LOCUS       NM_001253845            4213 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens adrenomedullin 2 (ADM2), transcript variant 2, mRNA.
ACCESSION   NM_001253845
VERSION     NM_001253845.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4213)
  AUTHORS   Hasan,S.R., Manolis,D., Stephenson,E., Ryskiewicz-Sokalska,O.A.,
            Maraveyas,A. and Nikitenko,L.L.
  TITLE     Calcitonin gene-related peptide and intermedin induce
            phosphorylation of p44/42 MAPK in primary human lymphatic
            endothelial cells in vitro
  JOURNAL   Cell Signal 121, 111261 (2024)
   PUBMED   38878805
  REMARK    GeneRIF: Calcitonin gene-related peptide and intermedin induce
            phosphorylation of p44/42 MAPK in primary human lymphatic
            endothelial cells in vitro.
REFERENCE   2  (bases 1 to 4213)
  AUTHORS   Tan,J., Liu,P.P., Cao,L.Y., Zou,Y., Zhang,Z.Y., Huang,J.L.,
            Zhang,Z.Q., Xu,D.F., Fan,L., Xia,L.Z., Xie,Q., Tian,L.F., Xin,C.L.,
            Li,Z.M. and Wu,Q.F.
  TITLE     Reduced PATL2 Impairs the Proliferation of Ovarian Granulosa Cells
            by Decreasing ADM2 Expression in Patients with PCOS
  JOURNAL   Reprod Sci 31 (4), 1034-1044 (2024)
   PUBMED   38087182
  REMARK    GeneRIF: Reduced PATL2 Impairs the Proliferation of Ovarian
            Granulosa Cells by Decreasing ADM2 Expression in Patients with
            PCOS.
REFERENCE   3  (bases 1 to 4213)
  AUTHORS   Zhang,Y.R., Liu,S.M., Chen,Y., Zhang,L.S., Ji,D.R., Zhao,J.,
            Yu,Y.R., Jia,M.Z., Tang,C.S., Huang,W., Zhou,Y.B., Chai,S.B. and
            Qi,Y.F.
  TITLE     Intermedin alleviates diabetic vascular calcification by inhibiting
            GLUT1 through activation of the cAMP/PKA signaling pathway
  JOURNAL   Atherosclerosis 385, 117342 (2023)
   PUBMED   37879153
  REMARK    GeneRIF: Intermedin alleviates diabetic vascular calcification by
            inhibiting GLUT1 through activation of the cAMP/PKA signaling
            pathway.
REFERENCE   4  (bases 1 to 4213)
  AUTHORS   Babin,K.M., Karim,J.A., Gordon,P.H., Lennon,J., Dickson,A. and
            Pioszak,A.A.
  TITLE     Adrenomedullin 2/intermedin is a slow off-rate, long-acting
            endogenous agonist of the adrenomedullin2 G protein-coupled
            receptor
  JOURNAL   J Biol Chem 299 (6), 104785 (2023)
   PUBMED   37146967
  REMARK    GeneRIF: Adrenomedullin 2/intermedin is a slow off-rate,
            long-acting endogenous agonist of the adrenomedullin2 G
            protein-coupled receptor.
REFERENCE   5  (bases 1 to 4213)
  AUTHORS   Bell,D. and McDermott,B.J.
  TITLE     Intermedin (adrenomedullin-2): a novel counter-regulatory peptide
            in the cardiovascular and renal systems
  JOURNAL   Br J Pharmacol 153 Suppl 1 (Suppl 1), S247-S262 (2008)
   PUBMED   17965749
  REMARK    GeneRIF: robust increase in expression of the peptide in
            hypertrophied and ischaemic myocardium indicates an important
            protective role for adrenomedullin 2 as an endogenous
            counter-regulatory peptide in the heart--REVIEW
            Review article
REFERENCE   6  (bases 1 to 4213)
  AUTHORS   Morimoto,R., Satoh,F., Murakami,O., Totsune,K., Suzuki,T.,
            Sasano,H., Ito,S. and Takahashi,K.
  TITLE     Expression of adrenomedullin2/intermedin in human brain, heart, and
            kidney
  JOURNAL   Peptides 28 (5), 1095-1103 (2007)
   PUBMED   17346853
  REMARK    GeneRIF: Study has shown expression of AM2/IMD in various types of
            cells in the central nervous system and the cardiovascular system,
            and suggested possible (patho)physiological roles of AM2/IMD in
            these systems.
