LOCUS       NM_024551               3971 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens adiponectin receptor 2 (ADIPOR2), transcript variant
            4, mRNA.
ACCESSION   NM_024551 NM_032665
VERSION     NM_024551.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3971)
  AUTHORS   Guo,Q.W., Lin,J., Shen,Y.L., Zheng,Y.J., Chen,X., Su,M.,
            Zhang,J.C., Wang,J.H., Tang,H., Su,G.M., Li,Z.K. and Fang,D.Z.
  TITLE     Reduced hepatic AdipoR2 by increased glucocorticoid mediates effect
            of psychosocial stress to elevate serum cholesterol
  JOURNAL   Mol Cell Endocrinol 592, 112282 (2024)
   PUBMED   38815796
  REMARK    GeneRIF: Reduced hepatic AdipoR2 by increased glucocorticoid
            mediates effect of psychosocial stress to elevate serum
            cholesterol.
REFERENCE   2  (bases 1 to 3971)
  AUTHORS   Ruiz,M., Devkota,R., Kaper,D., Ruhanen,H., Busayavalasa,K.,
            Radovic,U., Henricsson,M., Kakela,R., Boren,J. and Pilon,M.
  TITLE     AdipoR2 recruits protein interactors to promote fatty acid
            elongation and membrane fluidity
  JOURNAL   J Biol Chem 299 (6), 104799 (2023)
   PUBMED   37164154
  REMARK    GeneRIF: AdipoR2 recruits protein interactors to promote fatty acid
            elongation and membrane fluidity.
REFERENCE   3  (bases 1 to 3971)
  AUTHORS   Mihajlovic,M., Ninic,A., Ostojic,M., Sopic,M., Stefanovic,A.,
            Vekic,J., Antonic,T., Zeljkovic,D., Trifunovic,B.,
            Spasojevic-Kalimanovska,V., Bogavac Stanojevic,N., Jancic,I. and
            Zeljkovic,A.
  TITLE     Association of Adiponectin Receptors with Metabolic and Immune
            Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and
            Observational Findings
  JOURNAL   Int J Environ Res Public Health 19 (22), 14995 (2022)
   PUBMED   36429712
  REMARK    GeneRIF: Association of Adiponectin Receptors with Metabolic and
            Immune Homeostasis Parameters in Colorectal Cancer: In Silico
            Analysis and Observational Findings.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3971)
  AUTHORS   Ayyildiz,T., Dolar,E., Ugras,N., Dizdar,O.S., Erturk,B., Adim,S.B.
            and Yerci,O.
  TITLE     The expression and relationship of AdipoR1/R2 in gastric intestinal
            metaplasia
  JOURNAL   Niger J Clin Pract 24 (4), 608-613 (2021)
   PUBMED   33851685
  REMARK    GeneRIF: The expression and relationship of AdipoR1/R2 in gastric
            intestinal metaplasia.
REFERENCE   5  (bases 1 to 3971)
  AUTHORS   Jie,C., Xuan,W., Feng,H.D., Hua,D.M., Bo,W., Fei,S. and Hao,Z.
  TITLE     AdipoR2 inhibits human glioblastoma cell growth through the
            AMPK/mTOR pathway
  JOURNAL   Eur J Med Res 26 (1), 28 (2021)
   PUBMED   33752745
  REMARK    GeneRIF: AdipoR2 inhibits human glioblastoma cell growth through
            the AMPK/mTOR pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3971)
  AUTHORS   Berner,H.S., Lyngstadaas,S.P., Spahr,A., Monjo,M., Thommesen,L.,
            Drevon,C.A., Syversen,U. and Reseland,J.E.
  TITLE     Adiponectin and its receptors are expressed in bone-forming cells
  JOURNAL   Bone 35 (4), 842-849 (2004)
   PUBMED   15454091
  REMARK    GeneRIF: a link between adiponectin and bone homeostasis by
            demonstrating transcription, translation, and secretion of
            adiponectin, as well as expression of its receptors, AdipoR1 and
            AdipoR2, in bone-forming cells
REFERENCE   7  (bases 1 to 3971)
  AUTHORS   Staiger,H., Kaltenbach,S., Staiger,K., Stefan,N., Fritsche,A.,
            Guirguis,A., Peterfi,C., Weisser,M., Machicao,F., Stumvoll,M. and
            Haring,H.U.
