LOCUS       NM_001166504            2100 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens alcohol dehydrogenase 7 (class IV), mu or sigma
            polypeptide (ADH7), transcript variant 1, mRNA.
ACCESSION   NM_001166504
VERSION     NM_001166504.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Kashyap,Y., He,Y., Sadhu,N., Yao,Y., Wilkie,D.J., Molokie,R.E. and
            Wang,Z.J.
  TITLE     An alcohol dehydrogenase 7 gene polymorphism associates with both
            acute and chronic pain in sickle cell disease
  JOURNAL   Pharmacogenomics 24 (12), 641-649 (2023)
   PUBMED   37712142
  REMARK    GeneRIF: An alcohol dehydrogenase 7 gene polymorphism associates
            with both acute and chronic pain in sickle cell disease.
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Zeng,K., Li,Y., Gao,M., Liu,Y.P., Xu,F.L., Xia,X., Yao,J. and
            Wang,B.J.
  TITLE     Association of ADH7 Gene Polymorphism with Schizophrenia in the Han
            Population of Northern China: a Case-Control Study
  JOURNAL   J Mol Neurosci 70 (11), 1851-1857 (2020)
   PUBMED   32388801
  REMARK    GeneRIF: Association of ADH7 Gene Polymorphism with Schizophrenia
            in the Han Population of Northern China: a Case-Control Study.
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Latta,L., Nordstrom,K., Stachon,T., Langenbucher,A., Fries,F.N.,
            Szentmary,N., Seitz,B. and Kasmann-Kellner,B.
  TITLE     Expression of retinoic acid signaling components ADH7 and ALDH1A1
            is reduced in aniridia limbal epithelial cells and a siRNA primary
            cell based aniridia model
  JOURNAL   Exp Eye Res 179, 8-17 (2019)
   PUBMED   30292490
  REMARK    GeneRIF: These results provide evidence that PAX6 might drive
            corneal epithelial differentiation by direct or indirect control of
            retinoic acid signaling processes through ADH7 and ALDH1A1.
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Pastorino,R., Iuliano,L., Vecchioni,A., Arzani,D., Milic,M.,
            Annunziata,F., Zerbinati,C., Capoluongo,E., Bonassi,S., McKay,J.D.
            and Boccia,S.
  TITLE     Effect of alcohol dehydrogenase-1B and -7 polymorphisms on blood
            ethanol and acetaldehyde concentrations in healthy subjects with a
            history of moderate alcohol consumption
  JOURNAL   Drug Test Anal 10 (3), 488-495 (2018)
   PUBMED   28731573
  REMARK    GeneRIF: The results of the study do not support our hypothesis
            that ADH1B and ADH7 genotypes affect blood ethanol, and
            acetaldehyde concentration.
REFERENCE   5  (bases 1 to 2100)
  AUTHORS   Norden-Krichmar,T.M., Gizer,I.R., Wilhelmsen,K.C., Schork,N.J. and
            Ehlers,C.L.
  TITLE     Protective variant associated with alcohol dependence in a Mexican
            American cohort
  JOURNAL   BMC Med Genet 15, 136 (2014)
   PUBMED   25527893
  REMARK    GeneRIF: These results suggest that variants near ADH7 may play a
            role in protection from alcohol dependence in this Mexican American
            cohort.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2100)
  AUTHORS   Zgombic-Knight,M., Foglio,M.H. and Duester,G.
  TITLE     Genomic structure and expression of the ADH7 gene encoding human
            class IV alcohol dehydrogenase, the form most efficient for retinol
            metabolism in vitro
  JOURNAL   J Biol Chem 270 (9), 4305-4311 (1995)
   PUBMED   7876191
REFERENCE   7  (bases 1 to 2100)
  AUTHORS   Kedishvili,N.Y., Bosron,W.F., Stone,C.L., Hurley,T.D., Peggs,C.F.,
            Thomasson,H.R., Popov,K.M., Carr,L.G., Edenberg,H.J. and Li,T.K.
  TITLE     Expression and kinetic characterization of recombinant human
            stomach alcohol dehydrogenase. Active-site amino acid sequence
            explains substrate specificity compared with liver isozymes
  JOURNAL   J Biol Chem 270 (8), 3625-3630 (1995)
   PUBMED   7876099
REFERENCE   8  (bases 1 to 2100)
  AUTHORS   Cheung,B., Anderson,J.K., Holmes,R.S. and Beacham,I.R.
  TITLE     Human stomach class IV alcohol dehydrogenase: molecular genetic
            analysis
  JOURNAL   Alcohol Clin Exp Res 19 (1), 185-186 (1995)
   PUBMED   7771649
REFERENCE   9  (bases 1 to 2100)
  AUTHORS   Pares,X., Cederlund,E., Moreno,A., Saubi,N., Hoog,J.O. and
            Jornvall,H.
  TITLE     Class IV alcohol dehydrogenase (the gastric enzyme). Structural
            analysis of human sigma sigma-ADH reveals class IV to be variable
            and confirms the presence of a fifth mammalian alcohol
            dehydrogenase class
  JOURNAL   FEBS Lett 303 (1), 69-72 (1992)
   PUBMED   1592118
REFERENCE   10 (bases 1 to 2100)
  AUTHORS   Lange,L.G., Sytkowski,A.J. and Vallee,B.L.
  TITLE     Human liver alcohol dehydrogenase: purification, composition, and
            catalytic features
  JOURNAL   Biochemistry 15 (21), 4687-4693 (1976)
   PUBMED   9982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK301696.1, CD014081.1,
            DB350054.1 and CA311897.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001166504.1.