REFERENCE   7  (bases 1 to 4213)
  AUTHORS   Kindt,F., Wiegand,S., Loser,C., Nilles,M., Niemeier,V., Hsu,S.Y.,
            Steinhoff,M., Kummer,W., Gieler,U. and Haberberger,R.V.
  TITLE     Intermedin: a skin peptide that is downregulated in atopic
            dermatitis
  JOURNAL   J Invest Dermatol 127 (3), 605-613 (2007)
   PUBMED   17008878
  REMARK    GeneRIF: IMD expressed by pericytes in has a role in susceptibility
            of the skin of atopic dermatitis patients to inflammatory stimuli
REFERENCE   8  (bases 1 to 4213)
  AUTHORS   Takahashi,K., Kikuchi,K., Maruyama,Y., Urabe,T., Nakajima,K.,
            Sasano,H., Imai,Y., Murakami,O. and Totsune,K.
  TITLE     Immunocytochemical localization of adrenomedullin 2/intermedin-like
            immunoreactivity in human hypothalamus, heart and kidney
  JOURNAL   Peptides 27 (6), 1383-1389 (2006)
   PUBMED   16359754
  REMARK    GeneRIF: ADM2 may be related to the central and peripheral
            regulation of the circulation and water-electrolyte metabolism
REFERENCE   9  (bases 1 to 4213)
  AUTHORS   Roh,J., Chang,C.L., Bhalla,A., Klein,C. and Hsu,S.Y.
  TITLE     Intermedin is a calcitonin/calcitonin gene-related peptide family
            peptide acting through the calcitonin receptor-like
            receptor/receptor activity-modifying protein receptor complexes
  JOURNAL   J Biol Chem 279 (8), 7264-7274 (2004)
   PUBMED   14615490
  REMARK    GeneRIF: Intermedin is a calcitonin/calcitonin gene-related peptide
            family peptide acting through the calcitonin receptor-like
            receptor/receptor activity-modifying protein receptor complexes
REFERENCE   10 (bases 1 to 4213)
  AUTHORS   Takei,Y., Inoue,K., Ogoshi,M., Kawahara,T., Bannai,H. and Miyano,S.
  TITLE     Identification of novel adrenomedullin in mammals: a potent
            cardiovascular and renal regulator
  JOURNAL   FEBS Lett 556 (1-3), 53-58 (2004)
   PUBMED   14706825
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL096767.14, AB236970.1 and
            BC012864.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001253845.1.
            
            Summary: This gene encodes a member of the calcitonin gene-related
            peptide (CGRP)/calcitonin family of hormones that play a role in
            the regulation of cardiovascular homeostasis, prolactin release,
            anti-diuresis, anti-natriuresis, and regulation of food and water
            intake. The encoded protein is proteolytically processed to
            generate one or more biologically active peptides. [provided by
            RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1834441.1, AB236970.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395737.2/ ENSP00000379086.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AL096767.14        56972-57152
            182-716             AB236970.1         1-535
            717-3961            AL096767.14        58370-61614
            3962-4213           BC012864.1         973-1224
FEATURES             Location/Qualifiers
     source          1..4213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..4213
                     /gene="ADM2"
                     /gene_synonym="AM2; dJ579N16.4"
                     /note="adrenomedullin 2"
                     /db_xref="GeneID:79924"
                     /db_xref="HGNC:HGNC:28898"
                     /db_xref="MIM:608682"
