LOCUS       NM_001290629            2137 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens adiponectin receptor 1 (ADIPOR1), transcript variant
            5, mRNA.
ACCESSION   NM_001290629 NM_001127687
VERSION     NM_001290629.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2137)
  AUTHORS   Xu,A., Wang,L., Luo,M., Zhang,H., Ning,M., Pan,J., Duan,X., Wang,Y.
            and Liu,X.
  TITLE     Overexpression of salusin-beta downregulates adipoR1 expression to
            prevent fatty acid oxidation in HepG2 cells
  JOURNAL   Mol Med Rep 29 (2) (2024)
   PUBMED   38063230
  REMARK    GeneRIF: Overexpression of salusin-beta downregulates adipoR1
            expression to prevent fatty acid oxidation in HepG2 cells.
REFERENCE   2  (bases 1 to 2137)
  AUTHORS   Bui,K.C., Nguyen,T.M.L., Barat,S., Scholta,T., Xing,J., Bhuria,V.,
            Sipos,B., Wilkens,L., Nguyen,L.T., Le,H.S., Velavan,T.P., Bozko,P.
            and Plentz,R.R.
  TITLE     Novel Adiponectin Receptor Agonist Inhibits Cholangiocarcinoma via
            Adenosine Monophosphate-activated Protein Kinase
  JOURNAL   Curr Med Chem 31 (28), 4534-4548 (2024)
   PUBMED   38361349
  REMARK    GeneRIF: Novel Adiponectin Receptor Agonist Inhibits
            Cholangiocarcinoma via Adenosine Monophosphate-activated Protein
            Kinase.
REFERENCE   3  (bases 1 to 2137)
  AUTHORS   Kaiyrlykyzy,A., Umbayev,B., Masoud,A.R., Baibulatova,A., Tsoy,A.,
            Olzhayev,F., Alzhanova,D., Zholdasbekova,G., Davletov,K.,
            Akilzhanova,A. and Askarova,S.
  TITLE     Circulating adiponectin levels, expression of adiponectin
            receptors, and methylation of adiponectin gene promoter in relation
            to Alzheimer's disease
  JOURNAL   BMC Med Genomics 15 (1), 262 (2022)
   PUBMED   36527105
  REMARK    GeneRIF: Circulating adiponectin levels, expression of adiponectin
            receptors, and methylation of adiponectin gene promoter in relation
            to Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2137)
  AUTHORS   Mihajlovic,M., Ninic,A., Ostojic,M., Sopic,M., Stefanovic,A.,
            Vekic,J., Antonic,T., Zeljkovic,D., Trifunovic,B.,
            Spasojevic-Kalimanovska,V., Bogavac Stanojevic,N., Jancic,I. and
            Zeljkovic,A.
  TITLE     Association of Adiponectin Receptors with Metabolic and Immune
            Homeostasis Parameters in Colorectal Cancer: In Silico Analysis and
            Observational Findings
  JOURNAL   Int J Environ Res Public Health 19 (22), 14995 (2022)
   PUBMED   36429712
  REMARK    GeneRIF: Association of Adiponectin Receptors with Metabolic and
            Immune Homeostasis Parameters in Colorectal Cancer: In Silico
            Analysis and Observational Findings.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2137)
  AUTHORS   Ashwal,R., Hemi,R., Tirosh,A., Gordin,R., Yissachar,E.,
            Cohen-Dayag,A., Rosenberg,A., Karasik,A., Bluher,M. and Kanety,H.
  TITLE     Differential expression of novel adiponectin receptor-1 transcripts
            in skeletal muscle of subjects with normal glucose tolerance and
            type 2 diabetes
  JOURNAL   Diabetes 60 (3), 936-946 (2011)
   PUBMED   21289205
  REMARK    GeneRIF: AdipoR1 receptor expression in human skeletal muscle is
            subjected to posttranscriptional regulation, including alternative
            splicing and translational control.
REFERENCE   6  (bases 1 to 2137)
  AUTHORS   Staiger,H., Kaltenbach,S., Staiger,K., Stefan,N., Fritsche,A.,
            Guirguis,A., Peterfi,C., Weisser,M., Machicao,F., Stumvoll,M. and
            Haring,H.U.
  TITLE     Expression of adiponectin receptor mRNA in human skeletal muscle
            cells is related to in vivo parameters of glucose and lipid
            metabolism
  JOURNAL   Diabetes 53 (9), 2195-2201 (2004)
   PUBMED   15331527
  REMARK    GeneRIF: myotube mRNA levels of both receptors are associated with
            distinct metabolic functions but not with insulin sensitivity;
            AdipoR1, but not AdipoR2, expression correlated with insulin
            secretion.
REFERENCE   7  (bases 1 to 2137)
  AUTHORS   Wang,H., Zhang,H., Jia,Y., Zhang,Z., Craig,R., Wang,X. and
            Elbein,S.C.