            
            Summary: This gene encodes class IV alcohol dehydrogenase 7 mu or
            sigma subunit, which is a member of the alcohol dehydrogenase
            family. Members of this family metabolize a wide variety of
            substrates, including ethanol, retinol, other aliphatic alcohols,
            hydroxysteroids, and lipid peroxidation products. The enzyme
            encoded by this gene is inefficient in ethanol oxidation, but is
            the most active as a retinol dehydrogenase; thus it may participate
            in the synthesis of retinoic acid, a hormone important for cellular
            differentiation. The expression of this gene is much more abundant
            in stomach than liver, thus differing from the other known gene
            family members. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301696.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2154405
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-899               AK301696.1         1-899
            900-915             CD014081.1         963-978
            916-1325            AK301696.1         916-1325
            1326-1673           DB350054.1         57-404              c
            1674-2100           CA311897.1         21-447              c
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2100
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /note="alcohol dehydrogenase 7 (class IV), mu or sigma
                     polypeptide"
                     /db_xref="GeneID:131"
                     /db_xref="HGNC:HGNC:256"
                     /db_xref="MIM:600086"
     exon            1..108
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            109..210
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            211..349
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            350..437
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            438..654
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            655..915
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1051
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1190
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..2100
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2083..2088
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /note="hexamer: ATTAAA"
     polyA_site      2100
                     /gene="ADH7"
                     /gene_synonym="ADH4"
                     /note="major polyA site"
ORIGIN      
        1 aattaaacac ttggagatat tccttgagga atgaaatgct tggtgagcag gcatacagtg
       61 agggaaacac tggatatggt gtttcagaga atgtcagtgg aagcaggggt tattaaatgc
      121 aaagcagctg tgctttggga gcagaagcaa cccttctcca ttgaggaaat agaagttgcc
      181 ccaccaaaga ctaaagaagt tcgcattaag attttggcca caggaatctg tcgcacagat
      241 gaccatgtga taaaaggaac aatggtgtcc aagtttccag tgattgtggg acatgaggca
      301 actgggattg tagagagcat tggagaagga gtgactacag tgaaaccagg tgacaaagtc
      361 atccctctct ttctgccaca atgtagagaa tgcaatgctt gtcgcaaccc agatggcaac
      421 ctttgcatta ggagcgatat tactggtcgt ggagtactgg ctgatggcac caccagattt
      481 acatgcaagg gcaaaccagt ccaccacttc atgaacacca gtacatttac cgagtacaca
      541 gtggtggatg aatcttctgt tgctaagatt gatgatgcag ctcctcctga gaaagtctgt
      601 ttaattggct gtgggttttc cactggatat ggcgctgctg ttaaaactgg caaggtcaaa
      661 cctggttcca cttgcgtcgt ctttggcctg ggaggagttg gcctgtcagt catcatgggc
      721 tgtaagtcag ctggtgcatc taggatcatt gggattgacc tcaacaaaga caaatttgag
      781 aaggccatgg ctgtaggtgc cactgagtgt atcagtccca aggactctac caaacccatc
      841 agtgaggtgc tgtcagaaat gacaggcaac aacgtgggat acacctttga agttattggg
      901 catcttgaaa ccatgattga tgccctggca tcctgccaca tgaactatgg gaccagcgtg
      961 gttgtaggag ttcctccatc agccaagatg ctcacctatg acccgatgtt gctcttcact
     1021 ggacgcacat ggaagggatg tgtctttgga ggtttgaaaa gcagagatga tgtcccaaaa
     1081 ctagtgactg agttcctggc aaagaaattt gacctggacc agttgataac tcatgtttta
     1141 ccatttaaaa aaatcagtga aggatttgag ctgctcaatt caggacaaag cattcgaacg
     1201 gtcctgacgt tttgagatcc aaagtggcag gaggtctgtg ttgtcatggt gaactggagt
     1261 ttctcttgtg agagttccct catctgaaat catgtatctg tctcacaaat acaagcataa
     1321 gtagaagatt tgttgaagac atagaaccct tataaagaat tattaacctt tataaacatt
     1381 taaagtcttg tgagcacctg ggaattagta taataacaat gttaatattt ttgatttaca
     1441 ttttgtaagg ctataattgt atcttttaag aaaacataca cttggatttc tatgttgaaa
     1501 tggagatttt taagagtttt aaccagctgc tgcagatata taactcaaaa cagatatagc
     1561 gtataaagat atagtaaatg catctcctag agtaatattc acttaacaca ttgaaactat
     1621 tattttttag atttgaatat aaatgtattt tttaaacact tgttatgagt taagttggat
     1681 tacattttga aatcagttca ttccatgatg catattactg gattagatta agaaagacag
     1741 aaaagattaa gggacgggca catttttcaa cgattaagaa tcatcattac ataacttggt
     1801 gaaactgaaa aagtatatca tatgggtaca caaggctatt tgccagcata tattaatatt
     1861 ttagaaaata ttccttttgt aatactgaat ataaacatag agctagaatc atattatcat
     1921 acttatcata atgttcaatt tgatacagta gaattgcaag tccctaagtc cctattcact
     1981 gtgcttagta gtgactccat ttaataaaaa gtgtttttag tttttaacaa ctacactgat
     2041 gtatctatat atatctataa catgttaaaa attcttaaga aaattaaaaa ttatataaaa
//
