LOCUS       NM_001177800            4593 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens adiponectin, C1Q and collagen domain containing
            (ADIPOQ), transcript variant 1, mRNA.
ACCESSION   NM_001177800
VERSION     NM_001177800.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4593)
  AUTHORS   Mamashli,E., Goulding,R.P., Iranparvar,M., Skishahr,F.S.,
            Siahkouhian,M., Ramezanzade,R., Jaspers,R.T. and Davarnia,B.
  TITLE     Association of adiponectin gene single nucleotide polymorphisms
            with environmental risk factors in type 2 diabetes mellitus: An
            updated evidence of haplotype-based analysis study
  JOURNAL   Gene 933, 148816 (2025)
   PUBMED   39128620
  REMARK    GeneRIF: Association of adiponectin gene single nucleotide
            polymorphisms with environmental risk factors in type 2 diabetes
            mellitus: An updated evidence of haplotype-based analysis study.
REFERENCE   2  (bases 1 to 4593)
  AUTHORS   Szumilas,K., Wilk,A., Szumilas,P., Dziedziejko,V. and Pawlik,A.
  TITLE     Role of leptin and adiponectin in the pathogenesis of
            post-transplant diabetes mellitus
  JOURNAL   Prostaglandins Other Lipid Mediat 174, 106876 (2024)
   PUBMED   39032860
  REMARK    GeneRIF: Role of leptin and adiponectin in the pathogenesis of
            post-transplant diabetes mellitus.
            Review article
REFERENCE   3  (bases 1 to 4593)
  AUTHORS   Tang,Y., Yin,L. and Lin,F.
  TITLE     Association of rs2241766 and rs1501299 polymorphisms in the
            adiponectin gene with metabolic syndrome
  JOURNAL   Immun Inflamm Dis 12 (9), e70025 (2024)
   PUBMED   39290095
  REMARK    GeneRIF: Association of rs2241766 and rs1501299 polymorphisms in
            the adiponectin gene with metabolic syndrome.
REFERENCE   4  (bases 1 to 4593)
  AUTHORS   Fiorenza,M., Checa,A., Sandsdal,R.M., Jensen,S.B.K., Juhl,C.R.,
            Noer,M.H., Bogh,N.P., Lundgren,J.R., Janus,C., Stallknecht,B.M.,
            Holst,J.J., Madsbad,S., Wheelock,C.E. and Torekov,S.S.
  TITLE     Weight-loss maintenance is accompanied by interconnected
            alterations in circulating FGF21-adiponectin-leptin and bioactive
            sphingolipids
  JOURNAL   Cell Rep Med 5 (7), 101629 (2024)
   PUBMED   38959886
  REMARK    GeneRIF: Weight-loss maintenance is accompanied by interconnected
            alterations in circulating FGF21-adiponectin-leptin and bioactive
            sphingolipids.
REFERENCE   5  (bases 1 to 4593)
  AUTHORS   Schaffler,A., Orso,E., Palitzsch,K.D., Buchler,C., Drobnik,W.,
            Furst,A., Scholmerich,J. and Schmitz,G.
  TITLE     The human apM-1, an adipocyte-specific gene linked to the family of
            TNF's and to genes expressed in activated T cells, is mapped to
            chromosome 1q21.3-q23, a susceptibility locus identified for
            familial combined hyperlipidaemia (FCH)
  JOURNAL   Biochem Biophys Res Commun 260 (2), 416-425 (1999)
   PUBMED   10403784
REFERENCE   6  (bases 1 to 4593)
  AUTHORS   Schaffler,A., Langmann,T., Palitzsch,K.D., Scholmerich,J. and
            Schmitz,G.
  TITLE     Identification and characterization of the human adipocyte apM-1
            promoter
  JOURNAL   Biochim Biophys Acta 1399 (2-3), 187-197 (1998)
   PUBMED   9765595
REFERENCE   7  (bases 1 to 4593)
  AUTHORS   Nakano,Y., Tobe,T., Choi-Miura,N.H., Mazda,T. and Tomita,M.