  TITLE     Expression of adiponectin receptor mRNA in human skeletal muscle
            cells is related to in vivo parameters of glucose and lipid
            metabolism
  JOURNAL   Diabetes 53 (9), 2195-2201 (2004)
   PUBMED   15331527
  REMARK    GeneRIF: myotube mRNA levels of both receptors are associated with
            distinct metabolic functions but not with insulin sensitivity;
            AdipoR1, but not AdipoR2, expression correlated with insulin
            secretion.
REFERENCE   8  (bases 1 to 3971)
  AUTHORS   Civitarese,A.E., Jenkinson,C.P., Richardson,D., Bajaj,M., Cusi,K.,
            Kashyap,S., Berria,R., Belfort,R., DeFronzo,R.A., Mandarino,L.J.
            and Ravussin,E.
  TITLE     Adiponectin receptors gene expression and insulin sensitivity in
            non-diabetic Mexican Americans with or without a family history of
            Type 2 diabetes
  JOURNAL   Diabetologia 47 (5), 816-820 (2004)
   PUBMED   15105989
  REMARK    GeneRIF: Epression levels of AdipoRw as well as plasma adiponectin
            concentration were lower in people with a family history of Type 2.
REFERENCE   9  (bases 1 to 3971)
  AUTHORS   Kharroubi,I., Rasschaert,J., Eizirik,D.L. and Cnop,M.
  TITLE     Expression of adiponectin receptors in pancreatic beta cells
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1118-1122 (2003)
   PUBMED   14651988
  REMARK    GeneRIF: Here we report the marked expression of mRNAs for the
            adiponectin receptors AdipoR1 and AdipoR2 in human and rat
            pancreatic beta cells, at levels similar to liver and greater than
            muscle.
REFERENCE   10 (bases 1 to 3971)
  AUTHORS   Yamauchi,T., Kamon,J., Ito,Y., Tsuchida,A., Yokomizo,T., Kita,S.,
            Sugiyama,T., Miyagishi,M., Hara,K., Tsunoda,M., Murakami,K.,
            Ohteki,T., Uchida,S., Takekawa,S., Waki,H., Tsuno,N.H., Shibata,Y.,
            Terauchi,Y., Froguel,P., Tobe,K., Koyasu,S., Taira,K., Kitamura,T.,
            Shimizu,T., Nagai,R. and Kadowaki,T.
  TITLE     Cloning of adiponectin receptors that mediate antidiabetic
            metabolic effects
  JOURNAL   Nature 423 (6941), 762-769 (2003)
   PUBMED   12802337
  REMARK    GeneRIF: cloning of cDNAs encoding adiponectin receptors 1 and 2
            (AdipoR1 and AdipoR2) by expression cloning [AdipoR1 & AdipoR2]
            Erratum:[Nature. 2004 Oct 28;431(7012):1123]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005183.3 and AC005343.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024551.2.
            
            Summary: The adiponectin receptors, ADIPOR1 (MIM 607945) and
            ADIPOR2, serve as receptors for globular and full-length
            adiponectin (MIM 605441) and mediate increased AMPK (see MIM
            602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as
            well as fatty acid oxidation and glucose uptake by adiponectin
            (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128511.1, SRR1803612.46924.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357103.5/ ENSP00000349616.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC005183.3         33510-33631
            123-379             AC005343.1         121249-121505       c
            380-499             AC005343.1         102802-102921       c
            500-671             AC005343.1         97738-97909         c
            672-858             AC005343.1         95126-95312         c
            859-1046            AC005343.1         94687-94874         c
            1047-1240           AC005343.1         91690-91883         c
            1241-3971           AC005343.1         87089-89819         c
FEATURES             Location/Qualifiers
