LOCUS       NM_015999               2091 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens adiponectin receptor 1 (ADIPOR1), transcript variant
            1, mRNA.
ACCESSION   NM_015999
VERSION     NM_015999.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Xu,A., Wang,L., Luo,M., Zhang,H., Ning,M., Pan,J., Duan,X., Wang,Y.
            and Liu,X.
  TITLE     Overexpression of salusin-beta downregulates adipoR1 expression to
            prevent fatty acid oxidation in HepG2 cells
  JOURNAL   Mol Med Rep 29 (2) (2024)
   PUBMED   38063230
  REMARK    GeneRIF: Overexpression of salusin-beta downregulates adipoR1
            expression to prevent fatty acid oxidation in HepG2 cells.
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Bui,K.C., Nguyen,T.M.L., Barat,S., Scholta,T., Xing,J., Bhuria,V.,
            Sipos,B., Wilkens,L., Nguyen,L.T., Le,H.S., Velavan,T.P., Bozko,P.
            and Plentz,R.R.
  TITLE     Novel Adiponectin Receptor Agonist Inhibits Cholangiocarcinoma via
            Adenosine Monophosphate-activated Protein Kinase
  JOURNAL   Curr Med Chem 31 (28), 4534-4548 (2024)
   PUBMED   38361349
  REMARK    GeneRIF: Novel Adiponectin Receptor Agonist Inhibits
            Cholangiocarcinoma via Adenosine Monophosphate-activated Protein
            Kinase.
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Kaiyrlykyzy,A., Umbayev,B., Masoud,A.R., Baibulatova,A., Tsoy,A.,
            Olzhayev,F., Alzhanova,D., Zholdasbekova,G., Davletov,K.,
            Akilzhanova,A. and Askarova,S.
  TITLE     Circulating adiponectin levels, expression of adiponectin
            receptors, and methylation of adiponectin gene promoter in relation
            to Alzheimer's disease
  JOURNAL   BMC Med Genomics 15 (1), 262 (2022)
   PUBMED   36527105
  REMARK    GeneRIF: Circulating adiponectin levels, expression of adiponectin
            receptors, and methylation of adiponectin gene promoter in relation
            to Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Mihajlovic,M., Ninic,A., Ostojic,M., Sopic,M., Stefanovic,A.,
            Vekic,J., Antonic,T., Zeljkovic,D., Trifunovic,B.,
            Spasojevic-Kalimanovska,V., Bogavac Stanojevic,N., Jancic,I. and
            Zeljkovic,A.
  TITLE     Association of Adiponectin Receptors with Metabolic and Immune
            Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and
            Observational Findings
  JOURNAL   Int J Environ Res Public Health 19 (22), 14995 (2022)
   PUBMED   36429712
  REMARK    GeneRIF: Association of Adiponectin Receptors with Metabolic and
            Immune Homeostasis Parameters in Colorectal Cancer: In Silico
            Analysis and Observational Findings.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Ashwal,R., Hemi,R., Tirosh,A., Gordin,R., Yissachar,E.,
            Cohen-Dayag,A., Rosenberg,A., Karasik,A., Bluher,M. and Kanety,H.
  TITLE     Differential expression of novel adiponectin receptor-1 transcripts
            in skeletal muscle of subjects with normal glucose tolerance and
            type 2 diabetes
  JOURNAL   Diabetes 60 (3), 936-946 (2011)
   PUBMED   21289205
  REMARK    GeneRIF: AdipoR1 receptor expression in human skeletal muscle is
            subjected to posttranscriptional regulation, including alternative
            splicing and translational control.
REFERENCE   6  (bases 1 to 2091)
  AUTHORS   Staiger,H., Kaltenbach,S., Staiger,K., Stefan,N., Fritsche,A.,
            Guirguis,A., Peterfi,C., Weisser,M., Machicao,F., Stumvoll,M. and
            Haring,H.U.
  TITLE     Expression of adiponectin receptor mRNA in human skeletal muscle
            cells is related to in vivo parameters of glucose and lipid
            metabolism
  JOURNAL   Diabetes 53 (9), 2195-2201 (2004)
   PUBMED   15331527
  REMARK    GeneRIF: myotube mRNA levels of both receptors are associated with
            distinct metabolic functions but not with insulin sensitivity;
            AdipoR1, but not AdipoR2, expression correlated with insulin
            secretion.