  TITLE     Isolation and characterization of GBP28, a novel gelatin-binding
            protein purified from human plasma
  JOURNAL   J Biochem 120 (4), 803-812 (1996)
   PUBMED   8947845
REFERENCE   8  (bases 1 to 4593)
  AUTHORS   Hu,E., Liang,P. and Spiegelman,B.M.
  TITLE     AdipoQ is a novel adipose-specific gene dysregulated in obesity
  JOURNAL   J Biol Chem 271 (18), 10697-10703 (1996)
   PUBMED   8631877
REFERENCE   9  (bases 1 to 4593)
  AUTHORS   Maeda,K., Okubo,K., Shimomura,I., Funahashi,T., Matsuzawa,Y. and
            Matsubara,K.
  TITLE     cDNA cloning and expression of a novel adipose specific
            collagen-like factor, apM1 (AdiPose Most abundant Gene transcript
            1)
  JOURNAL   Biochem Biophys Res Commun 221 (2), 286-289 (1996)
   PUBMED   8619847
REFERENCE   10 (bases 1 to 4593)
  AUTHORS   Scherer,P.E., Williams,S., Fogliano,M., Baldini,G. and Lodish,H.F.
  TITLE     A novel serum protein similar to C1q, produced exclusively in
            adipocytes
  JOURNAL   J Biol Chem 270 (45), 26746-26749 (1995)
   PUBMED   7592907
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312868.1 and AC072018.6.
            
            On May 31, 2019 this sequence version replaced NM_001177800.1.
            
            Summary: This gene is expressed in adipose tissue exclusively. It
            encodes a protein with similarity to collagens X and VIII and
            complement factor C1q. The encoded protein circulates in the plasma
            and is involved with metabolic and hormonal processes. Mutations in
            this gene are associated with adiponectin deficiency. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Apr 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312868.1, DB222528.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-622               AK312868.1         7-628
            623-629             AC072018.6         7019-7025
            630-834             AK312868.1         636-840
            835-4593            AC072018.6         7231-10989
FEATURES             Location/Qualifiers
     source          1..4593
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.3"
     gene            1..4593
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /note="adiponectin, C1Q and collagen domain containing"
                     /db_xref="GeneID:9370"
                     /db_xref="HGNC:HGNC:13633"
                     /db_xref="MIM:605441"
     exon            1..40
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /inference="alignment:Splign:2.1.0"
     exon            41..91
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /inference="alignment:Splign:2.1.0"
     exon            92..313
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..834
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /note="gelatin-binding protein 28; adipose specific
                     collagen-like factor; 30 kDa adipocyte complement-related
                     protein; adipocyte complement-related 30 kDa protein;
                     adipose most abundant gene transcript 1 protein"
                     /codon_start=1
                     /product="adiponectin precursor"
                     /protein_id="NP_001171271.1"
                     /db_xref="CCDS:CCDS3284.1"
                     /db_xref="GeneID:9370"
