LOCUS       NM_006829                627 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens adipogenesis regulatory factor (ADIRF), mRNA.
ACCESSION   NM_006829
VERSION     NM_006829.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 627)
  AUTHORS   Xiong,R., Du,Y., Chen,S., Liu,T., Ding,X., Zhou,J., Wang,Z. and
            Yang,Q.
  TITLE     Hypermethylation of the ADIRF promoter regulates its expression
            level and is involved in NNK-induced malignant transformation of
            lung bronchial epithelial cells
  JOURNAL   Arch Toxicol 97 (12), 3243-3258 (2023)
   PUBMED   37777989
  REMARK    GeneRIF: Hypermethylation of the ADIRF promoter regulates its
            expression level and is involved in NNK-induced malignant
            transformation of lung bronchial epithelial cells.
REFERENCE   2  (bases 1 to 627)
  AUTHORS   Kamimura,K., Suda,T., Fukuhara,Y., Okuda,S., Watanabe,Y., Yokoo,T.,
            Osaki,A., Waguri,N., Ishikawa,T., Sato,T., Aoyagi,Y., Takamura,M.,
            Wakai,T. and Terai,S.
  TITLE     Adipose most abundant 2 protein is a predictive marker for
            cisplatin sensitivity in cancers
  JOURNAL   Sci Rep 11 (1), 6255 (2021)
   PUBMED   33737617
  REMARK    GeneRIF: Adipose most abundant 2 protein is a predictive marker for
            cisplatin sensitivity in cancers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 627)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 627)
  AUTHORS   Meng,J., Wang,L.H., Zou,C.L., Dai,S.M., Zhang,J. and Lu,Y.
  TITLE     C10orf116 Gene Copy Number Loss in Prostate Cancer:
            Clinicopathological Correlations and Prognostic Significance
  JOURNAL   Med Sci Monit 23, 5176-5183 (2017)
   PUBMED   29084195
  REMARK    GeneRIF: C10orf116 loss was associated with higher pathological
            stage, higher clinical stage, and lymph node metastasis in prostate
            cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 627)
  AUTHORS   Chen,L., Zhou,X.G., Zhou,X.Y., Zhu,C., Ji,C.B., Shi,C.M., Qiu,J.
            and Guo,X.R.
  TITLE     Overexpression of C10orf116 promotes proliferation, inhibits
            apoptosis and enhances glucose transport in 3T3-L1 adipocytes
  JOURNAL   Mol Med Rep 7 (5), 1477-1481 (2013)
   PUBMED   23467766
REFERENCE   6  (bases 1 to 627)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 627)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 627)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   9  (bases 1 to 627)
  AUTHORS   Ozyildirim,A.M., Wistow,G.J., Gao,J., Wang,J., Dickinson,D.P.,
            Frierson,H.F. Jr. and Laurie,G.W.
  TITLE     The lacrimal gland transcriptome is an unusually rich source of
            rare and poorly characterized gene transcripts
  JOURNAL   Invest Ophthalmol Vis Sci 46 (5), 1572-1580 (2005)
   PUBMED   15851553
REFERENCE   10 (bases 1 to 627)
  AUTHORS   Maeda,K., Okubo,K., Shimomura,I., Funahashi,T., Matsuzawa,Y. and
            Matsubara,K.
  TITLE     cDNA cloning and expression of a novel adipose specific
            collagen-like factor, apM1 (AdiPose Most abundant Gene transcript
            1)
  JOURNAL   Biochem Biophys Res Commun 221 (2), 286-289 (1996)
   PUBMED   8619847
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM789611.1, AI401530.1, BM850559.1, CD722742.1 and AL136982.11.
            
            On May 17, 2019 this sequence version replaced NM_006829.2.
            
            Summary: APM2 gene is exclusively expressed in adipose tissue. Its
            function is currently unknown. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB290291.1, DA559348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372013.8/ ENSP00000361083.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               BM789611.1         291-556
            267-448             AI401530.1         8-189               c
            449-560             BM850559.1         340-451
            561-621             CD722742.1         222-282
            622-627             AL136982.11        5043-5048
FEATURES             Location/Qualifiers
     source          1..627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..627
                     /gene="ADIRF"
                     /gene_synonym="AFRO; apM-2; APM2; C10orf116"
                     /note="adipogenesis regulatory factor"
                     /db_xref="GeneID:10974"
                     /db_xref="HGNC:HGNC:24043"
     exon            1..124
                     /gene="ADIRF"
                     /gene_synonym="AFRO; apM-2; APM2; C10orf116"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..294
                     /gene="ADIRF"
                     /gene_synonym="AFRO; apM-2; APM2; C10orf116"
                     /note="adipose specific 2; adipose most abundant gene
                     transcript 2 protein; adipogenesis factor rich in obesity;
                     adipose-specific protein 2"
                     /codon_start=1
                     /product="adipogenesis regulatory factor"
                     /protein_id="NP_006820.1"
                     /db_xref="CCDS:CCDS7381.1"
                     /db_xref="GeneID:10974"
                     /db_xref="HGNC:HGNC:24043"
                     /translation="MASKGLQDLKQQVEGTAQEAVSAAGAAAQQVVDQATEAGQKAMD
                     QLAKTTQETIDKTANQASDTFSGIGKKFGLLK"
     exon            125..187
                     /gene="ADIRF"
                     /gene_synonym="AFRO; apM-2; APM2; C10orf116"
                     /inference="alignment:Splign:2.1.0"
     exon            188..627
                     /gene="ADIRF"
                     /gene_synonym="AFRO; apM-2; APM2; C10orf116"
                     /inference="alignment:Splign:2.1.0"
     regulatory      425..430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADIRF"
                     /gene_synonym="AFRO; apM-2; APM2; C10orf116"
                     /note="hexamer: ATTAAA"
     polyA_site      443
                     /gene="ADIRF"
                     /gene_synonym="AFRO; apM-2; APM2; C10orf116"
                     /note="major polyA site"
ORIGIN      
        1 actctgggca ggatccaacg tcgctccagc tgctcttgac gactccacag ataccccgaa
       61 gccatggcaa gcaagggctt gcaggacctg aagcaacagg tggaggggac cgcccaggaa
      121 gccgtgtcag cggccggagc ggcagctcag caagtggtgg accaggccac agaggcgggg
      181 cagaaagcca tggaccagct ggccaagacc acccaggaaa ccatcgacaa gactgctaac
      241 caggcctctg acaccttctc tgggattggg aaaaaattcg gcctcctgaa atgacagcag
      301 ggagacttgg gtcggcctcc tgaaatgaca gcagggagac ttgggtgacc ccccttccag
      361 gcgccatcta gcacagcctg gccctgatct ccgggcagcc accacctcct cggtctgccc
      421 cctcattaaa attcacgttc ccaccctgtg tccacttcat gattcctcgc aagctgggcc
      481 cagtcctctc atcccaagag cagagccacc gtagccggag tcctagcctc ccaaattcgg
      541 aaatccaatc caacggtctc aggaatgttt tccatcccgc cacgcgcctc ccgaagctcc
      601 cagaccggag gctcagcccc catctcg
//