REFERENCE   7  (bases 1 to 2091)
  AUTHORS   Wang,H., Zhang,H., Jia,Y., Zhang,Z., Craig,R., Wang,X. and
            Elbein,S.C.
  TITLE     Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2
            diabetes and insulin resistance
  JOURNAL   Diabetes 53 (8), 2132-2136 (2004)
   PUBMED   15277397
  REMARK    GeneRIF: ADIPOR1 mRNA levels were significantly lower among
            transformed lymphocytes from diabetic African-American individuals
            than among control cell lines.
REFERENCE   8  (bases 1 to 2091)
  AUTHORS   Civitarese,A.E., Jenkinson,C.P., Richardson,D., Bajaj,M., Cusi,K.,
            Kashyap,S., Berria,R., Belfort,R., DeFronzo,R.A., Mandarino,L.J.
            and Ravussin,E.
  TITLE     Adiponectin receptors gene expression and insulin sensitivity in
            non-diabetic Mexican Americans with or without a family history of
            Type 2 diabetes
  JOURNAL   Diabetologia 47 (5), 816-820 (2004)
   PUBMED   15105989
  REMARK    GeneRIF: Epression levels of AdipoR1 as well as plasma adiponectin
            concentration were lower in people with a family history of Type 2.
REFERENCE   9  (bases 1 to 2091)
  AUTHORS   Kharroubi,I., Rasschaert,J., Eizirik,D.L. and Cnop,M.
  TITLE     Expression of adiponectin receptors in pancreatic beta cells
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1118-1122 (2003)
   PUBMED   14651988
  REMARK    GeneRIF: Here we report the marked expression of mRNAs for the
            adiponectin receptors AdipoR1 and AdipoR2 in human and rat
            pancreatic beta cells, at levels similar to liver and greater than
            muscle.
REFERENCE   10 (bases 1 to 2091)
  AUTHORS   Yamauchi,T., Kamon,J., Ito,Y., Tsuchida,A., Yokomizo,T., Kita,S.,
            Sugiyama,T., Miyagishi,M., Hara,K., Tsunoda,M., Murakami,K.,
            Ohteki,T., Uchida,S., Takekawa,S., Waki,H., Tsuno,N.H., Shibata,Y.,
            Terauchi,Y., Froguel,P., Tobe,K., Koyasu,S., Taira,K., Kitamura,T.,
            Shimizu,T., Nagai,R. and Kadowaki,T.
  TITLE     Cloning of adiponectin receptors that mediate antidiabetic
            metabolic effects
  JOURNAL   Nature 423 (6941), 762-769 (2003)
   PUBMED   12802337
  REMARK    GeneRIF: cloning of cDNAs encoding adiponectin receptors 1 and 2
            (AdipoR1 and AdipoR2) by expression cloning [AdipoR1 & AdipoR2]
            Erratum:[Nature. 2004 Oct 28;431(7012):1123]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096632.3, BC010743.1 and
            AI251444.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015999.5.
            
            Summary: This gene encodes a protein which acts as a receptor for
            adiponectin, a hormone secreted by adipocytes which regulates fatty
            acid catabolism and glucose levels. Binding of adiponectin to the
            encoded protein results in activation of an AMP-activated kinase
            signaling pathway which affects levels of fatty acid oxidation and
            insulin sensitivity. A pseudogene of this gene is located on
            chromosome 14. Multiple alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1, also known as R1T1) is a
            predominant transcript. All variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.945491.1,
                                           SRR3476690.34641.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340990.10/ ENSP00000341785.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC096632.3         67438-67466         c
            30-2076             BC010743.1         1-2047
            2077-2091           AI251444.1         10-24               c
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2091
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="adiponectin receptor 1"
                     /db_xref="GeneID:51094"
                     /db_xref="HGNC:HGNC:24040"
                     /db_xref="MIM:607945"
     exon            1..128
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            129..363
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1350
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="progestin and adipoQ receptor family member I;
                     progestin and adipoQ receptor family member 1"
