LOCUS       NM_018269               2181 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens acireductone dioxygenase 1 (ADI1), transcript variant
            1, mRNA.
ACCESSION   NM_018269
VERSION     NM_018269.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2181)
  AUTHORS   Bae,D.H., Lane,D.J.R., Siafakas,A.R., Sutak,R., Paluncic,J.,
            Huang,M.L.H., Jansson,P.J., Rahmanto,Y.S. and Richardson,D.R.
  TITLE     Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by
            a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting
            as a potential co-chaperone
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (10), 165844 (2020)
   PUBMED   32480040
  REMARK    GeneRIF: Acireductone dioxygenase 1 (ADI1) is regulated by cellular
            iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2
            acting as a potential co-chaperone.
REFERENCE   2  (bases 1 to 2181)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2181)
  AUTHORS   Qiang,L., Cao,H., Chen,J., Weller,S.G., Krueger,E.W., Zhang,L.,
            Razidlo,G.L. and McNiven,M.A.
  TITLE     Pancreatic tumor cell metastasis is restricted by MT1-MMP binding
            protein MTCBP-1
  JOURNAL   J Cell Biol 218 (1), 317-332 (2019)
   PUBMED   30487181
  REMARK    GeneRIF: Pancreatic tumor cell metastasis is restricted by MT1-MMP
            binding protein MTCBP-1.
REFERENCE   4  (bases 1 to 2181)
  AUTHORS   Su,L., Yang,K., Li,S., Liu,C., Han,J., Zhang,Y. and Xu,G.
  TITLE     Enolase-phosphatase 1 as a novel potential malignant glioma
            indicator promotes cell proliferation and migration
  JOURNAL   Oncol Rep 40 (4), 2233-2241 (2018)
   PUBMED   30066900
  REMARK    GeneRIF: High ADI1 expression is associated with malignant glioma.
REFERENCE   5  (bases 1 to 2181)
  AUTHORS   Deshpande,A.R., Pochapsky,T.C., Petsko,G.A. and Ringe,D.
  TITLE     Dual chemistry catalyzed by human acireductone dioxygenase
  JOURNAL   Protein Eng Des Sel 30 (3), 197-204 (2017)
   PUBMED   28062648
  REMARK    GeneRIF: The thermal stability of the HsARD isozymes is a function
            of the metal ion identity, with Ni2+-bound HsARD being the most
            stable followed by Co2+ and Fe2+, and Mn2+-bound HsARD being the
            least stable.
REFERENCE   6  (bases 1 to 2181)
  AUTHORS   Gotoh,I., Uekita,T. and Seiki,M.
  TITLE     Regulated nucleo-cytoplasmic shuttling of human aci-reductone
            dioxygenase (hADI1) and its potential role in mRNA processing
  JOURNAL   Genes Cells 12 (1), 105-117 (2007)
   PUBMED   17212658
  REMARK    GeneRIF: nucleo-cytoplasmic transport of hADI1 is regulated by a
            non-canonical nuclear export signal (NES) located in the N-terminal
            region of hADI1.
REFERENCE   7  (bases 1 to 2181)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 2181)
  AUTHORS   Hirano,W., Gotoh,I., Uekita,T. and Seiki,M.
  TITLE     Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding
            protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase
            (ARD) in the methionine salvage pathway
  JOURNAL   Genes Cells 10 (6), 565-574 (2005)
   PUBMED   15938715
REFERENCE   9  (bases 1 to 2181)
  AUTHORS   Uekita,T., Gotoh,I., Kinoshita,T., Itoh,Y., Sato,H., Shiomi,T.,
            Okada,Y. and Seiki,M.
