LOCUS       NM_004797               4542 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens adiponectin, C1Q and collagen domain containing
            (ADIPOQ), transcript variant 2, mRNA.
ACCESSION   NM_004797
VERSION     NM_004797.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4542)
  AUTHORS   Mamashli,E., Goulding,R.P., Iranparvar,M., Skishahr,F.S.,
            Siahkouhian,M., Ramezanzade,R., Jaspers,R.T. and Davarnia,B.
  TITLE     Association of adiponectin gene single nucleotide polymorphisms
            with environmental risk factors in type 2 diabetes mellitus: An
            updated evidence of haplotype-based analysis study
  JOURNAL   Gene 933, 148816 (2025)
   PUBMED   39128620
  REMARK    GeneRIF: Association of adiponectin gene single nucleotide
            polymorphisms with environmental risk factors in type 2 diabetes
            mellitus: An updated evidence of haplotype-based analysis study.
REFERENCE   2  (bases 1 to 4542)
  AUTHORS   Szumilas,K., Wilk,A., Szumilas,P., Dziedziejko,V. and Pawlik,A.
  TITLE     Role of leptin and adiponectin in the pathogenesis of
            post-transplant diabetes mellitus
  JOURNAL   Prostaglandins Other Lipid Mediat 174, 106876 (2024)
   PUBMED   39032860
  REMARK    GeneRIF: Role of leptin and adiponectin in the pathogenesis of
            post-transplant diabetes mellitus.
            Review article
REFERENCE   3  (bases 1 to 4542)
  AUTHORS   Tang,Y., Yin,L. and Lin,F.
  TITLE     Association of rs2241766 and rs1501299 polymorphisms in the
            adiponectin gene with metabolic syndrome
  JOURNAL   Immun Inflamm Dis 12 (9), e70025 (2024)
   PUBMED   39290095
  REMARK    GeneRIF: Association of rs2241766 and rs1501299 polymorphisms in
            the adiponectin gene with metabolic syndrome.
REFERENCE   4  (bases 1 to 4542)
  AUTHORS   Fiorenza,M., Checa,A., Sandsdal,R.M., Jensen,S.B.K., Juhl,C.R.,
            Noer,M.H., Bogh,N.P., Lundgren,J.R., Janus,C., Stallknecht,B.M.,
            Holst,J.J., Madsbad,S., Wheelock,C.E. and Torekov,S.S.
  TITLE     Weight-loss maintenance is accompanied by interconnected
            alterations in circulating FGF21-adiponectin-leptin and bioactive
            sphingolipids
  JOURNAL   Cell Rep Med 5 (7), 101629 (2024)
   PUBMED   38959886
  REMARK    GeneRIF: Weight-loss maintenance is accompanied by interconnected
            alterations in circulating FGF21-adiponectin-leptin and bioactive
            sphingolipids.
REFERENCE   5  (bases 1 to 4542)
  AUTHORS   Schaffler,A., Orso,E., Palitzsch,K.D., Buchler,C., Drobnik,W.,
            Furst,A., Scholmerich,J. and Schmitz,G.
  TITLE     The human apM-1, an adipocyte-specific gene linked to the family of
            TNF's and to genes expressed in activated T cells, is mapped to
            chromosome 1q21.3-q23, a susceptibility locus identified for
            familial combined hyperlipidaemia (FCH)
  JOURNAL   Biochem Biophys Res Commun 260 (2), 416-425 (1999)
   PUBMED   10403784
REFERENCE   6  (bases 1 to 4542)
  AUTHORS   Schaffler,A., Langmann,T., Palitzsch,K.D., Scholmerich,J. and
            Schmitz,G.
  TITLE     Identification and characterization of the human adipocyte apM-1
            promoter
  JOURNAL   Biochim Biophys Acta 1399 (2-3), 187-197 (1998)
   PUBMED   9765595
REFERENCE   7  (bases 1 to 4542)
  AUTHORS   Nakano,Y., Tobe,T., Choi-Miura,N.H., Mazda,T. and Tomita,M.