                     /db_xref="HGNC:HGNC:13633"
                     /db_xref="MIM:605441"
                     /translation="MLLLGAVLLLLALPGHDQETTTQGPGVLLPLPKGACTGWMAGIP
                     GHPGHNGAPGRDGRDGTPGEKGEKGDPGLIGPKGDIGETGVPGAEGPRGFPGIQGRKG
                     EPGEGAYVYRSAFSVGLETYVTIPNMPIRFTKIFYNQQNHYDGSTGKFHCNIPGLYYF
                     AYHITVYMKDVKVSLFKKDKAMLFTYDQYQENNVDQASGSVLLHLEVGDQVWLQVYGE
                     GERNGLYADNDNDSTFTGFLLYHDTN"
     exon            314..4593
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4574..4579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /note="hexamer: AATAAA"
     polyA_site      4593
                     /gene="ADIPOQ"
                     /gene_synonym="ACDC; ACRP30; ADIPQTL1; ADPN; APM-1; APM1;
                     GBP28"
                     /note="major polyA site"
ORIGIN      
        1 attctgactg cagtctgtgg ttctgattcc ataccagagg agacgggatt tcaccatgtt
       61 gtccaggctg gtctgaaact cctgacatca gggctcagga tgctgttgct gggagctgtt
      121 ctactgctat tagctctgcc cggtcatgac caggaaacca cgactcaagg gcccggagtc
      181 ctgcttcccc tgcccaaggg ggcctgcaca ggttggatgg cgggcatccc agggcatccg
      241 ggccataatg gggccccagg ccgtgatggc agagatggca cccctggtga gaagggtgag
      301 aaaggagatc caggtcttat tggtcctaag ggagacatcg gtgaaaccgg agtacccggg
      361 gctgaaggtc cccgaggctt tccgggaatc caaggcagga aaggagaacc tggagaaggt
      421 gcctatgtat accgctcagc attcagtgtg ggattggaga cttacgttac tatccccaac
      481 atgcccattc gctttaccaa gatcttctac aatcagcaaa accactatga tggctccact
      541 ggtaaattcc actgcaacat tcctgggctg tactactttg cctaccacat cacagtctat
      601 atgaaggatg tgaaggtcag cctcttcaag aaggacaagg ctatgctctt cacctatgat
      661 cagtaccagg aaaataatgt ggaccaggcc tccggctctg tgctcctgca tctggaggtg
      721 ggcgaccaag tctggctcca ggtgtatggg gaaggagagc gtaatggact ctatgctgat
      781 aatgacaatg actccacctt cacaggcttt cttctctacc atgacaccaa ctgatcacca
      841 ctaactcaga gcctcctcca ggccaaacag ccccaaagtc aattaaaggc tttcagtacg
      901 gttaggaagt tgattattat ttagttggag gcctttagat attattcatt catttactca
      961 ttcatttatt cattcattca tcgagtaact ttaaaaaaat catatgctat gttcccagtc
     1021 ctggggagct tcacaaacat gaccagataa ctgactagaa agaagtagtt gacagtgcta
     1081 ttttgtgccc actgtctctc ctgatgctca tatcaatcct ataaggcaca gggaacaagc
     1141 attctcctgt ttttacagat tgtatcctga ggctgagaga gttaagtgaa tgtctaaggt
     1201 cacacagtat taagtgacag tgctagaaat caaacccaga gctgtggact ttgttcacta
     1261 gactgtgccc ttttatagag gtacatgttc tctttggagt gttggtaggt gtctgtttcc
     1321 cacctcacct gagagccatt gaatttgcct tcctcatgaa ttaaaacctc ccccaagcag
     1381 agcttcctca gagaaagtgg ttctatgatg acgtcctgtc ttggaaggac tactactcaa
     1441 tggcccctgc actactctac ttcctcttac ctatgtccct tctcatgcct ttccctccaa
     1501 cggggaaagc caactccatc tctaagtgcc gaactcatcc ctgttcctca aggccacctg
     1561 gccaggagct tctctgatgt gatatccact tttttttttt ttgagatgga gtctcactct
     1621 gtcacccagg ctggagtaca gtgacacgac ctcggctcac tgcagcctcc ttctcctggg
     1681 tccaagcaat tattgtgcct cagcctcccg agtagctgag acttcaggtg cattccacca
     1741 cacatggcta atttttgtat ttttagtaga aatggggttt cgtcatgttg gccaggctgg
     1801 tctcgaactc ctggcctagg tgatccaccc gcctcgacct cccaaagtgc tgggattaca
     1861 ggcatgagcc accatgccca gtcgatatct cactttttat tttgccatgg atgagagtcc
     1921 tgggtgtgag gaacacctcc caccaggcta gaggcaactg cccaggaagg actgtgcttc