  TITLE     Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding
            protein-1 is a new member of the Cupin superfamily. A possible
            multifunctional protein acting as an invasion suppressor
            down-regulated in tumors
  JOURNAL   J Biol Chem 279 (13), 12734-12743 (2004)
   PUBMED   14718544
  REMARK    GeneRIF: MTCBP-1 is a new member of the Cupin superfamily with a
            role as an invasion suppressor down-regulated in tumors
REFERENCE   10 (bases 1 to 2181)
  AUTHORS   Yeh,C.T., Lai,H.Y., Chen,T.C., Chu,C.M. and Liaw,Y.F.
  TITLE     Identification of a hepatic factor capable of supporting hepatitis
            C virus replication in a nonpermissive cell line
  JOURNAL   J Virol 75 (22), 11017-11024 (2001)
   PUBMED   11602742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB129674.1, BC001467.2,
            AB073609.1 and AC114810.4.
            
            On Nov 22, 2018 this sequence version replaced NM_018269.3.
            
            Summary: This gene encodes an enzyme that belongs to the
            aci-reductone dioxygenase family of metal-binding enzymes, which
            are involved in methionine salvage. This enzyme may regulate mRNA
            processing in the nucleus, and may carry out different functions
            depending on its localization. Related pseudogenes have been
            defined on chromosomes 8 and 20. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.151555.1,
                                           SRR1803614.65319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMEA2162328
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327435.11/ ENSP00000333666.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CB129674.1         49-59
            12-1094             BC001467.2         1-1083
            1095-1628           AB073609.1         1094-1627
            1629-2181           AC114810.4         105469-106021       c
FEATURES             Location/Qualifiers
     source          1..2181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p25.3"
     gene            1..2181
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /note="acireductone dioxygenase 1"
                     /db_xref="GeneID:55256"
                     /db_xref="HGNC:HGNC:30576"
                     /db_xref="MIM:613400"
     exon            1..164
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..584
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /EC_number="1.13.11.54"
                     /EC_number="1.13.11.53"
                     /note="isoform 1 is encoded by transcript variant 1;
                     submergence induced protein 2; membrane-type 1 matrix
                     metalloproteinase cytoplasmic tail binding protein-1;
                     MT1-MMP cytoplasmic tail-binding protein-1; acireductone
                     dioxygenase (Ni(2+)-requiring); submergence-induced
                     protein-like factor; acireductone dioxygenase
                     (Fe(2+)-requiring)"
                     /codon_start=1
                     /product="acireductone dioxygenase isoform 1"
                     /protein_id="NP_060739.2"
                     /db_xref="CCDS:CCDS1653.1"
                     /db_xref="GeneID:55256"
                     /db_xref="HGNC:HGNC:30576"
                     /db_xref="MIM:613400"
                     /translation="MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDAD
                     KYENDPELEKIRRERNYSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGS
                     GYFDVRDKEDQWIRIFMEKGDMVTLPAGIYHRFTVDEKNYTKAMRLFVGEPVWTAYNR
                     PADHFEARGQYVKFLAQTA"
     exon            165..284
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /inference="alignment:Splign:2.1.0"
     exon            285..464
