LOCUS       NM_001039140            1327 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens adipose secreted signaling protein (ADISSP),
            transcript variant 1, mRNA.
ACCESSION   NM_001039140
VERSION     NM_001039140.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1327)
  AUTHORS   Chen,Q., Huang,L., Pan,D., Hu,K., Li,R., Friedline,R.H., Kim,J.K.,
            Zhu,L.J., Guertin,D.A. and Wang,Y.X.
  TITLE     A brown fat-enriched adipokine Adissp controls adipose
            thermogenesis and glucose homeostasis
  JOURNAL   Nat Commun 13 (1), 7633 (2022)
   PUBMED   36496438
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1327)
  AUTHORS   Gao,J., Wang,Y., Zhang,W., Zhang,J., Lu,S., Meng,K., Yin,X., Sun,Z.
            and He,Q.Y.
  TITLE     C20orf27 Promotes Cell Growth and Proliferation of Colorectal
            Cancer via the TGFbetaR-TAK1-NFkB Pathway
  JOURNAL   Cancers (Basel) 12 (2), 336 (2020)
   PUBMED   32024300
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1327)
  AUTHORS   Yadav,L., Tamene,F., Goos,H., van Drogen,A., Katainen,R.,
            Aebersold,R., Gstaiger,M. and Varjosalo,M.
  TITLE     Systematic Analysis of Human Protein Phosphatase Interactions and
            Dynamics
  JOURNAL   Cell Syst 4 (4), 430-444 (2017)
   PUBMED   28330616
REFERENCE   4  (bases 1 to 1327)
  AUTHORS   Boldt,K., van Reeuwijk,J., Lu,Q., Koutroumpas,K., Nguyen,T.M.,
            Texier,Y., van Beersum,S.E., Horn,N., Willer,J.R., Mans,D.A.,
            Dougherty,G., Lamers,I.J., Coene,K.L., Arts,H.H., Betts,M.J.,
            Beyer,T., Bolat,E., Gloeckner,C.J., Haidari,K., Hetterschijt,L.,
            Iaconis,D., Jenkins,D., Klose,F., Knapp,B., Latour,B.,
            Letteboer,S.J., Marcelis,C.L., Mitic,D., Morleo,M., Oud,M.M.,
            Riemersma,M., Rix,S., Terhal,P.A., Toedt,G., van Dam,T.J., de
            Vrieze,E., Wissinger,Y., Wu,K.M., Apic,G., Beales,P.L.,
            Blacque,O.E., Gibson,T.J., Huynen,M.A., Katsanis,N., Kremer,H.,
            Omran,H., van Wijk,E., Wolfrum,U., Kepes,F., Davis,E.E., Franco,B.,
            Giles,R.H., Ueffing,M., Russell,R.B. and Roepman,R.
  CONSRTM   UK10K Rare Diseases Group
  TITLE     An organelle-specific protein landscape identifies novel diseases
            and molecular mechanisms
  JOURNAL   Nat Commun 7, 11491 (2016)
   PUBMED   27173435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1327)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF978883.1, BG474804.1, AK024220.1 and DB317576.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001039140.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.64513.1,
                                           DRR138528.1074703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BF978883.1         54-88
            36-673              BG474804.1         7-644
            674-1325            AK024220.1         590-1241
            1326-1327           DB317576.1         10-11               c
FEATURES             Location/Qualifiers
     source          1..1327
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1327
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /note="adipose secreted signaling protein"
                     /db_xref="GeneID:54976"
                     /db_xref="HGNC:HGNC:15873"
                     /db_xref="MIM:620373"
     exon            1..91
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            92..271
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..777
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0687 protein C20orf27"
                     /codon_start=1
                     /product="adipose-secreted signaling protein isoform 1"
                     /protein_id="NP_001034229.1"
                     /db_xref="CCDS:CCDS33436.1"
                     /db_xref="GeneID:54976"
                     /db_xref="HGNC:HGNC:15873"
                     /db_xref="MIM:620373"
                     /translation="MAAANKGKCLPGVVGLAQALPVGPGRRAIAAGNKPRVRSIRFAA
                     GHDAEGSHSHVHFDEKLHDSVVMVTQESDSSFLVKVGFLKILHRYEITFTLPPVHRLS
                     KDVREAPVPSLHLKLLSVVPVPEGYSVKCEYSAHKEGVLKEEILLACEGGTGTCVRVT
                     VQARVMDRHHGTPMLLDGVKCVGAELEYDSEHSDWHGFD"
     exon            272..414
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            415..553
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            554..676
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     exon            677..1327
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1304..1309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /note="hexamer: AATAAA"
     polyA_site      1327
                     /gene="ADISSP"
                     /gene_synonym="C20orf27"
                     /note="major polyA site"
ORIGIN      
        1 cccttcctcg tgctcggcgt tgagctcctg cagccgccgc cgctgcagtg gtcgtccctg
       61 ccctccccgg ccccggggtg caccccgcaa ggctcccgct ggtgtccctg gagcatggga
      121 ggctgctgag cgtgagtggc ggtgtctggc aggagctgcg tggcagggag ggcgtccatg
      181 gctgcagcca acaagggtaa gtgccttcct ggcgtggtag gacttgcaca agctcttccg
      241 gtgggccctg gtaggagggc cattgctgca ggcaacaagc ccagagtccg gagtatccgc
      301 tttgcggcag gccacgatgc agaaggatcc cacagccacg tccactttga tgagaagctg
      361 catgactcgg tggtcatggt cacccaggag agtgacagca gctttctggt caaggttggc
      421 ttcctgaaga tcctgcacag gtatgagatt accttcactc tgcccccagt gcacaggctg
      481 agcaaggatg tccgcgaggc acctgtcccc agcctgcacc tcaagctcct cagcgtggtg
      541 cccgtccctg aaggttatag tgtcaagtgt gagtactcgg cgcacaaaga gggcgtcctc
      601 aaagaggaga tactgctagc ctgcgaaggt ggcactggca cctgtgtgcg cgtgacggtg
      661 caggcccgcg tcatggaccg gcaccacggc acgcccatgc tgctggatgg tgtcaagtgt
      721 gtgggcgccg agctggaata cgactcagag cacagcgact ggcacggctt tgactgaggc
      781 ccgaggcccc gcctgccccg ggcccctcag ccttaaaccc cgccttgtcc ccccgacatg
      841 ctgcgtgatg gtgtggcttc ctcgcccctc tctggggtgg gtgtgggggt ggagtggcct
      901 tgcccacgcc tctcacctct gccttcattt gtgctgccac cctgcccctc cctcgtcctc
      961 ctctcccact tcctcctctc tgtgtgcctc agtctcctgc cggaagaaat gggttgagcc
     1021 cgaaaggagg ctgtctgagg aagggagagg gagggcctgg ggtgggtccc ccactcccca
     1081 ccccaagcca cagggactcc caccagggtc tgggagagga cggagctggc tctgtggcgt
     1141 cgtggcccca ttactgctgc cttgcttcag ccacctctcc tgcccctccc tagtccccac
     1201 tgctgtccac catgagtagg agggaggtgc agtccccagc ccccacccct caggtctgtg
     1261 ttacttggtt tttaagcgac tggttgggat agaaccctaa agaaataaac ttccagtgga
     1321 taccgga
//
