggctgttct tgcttcagaa ccttctctga
     4381 cagacacggt aactaaatgt gaaaaaccaa taagctggtg actcatgaat acacacgagg
     4441 aaaagcagag gtttatttta tctgcctttt caacatttct ttccctctgt gaaatgattg
     4501 gtcagatgtc tttgagaagt gttaaactaa ttcacatggt agtgtagggc caacatacaa
     4561 gctaccagtc taatgtgtat agtagacttt gggaaaagcg attttttttc atgtattcat
     4621 tctgaatagt tgaaatgtat atttgtacag tcttttagac ctattcaagt gatgctcatg
     4681 atcctgttac tgtgtgccca tcatagattt ctttttttag tgttgccctt gctgtgtaat
     4741 aaacgctcta tctagtttac ctagcaaaag ctcaaaactg cgctagtatg gactttttgg
     4801 acagacttag tttttgcaca taaccttgta caatcttgca acagaggcca gccacgtaag
     4861 atatatatct ggactctctt gtattatagg atttttcttg ttctgaatat ccttgacatt
     4921 acagctgtca aaaacaaaaa ctggtatttc agatctgttt tctgaaatct tttaagctaa
     4981 aatcacatgc aagaattgac tttgcagcta ctaattttga caccttttag atctgtataa
     5041 aagtgtgttg tgttgaagca gcaaaccaat gagtgctgca ttttggatat ttagttttat
     5101 ctttagttca acaccatcat ggtggattca tttataccat ctaatatatg acacactgtt
     5161 gtagtatgta taattttgtg atctttattt tccctttgta ttcattttaa gcatctaaat
     5221 aaattgctgt attgtgctta atgtaaatat ttgctttatt acacatgaca gtcctgtgtg
     5281 tccattatat cttttgccat ttaatgccat aactctttca tcagagatgg cagccacagt
     5341 cacagaggaa acttgtggaa aacccaagat ctgtcatctg caaatagaat gctttctctt
     5401 gaggcacctg gtacaaaatc tgtttttctt tttttttttt tttttttttt ttttttttaa
     5461 ctgaaaaaca aacacccttg agtttttcag ttcacctttt gttaaggagc agagcctgca
     5521 tatatatgta aatgtctcaa tgataaaaaa aaaaatgtaa acatggattg gcattaattt
     5581 gcaagcagaa tcttaatagc ctgatgggtt ttttgtttgt tttttcttct agatgaagtt
     5641 aaacgttcgt tttcacctta cgatgggaac aactgtagtg caggcggctc tgcctctatt
     5701 tgccactctt ggccctcttg ctattaaggg aaaggctttg aagagcacag cactgacagg
     5761 gctgtaaaga tggaaggagc tggtattttt accatgcgta gattcccaag agaacttgta
     5821 ctaaaaagca gaaagttaca aggaagcaga attaggccaa catttccagc aattaaaaca
     5881 atgatgggaa actccaatcc atgaggaggc tggtcagtca cctcaaggat agtggcctaa
     5941 agaagtctga agtggctgat gtccataact tctgagtctg tttccaaaag aaagactctt
     6001 gttaatgctg ttaccagaga gtagagattt gaccagcctc tccctaaaat gtaagcttct
     6061 caacaacagt acaggaagaa gtgcaagagt agactagaac ctttaaggaa tttggggctg
     6121 gaacggagct atgttgcatc tgttgttata caggtagatt ataagttcta catgcaccag
     6181 ccaaaactta ggacaggatg tccccaaatt aagatactac agattaccaa atcagaaata
     6241 accagctgga tttaggccag ctcacattta tttggaaatt accctccctg attaacaggc
     6301 ttctgagttg tacgtggagg actaatgaga cttgtacaag acaccacggg gcttggggtc
     6361 caggtcccag ttggatatcg gaacagacac agataagtgt gtttcctcat taaggtggtg
     6421 agagtgtgcc ttttggcatt cagaaaaggg tttagccacc ctaagagttg gaaataaaga
     6481 ttcccaactg gaaatgttgc agaatcccta caagtgtctc aataaaagcc attttaaaag
     6541 aatattgttg ctactgtttg cttttcaaat aatctggaga tcgttggcta tggcaacgtg
     6601 ctgccaccta attagagaat gcctgtaaat gtaggctgaa cacttctaac atgagaaaac
     6661 ctaagtatcc ta
//