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /inference="alignment:Splign:2.1.0"
     exon            465..2181
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1071..1076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /note="hexamer: AATAAA"
     polyA_site      1094
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /note="major polyA site"
     regulatory      1260..1265
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /note="hexamer: AATAAA"
     polyA_site      1280
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /note="major polyA site"
     regulatory      1604..1609
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /note="hexamer: ATTAAA"
     polyA_site      1628
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
     regulatory      2161..2166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
                     /note="hexamer: AATAAA"
     polyA_site      2181
                     /gene="ADI1"
                     /gene_synonym="APL1; ARD; ARD'; Fe-ARD; HMFT1638; MTCBP1;
                     mtnD; Ni-ARD; SIPL"
ORIGIN      
        1 gagcgcggcc cctgggttcg aacacggcac ccgcactgcg cgtcatggtg caggcctggt
       61 atatggacga cgccccgggc gacccgcggc aaccccaccg ccccgacccc ggccgcccag
      121 tgggcctgga gcagctgcgg cggctcgggg tgctctactg gaagctggat gctgacaaat
      181 atgagaatga tccagaatta gaaaagatcc gaagagagag gaactactcc tggatggaca
      241 tcataaccat atgcaaagat aaactaccaa attatgaaga aaagattaag atgttctacg
      301 aggagcattt gcacttggac gatgagatcc gctacatcct ggatggcagt gggtacttcg
      361 atgtgaggga caaggaggac cagtggatcc ggatcttcat ggagaaggga gacatggtga
      421 cgctccccgc ggggatctat caccgcttca cggtggacga gaagaactac acgaaggcca
      481 tgcggctgtt tgtgggagaa ccggtgtgga cagcgtacaa ccggcccgct gaccattttg
      541 aagcccgcgg gcagtacgtg aaatttctgg cacagaccgc ctagcagtgc tgcctgggaa
      601 ctaacacgtg cctcgtaaag gtccccaatg taatgactga gcagaaaatc aatcactttc
      661 tctttgcttt tagaggatag ccttgaggct agattatctt tcctttgtaa gattatttga
      721 tcagaatatt ttgtaatgaa aggatctaga aagcaacttg gaagtgtaaa gagtcacctt
      781 cattttctgt aactcaatca agactggtgg gtccatggcc ctgtgttagt tcatgcattc
      841 agttgagtcc caaatgaaag tttcatctcc cgaaatgcag ttccttagat gcccatctgg
      901 acgtgatgcc gcgcctgccg tgtaagaagg tgcaatccta gataacacag ctagccagat
      961 agaagacact tttttctcca aaatgatgcc ttggggtggg gagtggtagg gggaagagct
     1021 cccaccctaa ggggcacaca ctgagttgct tatgccactt ccttgttcaa aataaagtaa
     1081 ctgccttaat cttatactca tggcttggag ttaccttata ttcaggtata tgtgatattt
     1141 tgcctggttt gttaaaattg ccccatttag attccttcta taattgttct tatagataag
     1201 taatttatat atgagctgtg ttagtatttt ttcagtgtga gatctctgga ttctttcaca
     1261 ataaagctgt tgaattttaa caggagtatt agtacataaa ttttctactc aacaattccg
     1321 agataggatt atgcctagtt tgtcatatca cagaaaaact ccaagttaac ttcatgtttt
     1381 ggaagggcag gtcgttttta aagtatttct ttttttaact ggatgaaaaa tcttcatgtt
     1441 aggattaatt ttcttaatca cctccacact gtacagagga aactcaagcc ttaaatgttt
     1501 aagtaaactc tgtctcagtt ttaggattaa aatacccacc ggtggtgtga tgatgccata
     1561 taccgcaggg cttgcttctg tcaagtgtga ctctatctca gtaattaaaa taagtgctga
     1621 tctactgatt ttttttaatg gattcatttc taaatgggca ttataaatag agcttgttca
     1681 tttttaagaa cgaaacattc atatgataaa ctatcgcttt aaattgcctt tcttgcttca
     1741 tataactttt ccctgtcagg atccttagtg tttgaaactc ctcgtgcggg gctggcctcc
     1801 tgcggactct agtttcgcct ccttgatgtg gcgcctggga tttcttcact tcagagctgt
     1861 atttttacag gcaagagtaa gttcctgggc acagtggctc atgcctgtaa tctcagctac
     1921 tcaggaggct aaggtgggag gattcttaga gcctgggagg tcgaggctgc agtgagctgt
     1981 gattgtggcc actgcactcc agcctgggtg acagagcgag actctgtctc aaaaaagaag
     2041 aaagagtaag agctgaggca tataatagaa ttctgctaaa gcacttaagg tgaaatcaca
     2101 ttttcttttc ccaggatgtt gctcacatct ttcgttttta ttgaggtgtc atttatatac
     2161 aataaaatgt actcattttc a
//
