LOCUS       NM_001258430            1706 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens adipose secreted signaling protein (ADISSP),
            transcript variant 3, mRNA.
ACCESSION   NM_001258430
VERSION     NM_001258430.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Chen,Q., Huang,L., Pan,D., Hu,K., Li,R., Friedline,R.H., Kim,J.K.,
            Zhu,L.J., Guertin,D.A. and Wang,Y.X.
  TITLE     A brown fat-enriched adipokine Adissp controls adipose
            thermogenesis and glucose homeostasis
  JOURNAL   Nat Commun 13 (1), 7633 (2022)
   PUBMED   36496438
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Gao,J., Wang,Y., Zhang,W., Zhang,J., Lu,S., Meng,K., Yin,X., Sun,Z.
            and He,Q.Y.
  TITLE     C20orf27 Promotes Cell Growth and Proliferation of Colorectal
            Cancer via the TGFbetaR-TAK1-NFkB Pathway
  JOURNAL   Cancers (Basel) 12 (2), 336 (2020)
   PUBMED   32024300
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC069204.1, AK024220.1 and DB317576.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001258430.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            an alternate splice site in the coding region, but maintains the
            reading frame, compared to variant 1. Variants 2 and 3 encoded the
            same isoform (2), which is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069204.1, ERR3218371.20204.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1346              BC069204.1         28-1373
            1347-1704           AK024220.1         884-1241
            1705-1706           DB317576.1         10-11               c
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1706
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /note="adipose secreted signaling protein"
                     /db_xref="GeneID:54976"
                     /db_xref="HGNC:HGNC:15873"
                     /db_xref="MIM:620373"
     exon            1..545
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            546..650
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     CDS             632..1156
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /note="isoform 2 is encoded by transcript variant 3;
                     UPF0687 protein C20orf27"
                     /codon_start=1
                     /product="adipose-secreted signaling protein isoform 2"
                     /protein_id="NP_001245359.1"
                     /db_xref="CCDS:CCDS58763.1"
                     /db_xref="GeneID:54976"
                     /db_xref="HGNC:HGNC:15873"
                     /db_xref="MIM:620373"
                     /translation="MAAANKGNKPRVRSIRFAAGHDAEGSHSHVHFDEKLHDSVVMVT
                     QESDSSFLVKVGFLKILHRYEITFTLPPVHRLSKDVREAPVPSLHLKLLSVVPVPEGY
                     SVKCEYSAHKEGVLKEEILLACEGGTGTCVRVTVQARVMDRHHGTPMLLDGVKCVGAE
                     LEYDSEHSDWHGFD"
     exon            651..793
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            794..932
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1055
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1706
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1683..1688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /note="major polyA site"
ORIGIN      
        1 cccttcctcg tgctcggcgt tgagctcctg cagccgccgc cgctgcagtg gtcgtccctg
       61 ccctccccgg ccccggggtg caccccgcaa ggtgaggcca cccctctgct ccctgcctcc
      121 cggttccttc ccgttcgccg aggtcccctc ccggtcccgg ccctgtcctg agcagtcagt
      181 gcctgggacc ccagcggccg tgatggcagg gctggggtgg ggggctccgc tgtcggggcc
      241 gggcctggag gactccccag cacctgaact agagtgatgt caggttcccg gggcgcagtg
      301 accgttagct ggtgcagctg gggtgttttc cgcgaagcga ttgtccgggg gcatgagtgc
      361 ggtagtgagg gcgggggcgt aatggggtca gcgccccctc ctccccacga ccctgttcat
      421 tgccgctgcc tcgctgcatg accttggacc agtagcatct ctgagcctcc gagcctcagc
      481 accctcagga aggagggcag tgatgtctgg gagtgcgggc tccggagact cctgcgtcag
      541 ccgaggctcc cgctggtgtc cctggagcat gggaggctgc tgagcgtgag tggcggtgtc
      601 tggcaggagc tgcgtggcag ggagggcgtc catggctgca gccaacaagg gcaacaagcc
      661 cagagtccgg agtatccgct ttgcggcagg ccacgatgca gaaggatccc acagccacgt
      721 ccactttgat gagaagctgc atgactcggt ggtcatggtc acccaggaga gtgacagcag
      781 ctttctggtc aaggttggct tcctgaagat cctgcacagg tatgagatta ccttcactct
      841 gcccccagtg cacaggctga gcaaggatgt ccgcgaggca cctgtcccca gcctgcacct
      901 caagctcctc agcgtggtgc ccgtccctga aggttatagt gtcaagtgtg agtactcggc
      961 gcacaaagag ggcgtcctca aagaggagat actgctagcc tgcgaaggtg gcactggcac
     1021 ctgtgtgcgc gtgacggtgc aggcccgcgt catggaccgg caccacggca cgcccatgct
     1081 gctggatggt gtcaagtgtg tgggcgccga gctggaatac gactcagagc acagcgactg
     1141 gcacggcttt gactgaggcc cgaggccccg cctgccccgg gcccctcagc cttaaacccc
     1201 gccttgtccc cccgacatgc tgcgtgatgg tgtggcttcc tcgcccctct ctggggtggg
     1261 tgtgggggtg gagtggcctt gcccacgcct ctcacctctg ccttcatttg tgctgccacc
     1321 ctgcccctcc ctcgtcctcc tctcccactt cctcctctct gtgtgcctca gtctcctgcc
     1381 ggaagaaatg ggttgagccc gaaaggaggc tgtctgagga agggagaggg agggcctggg
     1441 gtgggtcccc cactccccac cccaagccac agggactccc accagggtct gggagaggac
     1501 ggagctggct ctgtggcgtc gtggccccat tactgctgcc ttgcttcagc cacctctcct
     1561 gcccctccct agtccccact gctgtccacc atgagtagga gggaggtgca gtccccagcc
     1621 cccacccctc aggtctgtgt tacttggttt ttaagcgact ggttgggata gaaccctaaa
     1681 gaaataaact tccagtggat accgga
//