                     /codon_start=1
                     /product="adiponectin receptor protein 1"
                     /protein_id="NP_057083.2"
                     /db_xref="CCDS:CCDS1430.1"
                     /db_xref="GeneID:51094"
                     /db_xref="HGNC:HGNC:24040"
                     /db_xref="MIM:607945"
                     /translation="MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIAN
                     PPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPD
                     WLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPN
                     MYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMG
                     SFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGL
                     SGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWF
                     QSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDTLL"
     exon            364..480
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            481..652
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            653..839
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1027
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1221
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..2091
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1420
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="major polyA site"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="hexamer: AAGAAA"
     polyA_site      2091
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="major polyA site"
ORIGIN      
        1 aggtcgcgcg ccccttccgg cgcggggagg gcgctgaaga tcggggccgc tcggccgcag
       61 gccgcctcca gcgccgcggg atgtagcgcg ggggaccgcg gcccccagca gagcccgcct
      121 gcccggcttg tctaccatca gagggagatc tctgccccct ggggctgaga gaccccaacc
      181 tttccccaag ctgaagctgc agggtattga ggtaccagcc agatgtcttc ccacaaagga
      241 tctgtggtgg cacaggggaa tggggctcct gccagtaaca gggaagctga cacggtggaa
      301 ctggctgaac tgggacccct gctagaagag aagggcaaac gggtaatcgc caacccaccc
      361 aaagctgaag aagagcaaac atgcccagtg ccccaggaag aagaggagga ggtgcgggta
      421 ctgacacttc ccctgcaagc ccaccacgcc atggagaaga tggaagagtt tgtgtacaag
      481 gtctgggagg gacgttggag ggtcatccca tatgatgtgc tccctgactg gctaaaggac
      541 aacgactatc tgctacatgg tcatagacct cccatgccct cctttcgggc ttgcttcaag
      601 agcatcttcc gcattcatac agaaactggc aacatctgga cccatctgct tggtttcgtg
      661 ctgtttctct ttttgggaat cttgaccatg ctcagaccaa atatgtactt catggcccct
      721 ctacaggaga aggtggtttt tgggatgttc tttttgggtg cagtgctctg cctcagcttc
      781 tcctggctct ttcacaccgt ctattgtcat tcagagaaag tctctcggac tttttccaaa
      841 ctggactatt cagggattgc tcttctaatt atggggagct ttgtcccctg gctctattat
      901 tccttctact gctccccaca gccacggctc atctacctct ccatcgtctg tgtcctgggc
      961 atttctgcca tcattgtggc gcagtgggac cggtttgcca ctcctaagca ccggcagaca
     1021 agagcaggcg tgttcctggg acttggcttg agtggcgtcg tgcccaccat gcactttact
     1081 atcgctgagg gctttgtcaa ggccaccaca gtgggccaga tgggctggtt cttcctcatg
     1141 gctgtgatgt acatcactgg agctggcctt tatgctgctc gaattcctga gcgcttcttt
     1201 cctggaaaat ttgacatatg gttccagtct catcagattt tccatgtcct ggtggtggca
     1261 gcagcctttg tccacttcta tggagtctcc aaccttcagg aattccgtta cggcctagaa
     1321 ggcggctgta ctgatgacac ccttctctga gccttcccac ctgcggggtg gaggaggaac
     1381 ttcccaagtg cttttaaaaa taacttcttt gctgaagtga gaggaagagt ctgagttgtc
     1441 tgtttctaga agaaacctct tagagaattc agtaccaacc aagcttcagc ccactttcac
     1501 acccactggg caataaactt tccatttcca ttctcctagc tggggatggg gcatggtcaa
     1561 acttagccat cccctcctca gcaaggcatc taccggcccc tcacagagac agtactttga
     1621 aactcatgtt gagattttac cctctcctcc aaccattttg ggaaaattat ggactgggac
     1681 tcttcagaaa ttctgtcttt tcttctggaa gaaaatgtcc ctcccttacc cccatcctta
     1741 actttgtatc ctggcttata acaggccatc catttttgta gcacactttt caaaaacaat
     1801 tatataccct ggtcccatct ttctagggcc tggatctgct tatagagcag gaagaataaa
     1861 gccaccaact tttacctagc ccggctaatc atggaagtgt gtccaggctt caagtaactt
     1921 gagttttaat tttttttttt tcttggcaga gtaatgtaaa atttaaatgg ggaaagatat
     1981 ttaatattta atactaagct ttaaaaagaa acctgctatc attgctatgt atcttgatgc
     2041 aaagactatg atgttaataa aagaaagtac agaagacact tggcattcaa a
//