     source          1..3971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.33"
     gene            1..3971
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /note="adiponectin receptor 2"
                     /db_xref="GeneID:79602"
                     /db_xref="HGNC:HGNC:24041"
                     /db_xref="MIM:607946"
     exon            1..122
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /inference="alignment:Splign:2.1.0"
     exon            123..379
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1369
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /note="isoform 2 is encoded by transcript variant 4;
                     adiponectin receptor protein 2; progestin and adipoQ
                     receptor family member II; progestin and adipoQ receptor
                     family member 2"
                     /codon_start=1
                     /product="adiponectin receptor protein 2 isoform 2"
                     /protein_id="NP_078827.2"
                     /db_xref="CCDS:CCDS8511.1"
                     /db_xref="GeneID:79602"
                     /db_xref="HGNC:HGNC:24041"
                     /db_xref="MIM:607946"
                     /translation="MNEPTENRLGCSRTPEPDIRLRKGHQLDGTRRGDNDSHQGDLEP
                     ILEASVLSSHHKKSSEEHEYSDEAPQEDEGFMGMSPLLQAHHAMEKMEEFVCKVWEGR
                     WRVIPHDVLPDWLKDNDFLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGCVFFL
                     CLGIFYMFRPNISFVAPLQEKVVFGLFFLGAILCLSFSWLFHTVYCHSEGVSRLFSKL
                     DYSGIALLIMGSFVPWLYYSFYCNPQPCFIYLIVICVLGIAAIIVSQWDMFATPQYRG
                     VRAGVFLGLGLSGIIPTLHYVISEGFLKAATIGQIGWLMLMASLYITGAALYAARIPE
                     RFFPGKCDIWFHSHQLFHIFVVAGAFVHFHGVSNLQEFRFMIGGGCSEEDAL"
     exon            380..499
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /inference="alignment:Splign:2.1.0"
     exon            500..671
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /inference="alignment:Splign:2.1.0"
     exon            672..858
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1046
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1240
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..3971
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3951..3956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /note="hexamer: AATAAA"
     polyA_site      3971
                     /gene="ADIPOR2"
                     /gene_synonym="ACDCR2; PAQR2"
                     /note="major polyA site"
ORIGIN      
        1 agaagcggca tcgcggcggc ggcagcggcg gcggctacac cgggcttggc cccctccctc
       61 ctccgttccc ccctcctccc ccctcccctc agcggtggct cccaagaagt ccgagacacg
      121 cggatcaact cactatcctg aaggtccatt ctcccaagaa gaggggacag aaagacagat
      181 ctatttgtaa gaaaggcttg ggtatcccat gaacgagcca acagaaaacc gattggggtg
      241 cagcaggact ccagagccag atataaggct cagaaaaggg caccaactgg atggtacacg
      301 aagaggtgat aatgacagcc accaaggaga tttggagccc attttagagg catctgttct
      361 atcttcccat cataaaaaaa gctctgagga acatgaatac agtgatgaag ctcctcagga
      421 agatgagggc tttatgggca tgtcccctct cttacaagcc catcatgcta tggaaaaaat
      481 ggaagaattt gtttgtaagg tatgggaagg tcggtggcga gtgatccctc atgatgtact
      541 accagactgg ctcaaggata atgacttcct cttgcatgga caccggcctc ctatgccttc
      601 tttccgggcc tgttttaaga gcattttcag aatacacaca gaaacaggca acatttggac
      661 acatctctta ggttgtgtat tcttcctgtg cctggggatc ttttatatgt ttcgcccaaa
      721 tatctccttt gtggcccctc tgcaagagaa ggtggtcttt ggattatttt tcttaggagc
      781 cattctctgc ctttcttttt catggctctt ccacacagtc tactgccact cagagggggt
      841 ctctcggctc ttctctaaac tggattactc tggtattgct cttctgatta tgggaagttt
      901 tgttccttgg ctttattatt ctttctactg taatccacaa ccttgcttca tctacttgat
      961 tgtcatctgt gtgctgggca ttgcagccat tatagtctcc cagtgggaca tgtttgccac