     exon            1..221
                     /gene="ADM2"
                     /gene_synonym="AM2; dJ579N16.4"
                     /inference="alignment:Splign:2.1.0"
     exon            222..342
                     /gene="ADM2"
                     /gene_synonym="AM2; dJ579N16.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..679
                     /gene="ADM2"
                     /gene_synonym="AM2; dJ579N16.4"
                     /note="intermedin; protein ADM2"
                     /codon_start=1
                     /product="protein ADM2 preproprotein"
                     /protein_id="NP_001240774.1"
                     /db_xref="CCDS:CCDS33682.1"
                     /db_xref="GeneID:79924"
                     /db_xref="HGNC:HGNC:28898"
                     /db_xref="MIM:608682"
                     /translation="MARIPTAALGCISLLCLQLPGSLSRSLGGDPRPVKPREPPARSP
                     SSSLQPRHPAPRPVVWKLHRALQAQRGAGLAPVMGQPLRDGGRQHSGPRRHSGPRRTQ
                     AQLLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSYG"
     exon            343..4213
                     /gene="ADM2"
                     /gene_synonym="AM2; dJ579N16.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADM2"
                     /gene_synonym="AM2; dJ579N16.4"
                     /note="hexamer: AATAAA"
     polyA_site      4213
                     /gene="ADM2"
                     /gene_synonym="AM2; dJ579N16.4"
                     /note="major polyA site"
ORIGIN      
        1 ggaaaggcta cgtattcagc cctggaggtg ccatcccggg ccgcgactcc gctccaggca
       61 ggacccccaa cccgcccagc ccgctccgcc ttgcgccccg gacccgcggc cgaccccaga
      121 cccgctgccc gcttcgcgcc cgaggcctgc gccccgacgg acgcccgtgc ccagcttgcc
      181 acgcccacgc ccggcgcccc gaccgcggag gactccccga gccccgcccg ccatggcccg
      241 gatcccgacg gccgccctgg gttgcatcag cctcctctgc ctgcagctcc ctggctcgct
      301 gtcccgcagc ctgggcgggg acccgcgacc cgtcaaaccc agggagcccc cagcccggag
      361 cccttccagc agcctgcagc ccaggcaccc cgcaccccga cctgtggtct ggaagcttca
      421 ccgggccctc caggcacaga ggggtgccgg cctggcccct gttatgggtc agcctctccg
      481 ggatggtggc cgccaacact cgggcccccg aagacactcg ggcccccgca ggacccaagc
      541 ccagctcctg cgagtgggct gtgtgctggg cacctgccag gtgcagaatc tcagccaccg
      601 cctgtggcaa ctcatgggac cggccggccg gcaggactca gctcctgtgg accccagcag
      661 cccccacagc tatggctgag gtggggccgg gccacacccc tgcccatccc agccagggtg
      721 ctgtgccccc gtccagagct gcagctgagc cccatctgaa gcccagtccc tcggagctgc
      781 agacagcagg tcctgcagca acaatacctg cacggctttg cacacgtaaa cctaggctgg
      841 tctacacgca gtgctggtac gtcaaggagc ctaaacaccc tgaaattgtg accccctggg
      901 ggacagctgc cagacacagc tggcggcagc accagatgct aagcgcttca gagaggaggt
      961 gtctgcccag agatgtggag cagaagctgg gccctgaaca cacggggcca tgtctggacg
     1021 agcaggggag agaggctgaa ctggccagaa gtggcccctc cgctgctggt ccagtcagac
     1081 tgaagcccgg ccttgtgcct gggctgttcc tgctctcatg cacaaccagc ccttccacgt
     1141 gcctgcctgt gggacaggag ggggagcgtg ggatgctgta gcccccgggg ttgggcaagg
     1201 gaaggatggt ggccctccag aggtcatgaa gggacctctg tggctccagc tgccaaccct
     1261 ggagcccaga ccgaggtggc catggagact ccacctggat cccctgtagg aggccaggga
     1321 ggggaactca gcagttcagg agccacccca aaccattctg ggacagggac acccctttct
     1381 accccagggc agggcagggc tgggtggggc aagatccccc agcccgacta gacccacctc
     1441 acctgaaggg ggtgagaccc ttgttggcag ccagacaagg gtggggctcc acaggcagca