  TITLE     Isolation and characterization of GBP28, a novel gelatin-binding
            protein purified from human plasma
  JOURNAL   J Biochem 120 (4), 803-812 (1996)
   PUBMED   8947845
REFERENCE   8  (bases 1 to 4542)
  AUTHORS   Hu,E., Liang,P. and Spiegelman,B.M.
  TITLE     AdipoQ is a novel adipose-specific gene dysregulated in obesity
  JOURNAL   J Biol Chem 271 (18), 10697-10703 (1996)
   PUBMED   8631877
REFERENCE   9  (bases 1 to 4542)
  AUTHORS   Maeda,K., Okubo,K., Shimomura,I., Funahashi,T., Matsuzawa,Y. and
            Matsubara,K.
  TITLE     cDNA cloning and expression of a novel adipose specific
            collagen-like factor, apM1 (AdiPose Most abundant Gene transcript
            1)
  JOURNAL   Biochem Biophys Res Commun 221 (2), 286-289 (1996)
   PUBMED   8619847
REFERENCE   10 (bases 1 to 4542)
  AUTHORS   Scherer,P.E., Williams,S., Fogliano,M., Baldini,G. and Lodish,H.F.
  TITLE     A novel serum protein similar to C1q, produced exclusively in
            adipocytes
  JOURNAL   J Biol Chem 270 (45), 26746-26749 (1995)
   PUBMED   7592907
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291525.1, BC096308.3 and
            AC072018.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004797.3.
            
            Summary: This gene is expressed in adipose tissue exclusively. It
            encodes a protein with similarity to collagens X and VIII and
            complement factor C1q. The encoded protein circulates in the plasma
            and is involved with metabolic and hormonal processes. Mutations in
            this gene are associated with adiponectin deficiency. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D45371.1, BC096308.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320741.7/ ENSP00000320709.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AK291525.1         10-101
            93-931              BC096308.3         113-951
            932-932             AC072018.6         7379-7379
            933-1155            BC096308.3         953-1175
            1156-4542           AC072018.6         7603-10989
FEATURES             Location/Qualifiers
     source          1..4542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..4542
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /note="adiponectin, C1Q and collagen domain containing"
                     /db_xref="GeneID:9370"
                     /db_xref="HGNC:HGNC:13633"
                     /db_xref="MIM:605441"
     exon            1..40
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /inference="alignment:Splign:2.1.0"
     exon            41..262
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..783
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /note="gelatin-binding protein 28; adipose specific
                     collagen-like factor; 30 kDa adipocyte complement-related
                     protein; adipocyte complement-related 30 kDa protein;
                     adipose most abundant gene transcript 1 protein"
                     /codon_start=1
                     /product="adiponectin precursor"
                     /protein_id="NP_004788.1"
                     /db_xref="CCDS:CCDS3284.1"
                     /db_xref="GeneID:9370"