  TITLE     Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2
            diabetes and insulin resistance
  JOURNAL   Diabetes 53 (8), 2132-2136 (2004)
   PUBMED   15277397
  REMARK    GeneRIF: ADIPOR1 mRNA levels were significantly lower among
            transformed lymphocytes from diabetic African-American individuals
            than among control cell lines.
REFERENCE   8  (bases 1 to 2137)
  AUTHORS   Civitarese,A.E., Jenkinson,C.P., Richardson,D., Bajaj,M., Cusi,K.,
            Kashyap,S., Berria,R., Belfort,R., DeFronzo,R.A., Mandarino,L.J.
            and Ravussin,E.
  TITLE     Adiponectin receptors gene expression and insulin sensitivity in
            non-diabetic Mexican Americans with or without a family history of
            Type 2 diabetes
  JOURNAL   Diabetologia 47 (5), 816-820 (2004)
   PUBMED   15105989
  REMARK    GeneRIF: Epression levels of AdipoR1 as well as plasma adiponectin
            concentration were lower in people with a family history of Type 2.
REFERENCE   9  (bases 1 to 2137)
  AUTHORS   Kharroubi,I., Rasschaert,J., Eizirik,D.L. and Cnop,M.
  TITLE     Expression of adiponectin receptors in pancreatic beta cells
  JOURNAL   Biochem Biophys Res Commun 312 (4), 1118-1122 (2003)
   PUBMED   14651988
  REMARK    GeneRIF: Here we report the marked expression of mRNAs for the
            adiponectin receptors AdipoR1 and AdipoR2 in human and rat
            pancreatic beta cells, at levels similar to liver and greater than
            muscle.
REFERENCE   10 (bases 1 to 2137)
  AUTHORS   Yamauchi,T., Kamon,J., Ito,Y., Tsuchida,A., Yokomizo,T., Kita,S.,
            Sugiyama,T., Miyagishi,M., Hara,K., Tsunoda,M., Murakami,K.,
            Ohteki,T., Uchida,S., Takekawa,S., Waki,H., Tsuno,N.H., Shibata,Y.,
            Terauchi,Y., Froguel,P., Tobe,K., Koyasu,S., Taira,K., Kitamura,T.,
            Shimizu,T., Nagai,R. and Kadowaki,T.
  TITLE     Cloning of adiponectin receptors that mediate antidiabetic
            metabolic effects
  JOURNAL   Nature 423 (6941), 762-769 (2003)
   PUBMED   12802337
  REMARK    GeneRIF: cloning of cDNAs encoding adiponectin receptors 1 and 2
            (AdipoR1 and AdipoR2) by expression cloning [AdipoR1 & AdipoR2]
            Erratum:[Nature. 2004 Oct 28;431(7012):1123]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX461217.2, BI597715.1,
            BC010743.1 and AI251444.1.
            
            On Mar 18, 2014 this sequence version replaced NM_001127687.1.
            
            Summary: This gene encodes a protein which acts as a receptor for
            adiponectin, a hormone secreted by adipocytes which regulates fatty
            acid catabolism and glucose levels. Binding of adiponectin to the
            encoded protein results in activation of an AMP-activated kinase
            signaling pathway which affects levels of fatty acid oxidation and
            insulin sensitivity. A pseudogene of this gene is located on
            chromosome 14. Multiple alternatively spliced transcript variants
            have been found for this gene. [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (5, also known as R1T4) has an
            alternate 5' UTR, compared to variant 1. All variants encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC010743.1, SRR1803617.182207.1
                                    [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            regulatory uORF :: PMID: 21289205
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               BX461217.2         1-133
            134-768             BI597715.1         137-771
            769-2113            BC010743.1         703-2047
            2114-2137           AI251444.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..2137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2137
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="adiponectin receptor 1"
                     /db_xref="GeneID:51094"
                     /db_xref="HGNC:HGNC:24040"
                     /db_xref="MIM:607945"
     exon            1..98
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            99..165
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      120..362
                     /regulatory_class="uORF"
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21289205]"
                     /note="this uORF is predicted to encode an 80 aa peptide
                     (PMID:21289205)"
     regulatory      136..147
                     /regulatory_class="uORF"
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21289205]"
                     /note="this uORF is predicted to encode a 3 aa peptide
                     (PMID:21289205)"
     regulatory      139..147
                     /regulatory_class="uORF"
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21289205]"
                     /note="this uORF is predicted to encode a 2 aa peptide
                     (PMID:21289205)"