     1501 caggcgcccc accaccaccc agtttgggga cccagtggga ccaggtgcgg gggcagaggg
     1561 tgacttacca agagccaggg agggcagccc aggcccaagt gacagcaaga acaagaacca
     1621 ctgccggcgt gcacagactt ggtgtgtgtc cttccctggg gggacggggg actcacatgt
     1681 gcctgccact ggagcctctc aaccgtccag cagaacacgg ggttcagaaa gggctccttc
     1741 tgctatttag cgaacactga gcatttaatt tacaaatgtt tgctagggtc accctctcgg
     1801 ccatcccacg agggtcgcca tgatcacccc aactctagag gccgcagcag agctcaggac
     1861 attcccccac agagcttgcc cctcagttcc tacctccaag ggggagggtc ctggaagcgc
     1921 ccacccaggc gccgcccctg tgcttgctcc ccgagctcag ggattgccga gtccacgtaa
     1981 ctgacctgta ctccacgagg ccctgtggga acggtccagg ctggtcctgc cctgtggagg
     2041 cctccgtgca ctgagagatg tactaggatt gcagcaaagg tggtcagggt gatgggccgc
     2101 acagcgaggc agtcaaggcc agctccctgg gagaagcact gggtcaggtg aggtctgagg
     2161 acagcaggcc ttccctaggg gaaggagctg ggagtgccaa ggccccaggt gcacaggagg
     2221 cgtggctgct gagaggctgc agggtggagg ggcctcggcc tcagagtcat gtgccctgtg
     2281 accactgaag ggtgtcagca gagcacacgg catgaggaca gagggagggg cacggggagt
     2341 gaaggagggg gccctggggc aaggctcggg ggtcaggagc tcagcgtccg ctactcagcc
     2401 cagccaaaac cctcccagac gtctcctctc ctgcctgggc aaagtccagc ttggcacccc
     2461 gtctggggcc tgcctgtggt cagggccaag tgttccctcc tccaggaaag cctttaccct
     2521 cctcatgccc tgtagtcagg aggccgcctg ctgtaaccct ccgtgtcgcc tcgggtgcga
     2581 aatcagaccc acctgacacc atcacgcgga ggcccagcag cacctgcacc cacttccagc
     2641 tgctctggcc aaaatctccg ctcggccagg ccccgtggct cacacctgta atcctagcac
     2701 attgggaggc caaggcaggc acatcacctg agttcaggag ttcaagacca gcctggccaa
     2761 catggtgaaa tcccgtctct actaaaaaca gaaaattatc cgggcgtggt ggcacatgac
     2821 tgtaatccca gctactcagg aggctgaggc aggaggatca cttgaacctg ggaggcggag
     2881 gttgcagtga gctgagattg cgccattgca ctccagcctg ggcaacaaga gcaaaattct
     2941 gcctcaaaaa aaaaaatagt aataatacaa aaattagctg ggcgtggtgg cacatgccag
     3001 taattccatc tactcgggag gctgaggcag gagaatcgtc taagcccggg aggtggaggt
     3061 tgcagtgagc ccagatggcg ctgctgcact caagcttgga tgacagagca agactccgtt
     3121 tcaaaaaaaa aaaacctcct ctcttccttc acaccttcct ctgaatccca cccggtccca
     3181 cctcctgaac ctatccagac accttctcct gacccaggca ccacctgctt tcggggcgat
     3241 ggccgtagcc tcctcccagg cacctgtctg catccctctg gccagtgcat gctgagcacg
     3301 tgacctaccc gtgttgggac acgtgaggat acagccttga cccccagggg ctgacattct
     3361 agggggagat agaaggagac aaacgtagaa ggtagaataa gtgggtggtg gagtggcagg
     3421 gagtgctgag tgccacagga agtcagacaa ggaaggagag tgtggggcag gtgccgttta
     3481 aatggggggc gctggggtct cctcacagtt gcttctcagc tcagctgtgc caggatcttg
     3541 ttgagtcagg tcagctgccc acagccctct tgcctgaccc ctgaagccca gaactctgat
     3601 cttcacagcc ctaggtatgg ccccagcacc ccactgccct ctctcctgcc ccagccgact
     3661 gctgttccca gacttccctg gccacgctcc aagacgccag ctctgccgcg ggcactttgt
     3721 tctcacggtg tcctccatgc ctgcagggcc catgcatggg aagttgcgtt ggcggcctgg
     3781 gtgttggcgg ttccgtgcct gctccaactc tccgtgaggc ccctctccca gagcctgaca
     3841 cactctgtgg ccgaactcta ggcaggtgcc cctgagtcct ttcctcgacg aggcctgacc
     3901 ccatccccat cctcgctggg cccgccgacc ccggtgttag caagaatcct ctaaatcagt
     3961 ttatggagaa ttacccaccc tcgatatctg atcccattcc tcatctccca cccttgatct
     4021 catcaccctg ccggcctcct gcaagatcct cattgagcca ctccagtgag aatcccccta
     4081 ccctcgaagg ccgccctaac aacttcccat ccgctgaccc ctccaacgcc atcaatctcc
     4141 agctgtggtt gttgaactcg gaggtgagct cctctcacca ctctcttgaa taaagctttt
     4201 ctcaccattt taa
//