                     /db_xref="HGNC:HGNC:13633"
                     /db_xref="MIM:605441"
                     /translation="MLLLGAVLLLLALPGHDQETTTQGPGVLLPLPKGACTGWMAGIP
                     GHPGHNGAPGRDGRDGTPGEKGEKGDPGLIGPKGDIGETGVPGAEGPRGFPGIQGRKG
                     EPGEGAYVYRSAFSVGLETYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYF
                     AYHITVYMKDVKVSLFKKDKAMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGE
                     GERNGLYADNDNDSTFTGFLLYHDTN"
     exon            263..4542
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4523..4528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /note="hexamer: AATAAA"
     polyA_site      4542
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /note="major polyA site"
ORIGIN      
        1 attctgactg cagtctgtgg ttctgattcc ataccagagg ggctcaggat gctgttgctg
       61 ggagctgttc tactgctatt agctctgccc ggtcatgacc aggaaaccac gactcaaggg
      121 cccggagtcc tgcttcccct gcccaagggg gcctgcacag gttggatggc gggcatccca
      181 gggcatccgg gccataatgg ggccccaggc cgtgatggca gagatggcac ccctggtgag
      241 aagggtgaga aaggagatcc aggtcttatt ggtcctaagg gagacatcgg tgaaaccgga
      301 gtacccgggg ctgaaggtcc ccgaggcttt ccgggaatcc aaggcaggaa aggagaacct
      361 ggagaaggtg cctatgtata ccgctcagca ttcagtgtgg gattggagac ttacgttact
      421 atccccaaca tgcccattcg ctttaccaag atcttctaca atcagcaaaa ccactatgat
      481 ggctccactg gtaaattcca ctgcaacatt cctgggctgt actactttgc ctaccacatc
      541 acagtctata tgaaggatgt gaaggtcagc ctcttcaaga aggacaaggc tatgctcttc
      601 acctatgatc agtaccagga aaataatgtg gaccaggcct ccggctctgt gctcctgcat
      661 ctggaggtgg gcgaccaagt ctggctccag gtgtatgggg aaggagagcg taatggactc
      721 tatgctgata atgacaatga ctccaccttc acaggctttc ttctctacca tgacaccaac
      781 tgatcaccac taactcagag cctcctccag gccaaacagc cccaaagtca attaaaggct
      841 ttcagtacgg ttaggaagtt gattattatt tagttggagg cctttagata ttattcattc
      901 atttactcat tcatttattc attcattcat cgagtaactt taaaaaaatc atatgctatg
      961 ttcccagtcc tggggagctt cacaaacatg accagataac tgactagaaa gaagtagttg
     1021 acagtgctat tttgtgccca ctgtctctcc tgatgctcat atcaatccta taaggcacag
     1081 ggaacaagca ttctcctgtt tttacagatt gtatcctgag gctgagagag ttaagtgaat
     1141 gtctaaggtc acacagtatt aagtgacagt gctagaaatc aaacccagag ctgtggactt
     1201 tgttcactag actgtgccct tttatagagg tacatgttct ctttggagtg ttggtaggtg
     1261 tctgtttccc acctcacctg agagccattg aatttgcctt cctcatgaat taaaacctcc
     1321 cccaagcaga gcttcctcag agaaagtggt tctatgatga cgtcctgtct tggaaggact
     1381 actactcaat ggcccctgca ctactctact tcctcttacc tatgtccctt ctcatgcctt
     1441 tccctccaac ggggaaagcc aactccatct ctaagtgccg aactcatccc tgttcctcaa
     1501 ggccacctgg ccaggagctt ctctgatgtg atatccactt tttttttttt tgagatggag
     1561 tctcactctg tcacccaggc tggagtacag tgacacgacc tcggctcact gcagcctcct
     1621 tctcctgggt ccaagcaatt attgtgcctc agcctcccga gtagctgaga cttcaggtgc
     1681 attccaccac acatggctaa tttttgtatt tttagtagaa atggggtttc gtcatgttgg
     1741 ccaggctggt ctcgaactcc tggcctaggt gatccacccg cctcgacctc ccaaagtgct
     1801 gggattacag gcatgagcca ccatgcccag tcgatatctc actttttatt ttgccatgga
     1861 tgagagtcct gggtgtgagg aacacctccc accaggctag aggcaactgc ccaggaagga
     1921 ctgtgcttcc gtcacctcta aatcccttgc agatccttga taaatgcctc atgaagacca