     1981 cgtcacctct aaatcccttg cagatccttg ataaatgcct catgaagacc aatctcttga
     2041 atcccatatc tacccagaat taactccatt ccagtctctg catgtaatca gttttatcca
     2101 cagaaacatt ttcattttag gaaatccctg gttttaagta tcaatccttg ttcagctgga
     2161 caatatgaat cttttccact gaagttaggg atgactgtga ttttcagaac acgtccagaa
     2221 tttttcatca agaaggtagc ttgagcctga aatgcaaaac ccatggagga attctgaagc
     2281 cattgtctcc ttgagtacca acagggtcag ggaagactgg gcctcctgaa tttattattg
     2341 ttctttaaga attacaggtt gaggtagttg atggtggtaa acattctctc aggagacaat
     2401 aactccagtg atgttcttca aagattttag caaaaacaga gtaaatagca ttctctatca
     2461 atatataaat ttaaaaaact atctttttgc ttacagtttt aaattctgaa caattctctc
     2521 ttatatgtgt attgctaatc attaaggtat tattttttcc acatataaag ctttgtcttt
     2581 ttgttgttgt tgttgttttt aagatggagt ttccctctgt tgccaggcta gagtgcagtg
     2641 gcatgatctc ggcttactgc aacctttgcc tcccaggttc aagcgattct tctgcctcag
     2701 cctcccgagt agctgggacc acaggtgcct accaccatgc caggctaatt tttgtatttt
     2761 tagtaaagac agggtttcac catattggcc aggctggtct cgaactcctg accttgtgat
     2821 ctgcccgcct ccatttttgt tgttattttt tgagaaagat agatatgagg tttagagagg
     2881 gatgaagagg tgagagtaag ccttgtgtta gtcagaactc tgtgttgtga atgtcattca
     2941 caacagaaaa cccaaaatat tatgcaaact actgtaagca agaaaaataa aggaaaaatg
     3001 gaaacattta ttcctttgca taatagaaat taccagagtt gttctgtctt tagataaggt
     3061 ttgaaccaaa gctcaaaaca atcaagaccc ttttctgtat gtccttctgt tctgccttcc
     3121 gcagtgtagg ctttaccctc aggtgctaca cagtatagtt ctagggtttc cctcccgata
     3181 tcaaaaagac tgtggcctgc ccagctctcg tatccccaag ccacaccatc tggctaaatg
     3241 gacatcatgt tttctggtga tgcccaaaga ggagagagga agctctcttt cccagatgcc
     3301 ccagcaagtg taaccttgca tctcattgct ctggctgagt tgtgtgcctg tttctgacca
     3361 atcactgagt caggaggatg aaatattcat attgacttaa ttgcagctta agttaggggt
     3421 atgtagaggt attttcccta aagcaaaatt gggacactgt tatcagaaat aggagagtgg
     3481 atgatagatg caaaataata cctgtccaca acaaactctt aatgctgtgt ttgagctttc
     3541 atgagtttcc cagagagaca tagctggaaa attcctattg attttctcta aaatttcaac
     3601 aagtagctaa agtctggcta tgctcacagt ctcacatctg gttggggtgg gctccttaca
     3661 gaacacgctt tcacagttac cctaaactct ctggggcagg gttattcctt tgtggaacca
     3721 gaggcacaga gagagtcaac tgaggccaaa agaggcctga gagaaactga ggtcaagatt
     3781 tcaggattaa tggtcctgtg atgctttgaa gtacaattgt ggatttgtcc aattctcttt
     3841 agttctgtca gcttttgctt catatatttt agcgctctat tattagatat atacatgttt
     3901 agtattatgt cttattggtg catttactct cttatcatta tgtaatgtcc ttctttatct
     3961 gtgataattt tctgtgttct gaagtctact ttgtctaaaa ataacatacg cactcaactt
     4021 ccttttcttt cttccttcct ttctttcttc cttcctttct ttctctctct ctctctttcc
     4081 ttccttcctt cctccttttc tttctctctc tctctctctc tctttttttg acagactctc
     4141 gttctgtggc cctggctgga gttcagtggt gtgatcttgg ctcactgcta cctctaccat
     4201 gagcaattct cctgcctcag cctcccaagt agctggaact acaggctcat gccactgcgc
     4261 ccagctaatt tttgtatttt tcgtagagac ggggtttcac cacattcgtc aggttggttt
     4321 caaactcctg actttgtgat ccacccgcct cggcctccca aagtgctggg attacaggca
     4381 tgagccatca cacctggtca actttctttt gattagtgtt tttgtggtat atctttttcc
     4441 atcatgttac tttaaatata tctatattat tgtatttaaa atgtgtttct tacagactgc
     4501 atgtagttgg gtataatttt tatccagtct aaaaatatct gtcttttaat tggtgtttag
     4561 acaatttata tttaataaaa ttgttgaatt taa
//