     regulatory      144..362
                     /regulatory_class="uORF"
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:21289205]"
                     /note="this uORF is predicted to encode a 72 aa peptide
                     (PMID:21289205)"
     exon            166..400
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..1387
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="progestin and adipoQ receptor family member I;
                     progestin and adipoQ receptor family member 1"
                     /codon_start=1
                     /product="adiponectin receptor protein 1"
                     /protein_id="NP_001277558.1"
                     /db_xref="CCDS:CCDS1430.1"
                     /db_xref="GeneID:51094"
                     /db_xref="HGNC:HGNC:24040"
                     /db_xref="MIM:607945"
                     /translation="MSSHKGSVVAQGNGAPASNREADTVELAELGPLLEEKGKRVIAN
                     PPKAEEEQTCPVPQEEEEEVRVLTLPLQAHHAMEKMEEFVYKVWEGRWRVIPYDVLPD
                     WLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPN
                     MYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLDYSGIALLIMG
                     SFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGL
                     SGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWF
                     QSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDTLL"
     exon            401..517
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            518..689
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            690..876
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            877..1064
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1258
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..2135
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1457
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="major polyA site"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="hexamer: AAGAAA"
     polyA_site      2128
                     /gene="ADIPOR1"
                     /gene_synonym="ACDCR1; CGI-45; CGI45; PAQR1; TESBP1A"
                     /note="major polyA site"
ORIGIN      
        1 atcacgcact tcaggctgcg ataacgaggt ggagtgtaga atccgacgaa cgtcctctac
       61 cccggggcgg gtggaggtta cctggctgcg gcggggagtt tagaagacca aactggacaa
      121 tggactttgc tcactatgat gacatgatct ccattgacct ccatttgtct accatcagag
      181 ggagatctct gccccctggg gctgagagac cccaaccttt ccccaagctg aagctgcagg
      241 gtattgaggt accagccaga tgtcttccca caaaggatct gtggtggcac aggggaatgg
      301 ggctcctgcc agtaacaggg aagctgacac ggtggaactg gctgaactgg gacccctgct
      361 agaagagaag ggcaaacggg taatcgccaa cccacccaaa gctgaagaag agcaaacatg
      421 cccagtgccc caggaagaag aggaggaggt gcgggtactg acacttcccc tgcaagccca
      481 ccacgccatg gagaagatgg aagagtttgt gtacaaggtc tgggagggac gttggagggt
      541 catcccatat gatgtgctcc ctgactggct aaaggacaac gactatctgc tacatggtca
      601 tagacctccc atgccctcct ttcgggcttg cttcaagagc atcttccgca ttcatacaga
      661 aactggcaac atctggaccc atctgcttgg tttcgtgctg tttctctttt tgggaatctt
      721 gaccatgctc agaccaaata tgtacttcat ggcccctcta caggagaagg tggtttttgg
      781 gatgttcttt ttgggtgcag tgctctgcct cagcttctcc tggctctttc acaccgtcta
      841 ttgtcattca gagaaagtct ctcggacttt ttccaaactg gactattcag ggattgctct
      901 tctaattatg gggagctttg tcccctggct ctattattcc ttctactgct ccccacagcc
      961 acggctcatc tacctctcca tcgtctgtgt cctgggcatt tctgccatca ttgtggcgca
     1021 gtgggaccgg tttgccactc ctaagcaccg gcagacaaga gcaggcgtgt tcctgggact
     1081 tggcttgagt ggcgtcgtgc ccaccatgca ctttactatc gctgagggct ttgtcaaggc
     1141 caccacagtg ggccagatgg gctggttctt cctcatggct gtgatgtaca tcactggagc
     1201 tggcctttat gctgctcgaa ttcctgagcg cttctttcct ggaaaatttg acatatggtt
     1261 ccagtctcat cagattttcc atgtcctggt ggtggcagca gcctttgtcc acttctatgg
     1321 agtctccaac cttcaggaat tccgttacgg cctagaaggc ggctgtactg atgacaccct
     1381 tctctgagcc ttcccacctg cggggtggag gaggaacttc ccaagtgctt ttaaaaataa
     1441 cttctttgct gaagtgagag gaagagtctg agttgtctgt ttctagaaga aacctcttag
     1501 agaattcagt accaaccaag cttcagccca ctttcacacc cactgggcaa taaactttcc
     1561 atttccattc tcctagctgg ggatggggca tggtcaaact tagccatccc ctcctcagca
     1621 aggcatctac cggcccctca cagagacagt actttgaaac tcatgttgag attttaccct
     1681 ctcctccaac cattttggga aaattatgga ctgggactct tcagaaattc tgtcttttct
     1741 tctggaagaa aatgtccctc ccttaccccc atccttaact ttgtatcctg gcttataaca
     1801 ggccatccat ttttgtagca cacttttcaa aaacaattat ataccctggt cccatctttc
     1861 tagggcctgg atctgcttat agagcaggaa gaataaagcc accaactttt acctagcccg
     1921 gctaatcatg gaagtgtgtc caggcttcaa gtaacttgag ttttaatttt ttttttttct
     1981 tggcagagta atgtaaaatt taaatgggga aagatattta atatttaata ctaagcttta
     2041 aaaagaaacc tgctatcatt gctatgtatc ttgatgcaaa gactatgatg ttaataaaag
     2101 aaagtacaga agacacttgg cattcaaaga tttcaaa
//