     1981 atctcttgaa tcccatatct acccagaatt aactccattc cagtctctgc atgtaatcag
     2041 ttttatccac agaaacattt tcattttagg aaatccctgg ttttaagtat caatccttgt
     2101 tcagctggac aatatgaatc ttttccactg aagttaggga tgactgtgat tttcagaaca
     2161 cgtccagaat ttttcatcaa gaaggtagct tgagcctgaa atgcaaaacc catggaggaa
     2221 ttctgaagcc attgtctcct tgagtaccaa cagggtcagg gaagactggg cctcctgaat
     2281 ttattattgt tctttaagaa ttacaggttg aggtagttga tggtggtaaa cattctctca
     2341 ggagacaata actccagtga tgttcttcaa agattttagc aaaaacagag taaatagcat
     2401 tctctatcaa tatataaatt taaaaaacta tctttttgct tacagtttta aattctgaac
     2461 aattctctct tatatgtgta ttgctaatca ttaaggtatt attttttcca catataaagc
     2521 tttgtctttt tgttgttgtt gttgttttta agatggagtt tccctctgtt gccaggctag
     2581 agtgcagtgg catgatctcg gcttactgca acctttgcct cccaggttca agcgattctt
     2641 ctgcctcagc ctcccgagta gctgggacca caggtgccta ccaccatgcc aggctaattt
     2701 ttgtattttt agtaaagaca gggtttcacc atattggcca ggctggtctc gaactcctga
     2761 ccttgtgatc tgcccgcctc catttttgtt gttatttttt gagaaagata gatatgaggt
     2821 ttagagaggg atgaagaggt gagagtaagc cttgtgttag tcagaactct gtgttgtgaa
     2881 tgtcattcac aacagaaaac ccaaaatatt atgcaaacta ctgtaagcaa gaaaaataaa
     2941 ggaaaaatgg aaacatttat tcctttgcat aatagaaatt accagagttg ttctgtcttt
     3001 agataaggtt tgaaccaaag ctcaaaacaa tcaagaccct tttctgtatg tccttctgtt
     3061 ctgccttccg cagtgtaggc tttaccctca ggtgctacac agtatagttc tagggtttcc
     3121 ctcccgatat caaaaagact gtggcctgcc cagctctcgt atccccaagc cacaccatct
     3181 ggctaaatgg acatcatgtt ttctggtgat gcccaaagag gagagaggaa gctctctttc
     3241 ccagatgccc cagcaagtgt aaccttgcat ctcattgctc tggctgagtt gtgtgcctgt
     3301 ttctgaccaa tcactgagtc aggaggatga aatattcata ttgacttaat tgcagcttaa
     3361 gttaggggta tgtagaggta ttttccctaa agcaaaattg ggacactgtt atcagaaata
     3421 ggagagtgga tgatagatgc aaaataatac ctgtccacaa caaactctta atgctgtgtt
     3481 tgagctttca tgagtttccc agagagacat agctggaaaa ttcctattga ttttctctaa
     3541 aatttcaaca agtagctaaa gtctggctat gctcacagtc tcacatctgg ttggggtggg
     3601 ctccttacag aacacgcttt cacagttacc ctaaactctc tggggcaggg ttattccttt
     3661 gtggaaccag aggcacagag agagtcaact gaggccaaaa gaggcctgag agaaactgag
     3721 gtcaagattt caggattaat ggtcctgtga tgctttgaag tacaattgtg gatttgtcca
     3781 attctcttta gttctgtcag cttttgcttc atatatttta gcgctctatt attagatata
     3841 tacatgttta gtattatgtc ttattggtgc atttactctc ttatcattat gtaatgtcct
     3901 tctttatctg tgataatttt ctgtgttctg aagtctactt tgtctaaaaa taacatacgc
     3961 actcaacttc cttttctttc ttccttcctt tctttcttcc ttcctttctt tctctctctc
     4021 tctctttcct tccttccttc ctccttttct ttctctctct ctctctctct ctttttttga
     4081 cagactctcg ttctgtggcc ctggctggag ttcagtggtg tgatcttggc tcactgctac
     4141 ctctaccatg agcaattctc ctgcctcagc ctcccaagta gctggaacta caggctcatg
     4201 ccactgcgcc cagctaattt ttgtattttt cgtagagacg gggtttcacc acattcgtca
     4261 ggttggtttc aaactcctga ctttgtgatc cacccgcctc ggcctcccaa agtgctggga
     4321 ttacaggcat gagccatcac acctggtcaa ctttcttttg attagtgttt ttgtggtata
     4381 tctttttcca tcatgttact ttaaatatat ctatattatt gtatttaaaa tgtgtttctt
     4441 acagactgca tgtagttggg tataattttt atccagtcta aaaatatctg tcttttaatt
     4501 ggtgtttaga caatttatat ttaataaaat tgttgaattt aa
//