     1021 ccctcagtat cggggagtaa gagcaggagt gtttttgggc ctaggcctga gtggaatcat
     1081 tcctaccttg cactatgtca tctcggaggg gttccttaag gccgccacca tagggcagat
     1141 aggctggttg atgctgatgg ccagcctcta catcacagga gctgccctgt atgctgcccg
     1201 gatccccgaa cgctttttcc ctggcaaatg tgacatctgg tttcactctc atcagctgtt
     1261 tcatatcttt gtggttgctg gagcttttgt tcacttccat ggtgtctcaa acctccagga
     1321 gtttcgtttc atgatcggcg ggggctgcag tgaagaggat gcactgtgat acctaccagt
     1381 ctccagggac tatgacccta aaccagggcc tgcggcactt gcgggcctcc ctgctggcta
     1441 ctgatgccag taccagagga gccccaaaac tttgacagcc tcgtgggctt tgtgacggcc
     1501 cagtggctct gcgtggtaca tgactgagaa gagaaaaaca aaaataaatc atacctcaaa
     1561 ggatggagtg catcaattgg gagaaaagga gacatagccc aaaccctggc ttattcttgg
     1621 gatctactga ttgcgggctc tgcaagaccc ttggcaaact ggcttctgat ccatatcata
     1681 tttatttgta gaagatggcg aaacagttta gctggtggtt ctttcttctc cctttctctc
     1741 tctctatgac aataatacaa accaatttaa gtgaacattt atatccgata aggggtggga
     1801 gtgtgatttt aaatgctctt ttgggagaac aaagaaatta atgtaaataa gatttctaac
     1861 tgtttaaata agactttata taaatgttta aaacataggg gtaagggagg gagggagaat
     1921 ttttgtatag aatgaaacat gcaagtacca cacactgttt gaattttgca caaaaagtga
     1981 ctgtaggatc aggtgatagc cccggaatgt acagtgtctt ggtgcaccaa gatgccttct
     2041 aaaggctgac ataccttgga ccctaatggg gcagagagta tagccctagc ccagtggtga
     2101 catgaccact ccctttggga ggcctgaggt agaggggagt ggtatgtgtt ttctcagtgg
     2161 aagcagcaca tgagtgggtg acaggatgtt agataaaggc tctagttagg gtgtcattgt
     2221 catttgagag actgacacac tcctagcagc tggtaaaggg gtgctggagg ccatggagga
     2281 gctctagaaa cattagcatg ggctgatctg attacttcct ggcatcccgc tcacttttat
     2341 gggaagtctt attagaggga tgggacagtt ttccatatcc ttgctgtgga gctctggaac
     2401 actctctaaa tttccctcta ttaaaaatca ctgccctaac tacacttcct ccttgaggga
     2461 atagaaatgg acctttctct gacatagttc ttggcatggg agccagccac aaatgagatt
     2521 ctgacgtgtc caggtttctc ctgagctcat ctacatagat tggtagaccc ttcctttgga
     2581 ttaggaaaga tgagttttac ctctggtaca ctgtcttggt aagcctggat gtgacagaca
     2641 cctcggctct ccttgaataa gaaagccagc agaactctta aagccagttg tagtacggag
     2701 ttgtcagcac tcactgaacc tcactttaca gggataagag tggtgtggca ttttaaatac
     2761 aatggtatgt tattgccagg gagtgaggta caagacgatg gctcatgtca caggcctacc
     2821 tgatacggtg tcagagaaag tggtggggaa aggatctggt tcatggaatt ctgatcttgg
     2881 cccataggtg aaccaccaaa atagtgctcg agtcttaggt tactgtcatc aaagacttgg
     2941 gatgactcca ttatatcctg gggttgtggg tattagaact aaatatggag gtcctgagca
     3001 tggggactgg cgtcctcagt aggtgtttgg gaatatggga agggtctcct atttattcaa
     3061 tagagttttc tcagttattt tcctcccttg cccttgcaat ctccagcaaa aggtgggatc
     3121 taggaagaaa gaatccagtg tagaagttga gaagaacttg aacgttttgg ttctggataa
     3181 ggtcactgtc ctaggtgcta ggtggaccga gcaaaagact cagtggatga actggtgcag
     3241 tgcctgacag aataaagaac agtattaatc cctttgagaa agcatagtcc agcaggacag
     3301 tggccatttg gacagaagcc cacttagttt cttgggagca acagcacgta tcagaagcca
     3361 gacttgctct tcggtcatgc actttgggat acagcgtata ggtgcagccc tgtcacaaca
     3421 ccaacagaag tagcagcctc tgggtgcagt cacccacacc ccaaagctgg aaggatctgg
     3481 ttcaacatag cacaaaccct taggaaaaat gaaattaaca tcactgatgt gtaatccagt
     3541 aaaatctccc tttttcgggt gtgtatgtgg gcatgtgccc atttctatgt gtgtgtctac
     3601 gtgcagctca ctaccaacag cctcatgtgc acttgacctg acagtgctcg ctgagaactc
     3661 tcaccaggtt ggcgcctgaa tgccttactc tcagcagtca gaggcttgct tgctctgtgc
     3721 agatttttaa ttttcttttt tggccctagg ctggttggga cctctacagc ttcattcttt
     3781 caccattaaa tagtggcctt tttcagtatt ttccctcttc ccctttataa attatgctaa
     3841 agccacaaag cacatttttg gggatcatag aaggttgggg ttccagaaag gcatctgtgt
     3901 gatggttcca ttgatgtggg atttccctac ttgctgtatt ctcagtttct aataaaaaga
     3961 accaaatgaa a
//
